SE454693B - 2-amino-3-karbetoxiamino-6-(p-fluor-bensylamino)-pyridin-maleat, forfarande for framstellning av detta och ett lekemedel med analgetisk och/eller antiflogistisk effekt - Google Patents
2-amino-3-karbetoxiamino-6-(p-fluor-bensylamino)-pyridin-maleat, forfarande for framstellning av detta och ett lekemedel med analgetisk och/eller antiflogistisk effektInfo
- Publication number
- SE454693B SE454693B SE8105425A SE8105425A SE454693B SE 454693 B SE454693 B SE 454693B SE 8105425 A SE8105425 A SE 8105425A SE 8105425 A SE8105425 A SE 8105425A SE 454693 B SE454693 B SE 454693B
- Authority
- SE
- Sweden
- Prior art keywords
- amino
- fluoro
- benzylamino
- pyridine
- crystal modification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3034638 | 1980-09-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8105425L SE8105425L (sv) | 1982-03-14 |
| SE454693B true SE454693B (sv) | 1988-05-24 |
Family
ID=6111900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8105425A SE454693B (sv) | 1980-09-13 | 1981-09-11 | 2-amino-3-karbetoxiamino-6-(p-fluor-bensylamino)-pyridin-maleat, forfarande for framstellning av detta och ett lekemedel med analgetisk och/eller antiflogistisk effekt |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4481205A (Direct) |
| JP (1) | JPS5781465A (Direct) |
| KR (1) | KR860000585B1 (Direct) |
| AR (1) | AR229101A1 (Direct) |
| AT (1) | AT375924B (Direct) |
| AU (1) | AU541020B2 (Direct) |
| BE (1) | BE890331A (Direct) |
| CA (1) | CA1147736A (Direct) |
| CH (1) | CH646952A5 (Direct) |
| CS (1) | CS226037B2 (Direct) |
| DD (1) | DD201786A5 (Direct) |
| DK (1) | DK159878C (Direct) |
| EG (1) | EG15446A (Direct) |
| ES (1) | ES8206481A1 (Direct) |
| FI (1) | FI79531C (Direct) |
| FR (1) | FR2490225B1 (Direct) |
| GB (1) | GB2084138B (Direct) |
| GR (1) | GR75777B (Direct) |
| HU (1) | HU182720B (Direct) |
| IE (1) | IE51547B1 (Direct) |
| IL (1) | IL63801A (Direct) |
| IN (1) | IN155674B (Direct) |
| IT (1) | IT1171520B (Direct) |
| LU (1) | LU83633A1 (Direct) |
| NL (1) | NL189856C (Direct) |
| NO (1) | NO160919C (Direct) |
| PL (1) | PL130030B1 (Direct) |
| SE (1) | SE454693B (Direct) |
| SU (1) | SU1091855A3 (Direct) |
| YU (1) | YU43037B (Direct) |
| ZA (1) | ZA816336B (Direct) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3416609A1 (de) * | 1984-05-05 | 1985-11-07 | Degussa Ag, 6000 Frankfurt | 2-amino-3-ethoxycarbonylamino-6-(p-fluor-benzylamino)- pyridin-gluconat und pharmazeutische zubereitungen, die diese substanz enthalten |
| NO860825L (no) * | 1985-03-23 | 1986-09-24 | Degussa | Fremgangsmaate til fremstilling av 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin samt 2-amino-3-karbetoksyamino-6-(4-fluor-benzylamino)-pyridin. |
| JPH0568848U (ja) * | 1991-11-18 | 1993-09-17 | 京都機械工具株式会社 | チューブ絞り器 |
| DE4327516A1 (de) * | 1993-08-17 | 1995-02-23 | Asta Medica Ag | Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin |
| DE19625582A1 (de) * | 1996-06-27 | 1998-01-02 | Asta Medica Ag | Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen die mit einer unphysiologisch hohen Zellsterberate einhergehen |
| DE19716984A1 (de) * | 1997-04-23 | 1998-10-29 | Asta Medica Ag | Verfahren zur Herstellung von reinem Flupirtin-Maleat und dessen Modifikation A |
| US6187324B1 (en) * | 1998-08-11 | 2001-02-13 | Kabushiki Kaisha Ogi Kogei | Cosmetic composition comprising at least one of Kumazasa extract and medicinal carbon |
| US6821995B1 (en) | 1999-12-01 | 2004-11-23 | Duke University | Method of treating batten disease |
| DE10327674A1 (de) * | 2003-06-20 | 2005-01-05 | Awd.Pharma Gmbh & Co. Kg | Injizierbare Darreichungsform von Flupirtin |
| US7741358B2 (en) * | 2005-04-14 | 2010-06-22 | N.V. Organon | Crystal form of asenapine maleate |
| US20080279930A1 (en) * | 2007-05-07 | 2008-11-13 | Bernd Terhaag | Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof |
| US8501778B2 (en) | 2008-06-20 | 2013-08-06 | Nhwa Pharma. Corporation | Aralkyl piperidine derivatives and their uses as antalgic or ataractic agent |
| CA2738866A1 (en) * | 2008-08-06 | 2010-02-11 | Bionevia Pharmaceuticals, Inc. | Flupirtine hydrochloride maleic acid cocrystal |
| DE102009023162B4 (de) * | 2009-05-29 | 2011-07-07 | Corden PharmaChem GmbH, 68305 | Verfahren zur Herstellung von Flupirtin |
| CN102140077A (zh) * | 2010-01-28 | 2011-08-03 | 范扶民 | 氟吡汀a晶型及其制备方法 |
| WO2012004391A1 (en) | 2010-07-09 | 2012-01-12 | K.H.S. Pharma Holding Gmbh | Process for the preparation of flupirtine maleate |
| CN102241626B (zh) * | 2011-05-03 | 2013-07-03 | 北京华睿鼎信科技有限公司 | 一种马来酸氟吡汀的合成工艺 |
| WO2013080215A1 (en) | 2011-11-30 | 2013-06-06 | Arch Pharmalabs Limited | An improved process for the preparation of flupirtine and pharmaceutically acceptable salts thereof |
| CN103086963A (zh) * | 2013-01-29 | 2013-05-08 | 吉林修正药业新药开发有限公司 | 一种马来酸氟吡汀a晶型化合物及中间体的合成方法 |
| CN104086481B (zh) * | 2014-07-18 | 2016-05-11 | 四川新斯顿制药股份有限公司 | 一种马来酸氟吡汀的合成方法 |
| CN111100010A (zh) * | 2019-12-30 | 2020-05-05 | 山东省越兴化工有限公司 | 一种对氟苄胺的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1795858C2 (de) * | 1968-07-19 | 1979-01-11 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Benzylaminopyridine |
| US3969361A (en) * | 1972-05-10 | 1976-07-13 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler | 2-Benzoyl-3-amino-pyridines |
-
1981
- 1981-09-02 US US06/298,886 patent/US4481205A/en not_active Expired - Lifetime
- 1981-09-04 IE IE2055/81A patent/IE51547B1/en not_active IP Right Cessation
- 1981-09-04 GB GB8126788A patent/GB2084138B/en not_active Expired
- 1981-09-08 AR AR286685A patent/AR229101A1/es active
- 1981-09-09 YU YU2157/81A patent/YU43037B/xx unknown
- 1981-09-10 SU SU813332400A patent/SU1091855A3/ru active
- 1981-09-10 IN IN1018/CAL/81A patent/IN155674B/en unknown
- 1981-09-10 NO NO813082A patent/NO160919C/no unknown
- 1981-09-11 GR GR66021A patent/GR75777B/el unknown
- 1981-09-11 PL PL1981232999A patent/PL130030B1/pl unknown
- 1981-09-11 CS CS816725A patent/CS226037B2/cs unknown
- 1981-09-11 BE BE6/47521A patent/BE890331A/fr not_active IP Right Cessation
- 1981-09-11 LU LU83633A patent/LU83633A1/de unknown
- 1981-09-11 JP JP56143721A patent/JPS5781465A/ja active Granted
- 1981-09-11 AT AT0393481A patent/AT375924B/de not_active IP Right Cessation
- 1981-09-11 DD DD81233226A patent/DD201786A5/de unknown
- 1981-09-11 DK DK404681A patent/DK159878C/da active
- 1981-09-11 AU AU75163/81A patent/AU541020B2/en not_active Expired
- 1981-09-11 IL IL63801A patent/IL63801A/xx unknown
- 1981-09-11 IT IT49272/81A patent/IT1171520B/it active
- 1981-09-11 SE SE8105425A patent/SE454693B/sv not_active IP Right Cessation
- 1981-09-11 CH CH591081A patent/CH646952A5/de not_active IP Right Cessation
- 1981-09-11 NL NLAANVRAGE8104211,A patent/NL189856C/xx not_active IP Right Cessation
- 1981-09-11 ZA ZA816336A patent/ZA816336B/xx unknown
- 1981-09-11 HU HU812635A patent/HU182720B/hu not_active IP Right Cessation
- 1981-09-11 ES ES505423A patent/ES8206481A1/es not_active Expired
- 1981-09-11 KR KR1019810003406A patent/KR860000585B1/ko not_active Expired
- 1981-09-11 CA CA000385703A patent/CA1147736A/en not_active Expired
- 1981-09-11 FI FI812836A patent/FI79531C/fi not_active IP Right Cessation
- 1981-09-13 EG EG81515A patent/EG15446A/xx active
- 1981-09-14 FR FR8117328A patent/FR2490225B1/fr not_active Expired
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE454693B (sv) | 2-amino-3-karbetoxiamino-6-(p-fluor-bensylamino)-pyridin-maleat, forfarande for framstellning av detta och ett lekemedel med analgetisk och/eller antiflogistisk effekt | |
| EP0304019B1 (en) | Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) | |
| RU2323930C1 (ru) | Кристаллическая форма производного 1,2-дигидропиридина и способ ее получения | |
| AU2007336369A1 (en) | Polymorphs of a mGluR5 receptor antagonist | |
| CA2347515C (en) | Crystallization of doxorubicin hydrochloride | |
| KR102402501B1 (ko) | 피마살탄 트로메타민염 및 이를 포함하는 약제학적 조성물 | |
| WO1999048876A1 (en) | Crystalline sodium phenytoin monohydrate | |
| EP2573071A1 (en) | Preparation method of (s)-4-hydroxy-2-oxo-1-pyrrolidine acetamide | |
| DE3133519A1 (de) | "2-amino-3-carbethoxyamino-6-(p-fluor-benzylamino)-pyridin-maleat" | |
| CA2673510C (en) | Maleic acid monosalt of antiviral agent and pharmaceutical composition containing the same | |
| DE69128788T2 (de) | 1,2-dihydro-3h-dibenzoisochinolin-1,3-dione als antitumormittel | |
| IE912362A1 (en) | 3-[(5-methyl-2-furanyl)methyl]-N-(4-piperidinyl)- 3H-imidazo [4,5-b]-pyridin-2-amine 2-hydroxy-1,2,3-propanetricarboxylate | |
| EP2376499B1 (en) | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6)1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene citrate salt | |
| KR870000291B1 (ko) | 결정상 벤조티아진 디옥사이드 염의 제조방법 | |
| EP0451753A1 (de) | Im Ethylenteil substituierte Phenyl-alkylethylendiamin-Platin (II oder IV)-Derivate und Phenylalkyl-ethylendiamine | |
| DE69607443T2 (de) | Zwischenprodukte und ihre Anwendung für die Herstellung von N,N'-überbrückten Bisindolylmaleimiden | |
| CN109053808A (zh) | 一种高纯度双环铂针状晶体的工业化制备方法 | |
| KR101673979B1 (ko) | 화합물 jk12a 및 그 제조 | |
| CN113264873B (zh) | 一种依托考昔的纯化及制备方法 | |
| EP1413578A1 (en) | Novel crystal of arylethenesulfonamide derivative and process for producing the same | |
| US4276297A (en) | Pyridylaminotriazole therapeutic agents | |
| EP0189679B1 (en) | Novel crystalline form of 1-benzhydryl-4-allylpiperazine dihydrochloride and method for the production thereof | |
| CN120539296A (zh) | 一种多替拉韦的质控方法 | |
| CA2391429A1 (en) | Solid state forms of 5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]-2,4-thiazolidinedione | |
| KR20240168375A (ko) | 고순도 화합물의 제조 방법 및 정제 방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAL | Patent in force |
Ref document number: 8105425-6 Format of ref document f/p: F |
|
| NUG | Patent has lapsed |
Ref document number: 8105425-6 Format of ref document f/p: F |