SE465222C5 - Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning - Google Patents

Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning

Info

Publication number
SE465222C5
SE465222C5 SE8904239A SE8904239A SE465222C5 SE 465222 C5 SE465222 C5 SE 465222C5 SE 8904239 A SE8904239 A SE 8904239A SE 8904239 A SE8904239 A SE 8904239A SE 465222 C5 SE465222 C5 SE 465222C5
Authority
SE
Sweden
Prior art keywords
factor viii
human factor
recombinant human
derivative
dna segment
Prior art date
Application number
SE8904239A
Other languages
English (en)
Swedish (sv)
Other versions
SE8904239D0 (sv
SE465222B (sv
SE8904239L (sv
Inventor
A B Almstedt
E M Hellstroem
K Larsson
P Lind
H I Sandberg
J Spira
M Sydow-Baeckman
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20377785&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE465222(C5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Priority to SE8904239A priority Critical patent/SE465222C5/xx
Publication of SE8904239D0 publication Critical patent/SE8904239D0/xx
Priority to NZ236276A priority patent/NZ236276A/xx
Priority to DE1999175066 priority patent/DE19975066I2/de
Priority to DE69032600T priority patent/DE69032600T3/de
Priority to PCT/SE1990/000809 priority patent/WO1991009122A1/en
Priority to BR909007921A priority patent/BR9007921A/pt
Priority to DE69034040T priority patent/DE69034040T2/de
Priority to ES97103685T priority patent/ES2189897T3/es
Priority to JP3501715A priority patent/JP2644084B2/ja
Priority to AT97103685T priority patent/ATE232213T1/de
Priority to EP97103685A priority patent/EP0786474B1/en
Priority to ES91901327T priority patent/ES2119769T5/es
Priority to EP02009162A priority patent/EP1293513A3/en
Priority to AU70393/91A priority patent/AU645539B2/en
Priority to AT91901327T priority patent/ATE170219T1/de
Priority to SG9603152A priority patent/SG66753A1/en
Priority to DK97103685T priority patent/DK0786474T3/da
Priority to DK91901327T priority patent/DK0506757T4/da
Priority to CA002071875A priority patent/CA2071875C/en
Priority to EP91901327A priority patent/EP0506757B2/en
Priority to PT96208A priority patent/PT96208B/pt
Priority to IE451090A priority patent/IE904510A1/en
Publication of SE8904239L publication Critical patent/SE8904239L/
Publication of SE465222B publication Critical patent/SE465222B/sv
Priority to NO922325A priority patent/NO309041B1/no
Priority to FI922745A priority patent/FI104260B1/fi
Priority to HU95P/P00489P priority patent/HU211504A9/hu
Publication of SE465222C5 publication Critical patent/SE465222C5/xx
Priority to HK99104067A priority patent/HK1019449A1/xx
Priority to HK98109933A priority patent/HK1009290A1/xx
Priority to NL990035C priority patent/NL990035I2/nl
Priority to LU90457C priority patent/LU90457I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Confectionery (AREA)
SE8904239A 1989-12-15 1989-12-15 Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning SE465222C5 (sv)

Priority Applications (29)

Application Number Priority Date Filing Date Title
SE8904239A SE465222C5 (sv) 1989-12-15 1989-12-15 Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
NZ236276A NZ236276A (en) 1989-12-15 1990-11-29 Dna encoding factor viii: comprising two polypeptide chains, a 90 kda a chain polypeptide and an 80 kda c chain polypeptide
CA002071875A CA2071875C (en) 1989-12-15 1990-12-06 Recombinant human factor viii derivative
EP91901327A EP0506757B2 (en) 1989-12-15 1990-12-06 A recombinant human factor viii derivative
AU70393/91A AU645539B2 (en) 1989-12-15 1990-12-06 A recombinant human factor VIII derivative
DK91901327T DK0506757T4 (da) 1989-12-15 1990-12-06 Rekombinant human faktor VIII derivat
PCT/SE1990/000809 WO1991009122A1 (en) 1989-12-15 1990-12-06 A recombinant human factor viii derivative
BR909007921A BR9007921A (pt) 1989-12-15 1990-12-06 Sequencia de dna codificando para um derivado de fator viii humano,recombinante biologicamente ativo,vetor de expressao recombinante,cellula haspedeira de origem animal,processo para a fabricacao de um derivado e derivado de fator viii humano
DE69034040T DE69034040T2 (de) 1989-12-15 1990-12-06 Rekombinanter Abkömmling des menschlichen Faktors VIII
ES97103685T ES2189897T3 (es) 1989-12-15 1990-12-06 Un derivado del factor viii recombinante humano.
JP3501715A JP2644084B2 (ja) 1989-12-15 1990-12-06 組換えヒト▲ｖｉｉｉ▼因子誘導体
AT97103685T ATE232213T1 (de) 1989-12-15 1990-12-06 Rekombinanter abkömmling des menschlichen faktors viii
EP97103685A EP0786474B1 (en) 1989-12-15 1990-12-06 A recombinant human factor VIII derivative
ES91901327T ES2119769T5 (es) 1989-12-15 1990-12-06 Derivado del factor viii humano recombinante.
EP02009162A EP1293513A3 (en) 1989-12-15 1990-12-06 A recombinant human factor VIII derivative
DE1999175066 DE19975066I2 (de) 1989-12-15 1990-12-06 Rekombinanter Abk¦mmling des menschlichen Faktors III.
AT91901327T ATE170219T1 (de) 1989-12-15 1990-12-06 Rekombinanter abkömmling des menschlichen faktors iii
SG9603152A SG66753A1 (en) 1989-12-15 1990-12-06 A recombinant human factor viii derivative
DK97103685T DK0786474T3 (da) 1989-12-15 1990-12-06 Rekombinant human faktor VIII derivat
DE69032600T DE69032600T3 (de) 1989-12-15 1990-12-06 Rekombinanter abkömmling des menschlichen faktors iii
IE451090A IE904510A1 (en) 1989-12-15 1990-12-14 A recombinant human factor viii derivative
PT96208A PT96208B (pt) 1989-12-15 1990-12-14 Processo de obtencao de uma sequencia de adn codificando um derivado recombinante do factor viii humano, de um vector e de celula recombinante e de preparacao do referido derivado.
NO922325A NO309041B1 (no) 1989-12-15 1992-06-12 DNA-sekvens, rekombinant ekspresjonsvektor og vertscelle omfattende DNA-sekvensen, samt fremgangsmÕte for fremstilling av human faktor VIII-derivat
FI922745A FI104260B1 (fi) 1989-12-15 1992-06-12 Biologisesti aktiivista yhdistelmä-DNA-ihmisentekij-VIII-johdannaista koodittava DNA, tämän sisältävä yhdistelmä-DNA-ilmentämisvektori ja isäntäsolu sekä menetelmä biologisesti aktiivisen yhdistelmä-DNA-ihmisentekijä-VIII-johdannaisen valmistamiseksi
HU95P/P00489P HU211504A9 (en) 1989-12-15 1995-06-28 Recombinant human factor viii derivatives
HK99104067A HK1019449A1 (en) 1989-12-15 1998-08-14 A recombinant human factor viii derivative
HK98109933A HK1009290A1 (en) 1989-12-15 1998-08-14 A recombinant human factor viii derivative
NL990035C NL990035I2 (nl) 1989-12-15 1999-10-12 Een recombinante afgeleide van humane factor VIII.
LU90457C LU90457I2 (fr) 1989-12-15 1999-10-12 Refacto

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8904239A SE465222C5 (sv) 1989-12-15 1989-12-15 Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning

Publications (4)

Publication Number Publication Date
SE8904239D0 SE8904239D0 (sv) 1989-12-15
SE8904239L SE8904239L (sv) 1991-06-16
SE465222B SE465222B (sv) 1991-08-12
SE465222C5 true SE465222C5 (sv) 1998-02-10

Family

ID=20377785

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8904239A SE465222C5 (sv) 1989-12-15 1989-12-15 Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning

Country Status (21)

Country Link
EP (3) EP1293513A3 (xx)
JP (1) JP2644084B2 (xx)
AT (2) ATE232213T1 (xx)
AU (1) AU645539B2 (xx)
BR (1) BR9007921A (xx)
CA (1) CA2071875C (xx)
DE (3) DE19975066I2 (xx)
DK (2) DK0786474T3 (xx)
ES (2) ES2189897T3 (xx)
FI (1) FI104260B1 (xx)
HK (2) HK1009290A1 (xx)
HU (1) HU211504A9 (xx)
IE (1) IE904510A1 (xx)
LU (1) LU90457I2 (xx)
NL (1) NL990035I2 (xx)
NO (1) NO309041B1 (xx)
NZ (1) NZ236276A (xx)
PT (1) PT96208B (xx)
SE (1) SE465222C5 (xx)
SG (1) SG66753A1 (xx)
WO (1) WO1991009122A1 (xx)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
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US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
IL86693A (en) 1987-06-12 1994-06-24 Stichting Centraal Lab Proteins that have the activity IIIV of the blood, a process for their preparation that uses cells are produced through genetic engineering and pharmaceutical preparations that contain them
US6346513B1 (en) 1987-06-12 2002-02-12 Baxter Trading Gmbh Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
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US5744446A (en) * 1992-04-07 1998-04-28 Emory University Hybrid human/animal factor VIII
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US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
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IL113010A0 (en) * 1994-03-31 1995-10-31 Pharmacia Ab Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration
SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
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SE9503380D0 (sv) * 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
US5851800A (en) * 1996-05-14 1998-12-22 Pharmacia & Upjohn Ab Process for producing a protein
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