PT86960A - Process for the preparation of immunoglobulin conjugates - Google Patents

Process for the preparation of immunoglobulin conjugates

Info

Publication number
PT86960A
PT86960A PT86960A PT8696088A PT86960A PT 86960 A PT86960 A PT 86960A PT 86960 A PT86960 A PT 86960A PT 8696088 A PT8696088 A PT 8696088A PT 86960 A PT86960 A PT 86960A
Authority
PT
Portugal
Prior art keywords
preparation
immunoglobulin conjugates
conjugates
immunoglobulin
Prior art date
Application number
PT86960A
Other languages
English (en)
Other versions
PT86960B (pt
Inventor
Ian Farquhar Campbell Mckenzie
Geoffrey Allan Pietersz
Mark John Smyth
Original Assignee
Erba Farmitalia
Univ Melbourne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia, Univ Melbourne filed Critical Erba Farmitalia
Publication of PT86960A publication Critical patent/PT86960A/pt
Publication of PT86960B publication Critical patent/PT86960B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT86960A 1987-03-11 1988-03-11 Processo para a preparacao de conjugados de imunoglobulina PT86960B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPI080387 1987-03-11
AUPI295587 1987-07-07

Publications (2)

Publication Number Publication Date
PT86960A true PT86960A (pt) 1988-04-01
PT86960B PT86960B (pt) 1992-06-30

Family

ID=25643244

Family Applications (1)

Application Number Title Priority Date Filing Date
PT86960A PT86960B (pt) 1987-03-11 1988-03-11 Processo para a preparacao de conjugados de imunoglobulina

Country Status (29)

Country Link
US (1) US5798097A (pt)
JP (1) JP2736255B2 (pt)
KR (1) KR0130906B1 (pt)
CN (1) CN1045621C (pt)
AT (1) AT395375B (pt)
AU (1) AU622105B2 (pt)
BE (1) BE1001051A4 (pt)
CA (1) CA1329156C (pt)
CH (1) CH678815A5 (pt)
CZ (1) CZ161288A3 (pt)
DE (1) DE3808166C2 (pt)
DK (1) DK173792B1 (pt)
ES (1) ES2006109A6 (pt)
FI (1) FI98706C (pt)
FR (1) FR2612074B1 (pt)
GB (1) GB2203154B (pt)
GR (1) GR1000059B (pt)
HU (1) HU205266B (pt)
IE (1) IE64781B1 (pt)
IL (1) IL85688A0 (pt)
IT (1) IT8819746A0 (pt)
MY (1) MY103231A (pt)
NL (1) NL8800610A (pt)
NO (1) NO178954C (pt)
NZ (1) NZ223834A (pt)
PT (1) PT86960B (pt)
RU (1) RU2106147C1 (pt)
SE (1) SE503402C2 (pt)
YU (1) YU46858B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6824777B1 (en) 1992-10-09 2004-11-30 Licentia Ltd. Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
WO2002060950A2 (en) 1994-11-14 2002-08-08 Ludwig Institute For Cancer Research Flt4(vegfr-3) as a target for tumor imaging and anti-tumor therapy
CA2345276C (en) * 1998-10-09 2011-03-29 Ludwig Institute For Cancer Research Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy
EP1343531A2 (en) * 2000-12-21 2003-09-17 McGILL UNIVERSITY Conjugates of antibodies and anticancer drugs
EP1620564A4 (en) * 2003-04-18 2008-03-12 Cytovia Inc METHODS FOR TREATING DISEASES INDUCING APOPTOSIS INDUCTION AND SCREENING ASSAYS
GB0511266D0 (en) * 2005-06-02 2005-07-13 Trust Chemical compounds
US20080108138A1 (en) * 2006-06-13 2008-05-08 Vermette Patrick Bioactive compositions and their use in cell patterning
CN110251668A (zh) 2010-11-30 2019-09-20 霍夫曼-拉罗奇有限公司 低亲和力血脑屏障受体抗体及其用途
SMT202000088T1 (it) 2013-02-18 2020-03-13 Vegenics Pty Ltd Molecole leganti ligandi e relativi usi
EP4157241A4 (en) * 2020-05-29 2025-01-08 The Regents of the University of California AGENTS AND METHODS FOR THE TREATMENT OF TAUOPATHIES

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
AT343812B (de) * 1975-01-22 1978-06-26 Farmaceutici Italia Verfahren zur herstellung von neuen optisch aktiven daunosaminylderivaten von anthracyclinonen
AT346838B (de) * 1975-01-22 1978-11-27 Farmaceutici Italia Verfahren zur herstellung von neuen optisch aktiven anthracyclinonen
AT343811B (de) * 1975-01-22 1978-06-26 Farmaceutici Italia Verfahren zur herstellung von neuen optisch aktiven anthracyclinonen
GB1511680A (en) 1975-11-18 1978-05-24 Farmaceutici Italia Daunosaminyl anthracyclinones
GB1541436A (en) * 1976-02-02 1979-02-28 Searle & Co Immunological materials
US4950738A (en) * 1984-09-13 1990-08-21 Cytogen Corporation Amine derivatives of anthracycline antibiotics
US5162512A (en) * 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
US4867973A (en) * 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
JPS59186924A (ja) * 1983-04-08 1984-10-23 Kureha Chem Ind Co Ltd ヒト免疫グロブリン結合抗腫瘍剤
US4545985A (en) * 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
GB8413464D0 (en) * 1984-05-25 1984-07-04 Erba Farmitalia Anthracycline-anionic polymer conjugates
JPS61155334A (ja) * 1984-12-28 1986-07-15 Teijin Ltd 殺細胞性修飾免疫グロブリン及びその製造方法
FR2584293B1 (fr) * 1985-07-04 1989-03-17 Ire Celltarg Sa Anticorps utiles comme agents de pilotage et conjugues les incorporant

Also Published As

Publication number Publication date
JP2736255B2 (ja) 1998-04-02
IE880701L (en) 1988-09-11
SE503402C2 (sv) 1996-06-10
DE3808166C2 (de) 1997-08-28
AU622105B2 (en) 1992-04-02
NL8800610A (nl) 1988-10-03
US5798097A (en) 1998-08-25
NZ223834A (en) 1990-05-28
IL85688A0 (en) 1988-08-31
HU205266B (en) 1992-04-28
NO881105D0 (no) 1988-03-11
FI98706C (fi) 1997-08-11
CA1329156C (en) 1994-05-03
FR2612074A1 (fr) 1988-09-16
NL195078C (pt) 2003-07-30
GR1000059B (el) 1990-06-27
CN1045621C (zh) 1999-10-13
IE64781B1 (en) 1995-09-06
BE1001051A4 (fr) 1989-06-20
GR880100148A (en) 1989-01-31
RU2106147C1 (ru) 1998-03-10
ES2006109A6 (es) 1989-04-01
KR0130906B1 (ko) 1998-04-23
JPS63301832A (ja) 1988-12-08
NO178954B (no) 1996-04-01
DK131588D0 (da) 1988-03-11
GB2203154B (en) 1991-06-26
CH678815A5 (pt) 1991-11-15
MY103231A (en) 1993-05-29
YU48288A (en) 1989-08-31
NO178954C (no) 1996-07-10
FR2612074B1 (fr) 1991-06-21
SE8800886D0 (sv) 1988-03-11
FI881158L (fi) 1988-09-12
IT8819746A0 (it) 1988-03-11
GB8805865D0 (en) 1988-04-13
CN88101810A (zh) 1988-11-09
AU1288188A (en) 1988-09-15
FI881158A0 (fi) 1988-03-11
AT395375B (de) 1992-12-10
YU46858B (sh) 1994-06-24
DE3808166A1 (de) 1988-09-22
DK173792B1 (da) 2001-11-05
PT86960B (pt) 1992-06-30
GB2203154A (en) 1988-10-12
CZ281193B6 (cs) 1996-07-17
KR880010775A (ko) 1988-10-24
HUT46547A (en) 1988-11-28
FI98706B (fi) 1997-04-30
CZ161288A3 (en) 1996-07-17
NO881105L (no) 1988-09-12
DK131588A (da) 1988-09-12
ATA67488A (de) 1992-05-15
SE8800886L (sv) 1989-09-12

Similar Documents

Publication Publication Date Title
FI914174A7 (fi) Menetelmä piperidyylialkyyliamiinien valmistamiseksi
FI875660L (fi) Menetelmä terapeuttisesti käyttökelpoisten 5-fenyyli-2-pyrimidinonijohdannaisten valmistamiseksi
FI885361A7 (fi) Lääkeaine-monoklonaaliset vasta-aine-konjugaatit
FI875024A7 (fi) Menetelmä terapeuttisesti käyttökelpoisten 1-alkyyli-6-halogeenitetrahydronaftaleenijohdannaisten valmistamiseksi
PT86875A (pt) Process for the preparation of phenylcarbamate
NO176922C (no) Fremgangsmåte for fremstilling av bifunksjonelle proteiner
FI893100L (fi) Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi
PT86800A (pt) Process for the preparation of erythromycin derivatives
NO172447C (no) Fremgangsmaate for fremstilling av b-avermectiner
PT86687A (pt) Process for the preparation of novel polyamine derivatives
PT87191A (pt) Process for the preparation of nucleosides
FI881303A0 (fi) Menetelmä ibuprofeenin valmistamiseksi
FI906408L (fi) Menetelmä terapeuttisesti käyttökelpoisten 2-aminopyrimidiini-4-karboksamidijohdannaisten valmistamiseksi
FI91961C (fi) Menetelmä (S)- -etyyli-2-okso-1-pyrrolidiiniasetamidin valmistamiseksi
FI880467A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 3,4-dihydro-2H-bentsopyraanien valmistamiseksi
PT86960A (pt) Process for the preparation of immunoglobulin conjugates
FI890186A7 (fi) Menetelmä 1-hydroksialkyyli-5-nitroimidatsolien valmistamiseksi
FI882165A7 (fi) Menetelmä 4-amino-androsteenidioni-johdannaisten valmistamiseksi.
IS3589A7 (is) Aðferð við framleiðslu á efnasambandinu Indenoindoles I
FI890185A7 (fi) Menetelmä 1-alkyyli-5-nitroimidatsolien valmistamiseksi
PT87857A (pt) Process for the preparation of novel immunossupressant peptides
PT87359A (pt) Process for the preparation of pyrrolidine derivatives
FI890188A7 (fi) Menetelmä 1-hydroksialkyyli-2-metyyli-5-nitroimidatsolien valmistamiseksi
FI913464A7 (fi) Menetelmä 1-hydroksimetyylipyratsolien valmistamiseksi
FI891191A7 (fi) Menetelmä 3-eksometyleeni-kefam-johdannaisten valmistamiseksi

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19911206

PC3A Transfer or assignment

Free format text: 961212 PHARMACIA & UPJOHN S.P.A. IT

TE3A Change of address (patent)
PC3A Transfer or assignment

Free format text: PHARMACIA ITALIA S.P.A. IT

Effective date: 20021002

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20080311