SE503402C2 - Immunglobulinkojugat, förfarande för framställning av densamma samt komposition innehållande densamma - Google Patents

Immunglobulinkojugat, förfarande för framställning av densamma samt komposition innehållande densamma

Info

Publication number
SE503402C2
SE503402C2 SE8800886A SE8800886A SE503402C2 SE 503402 C2 SE503402 C2 SE 503402C2 SE 8800886 A SE8800886 A SE 8800886A SE 8800886 A SE8800886 A SE 8800886A SE 503402 C2 SE503402 C2 SE 503402C2
Authority
SE
Sweden
Prior art keywords
ida
antibody
conjugate
cells
mice
Prior art date
Application number
SE8800886A
Other languages
English (en)
Swedish (sv)
Other versions
SE8800886L (sv
SE8800886D0 (sv
Inventor
Ian Farquhar Campbell Mckenzie
Geoffrey Allan Pietersz
Mark John Smyth
Original Assignee
Erba Carlo Spa
Univ Melbourne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa, Univ Melbourne filed Critical Erba Carlo Spa
Publication of SE8800886D0 publication Critical patent/SE8800886D0/xx
Publication of SE8800886L publication Critical patent/SE8800886L/
Publication of SE503402C2 publication Critical patent/SE503402C2/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE8800886A 1987-03-11 1988-03-11 Immunglobulinkojugat, förfarande för framställning av densamma samt komposition innehållande densamma SE503402C2 (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPI080387 1987-03-11
AUPI295587 1987-07-07

Publications (3)

Publication Number Publication Date
SE8800886D0 SE8800886D0 (sv) 1988-03-11
SE8800886L SE8800886L (sv) 1989-09-12
SE503402C2 true SE503402C2 (sv) 1996-06-10

Family

ID=25643244

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8800886A SE503402C2 (sv) 1987-03-11 1988-03-11 Immunglobulinkojugat, förfarande för framställning av densamma samt komposition innehållande densamma

Country Status (29)

Country Link
US (1) US5798097A (no)
JP (1) JP2736255B2 (no)
KR (1) KR0130906B1 (no)
CN (1) CN1045621C (no)
AT (1) AT395375B (no)
AU (1) AU622105B2 (no)
BE (1) BE1001051A4 (no)
CA (1) CA1329156C (no)
CH (1) CH678815A5 (no)
CZ (1) CZ161288A3 (no)
DE (1) DE3808166C2 (no)
DK (1) DK173792B1 (no)
ES (1) ES2006109A6 (no)
FI (1) FI98706C (no)
FR (1) FR2612074B1 (no)
GB (1) GB2203154B (no)
GR (1) GR1000059B (no)
HU (1) HU205266B (no)
IE (1) IE64781B1 (no)
IL (1) IL85688A0 (no)
IT (1) IT8819746A0 (no)
MY (1) MY103231A (no)
NL (1) NL8800610A (no)
NO (1) NO178954C (no)
NZ (1) NZ223834A (no)
PT (1) PT86960B (no)
RU (1) RU2106147C1 (no)
SE (1) SE503402C2 (no)
YU (1) YU46858B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6824777B1 (en) * 1992-10-09 2004-11-30 Licentia Ltd. Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
JP4841724B2 (ja) * 1998-10-09 2011-12-21 ベジェニクス ピーティーワイ リミテッド 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３）
WO2002049672A2 (en) * 2000-12-21 2002-06-27 Mcgill University Conjugates of antibodies and anticancer drugs
ATE359300T1 (de) 2001-01-19 2007-05-15 Ludwig Inst Cancer Res Flt4 (vegfr-3) als ein ziel für krebs darstellung und anti-krebs-behandlung
EP1620564A4 (en) * 2003-04-18 2008-03-12 Cytovia Inc METHOD FOR TREATING DISEASES RESPONSING TO APOPTOSIS INDUCTION AND SCREENING TESTS
GB0511266D0 (en) * 2005-06-02 2005-07-13 Trust Chemical compounds
US20080108138A1 (en) * 2006-06-13 2008-05-08 Vermette Patrick Bioactive compositions and their use in cell patterning
EA034333B1 (ru) 2010-11-30 2020-01-29 Дженентек, Инк. Варианты антитела для переноса соединения через гематоэнцефалический барьер
SI2956476T1 (sl) 2013-02-18 2020-03-31 Vegenics Pty Limited Molekule za vezavo na ligande in uporabe le-teh

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT346838B (de) * 1975-01-22 1978-11-27 Farmaceutici Italia Verfahren zur herstellung von neuen optisch aktiven anthracyclinonen
AT343812B (de) * 1975-01-22 1978-06-26 Farmaceutici Italia Verfahren zur herstellung von neuen optisch aktiven daunosaminylderivaten von anthracyclinonen
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
AT343811B (de) * 1975-01-22 1978-06-26 Farmaceutici Italia Verfahren zur herstellung von neuen optisch aktiven anthracyclinonen
GB1511680A (en) 1975-11-18 1978-05-24 Farmaceutici Italia Daunosaminyl anthracyclinones
GB1541436A (en) * 1976-02-02 1979-02-28 Searle & Co Immunological materials
US5162512A (en) * 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
US4867973A (en) * 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
US4950738A (en) * 1984-09-13 1990-08-21 Cytogen Corporation Amine derivatives of anthracycline antibiotics
JPS59186924A (ja) * 1983-04-08 1984-10-23 Kureha Chem Ind Co Ltd ヒト免疫グロブリン結合抗腫瘍剤
US4545985A (en) 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
GB8413464D0 (en) * 1984-05-25 1984-07-04 Erba Farmitalia Anthracycline-anionic polymer conjugates
JPS61155334A (ja) * 1984-12-28 1986-07-15 Teijin Ltd 殺細胞性修飾免疫グロブリン及びその製造方法
FR2584293B1 (fr) * 1985-07-04 1989-03-17 Ire Celltarg Sa Anticorps utiles comme agents de pilotage et conjugues les incorporant

Also Published As

Publication number Publication date
KR880010775A (ko) 1988-10-24
FI881158A (fi) 1988-09-12
GR880100148A (en) 1989-01-31
DK131588A (da) 1988-09-12
YU46858B (sh) 1994-06-24
GB8805865D0 (en) 1988-04-13
NO178954B (no) 1996-04-01
MY103231A (en) 1993-05-29
FI98706B (fi) 1997-04-30
AU622105B2 (en) 1992-04-02
NO881105D0 (no) 1988-03-11
CN88101810A (zh) 1988-11-09
AU1288188A (en) 1988-09-15
GR1000059B (el) 1990-06-27
CZ281193B6 (cs) 1996-07-17
IL85688A0 (en) 1988-08-31
DK173792B1 (da) 2001-11-05
JP2736255B2 (ja) 1998-04-02
FI98706C (fi) 1997-08-11
CN1045621C (zh) 1999-10-13
FR2612074B1 (fr) 1991-06-21
FR2612074A1 (fr) 1988-09-16
NZ223834A (en) 1990-05-28
BE1001051A4 (fr) 1989-06-20
NO881105L (no) 1988-09-12
PT86960A (pt) 1988-04-01
DK131588D0 (da) 1988-03-11
NL8800610A (nl) 1988-10-03
HU205266B (en) 1992-04-28
CA1329156C (en) 1994-05-03
PT86960B (pt) 1992-06-30
IE64781B1 (en) 1995-09-06
ES2006109A6 (es) 1989-04-01
YU48288A (en) 1989-08-31
DE3808166A1 (de) 1988-09-22
SE8800886L (sv) 1989-09-12
KR0130906B1 (ko) 1998-04-23
CZ161288A3 (en) 1996-07-17
GB2203154B (en) 1991-06-26
ATA67488A (de) 1992-05-15
NO178954C (no) 1996-07-10
US5798097A (en) 1998-08-25
JPS63301832A (ja) 1988-12-08
FI881158A0 (fi) 1988-03-11
HUT46547A (en) 1988-11-28
IT8819746A0 (it) 1988-03-11
AT395375B (de) 1992-12-10
NL195078C (no) 2003-07-30
GB2203154A (en) 1988-10-12
CH678815A5 (no) 1991-11-15
RU2106147C1 (ru) 1998-03-10
SE8800886D0 (sv) 1988-03-11
DE3808166C2 (de) 1997-08-28
IE880701L (en) 1988-09-11

Similar Documents

Publication Publication Date Title
Smyth et al. Specific targeting of chlorambucil to tumors with the use of monoclonal antibodies
CA1222694A (en) Immunochemotherapy for malignant tumors, particularly pancreatic cancer
Pietersz et al. Immunochemotherapy of a murine thymoma with the use of idarubicin monoclonal antibody conjugates
Smyth et al. Selective enhancement of antitumor activity of N-acetyl melphalan upon conjugation to monoclonal antibodies
SE503402C2 (sv) Immunglobulinkojugat, förfarande för framställning av densamma samt komposition innehållande densamma
US5075108A (en) Melphalan derivatives
US5144012A (en) Cytotoxic drug conjugates
WO1998033528A9 (en) Induction of b cell tolerance
RU2009500C1 (ru) Способ получения цитотоксического коньюгата
Smyth et al. The in vitro and in vivo anti-tumour activity of N-AcMEL-(Fab') 2 conjugates
US20080095802A1 (en) Targeted delivery of cytotoxic drugs A) to activated lymphocytes in patients iwth transplanted organs, B) as radiosensitizers to cancer cells in paients undergoing radiation therapy, and C) in vitaminpbinding proteins as drug carriers in the diagnosis and treatment of cancer
EP1305051A2 (en) Targeted delivery of cytotoxic drugs a) to activated lymphocytes in patients with transplanted organs, b) as radiosensitizers to cancer cells in patients undergoing radiation therapy, and c) in vitamin-binding proteins as drug carriers in the diagnosis and treatment of cancer
AU2007201744A1 (en) Targeted delivery of cytotoxic drugs A) to activated lymphocytes in patients with transplanted organs, B) as radiosensitizers to cancer cells in patients undergoing radiation therapy, and C) in vitamin binding proteins as drug carriers in the diagnosis and treatment of cancer
WO2000009155A1 (en) Methods and compositions for preventing anti-gal production in xenograft recipients
WO1992014758A1 (en) Conjugate molecules

Legal Events

Date Code Title Description
NUG Patent has lapsed