GB2277915B - Microballs including a pharmaceutically active ingredient and a polymer - Google Patents

Microballs including a pharmaceutically active ingredient and a polymer

Info

Publication number
GB2277915B
GB2277915B GB9409565A GB9409565A GB2277915B GB 2277915 B GB2277915 B GB 2277915B GB 9409565 A GB9409565 A GB 9409565A GB 9409565 A GB9409565 A GB 9409565A GB 2277915 B GB2277915 B GB 2277915B
Authority
GB
United Kingdom
Prior art keywords
microballs
polymer
active ingredient
pharmaceutically active
pharmaceutically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9409565A
Other versions
GB9409565D0 (en
GB2277915A (en
Inventor
Jean-Marc Ruiz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of GB9409565D0 publication Critical patent/GB9409565D0/en
Publication of GB2277915A publication Critical patent/GB2277915A/en
Application granted granted Critical
Publication of GB2277915B publication Critical patent/GB2277915B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
GB9409565A 1993-05-15 1994-05-13 Microballs including a pharmaceutically active ingredient and a polymer Expired - Fee Related GB2277915B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939310030A GB9310030D0 (en) 1993-05-15 1993-05-15 Dry processed particles and process for the preparation of the same

Publications (3)

Publication Number Publication Date
GB9409565D0 GB9409565D0 (en) 1994-07-06
GB2277915A GB2277915A (en) 1994-11-16
GB2277915B true GB2277915B (en) 1997-10-29

Family

ID=10735537

Family Applications (2)

Application Number Title Priority Date Filing Date
GB939310030A Pending GB9310030D0 (en) 1993-05-15 1993-05-15 Dry processed particles and process for the preparation of the same
GB9409565A Expired - Fee Related GB2277915B (en) 1993-05-15 1994-05-13 Microballs including a pharmaceutically active ingredient and a polymer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB939310030A Pending GB9310030D0 (en) 1993-05-15 1993-05-15 Dry processed particles and process for the preparation of the same

Country Status (35)

Country Link
JP (1) JP3139913B2 (en)
KR (1) KR100341261B1 (en)
CN (1) CN1050534C (en)
AT (1) AT406017B (en)
AU (1) AU685094B2 (en)
BE (1) BE1008323A3 (en)
BR (1) BR9401968A (en)
CA (1) CA2123481C (en)
CH (1) CH688572A5 (en)
DE (1) DE4416812C2 (en)
DK (1) DK171454B1 (en)
DZ (1) DZ1779A1 (en)
ES (1) ES2097083B1 (en)
FI (1) FI112915B (en)
FR (1) FR2705232B1 (en)
GB (2) GB9310030D0 (en)
GR (1) GR1002034B (en)
HK (1) HK1002831A1 (en)
HU (1) HU220617B1 (en)
IE (1) IE940392A1 (en)
IN (1) IN182330B (en)
IT (1) IT1269508B (en)
LU (1) LU88482A1 (en)
MA (1) MA23194A1 (en)
NL (1) NL9400795A (en)
NO (1) NO307403B1 (en)
NZ (1) NZ260520A (en)
OA (1) OA09939A (en)
PL (1) PL175780B1 (en)
PT (1) PT101518B (en)
RU (1) RU2125869C1 (en)
SE (1) SE519004C2 (en)
SG (1) SG46631A1 (en)
TN (1) TNSN94046A1 (en)
ZA (1) ZA943316B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8920842B2 (en) 1999-11-15 2014-12-30 Piramal Healthcare (Canada) Ltd. Temperature controlled and pH dependent self gelling biopolymeric aqueous solution

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU220137B (en) * 1993-01-06 2001-11-28 Kinerton Ltd. Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides, process to prepare them and process to prepare microparticles
ATE381349T1 (en) * 1993-01-06 2008-01-15 Ipsen Mfg Ireland Ltd BIODEGRADABLE POLYESTERS FOR PRODUCING IONIC MOLECULAR CONJUGATES WITH BIOACTIVE POLYPEPTIDES
DE19604744A1 (en) 1996-02-09 1997-08-14 Henkel Kgaa Technical di- / triglyceride mixtures
IE960308A1 (en) 1996-04-23 1997-11-05 Kinerton Ltd Sustained release ionic conjugate
DE19617137C1 (en) * 1996-04-29 1997-02-27 Henkel Kgaa Use of branched alcohol ester(s) of olefin-di:carboxylic acid copolymers
US5858531A (en) * 1996-10-24 1999-01-12 Bio Syntech Method for preparation of polymer microparticles free of organic solvent traces
US6867181B1 (en) 1997-06-02 2005-03-15 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
KR100558119B1 (en) * 2000-06-16 2006-03-10 가부시키가이샤 닛폰 쇼쿠바이 Crosslinked polymer, method for manufacturing it and use thereof
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0461630A2 (en) * 1990-06-13 1991-12-18 Eisai Co., Ltd. Production process of microspheres
GB2246514A (en) * 1990-08-01 1992-02-05 Scras Sustained release particles preparation
WO1992006679A1 (en) * 1990-10-16 1992-04-30 Kabi Pharmacia Ab A method for drug formulation and a pharmaceutical composition
EP0490305A2 (en) * 1990-12-12 1992-06-17 Senju Pharmaceutical Co., Ltd. Microspheres for ophthalmic use
EP0557065A1 (en) * 1992-02-20 1993-08-25 Euroceltique S.A. Spheroid formulation
WO1993017668A1 (en) * 1992-03-12 1993-09-16 Alkermes Controlled Therapeutics, Inc. Controlled release acth containing microspheres
WO1993018753A1 (en) * 1992-03-20 1993-09-30 Kabi Pharmacia Ab Process for the preparation of sustained release pellets
WO1993025221A1 (en) * 1992-06-11 1993-12-23 Alkermes Controlled Therapeutics, Inc. Erythropoietin drug delivery system
WO1994000111A1 (en) * 1992-06-26 1994-01-06 Merck & Co., Inc. Spheronization process using charged resins
EP0585151A1 (en) * 1992-07-27 1994-03-02 Rhone Merieux S.A. Process to prepare micropheres for the sustained release of LHRH-hormone, microspheres and so-obtained compositions
EP0586838A1 (en) * 1992-07-16 1994-03-16 Tanabe Seiyaku Co., Ltd. Method for producing sustained release microsphere preparation
GB2273874A (en) * 1992-12-31 1994-07-06 Pertti Olavi Toermaelae Preparation of pharmaceuticals in a polymer matrix

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CH672887A5 (en) * 1987-10-14 1990-01-15 Debiopharm Sa
AU2810189A (en) * 1987-10-30 1989-05-23 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
DE3916020C2 (en) * 1989-05-17 1994-06-01 Burkhard Dr Wichert Retarding microparticles made from biodegradable polyesters; Process for their preparation without the use of toxic solvents and pharmaceutical preparations containing these microparticles
DE69123075T2 (en) * 1990-04-12 1997-03-20 Shionogi Seiyaku Kk Coated composition and process for its manufacture
GB9016885D0 (en) * 1990-08-01 1990-09-12 Scras Sustained release pharmaceutical compositions
SE467815B (en) * 1991-05-27 1992-09-21 Bengt Hjalmar Aagerup Med Firm METHOD FOR MAKING REPRODUCABLE PARTICLES OF DEFINED SIZE

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0461630A2 (en) * 1990-06-13 1991-12-18 Eisai Co., Ltd. Production process of microspheres
GB2246514A (en) * 1990-08-01 1992-02-05 Scras Sustained release particles preparation
WO1992006679A1 (en) * 1990-10-16 1992-04-30 Kabi Pharmacia Ab A method for drug formulation and a pharmaceutical composition
EP0490305A2 (en) * 1990-12-12 1992-06-17 Senju Pharmaceutical Co., Ltd. Microspheres for ophthalmic use
EP0557065A1 (en) * 1992-02-20 1993-08-25 Euroceltique S.A. Spheroid formulation
WO1993017668A1 (en) * 1992-03-12 1993-09-16 Alkermes Controlled Therapeutics, Inc. Controlled release acth containing microspheres
WO1993018753A1 (en) * 1992-03-20 1993-09-30 Kabi Pharmacia Ab Process for the preparation of sustained release pellets
WO1993025221A1 (en) * 1992-06-11 1993-12-23 Alkermes Controlled Therapeutics, Inc. Erythropoietin drug delivery system
WO1994000111A1 (en) * 1992-06-26 1994-01-06 Merck & Co., Inc. Spheronization process using charged resins
EP0586838A1 (en) * 1992-07-16 1994-03-16 Tanabe Seiyaku Co., Ltd. Method for producing sustained release microsphere preparation
EP0585151A1 (en) * 1992-07-27 1994-03-02 Rhone Merieux S.A. Process to prepare micropheres for the sustained release of LHRH-hormone, microspheres and so-obtained compositions
GB2273874A (en) * 1992-12-31 1994-07-06 Pertti Olavi Toermaelae Preparation of pharmaceuticals in a polymer matrix

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8920842B2 (en) 1999-11-15 2014-12-30 Piramal Healthcare (Canada) Ltd. Temperature controlled and pH dependent self gelling biopolymeric aqueous solution

Also Published As

Publication number Publication date
ES2097083B1 (en) 1997-12-01
JP3139913B2 (en) 2001-03-05
IT1269508B (en) 1997-04-01
FR2705232A1 (en) 1994-11-25
GR1002034B (en) 1995-10-31
PL175780B1 (en) 1999-02-26
DK54994A (en) 1994-11-16
DE4416812C2 (en) 2003-02-06
ZA943316B (en) 1995-01-16
OA09939A (en) 1994-11-15
TNSN94046A1 (en) 1995-04-25
HU220617B1 (en) 2002-03-28
DE4416812A1 (en) 1994-11-17
HK1002831A1 (en) 1998-09-18
NO941810D0 (en) 1994-05-13
NO941810L (en) 1994-11-16
HUT67599A (en) 1995-04-28
IN182330B (en) 1999-03-20
HU9401412D0 (en) 1994-08-29
DZ1779A1 (en) 2002-02-17
KR100341261B1 (en) 2002-09-27
CN1050534C (en) 2000-03-22
AU685094B2 (en) 1998-01-15
GB9409565D0 (en) 1994-07-06
CA2123481C (en) 2005-01-11
BE1008323A3 (en) 1996-04-02
BR9401968A (en) 1994-12-13
GB9310030D0 (en) 1993-06-30
IE940392A1 (en) 1994-11-16
LU88482A1 (en) 1994-12-01
ES2097083A1 (en) 1997-03-16
FI942222A0 (en) 1994-05-13
FI942222A (en) 1994-11-16
PT101518A (en) 1995-03-01
FR2705232B1 (en) 1995-08-25
SE9401557D0 (en) 1994-05-05
RU2125869C1 (en) 1999-02-10
CH688572A5 (en) 1997-11-28
ATA98794A (en) 1999-06-15
FI112915B (en) 2004-02-13
GB2277915A (en) 1994-11-16
AT406017B (en) 2000-01-25
ITMI940931A1 (en) 1995-11-11
DK171454B1 (en) 1996-11-04
ITMI940931A0 (en) 1994-05-11
NZ260520A (en) 1994-12-22
SG46631A1 (en) 1998-02-20
CN1104557A (en) 1995-07-05
MA23194A1 (en) 1994-12-31
NL9400795A (en) 1994-12-01
JPH072652A (en) 1995-01-06
SE9401557L (en) 1994-11-16
NO307403B1 (en) 2000-04-03
AU6308494A (en) 1994-11-17
PT101518B (en) 2000-12-29
CA2123481A1 (en) 1994-11-16
SE519004C2 (en) 2002-12-17

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20100513