RU94016386A - Способ сухого получения частиц на основе активного начала, сухие частицы, полученные этим способом и их содержащие фармацевтические композиции - Google Patents
Способ сухого получения частиц на основе активного начала, сухие частицы, полученные этим способом и их содержащие фармацевтические композицииInfo
- Publication number
- RU94016386A RU94016386A RU94016386/14A RU94016386A RU94016386A RU 94016386 A RU94016386 A RU 94016386A RU 94016386/14 A RU94016386/14 A RU 94016386/14A RU 94016386 A RU94016386 A RU 94016386A RU 94016386 A RU94016386 A RU 94016386A
- Authority
- RU
- Russia
- Prior art keywords
- dry
- particles
- biocompatible polymer
- pharmaceutical compositions
- participation
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims 5
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 229920000249 biocompatible polymer Polymers 0.000 claims 5
- 239000007791 liquid phase Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000011806 microball Substances 0.000 claims 1
- 239000011325 microbead Substances 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
Claims (1)
- Изобретение относится к способу сухого получения частиц практически сферической формы, состоящих из активнодействующего вещества, введенного в биосовместимый полимер с высокой температурой плавления. При осуществлении предлагаемого способа предусмотрены подмешивание при перемешивании указанного биосовместимого полимера и указанного активнодействующего вещества в несмешивающуюся несущую гомогенную вязкую фазу, упомянутые активнодействующее вещество и биосовместимый полимер не растворимы в указанной несущей гомогенной жидкой фазе, продолжение перемешивания до образования биосовместимых полимерных микрошариков и полного введения в них активнодействующего вещества, причем температура процесса превышает температуру стеклования биосовместимого полимера, а также выделение полученных таким образом микрошариков. Изобретение относится также к полученным этим сухим путем частицам и фармацевтическим композициям, содержащим такие частицы.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9310030,3 | 1993-05-15 | ||
GB939310030A GB9310030D0 (en) | 1993-05-15 | 1993-05-15 | Dry processed particles and process for the preparation of the same |
GB9310030.3 | 1993-05-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU94016386A true RU94016386A (ru) | 1996-03-27 |
RU2125869C1 RU2125869C1 (ru) | 1999-02-10 |
Family
ID=10735537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94016386A RU2125869C1 (ru) | 1993-05-15 | 1994-05-13 | Способ сухого получения частиц на основе активного начала, сухие частицы, полученные этим способом и их содержащие фармацевтические композиции |
Country Status (35)
Country | Link |
---|---|
JP (1) | JP3139913B2 (ru) |
KR (1) | KR100341261B1 (ru) |
CN (1) | CN1050534C (ru) |
AT (1) | AT406017B (ru) |
AU (1) | AU685094B2 (ru) |
BE (1) | BE1008323A3 (ru) |
BR (1) | BR9401968A (ru) |
CA (1) | CA2123481C (ru) |
CH (1) | CH688572A5 (ru) |
DE (1) | DE4416812C2 (ru) |
DK (1) | DK171454B1 (ru) |
DZ (1) | DZ1779A1 (ru) |
ES (1) | ES2097083B1 (ru) |
FI (1) | FI112915B (ru) |
FR (1) | FR2705232B1 (ru) |
GB (2) | GB9310030D0 (ru) |
GR (1) | GR1002034B (ru) |
HK (1) | HK1002831A1 (ru) |
HU (1) | HU220617B1 (ru) |
IE (1) | IE940392A1 (ru) |
IN (1) | IN182330B (ru) |
IT (1) | IT1269508B (ru) |
LU (1) | LU88482A1 (ru) |
MA (1) | MA23194A1 (ru) |
NL (1) | NL9400795A (ru) |
NO (1) | NO307403B1 (ru) |
NZ (1) | NZ260520A (ru) |
OA (1) | OA09939A (ru) |
PL (1) | PL175780B1 (ru) |
PT (1) | PT101518B (ru) |
RU (1) | RU2125869C1 (ru) |
SE (1) | SE519004C2 (ru) |
SG (1) | SG46631A1 (ru) |
TN (1) | TNSN94046A1 (ru) |
ZA (1) | ZA943316B (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU220137B (hu) * | 1993-01-06 | 2001-11-28 | Kinerton Ltd. | Biológiailag lebontható poliészterek és biológiailag aktív polipeptidek ionos molekuláris konjugátumai, eljárás ezek előállítására és eljárás mikrorészecskék előállítására |
ATE381349T1 (de) * | 1993-01-06 | 2008-01-15 | Ipsen Mfg Ireland Ltd | Bioabbaubare polyester zur herstellung ionischer molekularer konjugate mit bioaktiven polypeptiden |
DE19604744A1 (de) | 1996-02-09 | 1997-08-14 | Henkel Kgaa | Technische Di-/Triglyceridgemische |
IE960308A1 (en) | 1996-04-23 | 1997-11-05 | Kinerton Ltd | Sustained release ionic conjugate |
DE19617137C1 (de) * | 1996-04-29 | 1997-02-27 | Henkel Kgaa | Verwendung von Copolymerestern für die Herstellung von Mikrosphären |
US5858531A (en) * | 1996-10-24 | 1999-01-12 | Bio Syntech | Method for preparation of polymer microparticles free of organic solvent traces |
US6867181B1 (en) | 1997-06-02 | 2005-03-15 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
EP1229940B1 (en) | 1999-11-15 | 2014-05-14 | Piramal Healthcare (Canada) Limited | Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution |
KR100558119B1 (ko) * | 2000-06-16 | 2006-03-10 | 가부시키가이샤 닛폰 쇼쿠바이 | 가교 중합체, 그것의 제조 방법 및 용도 |
GB0705159D0 (en) * | 2007-03-19 | 2007-04-25 | Prosonix Ltd | Process for making crystals |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
CH672887A5 (ru) * | 1987-10-14 | 1990-01-15 | Debiopharm Sa | |
AU2810189A (en) * | 1987-10-30 | 1989-05-23 | Stolle Research & Development Corporation | Low residual solvent microspheres and microencapsulation process |
DE3916020C2 (de) * | 1989-05-17 | 1994-06-01 | Burkhard Dr Wichert | Retardierende Mikropartikel aus bioabbaubaren Polyestern; Verfahren zu deren Herstellung unter Verzicht auf toxische Lösungsmittel und diese Mikropartikel enthaltende pharmazentische Zubereitungen |
DE69123075T2 (de) * | 1990-04-12 | 1997-03-20 | Shionogi Seiyaku Kk | Ueberzogene Zusammensetzung sowie Verfahren zu ihrer Herstellung |
JP3116311B2 (ja) * | 1990-06-13 | 2000-12-11 | エーザイ株式会社 | マイクロスフィアの製法 |
GB9016885D0 (en) * | 1990-08-01 | 1990-09-12 | Scras | Sustained release pharmaceutical compositions |
GB2246514B (en) * | 1990-08-01 | 1993-12-15 | Scras | Sustained release pharmaceutical compositions and the preparation of particles for use therein |
SE9003296L (sv) * | 1990-10-16 | 1992-04-17 | Kabi Pharmacia Ab | Foerfarande foer att formulera laekemedel |
CA2055522A1 (en) * | 1990-12-12 | 1992-06-13 | Masako Andoh | Microspheres for ophthalmic use |
SE467815B (sv) * | 1991-05-27 | 1992-09-21 | Bengt Hjalmar Aagerup Med Firm | Metod foer att framstaella reproducerbara partiklar av definierad storlek |
GB9203689D0 (en) * | 1992-02-20 | 1992-04-08 | Euro Celtique Sa | Pharmaceutical composition |
CA2129514A1 (en) * | 1992-03-12 | 1993-09-16 | M. Amin Khan | Controlled released acth containing microspheres |
SE9200858L (sv) * | 1992-03-20 | 1993-09-21 | Kabi Pharmacia Ab | Metod för framställning av pellets med fördröjd frisättning |
PT644771E (pt) * | 1992-06-11 | 2002-12-31 | Alkermes Inc | Sistema de entrega da droga eritropoietina |
US5350584A (en) * | 1992-06-26 | 1994-09-27 | Merck & Co., Inc. | Spheronization process using charged resins |
JP2651320B2 (ja) * | 1992-07-16 | 1997-09-10 | 田辺製薬株式会社 | 徐放性マイクロスフェア製剤の製造方法 |
FR2693905B1 (fr) * | 1992-07-27 | 1994-09-02 | Rhone Merieux | Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues. |
GB2273874A (en) * | 1992-12-31 | 1994-07-06 | Pertti Olavi Toermaelae | Preparation of pharmaceuticals in a polymer matrix |
-
1993
- 1993-05-15 GB GB939310030A patent/GB9310030D0/en active Pending
-
1994
- 1994-04-28 GR GR940100215A patent/GR1002034B/el not_active IP Right Cessation
- 1994-05-05 SE SE9401557A patent/SE519004C2/sv not_active IP Right Cessation
- 1994-05-06 HU HU9401412A patent/HU220617B1/hu not_active IP Right Cessation
- 1994-05-09 CH CH01436/94A patent/CH688572A5/fr not_active IP Right Cessation
- 1994-05-09 BE BE9400480A patent/BE1008323A3/fr not_active IP Right Cessation
- 1994-05-11 LU LU88482A patent/LU88482A1/fr unknown
- 1994-05-11 ES ES09400996A patent/ES2097083B1/es not_active Expired - Fee Related
- 1994-05-11 IT ITMI940931A patent/IT1269508B/it active IP Right Grant
- 1994-05-11 OA OA60510A patent/OA09939A/fr unknown
- 1994-05-11 AT AT0098794A patent/AT406017B/de not_active IP Right Cessation
- 1994-05-11 FR FR9405782A patent/FR2705232B1/fr not_active Expired - Fee Related
- 1994-05-12 CA CA002123481A patent/CA2123481C/en not_active Expired - Fee Related
- 1994-05-12 IE IE039294A patent/IE940392A1/en not_active IP Right Cessation
- 1994-05-13 SG SG1996006870A patent/SG46631A1/en unknown
- 1994-05-13 AU AU63084/94A patent/AU685094B2/en not_active Ceased
- 1994-05-13 MA MA23503A patent/MA23194A1/fr unknown
- 1994-05-13 JP JP06099745A patent/JP3139913B2/ja not_active Expired - Fee Related
- 1994-05-13 GB GB9409565A patent/GB2277915B/en not_active Expired - Fee Related
- 1994-05-13 IN IN595DE1994 patent/IN182330B/en unknown
- 1994-05-13 RU RU94016386A patent/RU2125869C1/ru active
- 1994-05-13 FI FI942222A patent/FI112915B/fi active
- 1994-05-13 BR BR9401968A patent/BR9401968A/pt not_active Application Discontinuation
- 1994-05-13 TN TNTNSN94046A patent/TNSN94046A1/fr unknown
- 1994-05-13 DK DK054994A patent/DK171454B1/da not_active IP Right Cessation
- 1994-05-13 ZA ZA943316A patent/ZA943316B/xx unknown
- 1994-05-13 PL PL94303441A patent/PL175780B1/pl not_active IP Right Cessation
- 1994-05-13 PT PT101518A patent/PT101518B/pt not_active IP Right Cessation
- 1994-05-13 CN CN94105512A patent/CN1050534C/zh not_active Expired - Fee Related
- 1994-05-13 NO NO941810A patent/NO307403B1/no not_active IP Right Cessation
- 1994-05-13 NZ NZ260520A patent/NZ260520A/en not_active IP Right Cessation
- 1994-05-13 DE DE4416812A patent/DE4416812C2/de not_active Expired - Fee Related
- 1994-05-14 KR KR1019940010570A patent/KR100341261B1/ko not_active IP Right Cessation
- 1994-05-15 DZ DZ940045A patent/DZ1779A1/fr active
- 1994-05-16 NL NL9400795A patent/NL9400795A/nl active Search and Examination
-
1998
- 1998-03-10 HK HK98101938A patent/HK1002831A1/xx not_active IP Right Cessation
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