DE3750106T3 - Rekombinanter B-Zell-Differenzierungsfaktor. - Google Patents

Rekombinanter B-Zell-Differenzierungsfaktor.

Info

Publication number
DE3750106T3
DE3750106T3 DE3750106T DE3750106T DE3750106T3 DE 3750106 T3 DE3750106 T3 DE 3750106T3 DE 3750106 T DE3750106 T DE 3750106T DE 3750106 T DE3750106 T DE 3750106T DE 3750106 T3 DE3750106 T3 DE 3750106T3
Authority
DE
Germany
Prior art keywords
recombinant
cell differentiation
differentiation factor
factor
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3750106T
Other languages
English (en)
Other versions
DE3750106T2 (de
DE3750106D1 (de
Inventor
Tadamitsu Kishimoto
Toshio Hirano
Hiroshi Matsui
Yoshiyuki Takahara
Yukio Akiyama
Akira Okano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27470335&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3750106(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP61184858A external-priority patent/JP2676336B2/ja
Priority claimed from JP61200433A external-priority patent/JPS6356291A/ja
Priority claimed from JP61302699A external-priority patent/JP2676341B2/ja
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of DE3750106D1 publication Critical patent/DE3750106D1/de
Publication of DE3750106T2 publication Critical patent/DE3750106T2/de
Application granted granted Critical
Publication of DE3750106T3 publication Critical patent/DE3750106T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE3750106T 1986-08-06 1987-08-06 Rekombinanter B-Zell-Differenzierungsfaktor. Expired - Lifetime DE3750106T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP61184858A JP2676336B2 (ja) 1986-08-06 1986-08-06 ヒトｂ細胞分化因子の遺伝子
JP61200433A JPS6356291A (ja) 1986-08-27 1986-08-27 リコンビナントｂｃｄｆ
JP61302699A JP2676341B2 (ja) 1986-12-18 1986-12-18 Ｂ細胞分化因子の製造法
JP11633287 1987-05-13

Publications (3)

Publication Number Publication Date
DE3750106D1 DE3750106D1 (de) 1994-07-28
DE3750106T2 DE3750106T2 (de) 1995-03-16
DE3750106T3 true DE3750106T3 (de) 1999-04-22

Family

ID=27470335

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3750106T Expired - Lifetime DE3750106T3 (de) 1986-08-06 1987-08-06 Rekombinanter B-Zell-Differenzierungsfaktor.

Country Status (3)

Country Link
US (2) US5362489A (de)
EP (2) EP0585957A1 (de)
DE (1) DE3750106T3 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554513A (en) * 1979-11-21 1996-09-10 Yeda Research & Development Co. Ltd. Production of recombinant human interferon-beta2
US5510472A (en) * 1979-11-21 1996-04-23 Yeda Research And Development Co. Ltd. Production of recombinant human interferon-beta2
DE220574T1 (de) * 1985-10-14 1987-11-26 Yeda Research And Development Co., Ltd., Rehovot Menschliches interferon-beta2a und interferon-beta2b
US6348191B1 (en) 1986-07-08 2002-02-19 Genetics Institute, Inc. Production and use of IL-6
US6284237B1 (en) 1986-07-08 2001-09-04 Steven C. Clark Methods of treatment using IL-6
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
JPH0276820A (ja) * 1988-06-15 1990-03-16 Ajinomoto Co Inc 骨髄移植療法支持剤
US5186931A (en) * 1986-08-06 1993-02-16 Ajinomoto Co., Inc. Composition and method for supporting bone marrow transplantation
DE3767629D1 (de) * 1986-09-20 1991-02-28 Tasuku Honjo Menschlicher b-zellen-differenzierungsfaktor und verfahren zu dessen herstellung.
NZ226799A (en) * 1987-11-06 1991-08-27 Oncogen Breast cancer inhibitory factor and method for inhibiting proliferation of neoplastic cells and compositions therefor
HUT52962A (en) * 1988-03-04 1990-09-28 Sandoz Ag Process for production of medical compositions eliminating bone-absorption and promoting forming of bones
JPH0236129A (ja) * 1988-07-22 1990-02-06 Ajinomoto Co Inc ワクチン効果増強剤
JPH0372429A (ja) * 1988-10-07 1991-03-27 Chugai Pharmaceut Co Ltd 血小板減少症の治療剤
AU639428B2 (en) * 1988-12-01 1993-07-29 Imclone Systems, Inc. Synthetic interleukin-6
JP2805224B2 (ja) * 1989-01-13 1998-09-30 味の素株式会社 血小板減少症治療剤
JPH0331215A (ja) * 1989-06-27 1991-02-12 Ajinomoto Co Inc 制癌療法支持剤
JPH04218000A (ja) * 1990-02-13 1992-08-07 Kirin Amgen Inc 修飾ポリペプチド
ES2118756T5 (es) * 1990-08-29 2004-01-16 Genetics Institute, Llc Estimuladores de hematopoyesis de multiples dominios.
EP0547223B1 (de) * 1990-08-31 1996-10-16 Santen Pharmaceutical Co., Ltd. Arznei gegen hornhautbeschädigungen
WO1992014832A1 (en) * 1991-02-26 1992-09-03 Ajinomoto Co., Inc. Processes for purifying human bcdf
US5641868A (en) * 1991-04-18 1997-06-24 Toray Industries, Inc. Interlekin-6 compositions, and a production process thereof
ZA924674B (en) * 1991-07-02 1993-04-28 Imclone Systems Inc Cysteine depleted il-6 mutein
US5338834A (en) * 1993-01-26 1994-08-16 Allelix Biopharmaceuticals Inc. Ultrapure human interleukin-6
WO1996025433A1 (en) * 1995-02-15 1996-08-22 Mount Sinai School Of Medicine Of The City University Of New York B cell differentiation and proliferation factors and methods for obtaining and using the same
US7115665B1 (en) 2000-11-16 2006-10-03 Onocozyme Pharma, Inc. Inhibitors of endo-exonuclease activity for treating cancer
EP1231910B1 (de) * 1999-11-16 2009-05-20 Oncozyme Pharma Inc. Pentamidine zur behandlung von krebs
CN1210294C (zh) 2001-07-13 2005-07-13 一泰医药研究（深圳）有限公司 序列号21的生物活性肽
AU2007285695B2 (en) 2006-08-18 2012-05-24 Ablynx N.V. Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling
JP5502494B2 (ja) 2007-01-22 2014-05-28 ターガセプト・インコーポレイテッド メタニコチンアナログの鼻腔内、バッカル、または舌下投与
EP2373793B1 (de) * 2008-12-18 2017-08-23 ITI Scotland Limited Verfahren zum zusammensetzen von polynukleinsäuresequenzen
EP2417163B1 (de) 2009-04-10 2019-02-27 Ablynx N.V. Verbesserte, gegen il-6r gerichtete aminosauresequenzen und polypeptide, die diese enthalten, zur behandlung von erkrankungen und storungen, die mit il-6r in zusammenhang stehen
WO2010115995A2 (en) 2009-04-10 2010-10-14 Ablynx Nv Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
GB2481425A (en) 2010-06-23 2011-12-28 Iti Scotland Ltd Method and device for assembling polynucleic acid sequences
WO2013041722A1 (en) 2011-09-23 2013-03-28 Ablynx Nv Prolonged inhibition of interleukin-6 mediated signaling
US10118967B2 (en) 2014-10-21 2018-11-06 Ablynx N.V. Methods for treating rheumatoid arthritis by administering IL-6 receptor antibodies
US11897951B2 (en) 2020-12-18 2024-02-13 Ablynx N.V. Polypeptides comprising immunoglobulin single variable domains targeting IL-6 and TNF-α

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US4338397A (en) * 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
US4568640A (en) * 1981-05-11 1986-02-04 Harvey Rubin Method of inserting amino acid analogs into proteins
US4559302A (en) * 1982-11-01 1985-12-17 Eli Lilly And Company DNA for directing transcription and expression of structural genes
US4730036A (en) * 1984-01-03 1988-03-08 Sloan-Kettering Institute For Cancer Research Purifications of B-cell inducing factor (BIF) and B-cell growth factor (BGF)
JPS60169424A (ja) * 1984-02-15 1985-09-02 Chuzo Kishimoto 新規ヒトｂ細胞分化因子，その製造法およびその使用法
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
JPH0657720B2 (ja) * 1985-02-14 1994-08-03 忠三 岸本 Ｂ細胞分化因子
DE220574T1 (de) * 1985-10-14 1987-11-26 Yeda Research And Development Co., Ltd., Rehovot Menschliches interferon-beta2a und interferon-beta2b
US4782139A (en) * 1985-10-28 1988-11-01 Eli Lilly And Company Selective chemical removal of a protein amino-terminal residue
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
US5186931A (en) * 1986-08-06 1993-02-16 Ajinomoto Co., Inc. Composition and method for supporting bone marrow transplantation
DE3767629D1 (de) * 1986-09-20 1991-02-28 Tasuku Honjo Menschlicher b-zellen-differenzierungsfaktor und verfahren zu dessen herstellung.
JP2805224B2 (ja) * 1989-01-13 1998-09-30 味の素株式会社 血小板減少症治療剤

Also Published As

Publication number Publication date
EP0257406B2 (de) 1998-08-12
US5541088A (en) 1996-07-30
EP0257406B1 (de) 1994-06-22
EP0257406A3 (en) 1988-10-26
DE3750106T2 (de) 1995-03-16
EP0585957A1 (de) 1994-03-09
DE3750106D1 (de) 1994-07-28
EP0257406A2 (de) 1988-03-02
US5362489A (en) 1994-11-08

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings