SE8007998L - Forfarande for framstellning av interferon - Google Patents

Forfarande for framstellning av interferon

Info

Publication number
SE8007998L
SE8007998L SE8007998A SE8007998A SE8007998L SE 8007998 L SE8007998 L SE 8007998L SE 8007998 A SE8007998 A SE 8007998A SE 8007998 A SE8007998 A SE 8007998A SE 8007998 L SE8007998 L SE 8007998L
Authority
SE
Sweden
Prior art keywords
interferon
human
dna
highly purified
purified form
Prior art date
Application number
SE8007998A
Other languages
Unknown language ( )
English (en)
Other versions
SE461223B (sv
SE461223C (sv
Inventor
M Revel
P Tiollais
Original Assignee
Yeda Res & Dev
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11051449&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE8007998(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yeda Res & Dev, Pasteur Institut filed Critical Yeda Res & Dev
Publication of SE8007998L publication Critical patent/SE8007998L/sv
Publication of SE461223B publication Critical patent/SE461223B/sv
Publication of SE461223C publication Critical patent/SE461223C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
SE8007998A 1979-11-21 1980-11-14 mRNA och cDNA för humant fibroblastinterferon, förfarande för deras framställning samt användning därav SE461223C (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL58765A IL58765A (en) 1979-11-21 1979-11-21 Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta

Publications (3)

Publication Number Publication Date
SE8007998L true SE8007998L (sv) 1981-05-22
SE461223B SE461223B (sv) 1990-01-22
SE461223C SE461223C (sv) 1997-02-02

Family

ID=11051449

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8007998A SE461223C (sv) 1979-11-21 1980-11-14 mRNA och cDNA för humant fibroblastinterferon, förfarande för deras framställning samt användning därav
SE8603145A SE469660B (sv) 1979-11-21 1986-07-17 Humant fibroblastinterferon-beta, framstaellning och anvaendning daerav

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8603145A SE469660B (sv) 1979-11-21 1986-07-17 Humant fibroblastinterferon-beta, framstaellning och anvaendning daerav

Country Status (9)

Country Link
US (4) US5468607A (sv)
JP (3) JP2555279B2 (sv)
CH (2) CH684892A5 (sv)
DE (2) DE3051086C2 (sv)
FR (1) FR2475901A1 (sv)
GB (1) GB2063882B (sv)
IL (1) IL58765A (sv)
IT (1) IT1194820B (sv)
SE (2) SE461223C (sv)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56131598A (en) * 1980-03-19 1981-10-15 Japan Found Cancer Novel recombinant plasmid having gene of human fibroblastic interferon messenger rna
US5510472A (en) * 1979-11-21 1996-04-23 Yeda Research And Development Co. Ltd. Production of recombinant human interferon-beta2
US5554513A (en) * 1979-11-21 1996-09-10 Yeda Research & Development Co. Ltd. Production of recombinant human interferon-beta2
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
ATE56471T1 (de) 1980-04-03 1990-09-15 Biogen Inc Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
NZ198445A (en) * 1980-09-25 1984-05-31 Genentech Inc Production of human fibroblast interferon by recombinant dna technology
US5582824A (en) * 1981-10-19 1996-12-10 Genentech, Inc. Recombinant DES-CYS-TYR-CYS human immune interferon
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
DE3220116A1 (de) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung
US4737462A (en) * 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4966843A (en) * 1982-11-01 1990-10-30 Cetus Corporation Expression of interferon genes in Chinese hamster ovary cells
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4855238A (en) 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
US5998578A (en) * 1984-05-18 1999-12-07 New England Medical Center Hospitals, Inc. Biologically active fragments of IL-1β
EP0569687B1 (en) * 1984-05-18 2002-08-21 New England Medical Center Hospitals, Inc. Human IL-1 cDNA sequences encoding biologically-active human IL-1 proteins
US5122459A (en) * 1984-12-31 1992-06-16 Immunex Corporation Gene encoding biologically active human interleukin 1
EP0218700A4 (en) * 1985-04-23 1988-09-19 Medical Biology Inst IDENTIFICATION OF AN IgE BINDING PROTEIN BY MOLECULAR CLONING.
DE3683186D1 (de) 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.
DE220574T1 (de) * 1985-10-14 1987-11-26 Yeda Research And Development Co., Ltd., Rehovot Menschliches interferon-beta2a und interferon-beta2b
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
US6284237B1 (en) 1986-07-08 2001-09-04 Steven C. Clark Methods of treatment using IL-6
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
EP0257406B2 (en) * 1986-08-06 1998-08-12 Ajinomoto Co., Inc. Recombinant B-cell differentiation factor
US4939093A (en) * 1987-02-02 1990-07-03 Cetus Corporation Human IL-2 like polypeptides, DNA sequences and recombinant DNA molecules therefore and methods for the production and use thereof
US4961969A (en) * 1987-05-11 1990-10-09 Cetus Corporation Process for recovering microbially produced interferon-β
IL88375A (en) * 1988-11-14 1995-07-31 Yeda Res & Dev Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method
US5338834A (en) * 1993-01-26 1994-08-16 Allelix Biopharmaceuticals Inc. Ultrapure human interleukin-6
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US20030026779A1 (en) * 1999-10-15 2003-02-06 Liming Yu Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc
US20050002902A1 (en) * 1995-12-28 2005-01-06 Liming Yu Hybrid with interferon-alpha and an immunoglobulin Fc for treatment of tumors and viral infections
WO2004039826A1 (en) * 2001-11-14 2004-05-13 Centocor, Inc. Anti-il-6 antibodies, compositions, methods and uses
US20050100550A1 (en) * 2003-11-10 2005-05-12 Mohit Trikha Anti-angiogenic uses of IL-6 antagonists
NZ548256A (en) 2004-02-02 2010-02-26 Ambrx Inc Modified human four helical bundle polypeptides and their uses
PE20061324A1 (es) 2005-04-29 2007-01-15 Centocor Inc Anticuerpos anti-il-6, composiciones, metodos y usos
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US20090238825A1 (en) * 2007-05-21 2009-09-24 Kovacevich Brian R Novel rabbit antibody humanization methods and humanized rabbit antibodies
US7906117B2 (en) 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US20090104187A1 (en) * 2007-05-21 2009-04-23 Alder Biopharmaceuticals, Inc. Novel Rabbit Antibody Humanization Methods and Humanized Rabbit Antibodies
WO2008144763A2 (en) * 2007-05-21 2008-11-27 Alder Biopharmaceuticals, Inc. Antibodies to il-6 and use thereof
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
CN103694337B (zh) 2008-02-08 2016-03-02 Ambrx公司 经修饰瘦素多肽和其用途
US8777182B2 (en) 2008-05-20 2014-07-15 Grinon Industries Fluid transfer assembly and methods of fluid transfer
US8188235B2 (en) 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US9452227B2 (en) * 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
WO2011066369A2 (en) 2009-11-24 2011-06-03 Alder Biopharmaceuticals, Inc. Antagonists of il-6 to raise albumin and/or lower crp
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
ES2847891T3 (es) 2010-11-23 2021-08-04 Vitaeris Inc Anticuerpos anti-IL-6 para el tratamiento de la mucositis oral

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237224A (en) * 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
FR2321298A1 (fr) * 1975-08-01 1977-03-18 Anvar Procede de preparation de produits a activite interferon
NZ187300A (en) * 1977-05-27 1982-08-17 Univ California Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism
JPS5663996A (en) * 1979-10-30 1981-05-30 Japan Found Cancer Novel recombinant having gene complementary to human interferon messenger rna
US5326859A (en) * 1979-10-30 1994-07-05 Juridical Foundation, Japanese Foundation For Cancer Research DNA and recombinant plasmid
FI77877C (sv) * 1979-04-20 1989-05-10 Technobiotic Ltd Förfarande för framställning och rening av human Le-formig interferonp rotein.
US4262090A (en) * 1979-06-04 1981-04-14 Cetus Corporation Interferon production
US4289689A (en) * 1980-03-14 1981-09-15 Hoffmann-La Roche Inc. Preparation of homogeneous human fibroblast interferon
JPS5655731A (en) * 1979-10-11 1981-05-16 Ogura Clutch Co Ltd Clutch/brake device
NL7907791A (nl) * 1979-10-23 1981-04-27 Stichting Rega V Z W Werkwijze voor het zuiveren van interferon.
ATE56471T1 (de) * 1980-04-03 1990-09-15 Biogen Inc Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.
EP0041767B1 (en) * 1980-06-06 1993-03-03 Biogen, Inc. Improved vectors and methods for making such vectors and for expressing cloned genes

Also Published As

Publication number Publication date
FR2475901A1 (fr) 1981-08-21
DE3043981C2 (sv) 1989-11-30
DE3051086C2 (sv) 1992-11-05
CH684892A5 (de) 1995-01-31
IT8026172A0 (it) 1980-11-21
JPS5685296A (en) 1981-07-11
GB2063882B (en) 1984-05-31
JP2548201B2 (ja) 1996-10-30
SE8603145L (sv) 1986-07-17
SE461223B (sv) 1990-01-22
US5468609A (en) 1995-11-21
IL58765A0 (en) 1980-02-29
US5468607A (en) 1995-11-21
SE461223C (sv) 1997-02-02
CH664967A5 (de) 1988-04-15
IL58765A (en) 1986-09-30
GB2063882A (en) 1981-06-10
US5468608A (en) 1995-11-21
JP2555279B2 (ja) 1996-11-20
US5541312A (en) 1996-07-30
SE469660B (sv) 1993-08-16
SE8603145D0 (sv) 1986-07-17
IT1194820B (it) 1988-09-28
JPH02211879A (ja) 1990-08-23
DE3043981A1 (de) 1981-10-01
JPS63164896A (ja) 1988-07-08
FR2475901B1 (sv) 1985-02-15

Similar Documents

Publication Publication Date Title
SE8007998L (sv) Forfarande for framstellning av interferon
Horii et al. Organization of the recA gene of Escherichia coli.
Bland et al. The tobacco mitochondrial ATPase subunit 9 gene is closely linked to an open reading frame for a ribosomal protein
RU2206611C2 (ru) ФРАГМЕНТ ДНК, ПЛАЗМИДНЫЙ ВЕКТОР, СПОСОБ ПОЛУЧЕНИЯ ПОЛИПЕПТИДА И ПОЛИПЕПТИД, ОБЛАДАЮЩИЙ IL-1β ПРОТЕАЗНОЙ АКТИВНОСТЬЮ
Nickel et al. Transfection and transient expression of chloramphenicol acetyltransferase gene in the protozoan parasite Entamoeba histolytica.
Som et al. Regulatory regions of ColE1 that are involved in determination of plasmid copy number.
ATE64416T1 (de) Die verwendung des gal 1 hefe-promotors.
Kodaira et al. The dnaX gene encodes the DNA polymerase III holoenzyme τ subunit, precursor of the γ subunit, the dnaZ gene product
UA13380A (uk) Спосіб одержаhhя лейкоцитарhого іhтерфероhу
DE3280422D1 (de) Verfahren und produkte zur leichten mikrobiologischen expression von dns-sequenzen.
Wikström et al. Importance of mRNA folding and start codon accessibility in the expression of genes in a ribosomal protein operon of Escherichia coli
KR880014110A (ko) 인체 프로아포지방단백질 a-i의 발현
US4652525A (en) Recombinant bacterial plasmids containing the coding sequences of insulin genes
ATE239036T1 (de) Rekombinantes core-streptavidin
Takahashi et al. A large number of tRNA genes are symmetrically located in fission yeast centromeres
JPH0745516B2 (ja) ヒトγ―インターフェロン活性を有するポリペプチドおよびその製造法
Panayotatos DNA replication regulated by the priming promoter
Tatti et al. Utilization of one promoter by two forms of RNA polymerase from Bacillus subtilis
Bennett et al. Nucleotide sequence of the promoter-operator region of the tryptophan operon of Salmonella typhimurium
NZ334568A (en) Nucleic acid and amino acid sequences relating to helicobacter pylori and vaccine compositions thereof
Kim et al. Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian Θ I globin promoters
DE59109072D1 (de) Klonierung der N-Methylhydantoinase
KR930702528A (ko) 스트렙토마이세스 리비단으로부터 분리하고 정제한 단백질 가수분해 효소 x를 암호화하는 dna 시퀸스
Winkler et al. The group IIB intron from the green alga Scenedesmus obliquus mitochondrion: molecular characterization of the in vitro splicing products
ATE43139T1 (de) Klonierungs- und expressionsvektoren fuer gammainterferon, transformierte bakterien und verfahren zur herstellung von gamma-interferon.

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8007998-1

Format of ref document f/p: F