SE448732B - N-(5-tetrazolyl)-1-oxo-1h-tiazolo /3,2-a/-pyrimidin-2-karboxamider med antiallergisk och antiulceros verkan samt motsvarande 2-karboxylsyror - Google Patents

N-(5-tetrazolyl)-1-oxo-1h-tiazolo /3,2-a/-pyrimidin-2-karboxamider med antiallergisk och antiulceros verkan samt motsvarande 2-karboxylsyror

Info

Publication number
SE448732B
SE448732B SE8008189A SE8008189A SE448732B SE 448732 B SE448732 B SE 448732B SE 8008189 A SE8008189 A SE 8008189A SE 8008189 A SE8008189 A SE 8008189A SE 448732 B SE448732 B SE 448732B
Authority
SE
Sweden
Prior art keywords
oxo
pyrimidine
ethyl
mmol
cooled
Prior art date
Application number
SE8008189A
Other languages
English (en)
Swedish (sv)
Other versions
SE8008189L (sv
Inventor
S B Kadin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE8008189L publication Critical patent/SE8008189L/xx
Publication of SE448732B publication Critical patent/SE448732B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
SE8008189A 1979-11-23 1980-11-21 N-(5-tetrazolyl)-1-oxo-1h-tiazolo /3,2-a/-pyrimidin-2-karboxamider med antiallergisk och antiulceros verkan samt motsvarande 2-karboxylsyror SE448732B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9663179A 1979-11-23 1979-11-23

Publications (2)

Publication Number Publication Date
SE8008189L SE8008189L (sv) 1981-05-24
SE448732B true SE448732B (sv) 1987-03-16

Family

ID=22258306

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8008189A SE448732B (sv) 1979-11-23 1980-11-21 N-(5-tetrazolyl)-1-oxo-1h-tiazolo /3,2-a/-pyrimidin-2-karboxamider med antiallergisk och antiulceros verkan samt motsvarande 2-karboxylsyror

Country Status (35)

Country Link
JP (1) JPS5687586A (ru)
KR (1) KR830004322A (ru)
AR (2) AR228859A1 (ru)
AT (1) AT380883B (ru)
AU (1) AU520995B2 (ru)
BE (1) BE886319A (ru)
CA (1) CA1143731A (ru)
CH (1) CH649299A5 (ru)
CS (1) CS241476B2 (ru)
DD (1) DD154608A5 (ru)
DE (2) DE3050491C2 (ru)
DK (1) DK151811C (ru)
EG (1) EG14929A (ru)
ES (1) ES8203363A1 (ru)
FI (1) FI67706C (ru)
FR (1) FR2470132A1 (ru)
GB (1) GB2063862B (ru)
GR (1) GR72132B (ru)
GT (1) GT198066458A (ru)
HU (1) HU179091B (ru)
IE (1) IE50404B1 (ru)
IL (1) IL61535A (ru)
IN (1) IN154926B (ru)
IT (1) IT1209373B (ru)
LU (1) LU82950A1 (ru)
NL (1) NL182565C (ru)
NO (1) NO803521L (ru)
NZ (1) NZ195596A (ru)
PH (1) PH16666A (ru)
PL (1) PL132354B1 (ru)
PT (1) PT72090B (ru)
SE (1) SE448732B (ru)
SU (1) SU1042620A3 (ru)
YU (1) YU41953B (ru)
ZA (1) ZA807293B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
US4457932A (en) * 1983-07-22 1984-07-03 Bristol-Myers Company Anti-ulcer agents
GB8422916D0 (en) * 1984-09-11 1984-10-17 May & Baker Ltd Compositions of matter
JP2690742B2 (ja) * 1987-03-30 1997-12-17 第一製薬株式会社 複素環アミン誘導体
ES2087072T3 (es) * 1988-03-28 1996-07-16 Janssen Pharmaceutica Nv Agentes para conservar o restablecer la salud de la piel.
TWI500623B (zh) * 2009-10-13 2015-09-21 Torrent Pharmaceuticals Ltd 新穎稠合噻唑及噁唑嘧啶酮

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1331059A (en) 1971-04-19 1973-09-19 Lilly Industries Ltd Pyrimidotriazinone compounds
US4041163A (en) * 1976-03-29 1977-08-09 Pfizer Inc. N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents
DE2810863A1 (de) * 1978-03-13 1979-09-27 Boehringer Mannheim Gmbh 1-oxo-1h-pyrimido eckige klammer auf 6,1-b eckige klammer zu benzthiazol-derivate und verfahren zu ihrer herstellung
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones

Also Published As

Publication number Publication date
JPS5687586A (en) 1981-07-16
FR2470132A1 (fr) 1981-05-29
GB2063862B (en) 1983-06-22
DE3043979A1 (de) 1981-09-03
PL228008A1 (ru) 1981-12-11
HU179091B (en) 1982-08-28
NL182565C (nl) 1988-04-05
DK151811B (da) 1988-01-04
NL8006362A (nl) 1981-06-16
AR228859A1 (es) 1983-04-29
ATA570780A (de) 1985-12-15
CH649299A5 (fr) 1985-05-15
ES497066A0 (es) 1982-04-01
CS782080A2 (en) 1985-06-13
YU295080A (en) 1983-06-30
IL61535A0 (en) 1980-12-31
FI803628L (fi) 1981-05-24
SE8008189L (sv) 1981-05-24
FI67706B (fi) 1985-01-31
FR2470132B1 (ru) 1983-07-29
GB2063862A (en) 1981-06-10
AR231296A1 (es) 1984-10-31
BE886319A (fr) 1981-05-25
NO803521L (no) 1981-05-25
PT72090A (en) 1980-12-01
DD154608A5 (de) 1982-04-07
GT198066458A (es) 1982-05-15
PL132354B1 (en) 1985-02-28
JPS617432B2 (ru) 1986-03-06
IL61535A (en) 1984-06-29
EG14929A (en) 1989-01-30
NL182565B (nl) 1987-11-02
IN154926B (ru) 1984-12-22
DK151811C (da) 1988-06-06
AT380883B (de) 1986-07-25
CS241476B2 (en) 1986-03-13
PT72090B (en) 1981-09-29
SU1042620A3 (ru) 1983-09-15
KR830004322A (ko) 1983-07-09
IE802418L (en) 1981-05-23
DK413180A (da) 1981-05-24
DE3043979C2 (de) 1986-08-21
FI67706C (fi) 1985-05-10
ES8203363A1 (es) 1982-04-01
IT1209373B (it) 1989-07-16
CA1143731A (en) 1983-03-29
GR72132B (ru) 1983-09-19
IT8026176A0 (it) 1980-11-21
DE3050491C2 (de) 1985-10-10
NZ195596A (en) 1984-05-31
AU520995B2 (en) 1982-03-11
IE50404B1 (en) 1986-04-16
PH16666A (en) 1983-12-13
LU82950A1 (fr) 1981-06-04
AU6459580A (en) 1981-05-28
ZA807293B (en) 1981-12-30
YU41953B (en) 1988-02-29

Similar Documents

Publication Publication Date Title
HU211557A9 (en) Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same
US4603203A (en) 3-aminopyrazolo[3,4-d]pyrimidine derivatives and production thereof
HU179492B (en) Process for producing 1,2,4-thiadiasole derivatives
EP0391644B1 (en) Aryl-substituted rhodanine derivatives
FI75821B (fi) Foerfarande foer framstaellning av terapeutiskt aktiva 2-guanidino-4-heteroaryltiazoler.
US4734413A (en) Substituted 1,2,4-triazolo[1,5-A]triazines as bronchodilators
SE448732B (sv) N-(5-tetrazolyl)-1-oxo-1h-tiazolo /3,2-a/-pyrimidin-2-karboxamider med antiallergisk och antiulceros verkan samt motsvarande 2-karboxylsyror
US4435407A (en) Certain substituted β-oxo-α-carbamoylpyrrolepropionitriles
US3468888A (en) 2-substituted pyrimido(1,2-a) benzimidazoles
US4705787A (en) Quinazolinone derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
US4423048A (en) Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides and intermediates therefor
US4535081A (en) Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides and intermediates therefor
US4414388A (en) 1-Oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides
US4297365A (en) Benzimidazoles and pharmaceutical preparations containing such compounds
CA1088064A (en) 2,5-dihydro-1,2-thiazino[5,6-b]indol-3- carboxamides-1,1-dioxides, processes for their preparation and their pharmaceutical compositions
US3898218A (en) Process for the preparation of substituted pyrano (3,2-c) (1,2)benzothiazine 6,6-dioxides
EP0081955B1 (en) Benzo-fused heterocyclic compounds
US4500708A (en) Benzothiazine derivatives
US4269774A (en) Thiazolo[5,4-d][2]benzazepines
US4761474A (en) 3-(1H-tetrazol-5-yl)thieno[2,3-d]pyrimidin-4(3H)-ones
FI71158C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 1-xo-1h-tiazolo/3,2-a/pyrimidin-2-karboxylsyror
US3966716A (en) 2H-1,3,2-dioxaborino-[5,4-c]-1,2-benzo-thiazine 6,6-dioxides
US4386097A (en) Benzimidazoles, processes for their preparation and pharmaceutical preparations containing such compounds
EP0279298B1 (en) Tricyclic triazolopyrimidine derivatives
US4321199A (en) Thiazolo[5,4-d][2] benzazepines and intermediates

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8008189-6

Effective date: 19900706

Format of ref document f/p: F