RU99109690A - Нарингин и нарингенин в качестве ингибитора 3-гидрокси-3-метилглутарил коа (hmg-coа) редуктазы - Google Patents

Нарингин и нарингенин в качестве ингибитора 3-гидрокси-3-метилглутарил коа (hmg-coа) редуктазы

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Publication number
RU99109690A
RU99109690A RU99109690/14A RU99109690A RU99109690A RU 99109690 A RU99109690 A RU 99109690A RU 99109690/14 A RU99109690/14 A RU 99109690/14A RU 99109690 A RU99109690 A RU 99109690A RU 99109690 A RU99109690 A RU 99109690A
Authority
RU
Russia
Prior art keywords
coa
naringin
naringenin
hmg
hydroxy
Prior art date
Application number
RU99109690/14A
Other languages
English (en)
Other versions
RU2174393C2 (ru
Inventor
Сонг-Хае БОК
Кванг-Хее СОН
Тае-Соок ДЗЕОНГ
Биенг-Мог КВОН
Янг-Коок КИМ
Долл ЧОЙ
Сунг-Ук КИМ
Ки-Хван БАЕ
Йонг-Бок ПАРК
Миунг-Соок ЧОЙ
Ингиу ХВАНГ
Сурк-Сик МООН
Йонг-Коок КВОН
Дзунг-Ах АХН
Еун-Соок ЛИ
Original Assignee
Корея Инститьют Оф Сайенс Энд Текнолоджи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019960045735A external-priority patent/KR100213895B1/ko
Application filed by Корея Инститьют Оф Сайенс Энд Текнолоджи filed Critical Корея Инститьют Оф Сайенс Энд Текнолоджи
Publication of RU99109690A publication Critical patent/RU99109690A/ru
Application granted granted Critical
Publication of RU2174393C2 publication Critical patent/RU2174393C2/ru

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Claims (4)

1. Применение нарингина или нарингенина для ингибирования активности 3-гидрокси-3-метилглутарил Коа (HMG-CоА) редуктазы у млекопитающего.
2. Применение по п.1, где млекопитающим является человек.
3. Применение по п. 1, где нарингин или нарингенин вводится млекопитающему в виде композиции, содержащей его, причем указанная композиция выбрана из группы, включающей: фармацевтическую композицию, композицию в виде пищевого продукта и композицию в виде напитка.
4. Применение по п.3, где эффективное количество нарингина или нарингенина, содержащегося в композиции, находится в диапазоне 0,5 - 300 мг/мг массы тела/сут.
RU99109690/14A 1996-10-14 1997-10-13 Нарингин и нарингенин в качестве ингибитора 3-гидрокси-3-метилглутарил коа (hmg-coа) редуктазы RU2174393C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1019960045735A KR100213895B1 (ko) 1996-10-14 1996-10-14 감귤류 과피 추출물, 이로부터 분리 정제된 헤스페리딘 또는 나린진을 포함하는 심혈관 질환 예방및 치료제 조성물
KR96-45735 1996-10-14
KR1996-45735 1996-10-14

Publications (2)

Publication Number Publication Date
RU99109690A true RU99109690A (ru) 2001-02-20
RU2174393C2 RU2174393C2 (ru) 2001-10-10

Family

ID=19477355

Family Applications (2)

Application Number Title Priority Date Filing Date
RU99109602/14A RU2174392C2 (ru) 1996-10-14 1997-10-13 Гесперидин и гесперетин в качестве ингибиторов 3-гидрокси-3-метилглутарил-коа (гмг-коа)-редуктазы
RU99109690/14A RU2174393C2 (ru) 1996-10-14 1997-10-13 Нарингин и нарингенин в качестве ингибитора 3-гидрокси-3-метилглутарил коа (hmg-coа) редуктазы

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RU99109602/14A RU2174392C2 (ru) 1996-10-14 1997-10-13 Гесперидин и гесперетин в качестве ингибиторов 3-гидрокси-3-метилглутарил-коа (гмг-коа)-редуктазы

Country Status (10)

Country Link
US (3) US5877208A (ru)
EP (3) EP1014968B1 (ru)
JP (3) JP2001502320A (ru)
KR (3) KR100213895B1 (ru)
CN (3) CN1233182A (ru)
CA (3) CA2268438C (ru)
DE (3) DE69718030T2 (ru)
HK (2) HK1022105A1 (ru)
RU (2) RU2174392C2 (ru)
WO (3) WO1998016220A1 (ru)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239114B1 (en) * 1997-09-26 2001-05-29 Kgk Synergize Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols
JP2001520992A (ja) * 1997-10-28 2001-11-06 コリア インスティテュート オブ サイエンス アンド テクノロジー アシルｃｏａ−コレステロール−ｏ−アシルトランスフェラーゼ抑制剤、動脈壁上でのマクロファージ−脂質複合体蓄積の抑制剤および肝疾患予防または治療剤としてのナリンジンおよびナリンゲニン
CN1327384A (zh) * 1998-10-20 2001-12-19 韩国科学技术研究院 作为血浆高密度脂蛋白浓度增高剂的生物类黄酮
CN1337966A (zh) * 1999-01-27 2002-02-27 齐林斯基实验室 具有提高的生物利用度的橙皮素前体
US20050037116A1 (en) * 1999-03-23 2005-02-17 Alejandro Mendez Synthetic solution for preserving fresh flowers, fruits, and vegetables without the use of refrigeration, and method of producing same
US6797300B2 (en) * 1999-03-23 2004-09-28 Alejandro Mendez Composition for preserving fresh cut flowers, fresh fruits and vegetables without the use of refrigeration
US6123968A (en) * 1999-03-23 2000-09-26 Mendez; Alejandro Composition for extending shelf life for fresh fruits and vegetables without the use of refrigeration
KR100314668B1 (ko) * 1999-05-26 2001-11-17 은종방 감귤과피에서 펙틴과 헤스페리딘의 연속추출방법
US6426362B1 (en) 1999-10-08 2002-07-30 Galileo Laboratories, Inc. Formulations of tocopherols and methods of making and using them
US20020006953A1 (en) * 1999-11-05 2002-01-17 Carla R. McGill Modification of cholesterol concentrations with citus phytochemicals
AU2001213670A1 (en) * 2000-09-25 2002-04-08 Alejandro Mendez Composition for preserving fruits and vegetables, method of making said composition, and method of using said composition without refrigeration
AU2001232182A1 (en) * 2001-01-15 2002-07-24 Kgk Synergize Compositions and methods for regulating lipoproteins and hypercholesterolmia with limonoids flavonoids and tocotrienols
DE10122898A1 (de) * 2001-05-11 2002-11-14 Haarmann & Reimer Gmbh Verwendung von Hydroxyflavanonen zur Maskierung des bitteren Geschmacks
US8337914B2 (en) * 2002-02-27 2012-12-25 Access Business Group International Llc Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation
US20030170327A1 (en) * 2002-03-05 2003-09-11 Dahl Eva Marie Vitamin and zinc monomethionine compositions
KR20030082219A (ko) * 2002-04-17 2003-10-22 한국생명공학연구원 플라바논 에스테르 유도체 및 이를 포함하는 혈중 지질농도 관련 질환의 예방 및 치료용 조성물
KR100479736B1 (ko) * 2002-06-28 2005-03-30 (주)바이오뉴트리젠 천연 식물체 유래의 혼합분말 또는 추출물을 포함하는 지방간 예방용 식품
FR2841472B1 (fr) * 2002-06-28 2006-02-24 Agronomique Inst Nat Rech Composition nutritionnelle ou therapeutique contenant le compose hesperidine ou l'un de ses derives
AU2003256104A1 (en) * 2002-08-14 2004-03-03 Bionutrigen Co., Ltd Powder or extracts of plant leaves with anti-obesity effects and anti-obesity food comprising them
US20050080024A1 (en) * 2002-08-15 2005-04-14 Joseph Tucker Nitric oxide donating derivatives for the treatment of cardiovascular disorders
US20050080021A1 (en) * 2002-08-15 2005-04-14 Joseph Tucker Nitric oxide donating derivatives of stilbenes, polyphenols and flavonoids for the treatment of cardiovascular disorders
US20040033480A1 (en) * 2002-08-15 2004-02-19 Wong Norman C.W. Use of resveratrol to regulate expression of apolipoprotein A1
JP2005130811A (ja) * 2003-10-31 2005-05-26 Yutaka Miyauchi 柑橘類の果皮を原材料とする液状飲用物
JP2005137204A (ja) * 2003-11-04 2005-06-02 Yutaka Miyauchi 液状飲用物
KR100702567B1 (ko) * 2004-06-09 2007-04-02 퓨리메드 주식회사 심근경색 발작 후 회복을 위한 지각 추출물 및 이를 함유하는 약학적 조성물과 건강 식품
JP4745764B2 (ja) * 2004-09-09 2011-08-10 花王株式会社 Ａｍｐｋ活性化剤
CN1760363B (zh) * 2004-10-14 2010-04-28 蒋继宏 杜仲3-羟基-3-甲基戊二酰辅酶a还原酶蛋白编码序列
EP2332527A3 (en) 2004-10-20 2011-11-16 Resverlogix Corp. Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases
US20070087977A1 (en) * 2004-11-16 2007-04-19 Wendye Robbins Methods and compositions for treating pain
AU2005307772B2 (en) * 2004-11-16 2010-06-10 Limerick Biopharma, Inc. Methods and compositions for treating pain
EP2368442B1 (en) 2005-07-27 2014-12-17 Symrise AG Use of hesperetin for enhancing the sweet taste
AU2006275514B2 (en) * 2005-07-29 2012-04-05 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
WO2007150063A2 (en) * 2006-06-23 2007-12-27 Cargill Incorporated Compositions for lowering blood serum cholesterol and use in foods, beverages, and health supplements
PT2118074E (pt) 2007-02-01 2014-03-20 Resverlogix Corp Compostos para a prevenção e tratamento de doenças cardiovasculares
JP2009256256A (ja) * 2008-04-18 2009-11-05 Kyushu Univ 組成物及び飲食品
CA2711103C (en) 2008-06-26 2016-08-09 Resverlogix Corp. Methods of preparing quinazolinone derivatives
CA2747417C (en) 2009-01-08 2017-01-03 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
CA3146333A1 (en) 2009-03-18 2010-09-23 Resverlogix Corp. Phenyl-quinazolin-4(3h)-one and phenyl-pyrido[2,3-d]pyrimidin-4(3h)-one derivatives and compositions thereof useful as anti-inflammatory agents
LT2421533T (lt) 2009-04-22 2018-12-27 Resverlogix Corp. Nauji priešuždegiminiai agentai
US8323513B2 (en) 2009-07-28 2012-12-04 Cp Kelco Aps Dewatering biomass material comprising polysaccharide, method for extracting polysaccharide from biomass material, and dewatered biomass material
US8877221B2 (en) 2010-10-27 2014-11-04 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same
US9107983B2 (en) 2010-10-27 2015-08-18 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising statins
WO2012091440A2 (en) * 2010-12-30 2012-07-05 Lg Life Sciences Ltd. Composition for improvement, treatment and prevention of gastrointestinal motility disorders
US9499640B2 (en) 2011-01-21 2016-11-22 Cp Kelco Aps Preservation of biomass material comprising polysaccharide and method for extracting polysaccharide from preserved biomass material
WO2012170417A2 (en) 2011-06-06 2012-12-13 Warsaw Orthopedic, Inc. Methods and compositions to enhance bone growth comprising a statin
JP5992049B2 (ja) 2011-11-01 2016-09-14 レスバーロジックス コーポレイション 置換されたキナゾリノンのための経口速放性製剤
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
AU2013365926B9 (en) 2012-12-21 2019-01-17 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
CN103304610A (zh) * 2012-12-24 2013-09-18 李玉山 一种甲基橙皮苷的制备工艺
US10813972B2 (en) 2013-02-06 2020-10-27 Malaysian Palm Oil Board Treatment of DNA damage and mitochondrial dysfunction using palm fruit juice
CN103263427A (zh) * 2013-05-07 2013-08-28 浙江大学 新橙皮苷在制备防治高脂血症药物中的应用
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose
TWI634886B (zh) * 2014-08-22 2018-09-11 財團法人國防教育研究基金會 Compound composition for liver-free side effects with reduced liver fat for treating symptoms of non-alcoholic fatty liver disease (NAFLD)
WO2016147053A1 (en) 2015-03-13 2016-09-22 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
KR102139253B1 (ko) * 2018-05-04 2020-07-29 (주)노아스 시트러스 과피 추출물을 포함하는 카페인에 의한 수면장애 개선용 조성물
KR102113583B1 (ko) * 2019-10-25 2020-05-21 경희대학교 산학협력단 레몬 추출물 및 오렌지 추출물을 포함하는 카페인에 의한 수면장애 개선용 조성물
WO2022107093A1 (en) * 2020-11-20 2022-05-27 Esserre Pharma Srl Composition comprising natural extracts and uses thereof
CN115896201B (zh) * 2023-01-09 2023-05-26 成都欧康医药股份有限公司 一种4-甲氧基-3,5`,7`-三羟基黄烷酮的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1179019A (en) * 1967-05-23 1970-01-28 Produits Chimique Soc Et Polynicotinic Esters of Flavonoids
US4277464A (en) * 1975-09-19 1981-07-07 General Foods Corporation Preventing tooth demineralization using aspartame
JPS54154569A (en) * 1978-05-20 1979-12-05 Lotte Co Ltd Chewing gum for sports
US4497842A (en) * 1982-01-18 1985-02-05 Ehrlich Joseph R Beverages obtained from alcoholic treatment of roasted citrus fruit peels
US4497838A (en) * 1982-02-17 1985-02-05 Tropicana Products, Inc. Process for the production of useful products from orange peel
JPS60214858A (ja) * 1984-04-09 1985-10-28 Toshio Horiuchi 血糖改善食品
EP0185117A1 (de) * 1984-12-21 1986-06-25 IPEX Getränke-Herstellungs- und Vertriebsgesellschaft mbH Getränk
JPS63104920A (ja) * 1986-10-21 1988-05-10 Tsumura & Co アルド−スリダクタ−ゼ阻害剤
EP0348509B1 (en) * 1987-12-10 1993-03-24 TSUMURA & CO. Anti-retroviral drug
FR2633182B1 (fr) * 1988-06-23 1993-07-23 Beljanski Mirko Composition pharmaceutique anticancereuse et methode d'utilisation de l'invention
MC2041A1 (fr) * 1988-06-24 1990-05-30 Johannes Cornelius Str Andries Agents anti-atherogenic
US4997658A (en) * 1988-11-21 1991-03-05 Merck & Co., Inc. Method for enhancing the lowering of plasma cholesterol levels
JPH03275625A (ja) * 1990-03-23 1991-12-06 Nippon Oil & Fats Co Ltd 制癌剤およびその製造法
JPH04295428A (ja) * 1991-03-22 1992-10-20 Dai Ichi Seiyaku Co Ltd 抗アレルギー剤
JPH04346933A (ja) * 1991-05-24 1992-12-02 Pokka Corp 虫歯菌、歯周病原菌増殖阻害剤
JP3159509B2 (ja) * 1992-03-30 2001-04-23 サンスター株式会社 プロテアーゼ阻害剤
AU6666594A (en) * 1993-04-20 1994-11-08 Procter & Gamble Company, The Methods of using hesperetin for sebum control and treatment of acne
JPH0725761A (ja) * 1993-07-09 1995-01-27 Kureha Chem Ind Co Ltd 軟骨保護剤
CN1327384A (zh) * 1998-10-20 2001-12-19 韩国科学技术研究院 作为血浆高密度脂蛋白浓度增高剂的生物类黄酮
DE10152638A1 (de) * 2001-10-16 2003-04-24 Ralph Peter Hegler Vorrichtung zur Herstellung von gewellten Kunststoff-Rohren

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