SE454588B - Ester- och amid-derivat av 13,14-didehydroprostaglandiner och en farmaceutisk komposition innehallande dessa - Google Patents

Ester- och amid-derivat av 13,14-didehydroprostaglandiner och en farmaceutisk komposition innehallande dessa

Info

Publication number
SE454588B
SE454588B SE8206731A SE8206731A SE454588B SE 454588 B SE454588 B SE 454588B SE 8206731 A SE8206731 A SE 8206731A SE 8206731 A SE8206731 A SE 8206731A SE 454588 B SE454588 B SE 454588B
Authority
SE
Sweden
Prior art keywords
prost
ethyl ester
ynoic acid
cyclohexyl
trihydroxy
Prior art date
Application number
SE8206731A
Other languages
English (en)
Swedish (sv)
Other versions
SE8206731D0 (sv
SE8206731L (sv
Inventor
F Faustini
V Villa
C Gandolfi
Salle E Di
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of SE8206731D0 publication Critical patent/SE8206731D0/xx
Publication of SE8206731L publication Critical patent/SE8206731L/
Publication of SE454588B publication Critical patent/SE454588B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE8206731A 1981-11-27 1982-11-25 Ester- och amid-derivat av 13,14-didehydroprostaglandiner och en farmaceutisk komposition innehallande dessa SE454588B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8135799 1981-11-27

Publications (3)

Publication Number Publication Date
SE8206731D0 SE8206731D0 (sv) 1982-11-25
SE8206731L SE8206731L (sv) 1983-05-28
SE454588B true SE454588B (sv) 1988-05-16

Family

ID=10526190

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8206731A SE454588B (sv) 1981-11-27 1982-11-25 Ester- och amid-derivat av 13,14-didehydroprostaglandiner och en farmaceutisk komposition innehallande dessa

Country Status (19)

Country Link
US (1) US4543353A (enExample)
JP (1) JPS58103356A (enExample)
AT (1) AT392964B (enExample)
AU (1) AU552847B2 (enExample)
BE (1) BE895137A (enExample)
CA (1) CA1237718A (enExample)
CH (1) CH656877A5 (enExample)
DE (1) DE3241399A1 (enExample)
DK (1) DK528982A (enExample)
FI (1) FI77442C (enExample)
FR (1) FR2517302A1 (enExample)
GB (1) GB2111986B (enExample)
IE (1) IE54347B1 (enExample)
IL (1) IL67103A (enExample)
IT (1) IT1153080B (enExample)
NL (1) NL8204611A (enExample)
SE (1) SE454588B (enExample)
SU (2) SU1301309A3 (enExample)
ZA (1) ZA827825B (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2130575B (en) * 1982-11-09 1985-12-11 Erba Farmitalia Amide derivatives of 13, 14-didehydro-cycloalkyl-prostaglandins
GB8329559D0 (en) * 1983-11-04 1983-12-07 Erba Farmitalia Furyl derivatives of 16-substituted prostaglandins preparations
US4877871A (en) * 1988-06-14 1989-10-31 Nabisco Brands, Inc. Synthesis of sucrose polyester
US5972991A (en) * 1992-09-21 1999-10-26 Allergan Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
CA2364948C (en) 1999-03-05 2011-04-26 Duke University C16 unsaturated fp-selective prostaglandins analogs
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
US8758733B2 (en) 2002-02-04 2014-06-24 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US9216183B2 (en) 2002-02-04 2015-12-22 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
WO2010102078A1 (en) 2009-03-04 2010-09-10 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
US7851504B2 (en) 2005-03-16 2010-12-14 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
CN104983712A (zh) * 2006-01-24 2015-10-21 株式会社·R-技术上野 软明胶胶囊制剂
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) * 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
CA2665081C (en) * 2006-10-02 2015-12-01 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates
US7507817B2 (en) * 2006-11-17 2009-03-24 Allergan, Inc. Prostaglandin prodrugs
JP2010529101A (ja) * 2007-06-04 2010-08-26 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
US7964595B2 (en) * 2008-01-18 2011-06-21 Allergan, Inc. Thiophenyl prostaglandin derivatives for treating glaucoma and ocular hypertension
KR20110017878A (ko) * 2008-05-09 2011-02-22 알러간, 인코포레이티드 치료학적인 치환된 티아졸리딘온, 옥사졸리딘온, 및 관련 화합물
JP2011520807A (ja) * 2008-05-09 2011-07-21 アラーガン インコーポレイテッド 治療用置換ヒダントイン類および関連化合物
US8722739B2 (en) * 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US20100204335A1 (en) * 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
CN108191846B (zh) 2008-12-04 2021-08-20 于崇曦 高穿透性组合物及其应用
NZ716349A (en) 2009-11-09 2017-07-28 Allergan Inc Compositions and methods for stimulating hair growth
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure
US8859616B2 (en) 2011-01-21 2014-10-14 Allergan, Inc. Compounds and methods for enhancing hair growth
JP5925158B2 (ja) * 2013-06-04 2016-05-25 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ
JP6030168B2 (ja) * 2015-03-09 2016-11-24 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ
JP6306067B2 (ja) * 2016-01-08 2018-04-04 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE445717C (de) * 1924-05-16 1927-06-17 Chr Jonathan Sternkopf Vorrichtung zum Herstellen von Holzschliff fuer die Papier- u. dgl. Fabrikation
GB1425962A (en) * 1972-04-13 1976-02-25 Erba Carlo Spa Lactols and lactones
IT1053781B (it) * 1974-09-25 1981-10-10 Erba C S P A Ora Farmitalia Omega nor cicloalcil 13.14 deidro prostaglandine
IL51877A (en) * 1976-06-01 1981-09-13 Carlo Erba Sa -nor-16-benzyl or phenoxy-13,14-dehydro-prostaglandins and process for their preparation
FI71138C (fi) * 1976-12-31 1986-11-24 Erba Farmitalia Foerfarande foer framstaellning av terapeutiskt aktiva bisykliska prostaglandiner
IT1088966B (it) * 1977-11-15 1985-06-10 Erba Carlo Spa 13,14-dideidro-prostaglandine
SE434069B (sv) * 1980-07-09 1984-07-02 Mo Och Domsjoe Ab Forfarande for framstellning av slipmassa
SE446993B (sv) * 1980-07-09 1986-10-20 Mo Och Domsjoe Ab Forfarande for framstellning av blekt slipmassa

Also Published As

Publication number Publication date
FR2517302A1 (fr) 1983-06-03
JPS58103356A (ja) 1983-06-20
FI824017L (fi) 1983-05-28
DK528982A (da) 1983-05-28
GB2111986A (en) 1983-07-13
US4543353A (en) 1985-09-24
IE54347B1 (en) 1989-08-30
DE3241399C2 (enExample) 1990-10-31
ZA827825B (en) 1983-08-31
IL67103A (en) 1986-11-30
FR2517302B1 (enExample) 1984-12-14
AU8979782A (en) 1983-06-02
SE8206731D0 (sv) 1982-11-25
FI77442B (fi) 1988-11-30
SE8206731L (sv) 1983-05-28
IE822568L (en) 1983-05-27
GB2111986B (en) 1985-05-15
BE895137A (fr) 1983-05-25
AT392964B (de) 1991-07-25
CH656877A5 (de) 1986-07-31
JPH0369899B2 (enExample) 1991-11-05
FI824017A0 (fi) 1982-11-23
AU552847B2 (en) 1986-06-26
IT1153080B (it) 1987-01-14
IT8224327A1 (it) 1984-05-19
IT8224327A0 (it) 1982-11-19
DE3241399A1 (de) 1983-06-01
CA1237718A (en) 1988-06-07
SU1321372A3 (ru) 1987-06-30
SU1301309A3 (ru) 1987-03-30
NL8204611A (nl) 1983-06-16
ATA421482A (de) 1990-12-15
FI77442C (fi) 1989-03-10
IL67103A0 (en) 1983-02-23

Similar Documents

Publication Publication Date Title
US4543353A (en) Ester and amide derivatives of 13,14-didehydro prostaglandins
US5767092A (en) Treatment of radiation-damaged bone marrow using galactosyl ceramides
KR100526282B1 (ko) 디플루오로프로스타글란딘유도체및그의용도
JP3612178B2 (ja) プロスタグランジン誘導体を含有する緑内障または眼圧亢進の局所治療のための眼科用組成物
CA1264320A (en) Prostaglandin analogues, process for their preparation and pharmaceutical compositions containing them
CA1074804A (en) Prostaglandin derivatives and process of preparing the same
US4585791A (en) Furyl derivatives of 16-substituted prostaglandins
EP1088816A2 (en) Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
US4626597A (en) 16-fluoro-16,17-didehydro prostanoids and process for their preparation
US5332730A (en) Azido derivatives of cyclopentane heptanoic or heptenoic acid
US5741812A (en) Thromboxane ligands without blood clotting side effects
JPH05502043A (ja) プロスタグランジン誘導体の合成方法
US4285966A (en) Certain 15-epi-prostacyclins
US4175078A (en) Cardenolide and bufadienolide derivatives of ajmaline and process for producing same
JP3108474B2 (ja) 活性型ビタミンｄ誘導体
EP0471856B1 (en) 15-deoxyprostaglandin derivative
EP0399839A2 (en) Intraocular pressure reducing 15-acyl prostaglandins
GB1581321A (en) Prostaglandins
US5292754A (en) Treatment for hypertension or glaucoma in eyes
DE2542686A1 (de) 2a,2b-dihomo-15-methyl- und -15- aethyl-pgf-und pge-verbindungen und verfahren zu deren herstellung
JPH02196767A (ja) ヒドロキサム酸誘導体
US3994956A (en) Substituted anilide esters of 16-phenoxy and 17-phenyl PGE2 type compounds
US5650431A (en) Thromboxane ligands without blood clotting side effects
CA1087178A (en) 1,3-benzodioxan-prostandic acid derivatives and process for producing them
GB2130575A (en) Amide derivatives of 13, 14-didehydro-cycloalkyl-prostaglandins

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8206731-5

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8206731-5

Format of ref document f/p: F