KR100702567B1 - 심근경색 발작 후 회복을 위한 지각 추출물 및 이를 함유하는 약학적 조성물과 건강 식품 - Google Patents
심근경색 발작 후 회복을 위한 지각 추출물 및 이를 함유하는 약학적 조성물과 건강 식품 Download PDFInfo
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- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
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- 230000002829 reductive effect Effects 0.000 description 1
- YXJHJCDOUFKMBG-BMZHGHOISA-M riboflavin sodium Chemical compound [Na+].OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)[N-]C2=O YXJHJCDOUFKMBG-BMZHGHOISA-M 0.000 description 1
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- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
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- 238000002791 soaking Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000001562 sternum Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
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- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
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- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
- A23G9/32—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor characterised by the composition containing organic or inorganic compounds
- A23G9/42—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
- A23L13/60—Comminuted or emulsified meat products, e.g. sausages; Reformed meat from comminuted meat product
- A23L13/65—Sausages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Description
대조군 | 실험군 | |||||||
시간 (min) | 혈압 (mmHg) | 대동맥 박출량 (㎖/min) | 관상동맥 관류량 (㎖/min) | 심장 박출량 (㎖/min) | 혈압 (mmHg) | 대동맥 박출량 (㎖/min) | 관상동맥 관류량 (㎖/min) | 심장 박출량 (㎖/min) |
20 | 93.70 ±1.00 | 70.30 ±1.17 | 22.90 ±0.82 | 92.20 ±1.47 | 90.30 ±1.01 | 69.00 ±1.15 | 22.05 ±1.15 | 91.05 ±1.15 |
25 | 93.50 ±0.87 | 67.00 ±1.32 | 23.30 ±0.75 | 90.30 ±1.51 | 89.40 ±1.63 | 67.33 ±2.40 | 22.67 ±1.20 | 89.67 ±2.38 |
30 | 93.80 ±1.14 | 66.70 ±0.94 | 22.00 ±0.97 | 88.70 ±1.28 | 87.60 ±2.09 | 65.00 ±3.21 | 21.80 ±0.90 | 86.80 ±3.19 |
35 | 92.30 ±1.18 | 66.20 ±1.22 | 22.80 ±0.39 | 89.00 ±1.26 | 87.60 ±1.80 | 67.03 ±3.79 | 23.06 ±1.30 | 90.09 ±3.77 |
70 | 64.30 ±1.11 | 34.70 ±1.01 | 13.80 ±0.53 | 48.50 ±1.11 | 73.30 ±2.91 | 45.67 ** ±3.38 | 17.33 ±1.86 | 62.67 ** ±3.35 |
80 | 63.70 ±1.16 | 34.90 ±1.15 | 13.90 ±0.81 | 48.80 ±1.31 | 73.60 ** ±3.32 | 47.67 ** ±2.96 | 19.00 ** ±1.76 | 66.67 ** ±2.93 |
90 | 59.00 ±1.30 | 32.40 ±1.38 | 12.70 ±0.72 | 45.10 ±1.64 | 72.60 ** ±3.31 | 42.00 ** ±3.06 | 19.87 ** ±0.80 | 61.87 ** ±3.01 |
100 | 58.60 ±1.46 | 31.70 ±1.12 | 13.40 ±1.14 | 45.10 ±1.68 | 71.80 ** ±2.53 | 43.33 ** ±2.73 | 18.58 ** ±1.20 | 61.91 ** ±2.71 |
110 | 54.10 ±1.12 | 32.40 ±1.40 | 12.90 ±0.67 | 45.30 ±1.61 | 71.50 ** ±2.13 | 44.02 ** ±1.30 | 17.90 ** ±1.30 | 61.92 ** ±1.30 |
120 | 51.60 ±1.01 | 31.70 ±1.64 | 13.80 ±0.88 | 45.50 ±1.55 | 69.70 ** ±2.32 | 51.03 ** ±2.65 | 18.80 ** ±1.70 | 69.83 ** ±2.62 |
① * : 대조군과 비교하여 확률(P)〈 0.05 ② **: 대조군과 비교하여 확률(P)〈0.01 ③ 각 수치는 평균±표준오차임 |
대조군 (단위: %) | 실험군 (단위: %) | ||||||||
시간 (min) | 혈압 | 대동맥 박출량 | 관상동맥 관류량 | 심장 박출량 | 혈압 | 대동맥 박출량 | 관상동맥 관류량 | 심장 박출량 | |
허혈성쇼크 전 | ~ 20 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
허혈성쇼크 후 | 10 | 68.4 | 52.0 | 61.1 | 53.8 | 82.1 | 68.5 | 76.2 | 70.2 |
20 | 68.1 | 52.3 | 62.5 | 54.1 | 82.4 | 71.5 | 83.6 | 74.7 | |
30 | 63.1 | 48.6 | 57.1 | 50.0 | 81.3 | 63.0 | 87.4 | 69.3 | |
40 | 62.7 | 47.5 | 60.3 | 50.0 | 80.4 | 65.0 | 81.7 | 69.3 | |
50 | 58.0 | 48.6 | 58.0 | 50.2 | 80.0 | 66.0 | 78.8 | 69.4 | |
60 | 55.2 | 47.5 | 62.1 | 50.5 | 78.1 | 76.5 | 82.7 | 78.2 |
Claims (5)
- 지각을 물 또는 에탄올 수용액으로 추출하여 제조되는 심근경색 발작 후 회복을 위한 지각(Poncirus trifoliata) 추출물.
- 삭제
- 삭제
- 제1항의 지각 추출물을 유효성분으로 함유하는 심근경색 발작 후 회복을 위한 약학적 조성물.
- 제1항의 지각 추출물을 유효성분으로 함유하는 심근경색 발작 후 회복 개선을 위한 건강 식품.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020040042192A KR100702567B1 (ko) | 2004-06-09 | 2004-06-09 | 심근경색 발작 후 회복을 위한 지각 추출물 및 이를 함유하는 약학적 조성물과 건강 식품 |
EP05765052A EP1819351A4 (en) | 2004-06-09 | 2005-06-09 | EXTRACTS FROM PONCIRUS TRIFOLIATA FOR THE PREVENTION AND TREATMENT OF ISCHEMIC DISEASES AND THEIR PHARMACEUTICAL COMPOSITION AND FOODS CONCERNED TO PROMOTE HEALTH |
JP2007527010A JP2008501790A (ja) | 2004-06-09 | 2005-06-09 | 虚血性心疾患予防又は治療用枳殻抽出物及びこれを含有する薬学的組成物と健康食品 |
US11/570,333 US20080003269A1 (en) | 2004-06-09 | 2005-06-09 | Poncirus Trifoliata Extract for Preventing and Treating Ischemic Heart Diseases and Pharmaceutical Composition and Health Food Containing the Same |
PCT/KR2005/001741 WO2005120534A1 (en) | 2004-06-09 | 2005-06-09 | Poncirus trifoliata extract for preventing and treating ischemic heart diseases and phar¬ maceutical composition and health food containing the same |
AU2005251642A AU2005251642A1 (en) | 2004-06-09 | 2005-06-09 | Poncirus trifoliata extract for preventing and treating ischemic heart diseases and phar¬ maceutical composition and health food containing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020040042192A KR100702567B1 (ko) | 2004-06-09 | 2004-06-09 | 심근경색 발작 후 회복을 위한 지각 추출물 및 이를 함유하는 약학적 조성물과 건강 식품 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20050117027A KR20050117027A (ko) | 2005-12-14 |
KR100702567B1 true KR100702567B1 (ko) | 2007-04-02 |
Family
ID=35502825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020040042192A KR100702567B1 (ko) | 2004-06-09 | 2004-06-09 | 심근경색 발작 후 회복을 위한 지각 추출물 및 이를 함유하는 약학적 조성물과 건강 식품 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20080003269A1 (ko) |
EP (1) | EP1819351A4 (ko) |
JP (1) | JP2008501790A (ko) |
KR (1) | KR100702567B1 (ko) |
AU (1) | AU2005251642A1 (ko) |
WO (1) | WO2005120534A1 (ko) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998016239A1 (en) * | 1996-10-14 | 1998-04-23 | Korea Institute Of Science And Technology | CITRUS PEEL EXTRACT AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR |
WO1999021570A1 (en) * | 1997-10-28 | 1999-05-06 | Korea Institute Of Science And Technology | Citrus peel extract as inhibitor of acyl coa-cholesterol-o-acyltransferase, inhibitor of macrophage-lipid complex accumulation on the arterial wall and preventive or treating agent for hepatic diseases |
US6221357B1 (en) | 1999-09-02 | 2001-04-24 | Korea Research Institute Of Bioscience And Biotechnology | Flavonoids derived from citrus peels as collagen-induced platelet aggregation inhibitor |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ177020A (en) * | 1974-04-11 | 1978-09-20 | Ortho Pharma Corp | Utero-evacuant substances and method of extraction from the zoapatle plant |
US4906471A (en) * | 1986-09-08 | 1990-03-06 | Yaguang Liu | Pharmaceutical composition for the reducing both hyperlipidemia and platelet-aggregation (PHP) |
JPH02167216A (ja) * | 1988-09-02 | 1990-06-27 | Kao Corp | 入浴剤 |
JPH0892115A (ja) * | 1994-07-20 | 1996-04-09 | Satoshi Mochizuki | 降コレステロール食材とその製造方法及び食品 |
KR100254908B1 (ko) * | 1997-10-28 | 2000-05-01 | 복성해 | 비타민 씨와 귤피 추출 농축액을 활성성분으로서 포함하는 3-하이드록시-3-메틸글루타릴 코에이 환원효소 활성 저해제 조성물 |
CA2345618A1 (en) * | 1999-08-19 | 2001-03-01 | Korea Research Institute Of Bioscience And Biotechnology | Flavonoids derived from citrus peels as collagen-induced platelet aggregation inhibitor |
WO2002007743A2 (de) * | 2000-07-26 | 2002-01-31 | Vitaplant Ag | Piper methysticum pflanzenextrakt |
US6855704B2 (en) * | 2002-10-09 | 2005-02-15 | Apr Llc | Process for isolating conjugated estrogens |
-
2004
- 2004-06-09 KR KR1020040042192A patent/KR100702567B1/ko active IP Right Grant
-
2005
- 2005-06-09 US US11/570,333 patent/US20080003269A1/en not_active Abandoned
- 2005-06-09 WO PCT/KR2005/001741 patent/WO2005120534A1/en active Application Filing
- 2005-06-09 AU AU2005251642A patent/AU2005251642A1/en not_active Abandoned
- 2005-06-09 EP EP05765052A patent/EP1819351A4/en not_active Withdrawn
- 2005-06-09 JP JP2007527010A patent/JP2008501790A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998016239A1 (en) * | 1996-10-14 | 1998-04-23 | Korea Institute Of Science And Technology | CITRUS PEEL EXTRACT AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR |
WO1999021570A1 (en) * | 1997-10-28 | 1999-05-06 | Korea Institute Of Science And Technology | Citrus peel extract as inhibitor of acyl coa-cholesterol-o-acyltransferase, inhibitor of macrophage-lipid complex accumulation on the arterial wall and preventive or treating agent for hepatic diseases |
US6221357B1 (en) | 1999-09-02 | 2001-04-24 | Korea Research Institute Of Bioscience And Biotechnology | Flavonoids derived from citrus peels as collagen-induced platelet aggregation inhibitor |
Also Published As
Publication number | Publication date |
---|---|
AU2005251642A1 (en) | 2005-12-22 |
WO2005120534A1 (en) | 2005-12-22 |
KR20050117027A (ko) | 2005-12-14 |
EP1819351A1 (en) | 2007-08-22 |
EP1819351A4 (en) | 2007-08-29 |
JP2008501790A (ja) | 2008-01-24 |
US20080003269A1 (en) | 2008-01-03 |
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