SE461223C - mRNA och cDNA för humant fibroblastinterferon, förfarande för deras framställning samt användning därav - Google Patents
mRNA och cDNA för humant fibroblastinterferon, förfarande för deras framställning samt användning däravInfo
- Publication number
- SE461223C SE461223C SE8007998A SE8007998A SE461223C SE 461223 C SE461223 C SE 461223C SE 8007998 A SE8007998 A SE 8007998A SE 8007998 A SE8007998 A SE 8007998A SE 461223 C SE461223 C SE 461223C
- Authority
- SE
- Sweden
- Prior art keywords
- mrna
- induced
- cdna
- dna
- interferon
- Prior art date
Links
- 108020004999 messenger RNA Proteins 0.000 title claims description 156
- 239000002299 complementary DNA Substances 0.000 title claims description 62
- 238000000034 method Methods 0.000 title claims description 26
- 102000003996 Interferon-beta Human genes 0.000 title claims description 13
- 108090000467 Interferon-beta Proteins 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title description 8
- 102000014150 Interferons Human genes 0.000 claims description 81
- 108010050904 Interferons Proteins 0.000 claims description 81
- 229940079322 interferon Drugs 0.000 claims description 79
- 210000004027 cell Anatomy 0.000 claims description 50
- 239000013598 vector Substances 0.000 claims description 40
- 239000000463 material Substances 0.000 claims description 32
- 230000001580 bacterial effect Effects 0.000 claims description 19
- 210000002950 fibroblast Anatomy 0.000 claims description 19
- 238000012360 testing method Methods 0.000 claims description 19
- 238000009396 hybridization Methods 0.000 claims description 16
- 229920001184 polypeptide Polymers 0.000 claims description 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 230000000694 effects Effects 0.000 claims description 15
- 239000002773 nucleotide Substances 0.000 claims description 15
- 125000003729 nucleotide group Chemical group 0.000 claims description 15
- 238000013519 translation Methods 0.000 claims description 12
- 230000015572 biosynthetic process Effects 0.000 claims description 11
- 210000000287 oocyte Anatomy 0.000 claims description 11
- 238000003786 synthesis reaction Methods 0.000 claims description 10
- 238000012258 culturing Methods 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
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- 238000004113 cell culture Methods 0.000 claims description 6
- 238000010367 cloning Methods 0.000 claims description 6
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- 238000000856 sucrose gradient centrifugation Methods 0.000 claims description 6
- 230000000295 complement effect Effects 0.000 claims description 4
- 239000000411 inducer Substances 0.000 claims description 4
- 239000013049 sediment Substances 0.000 claims description 4
- 210000003527 eukaryotic cell Anatomy 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- 238000002955 isolation Methods 0.000 claims description 3
- 102000004889 Interleukin-6 Human genes 0.000 claims 12
- 108090001005 Interleukin-6 Proteins 0.000 claims 12
- 241000894006 Bacteria Species 0.000 claims 10
- 239000011159 matrix material Substances 0.000 claims 5
- 229960001388 interferon-beta Drugs 0.000 claims 3
- 238000011065 in-situ storage Methods 0.000 claims 2
- 210000001236 prokaryotic cell Anatomy 0.000 claims 2
- 239000002799 interferon inducing agent Substances 0.000 claims 1
- 108020004414 DNA Proteins 0.000 description 54
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 20
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
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- 108010067304 (2'-5')oligo-isoadenylate synthetase Proteins 0.000 description 2
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- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
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- 229960000723 ampicillin Drugs 0.000 description 2
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- YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 2
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- GMKMEZVLHJARHF-UHFFFAOYSA-N (2R,6R)-form-2.6-Diaminoheptanedioic acid Natural products OC(=O)C(N)CCCC(N)C(O)=O GMKMEZVLHJARHF-UHFFFAOYSA-N 0.000 description 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- BHNQPLPANNDEGL-UHFFFAOYSA-N 2-(4-octylphenoxy)ethanol Chemical compound CCCCCCCCC1=CC=C(OCCO)C=C1 BHNQPLPANNDEGL-UHFFFAOYSA-N 0.000 description 1
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- 241000713838 Avian myeloblastosis virus Species 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102000004594 DNA Polymerase I Human genes 0.000 description 1
- 108010017826 DNA Polymerase I Proteins 0.000 description 1
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- 241000701959 Escherichia virus Lambda Species 0.000 description 1
- 101100396576 Gallus gallus IFNB gene Proteins 0.000 description 1
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- 102000003960 Ligases Human genes 0.000 description 1
- 239000006137 Luria-Bertani broth Substances 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
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- 102000004357 Transferases Human genes 0.000 description 1
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- 241000711975 Vesicular stomatitis virus Species 0.000 description 1
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- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
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- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
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- 244000309466 calf Species 0.000 description 1
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- 239000012894 fetal calf serum Substances 0.000 description 1
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- 229940047124 interferons Drugs 0.000 description 1
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- GMKMEZVLHJARHF-SYDPRGILSA-N meso-2,6-diaminopimelic acid Chemical compound [O-]C(=O)[C@@H]([NH3+])CCC[C@@H]([NH3+])C([O-])=O GMKMEZVLHJARHF-SYDPRGILSA-N 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL58765A IL58765A (en) | 1979-11-21 | 1979-11-21 | Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8007998L SE8007998L (sv) | 1981-05-22 |
| SE461223B SE461223B (sv) | 1990-01-22 |
| SE461223C true SE461223C (sv) | 1997-02-02 |
Family
ID=11051449
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8007998A SE461223C (sv) | 1979-11-21 | 1980-11-14 | mRNA och cDNA för humant fibroblastinterferon, förfarande för deras framställning samt användning därav |
| SE8603145A SE469660B (sv) | 1979-11-21 | 1986-07-17 | Humant fibroblastinterferon-beta, framstaellning och anvaendning daerav |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8603145A SE469660B (sv) | 1979-11-21 | 1986-07-17 | Humant fibroblastinterferon-beta, framstaellning och anvaendning daerav |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US5468607A (fr) |
| JP (3) | JP2555279B2 (fr) |
| CH (2) | CH684892A5 (fr) |
| DE (2) | DE3051086C2 (fr) |
| FR (1) | FR2475901A1 (fr) |
| GB (1) | GB2063882B (fr) |
| IL (1) | IL58765A (fr) |
| IT (1) | IT1194820B (fr) |
| SE (2) | SE461223C (fr) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56131598A (en) * | 1980-03-19 | 1981-10-15 | Japan Found Cancer | Novel recombinant plasmid having gene of human fibroblastic interferon messenger rna |
| US5510472A (en) * | 1979-11-21 | 1996-04-23 | Yeda Research And Development Co. Ltd. | Production of recombinant human interferon-beta2 |
| US5554513A (en) * | 1979-11-21 | 1996-09-10 | Yeda Research & Development Co. Ltd. | Production of recombinant human interferon-beta2 |
| DK33181A (da) * | 1980-02-06 | 1981-08-07 | Searle & Co | Fremgangsmaade til fremstilling af et interferonlignende protein |
| DE3005843A1 (de) * | 1980-02-16 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus |
| DE3005897A1 (de) * | 1980-02-16 | 1981-09-03 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus |
| PT72786B (en) | 1980-04-03 | 1983-01-10 | Biogen Nv | Process for producing dna sequences recombinant dna molecules and human fibroplast interferon-like polypeptides |
| DE3176011D1 (en) * | 1980-06-12 | 1987-04-23 | Japan Found Cancer | Plasmid |
| GR81946B (fr) * | 1980-09-25 | 1984-12-12 | Genentech Inc | |
| US5582824A (en) * | 1981-10-19 | 1996-12-10 | Genentech, Inc. | Recombinant DES-CYS-TYR-CYS human immune interferon |
| AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| JPS58110548A (ja) * | 1981-12-24 | 1983-07-01 | Asahi Chem Ind Co Ltd | 新規な生理活性ペプチド |
| US6432677B1 (en) | 1982-03-08 | 2002-08-13 | Genentech, Inc. | Non-human animal interferons |
| IE54592B1 (en) * | 1982-03-08 | 1989-12-06 | Genentech Inc | Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby |
| US5827694A (en) * | 1982-03-08 | 1998-10-27 | Genentech, Inc. | DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| DE3220116A1 (de) * | 1982-05-28 | 1983-12-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung |
| US4737462A (en) * | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
| US4966843A (en) * | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
| US5831023A (en) * | 1982-11-01 | 1998-11-03 | Genentech, Inc. | Recombinant animal interferon polypeptides |
| US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
| EP0569687B1 (fr) * | 1984-05-18 | 2002-08-21 | New England Medical Center Hospitals, Inc. | Séquences de cADN de l'IL-1 humaine codant pour des protéines biologiquement actives de l'IL-1 humaine |
| US5998578A (en) * | 1984-05-18 | 1999-12-07 | New England Medical Center Hospitals, Inc. | Biologically active fragments of IL-1β |
| US5122459A (en) * | 1984-12-31 | 1992-06-16 | Immunex Corporation | Gene encoding biologically active human interleukin 1 |
| WO1986006407A1 (fr) * | 1985-04-23 | 1986-11-06 | Medical Biology Institute | IDENTIFICATION D'UNE PROTEINE DE LIAISON IgE PAR CLONAGE MOLECULAIRE |
| EP0200986B2 (fr) * | 1985-04-25 | 1998-03-11 | F. Hoffmann-La Roche Ag | Recombinant interleukine-1 humain |
| DE3650790T2 (de) * | 1985-10-14 | 2008-01-24 | Yeda Research And Development Co., Ltd. | Menschlisches Interferon-Beta 2A zur Verwendung als Arzneimittel |
| US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| US6284237B1 (en) | 1986-07-08 | 2001-09-04 | Steven C. Clark | Methods of treatment using IL-6 |
| IE67035B1 (en) * | 1986-07-08 | 1996-02-21 | Genetics Inst | Production and use of non-glycosylated IL-6 |
| DE3750106T3 (de) * | 1986-08-06 | 1999-04-22 | Ajinomoto Co., Inc., Tokio/Tokyo | Rekombinanter B-Zell-Differenzierungsfaktor. |
| US4939093A (en) * | 1987-02-02 | 1990-07-03 | Cetus Corporation | Human IL-2 like polypeptides, DNA sequences and recombinant DNA molecules therefore and methods for the production and use thereof |
| US4961969A (en) * | 1987-05-11 | 1990-10-09 | Cetus Corporation | Process for recovering microbially produced interferon-β |
| IL88375A (en) * | 1988-11-14 | 1995-07-31 | Yeda Res & Dev | Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method |
| US5338834A (en) * | 1993-01-26 | 1994-08-16 | Allelix Biopharmaceuticals Inc. | Ultrapure human interleukin-6 |
| US5723125A (en) * | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
| US20050002902A1 (en) * | 1995-12-28 | 2005-01-06 | Liming Yu | Hybrid with interferon-alpha and an immunoglobulin Fc for treatment of tumors and viral infections |
| US20030026779A1 (en) * | 1999-10-15 | 2003-02-06 | Liming Yu | Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc |
| MXPA04004671A (es) * | 2001-11-14 | 2005-08-25 | Johnson & Johnson | Anticuerpos anti-interleucina-6, composiciones, metodos y usos. |
| US20050100550A1 (en) * | 2003-11-10 | 2005-05-12 | Mohit Trikha | Anti-angiogenic uses of IL-6 antagonists |
| WO2005074546A2 (fr) | 2004-02-02 | 2005-08-18 | Ambrx, Inc. | Polypeptides d'hormone de croissance humaine modifies et utilisations |
| PA8672101A1 (es) | 2005-04-29 | 2006-12-07 | Centocor Inc | Anticuerpos anti-il-6, composiciones, métodos y usos |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US7906117B2 (en) * | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| MX2009012493A (es) * | 2007-05-21 | 2010-01-20 | Alder Biopharmaceuticals Inc | Metodos de humanizacion de anticuerpo de conejo novedosos y anticuerpos de conejo humanizados. |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
| ES2610607T3 (es) | 2007-05-21 | 2017-04-28 | Alderbio Holdings Llc | Anticuerpos contra IL-6 y usos de los mismos |
| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| EP3103880A1 (fr) | 2008-02-08 | 2016-12-14 | Ambrx, Inc. | Polypeptides d'insuline modifiés et utilisations de ceux-ci |
| US8777182B2 (en) | 2008-05-20 | 2014-07-15 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
| US8188235B2 (en) * | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8323649B2 (en) * | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| US9452227B2 (en) * | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| US9724410B2 (en) | 2009-11-24 | 2017-08-08 | Alderbio Holdings Llc | Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity |
| AU2011332817A1 (en) | 2010-11-23 | 2013-06-13 | Alder Biopharmaceuticals, Inc. | Anti-IL-6 antibodies for the treatment of anemia |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4237224A (en) * | 1974-11-04 | 1980-12-02 | Board Of Trustees Of The Leland Stanford Jr. University | Process for producing biologically functional molecular chimeras |
| FR2321298A1 (fr) * | 1975-08-01 | 1977-03-18 | Anvar | Procede de preparation de produits a activite interferon |
| NZ187300A (en) * | 1977-05-27 | 1982-08-17 | Univ California | Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism |
| US5326859A (en) * | 1979-10-30 | 1994-07-05 | Juridical Foundation, Japanese Foundation For Cancer Research | DNA and recombinant plasmid |
| JPS5663996A (en) * | 1979-10-30 | 1981-05-30 | Japan Found Cancer | Novel recombinant having gene complementary to human interferon messenger rna |
| FI77877C (fi) * | 1979-04-20 | 1989-05-10 | Technobiotic Ltd | Foerfarande foer framstaellning och rening av human le-formig interferonprotein. |
| US4262090A (en) * | 1979-06-04 | 1981-04-14 | Cetus Corporation | Interferon production |
| US4289689A (en) * | 1980-03-14 | 1981-09-15 | Hoffmann-La Roche Inc. | Preparation of homogeneous human fibroblast interferon |
| JPS5655731A (en) * | 1979-10-11 | 1981-05-16 | Ogura Clutch Co Ltd | Clutch/brake device |
| NL7907791A (nl) * | 1979-10-23 | 1981-04-27 | Stichting Rega V Z W | Werkwijze voor het zuiveren van interferon. |
| PT72786B (en) * | 1980-04-03 | 1983-01-10 | Biogen Nv | Process for producing dna sequences recombinant dna molecules and human fibroplast interferon-like polypeptides |
| DE3177298T2 (de) * | 1980-06-06 | 1993-07-01 | Biogen Inc | Verbesserte vektoren, verfahren zur herstellung solcher vektoren und zur expression von klonierten genen. |
-
1979
- 1979-11-21 IL IL58765A patent/IL58765A/xx unknown
-
1980
- 1980-11-14 SE SE8007998A patent/SE461223C/sv not_active IP Right Cessation
- 1980-11-19 GB GB8037067A patent/GB2063882B/en not_active Expired
- 1980-11-20 US US06/208,925 patent/US5468607A/en not_active Expired - Lifetime
- 1980-11-21 CH CH3224/93A patent/CH684892A5/de not_active IP Right Cessation
- 1980-11-21 DE DE3051086A patent/DE3051086C2/de not_active Expired - Lifetime
- 1980-11-21 DE DE19803043981 patent/DE3043981A1/de active Granted
- 1980-11-21 CH CH8627/80A patent/CH664967A5/de not_active IP Right Cessation
- 1980-11-21 FR FR8024833A patent/FR2475901A1/fr active Granted
- 1980-11-21 JP JP55164482A patent/JP2555279B2/ja not_active Expired - Lifetime
- 1980-11-21 IT IT26172/80A patent/IT1194820B/it active
-
1982
- 1982-09-28 US US06/425,933 patent/US5468609A/en not_active Expired - Lifetime
- 1982-09-28 US US06/425,935 patent/US5468608A/en not_active Expired - Lifetime
- 1982-09-28 US US06/425,934 patent/US5541312A/en not_active Expired - Lifetime
-
1986
- 1986-07-17 SE SE8603145A patent/SE469660B/sv not_active IP Right Cessation
-
1987
- 1987-06-24 JP JP62157455A patent/JP2548201B2/ja not_active Expired - Lifetime
-
1989
- 1989-04-13 JP JP1094314A patent/JPH02211879A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63164896A (ja) | 1988-07-08 |
| JPS5685296A (en) | 1981-07-11 |
| SE8007998L (sv) | 1981-05-22 |
| FR2475901A1 (fr) | 1981-08-21 |
| GB2063882B (en) | 1984-05-31 |
| IT1194820B (it) | 1988-09-28 |
| SE8603145D0 (sv) | 1986-07-17 |
| DE3043981C2 (fr) | 1989-11-30 |
| CH664967A5 (de) | 1988-04-15 |
| US5468609A (en) | 1995-11-21 |
| SE469660B (sv) | 1993-08-16 |
| US5468608A (en) | 1995-11-21 |
| SE8603145L (sv) | 1986-07-17 |
| SE461223B (sv) | 1990-01-22 |
| CH684892A5 (de) | 1995-01-31 |
| IT8026172A0 (it) | 1980-11-21 |
| DE3051086C2 (fr) | 1992-11-05 |
| JP2548201B2 (ja) | 1996-10-30 |
| FR2475901B1 (fr) | 1985-02-15 |
| IL58765A (en) | 1986-09-30 |
| US5468607A (en) | 1995-11-21 |
| IL58765A0 (en) | 1980-02-29 |
| DE3043981A1 (de) | 1981-10-01 |
| GB2063882A (en) | 1981-06-10 |
| JPH02211879A (ja) | 1990-08-23 |
| US5541312A (en) | 1996-07-30 |
| JP2555279B2 (ja) | 1996-11-20 |
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