IL58765A - Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta - Google Patents

Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta

Info

Publication number
IL58765A
IL58765A IL58765A IL5876579A IL58765A IL 58765 A IL58765 A IL 58765A IL 58765 A IL58765 A IL 58765A IL 5876579 A IL5876579 A IL 5876579A IL 58765 A IL58765 A IL 58765A
Authority
IL
Israel
Prior art keywords
production
interferon
messenger rna
essentially pure
human fibroblast
Prior art date
Application number
IL58765A
Other languages
English (en)
Other versions
IL58765A0 (en
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11051449&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL58765(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL58765A priority Critical patent/IL58765A/xx
Publication of IL58765A0 publication Critical patent/IL58765A0/xx
Priority to SE8007998A priority patent/SE461223C/sv
Priority to GB8037067A priority patent/GB2063882B/en
Priority to US06/208,925 priority patent/US5468607A/en
Priority to DE3051086A priority patent/DE3051086C2/de
Priority to JP55164482A priority patent/JP2555279B2/ja
Priority to CH788880A priority patent/CH685299A5/de
Priority to IT26172/80A priority patent/IT1194820B/it
Priority to CH3224/93A priority patent/CH684892A5/de
Priority to FR8024833A priority patent/FR2475901A1/fr
Priority to DE19803043981 priority patent/DE3043981A1/de
Priority to CH8627/80A priority patent/CH664967A5/de
Priority to US06/425,934 priority patent/US5541312A/en
Priority to US06/425,933 priority patent/US5468609A/en
Priority to US06/425,935 priority patent/US5468608A/en
Priority to SE8603145A priority patent/SE469660B/sv
Publication of IL58765A publication Critical patent/IL58765A/xx
Priority to JP62157455A priority patent/JP2548201B2/ja
Priority to JP1094314A priority patent/JPH02211879A/ja
Priority to US07/449,447 priority patent/US5554513A/en
Priority to US07/657,258 priority patent/US5554514A/en
Priority to US07/883,633 priority patent/US5510472A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
IL58765A 1979-11-21 1979-11-21 Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta IL58765A (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IL58765A IL58765A (en) 1979-11-21 1979-11-21 Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
SE8007998A SE461223C (sv) 1979-11-21 1980-11-14 mRNA och cDNA för humant fibroblastinterferon, förfarande för deras framställning samt användning därav
GB8037067A GB2063882B (en) 1979-11-21 1980-11-19 Production of interferon by genetic
US06/208,925 US5468607A (en) 1979-11-21 1980-11-20 Production of interferon
CH8627/80A CH664967A5 (de) 1979-11-21 1980-11-21 Im wesentlichen reine mrna's des menschlichen fibroblasten-interferons.
JP55164482A JP2555279B2 (ja) 1979-11-21 1980-11-21 インタ−フエロンに転換可能なｍＲＮＡ及びその製造方法
FR8024833A FR2475901A1 (fr) 1979-11-21 1980-11-21 Procede de production d'interferon
DE19803043981 DE3043981A1 (de) 1979-11-21 1980-11-21 Verfahren zur gewinnung von fuer interferon in menschlichen zellen kodierender dna, verfahren zur anreicherung von interferon boten-rna (mrna) oder einer induzierbaren mrna eines anderen proteins oder polypeptids, vektoren, verfahren zur abtrennung von mrna eines induzierbaren proteins von anderen mrna's, mrna von menschlichem interferon, in einen vektor einbaubare und fuer ein polypeptid mit interferon-aktivitaet kodierende dna, sowie menschliches interferon (beta)-1 und(beta)-2 in hochgereinigter form
CH788880A CH685299A5 (de) 1979-11-21 1980-11-21 Menschliches Fibroblasteninterferon beta 2, Verfahren zur Herstellung von menschlichem Fibroblasteninterferon beta 1 und beta 2 und deren Verwendung.
IT26172/80A IT1194820B (it) 1979-11-21 1980-11-21 Procedimento per la produzione di interferone
CH3224/93A CH684892A5 (de) 1979-11-21 1980-11-21 DNA, welche für ein Polypeptid mit der Aktivität von menschlichem Interferon und beta 2 kodiert und Verfahren zu dessen Herstellung.
DE3051086A DE3051086C2 (fr) 1979-11-21 1980-11-21
US06/425,934 US5541312A (en) 1979-11-21 1982-09-28 Production of interferon
US06/425,933 US5468609A (en) 1979-11-21 1982-09-28 Production of interferon
US06/425,935 US5468608A (en) 1979-11-21 1982-09-28 Production of interferon
SE8603145A SE469660B (sv) 1979-11-21 1986-07-17 Humant fibroblastinterferon-beta, framstaellning och anvaendning daerav
JP62157455A JP2548201B2 (ja) 1979-11-21 1987-06-24 ヒトインタ−フェロンの製造方法及び高純度ヒトインタ−フェロン
JP1094314A JPH02211879A (ja) 1979-11-21 1989-04-13 ヒトインターフエロンβ２のｃＤＮＡ及びその製造法
US07/449,447 US5554513A (en) 1979-11-21 1989-12-12 Production of recombinant human interferon-beta2
US07/657,258 US5554514A (en) 1979-11-21 1991-02-19 Production of recombinant human interferon beta2.sbsb.B
US07/883,633 US5510472A (en) 1979-11-21 1992-05-15 Production of recombinant human interferon-beta2

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL58765A IL58765A (en) 1979-11-21 1979-11-21 Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta

Publications (2)

Publication Number Publication Date
IL58765A0 IL58765A0 (en) 1980-02-29
IL58765A true IL58765A (en) 1986-09-30

Family

ID=11051449

Family Applications (1)

Application Number Title Priority Date Filing Date
IL58765A IL58765A (en) 1979-11-21 1979-11-21 Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta

Country Status (9)

Country Link
US (4) US5468607A (fr)
JP (3) JP2555279B2 (fr)
CH (2) CH684892A5 (fr)
DE (2) DE3051086C2 (fr)
FR (1) FR2475901A1 (fr)
GB (1) GB2063882B (fr)
IL (1) IL58765A (fr)
IT (1) IT1194820B (fr)
SE (2) SE461223C (fr)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56131598A (en) * 1980-03-19 1981-10-15 Japan Found Cancer Novel recombinant plasmid having gene of human fibroblastic interferon messenger rna
US5510472A (en) * 1979-11-21 1996-04-23 Yeda Research And Development Co. Ltd. Production of recombinant human interferon-beta2
US5554513A (en) * 1979-11-21 1996-09-10 Yeda Research & Development Co. Ltd. Production of recombinant human interferon-beta2
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
PT72786B (en) 1980-04-03 1983-01-10 Biogen Nv Process for producing dna sequences recombinant dna molecules and human fibroplast interferon-like polypeptides
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
GR81946B (fr) * 1980-09-25 1984-12-12 Genentech Inc
US5582824A (en) * 1981-10-19 1996-12-10 Genentech, Inc. Recombinant DES-CYS-TYR-CYS human immune interferon
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
DE3220116A1 (de) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung
US4737462A (en) * 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4966843A (en) * 1982-11-01 1990-10-30 Cetus Corporation Expression of interferon genes in Chinese hamster ovary cells
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
EP0569687B1 (fr) * 1984-05-18 2002-08-21 New England Medical Center Hospitals, Inc. Séquences de cADN de l'IL-1 humaine codant pour des protéines biologiquement actives de l'IL-1 humaine
US5998578A (en) * 1984-05-18 1999-12-07 New England Medical Center Hospitals, Inc. Biologically active fragments of IL-1β
US5122459A (en) * 1984-12-31 1992-06-16 Immunex Corporation Gene encoding biologically active human interleukin 1
WO1986006407A1 (fr) * 1985-04-23 1986-11-06 Medical Biology Institute IDENTIFICATION D'UNE PROTEINE DE LIAISON IgE PAR CLONAGE MOLECULAIRE
EP0200986B2 (fr) * 1985-04-25 1998-03-11 F. Hoffmann-La Roche Ag Recombinant interleukine-1 humain
DE3650790T2 (de) * 1985-10-14 2008-01-24 Yeda Research And Development Co., Ltd. Menschlisches Interferon-Beta 2A zur Verwendung als Arzneimittel
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
US6284237B1 (en) 1986-07-08 2001-09-04 Steven C. Clark Methods of treatment using IL-6
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
DE3750106T3 (de) * 1986-08-06 1999-04-22 Ajinomoto Co., Inc., Tokio/Tokyo Rekombinanter B-Zell-Differenzierungsfaktor.
US4939093A (en) * 1987-02-02 1990-07-03 Cetus Corporation Human IL-2 like polypeptides, DNA sequences and recombinant DNA molecules therefore and methods for the production and use thereof
US4961969A (en) * 1987-05-11 1990-10-09 Cetus Corporation Process for recovering microbially produced interferon-β
IL88375A (en) * 1988-11-14 1995-07-31 Yeda Res & Dev Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method
US5338834A (en) * 1993-01-26 1994-08-16 Allelix Biopharmaceuticals Inc. Ultrapure human interleukin-6
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US20050002902A1 (en) * 1995-12-28 2005-01-06 Liming Yu Hybrid with interferon-alpha and an immunoglobulin Fc for treatment of tumors and viral infections
US20030026779A1 (en) * 1999-10-15 2003-02-06 Liming Yu Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc
MXPA04004671A (es) * 2001-11-14 2005-08-25 Johnson & Johnson Anticuerpos anti-interleucina-6, composiciones, metodos y usos.
US20050100550A1 (en) * 2003-11-10 2005-05-12 Mohit Trikha Anti-angiogenic uses of IL-6 antagonists
WO2005074546A2 (fr) 2004-02-02 2005-08-18 Ambrx, Inc. Polypeptides d'hormone de croissance humaine modifies et utilisations
PA8672101A1 (es) 2005-04-29 2006-12-07 Centocor Inc Anticuerpos anti-il-6, composiciones, métodos y usos
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US7906117B2 (en) * 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
MX2009012493A (es) * 2007-05-21 2010-01-20 Alder Biopharmaceuticals Inc Metodos de humanizacion de anticuerpo de conejo novedosos y anticuerpos de conejo humanizados.
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US20090238825A1 (en) * 2007-05-21 2009-09-24 Kovacevich Brian R Novel rabbit antibody humanization methods and humanized rabbit antibodies
ES2610607T3 (es) 2007-05-21 2017-04-28 Alderbio Holdings Llc Anticuerpos contra IL-6 y usos de los mismos
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
EP3103880A1 (fr) 2008-02-08 2016-12-14 Ambrx, Inc. Polypeptides d'insuline modifiés et utilisations de ceux-ci
US8777182B2 (en) 2008-05-20 2014-07-15 Grinon Industries Fluid transfer assembly and methods of fluid transfer
US8188235B2 (en) * 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8323649B2 (en) * 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US9452227B2 (en) * 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
US9724410B2 (en) 2009-11-24 2017-08-08 Alderbio Holdings Llc Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity
AU2011332817A1 (en) 2010-11-23 2013-06-13 Alder Biopharmaceuticals, Inc. Anti-IL-6 antibodies for the treatment of anemia

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237224A (en) * 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
FR2321298A1 (fr) * 1975-08-01 1977-03-18 Anvar Procede de preparation de produits a activite interferon
NZ187300A (en) * 1977-05-27 1982-08-17 Univ California Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism
US5326859A (en) * 1979-10-30 1994-07-05 Juridical Foundation, Japanese Foundation For Cancer Research DNA and recombinant plasmid
JPS5663996A (en) * 1979-10-30 1981-05-30 Japan Found Cancer Novel recombinant having gene complementary to human interferon messenger rna
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
US4262090A (en) * 1979-06-04 1981-04-14 Cetus Corporation Interferon production
US4289689A (en) * 1980-03-14 1981-09-15 Hoffmann-La Roche Inc. Preparation of homogeneous human fibroblast interferon
JPS5655731A (en) * 1979-10-11 1981-05-16 Ogura Clutch Co Ltd Clutch/brake device
NL7907791A (nl) * 1979-10-23 1981-04-27 Stichting Rega V Z W Werkwijze voor het zuiveren van interferon.
PT72786B (en) * 1980-04-03 1983-01-10 Biogen Nv Process for producing dna sequences recombinant dna molecules and human fibroplast interferon-like polypeptides
DE3177298T2 (de) * 1980-06-06 1993-07-01 Biogen Inc Verbesserte vektoren, verfahren zur herstellung solcher vektoren und zur expression von klonierten genen.

Also Published As

Publication number Publication date
JPS63164896A (ja) 1988-07-08
JPS5685296A (en) 1981-07-11
SE8007998L (sv) 1981-05-22
FR2475901A1 (fr) 1981-08-21
GB2063882B (en) 1984-05-31
IT1194820B (it) 1988-09-28
SE8603145D0 (sv) 1986-07-17
DE3043981C2 (fr) 1989-11-30
CH664967A5 (de) 1988-04-15
US5468609A (en) 1995-11-21
SE469660B (sv) 1993-08-16
US5468608A (en) 1995-11-21
SE461223C (sv) 1997-02-02
SE8603145L (sv) 1986-07-17
SE461223B (sv) 1990-01-22
CH684892A5 (de) 1995-01-31
IT8026172A0 (it) 1980-11-21
DE3051086C2 (fr) 1992-11-05
JP2548201B2 (ja) 1996-10-30
FR2475901B1 (fr) 1985-02-15
US5468607A (en) 1995-11-21
IL58765A0 (en) 1980-02-29
DE3043981A1 (de) 1981-10-01
GB2063882A (en) 1981-06-10
JPH02211879A (ja) 1990-08-23
US5541312A (en) 1996-07-30
JP2555279B2 (ja) 1996-11-20

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