HUP0003482A2 - Gömbszerű lineáris poliszacharidokat tartalmazó mikrorészecskék - Google Patents

Gömbszerű lineáris poliszacharidokat tartalmazó mikrorészecskék

Info

Publication number
HUP0003482A2
HUP0003482A2 HU0003482A HUP0003482A HUP0003482A2 HU P0003482 A2 HUP0003482 A2 HU P0003482A2 HU 0003482 A HU0003482 A HU 0003482A HU P0003482 A HUP0003482 A HU P0003482A HU P0003482 A2 HUP0003482 A2 HU P0003482A2
Authority
HU
Hungary
Prior art keywords
containing linear
microparticles containing
spherical microparticles
linear polysaccharides
microparticles
Prior art date
Application number
HU0003482A
Other languages
English (en)
Inventor
Holger Bengs
Gitte Böhm
Jurgen Grande
Arnold Schneller
Original Assignee
Aventis Research And Technologies Gmbh And Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Research And Technologies Gmbh And Co. Kg filed Critical Aventis Research And Technologies Gmbh And Co. Kg
Publication of HUP0003482A2 publication Critical patent/HUP0003482A2/hu
Publication of HUP0003482A3 publication Critical patent/HUP0003482A3/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/12Powdering or granulating
    • C08J3/14Powdering or granulating by precipitation from solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

A találmány olyan mikrorészecskékkel foglalkozik,amelyeknek egységes, gömbszerű alakjuk van és nagyon szűkméreteloszlást mutatnak. Ezek a mikrorészecskék egészben vagy részbenvalamely lineáris, vízben oldhatatlan poliszacharidból, előnyösen 1,4-a-D-glukánból állnak, de ezek tartalmazhatnak más, biológiailaglebontható polimereket és/vagy aktív alkotórészeket is. Ezeket többekközött alkalmazni lehet aktív alkotórészek szabályozottkibocsátásához. Ezek előállítása úgy megy végbe, hogy az 1,4-a-D-poliglukánt vagy valamely egyéb poliszacharidot oldószerbenfeloldanak, az oldatot valamely kicsapószerrel összekeverik, akeveréket lehűtik és a keletkezett részecskéket elkülönítik. Ó
HU0003482A 1997-08-28 1998-08-20 Spherical microparticles containing linear polysaccharides HUP0003482A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19737481A DE19737481A1 (de) 1997-08-28 1997-08-28 Sphärische lineare Polysaccharide enthaltende Mikropartikel
PCT/EP1998/005297 WO1999011695A1 (de) 1997-08-28 1998-08-20 Sphärische lineare polysaccharide enthaltende mikropartikel

Publications (2)

Publication Number Publication Date
HUP0003482A2 true HUP0003482A2 (hu) 2001-05-28
HUP0003482A3 HUP0003482A3 (en) 2001-06-28

Family

ID=7840425

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003482A HUP0003482A3 (en) 1997-08-28 1998-08-20 Spherical microparticles containing linear polysaccharides

Country Status (14)

Country Link
US (2) US6703048B1 (hu)
EP (1) EP1012204B1 (hu)
JP (1) JP2001514315A (hu)
KR (1) KR20010023330A (hu)
CN (1) CN1177884C (hu)
AU (1) AU9532798A (hu)
CA (1) CA2302346A1 (hu)
DE (2) DE19737481A1 (hu)
ES (1) ES2191970T3 (hu)
HU (1) HUP0003482A3 (hu)
NO (1) NO20000913D0 (hu)
PL (1) PL338802A1 (hu)
WO (1) WO1999011695A1 (hu)
ZA (1) ZA987786B (hu)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19737481A1 (de) * 1997-08-28 1999-03-04 Hoechst Ag Sphärische lineare Polysaccharide enthaltende Mikropartikel
HUP0101912A2 (hu) * 1998-04-09 2001-10-28 Axiva Gmbh Különleges hatóanyag-hordozó tüdőben való alkalmazáshoz
DE19816070A1 (de) * 1998-04-09 1999-10-14 Aventis Res & Tech Gmbh & Co Retardtablette hergestellt aus linearen wasserunlöslichen Polysacchariden
DE19839214C1 (de) * 1998-08-28 2000-05-25 Aventis Res & Tech Gmbh & Co Verfahren zur Herstellung von sphärischen Mikropartikeln mit glatter Oberfläche, die ganz oder teilweise aus mindestens einem wasserunlöslichen linearen Polysaccharid bestehen, sowie mit diesem Verfahren erhältliche Mikropartikel und deren Verwendung
DE19839212C2 (de) * 1998-08-28 2002-05-23 Celanese Ventures Gmbh Verfahren zur Herstellung von sphärischen Nanopartikeln, die ganz oder teilweise aus mindestens einem wasserunlöslichen linearen Polysaccharid bestehen
DE19839216C1 (de) * 1998-08-28 2000-01-20 Aventis Res & Tech Gmbh & Co Verfahren zur Herstellung von sphärischen Mikropartikeln, die ganz oder teilweise aus mindestens einem wasserunlöslichen Verzweigungen enthaltenden Polyglucan bestehen, sowie mit diesem Verfahren erhältliche Mikropartikel und die Verwendung
DE19847593A1 (de) * 1998-10-15 2000-04-20 Aventis Res & Tech Gmbh & Co Zusammensetzung für die parenterale Applikation von Wirkstoffen
DE19852826A1 (de) * 1998-11-17 2000-05-18 Aventis Res & Tech Gmbh & Co Poly(alpha-1,4-D-Glucan)
DE19860371A1 (de) * 1998-12-28 2000-06-29 Aventis Res & Tech Gmbh & Co Kosmetische oder medizinische Zubereitung für die topische Anwendung
ES2255317T3 (es) 1998-12-28 2006-06-16 Sudzucker Aktiengesellschaft Protector solar con microparticulas a base de poliglucano lineal insoluble en agua.
DE19860367A1 (de) * 1998-12-28 2000-08-03 Aventis Res & Tech Gmbh & Co Mundpflegemittel enthaltend ein lineares wasserunlösliches Poly-alpha-glucan
DE19860366A1 (de) * 1998-12-28 2000-06-29 Aventis Res & Tech Gmbh & Co Kosmetische oder medizinische Zubereitung für die topische Anwendung
DE19860374A1 (de) * 1998-12-28 2000-07-06 Aventis Res & Tech Gmbh & Co Verwendung von resistenter Stärke als Mehlersatzstoff für Nahrungsmittel und Nahrungsmittelinhaltsstoffe
DE19860373B4 (de) * 1998-12-28 2004-02-19 Celanese Ventures Gmbh Mundpflegemittel und Verwendung von sphärischen Mikropartikeln
DE19902917C2 (de) * 1999-01-26 2001-03-29 Aventis Res & Tech Gmbh & Co Wasserunlösliche lineare Polysaccharide zur Filtration
DE19911058B4 (de) 1999-03-12 2004-09-30 Biotec Asa Verwendung von nanoskaligen wasserlöslichen β-(1,3)-Glucanen
DE10053267B4 (de) * 2000-10-26 2005-12-22 Celanese Ventures Gmbh Verfahren zur Herstellung von mikrosphärischen Kristalliten, danach hergestellte mikrosphärische Kristallite und deren Verwendung
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
KR100457546B1 (ko) * 2001-05-02 2004-11-18 주식회사 바이오프로젠 폴리프럭토오스 또는 그 유도체를 이용한 미소구 및 그제조방법
IL160570A0 (en) 2001-09-26 2004-07-25 Baxter Int Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
WO2005005484A1 (ja) 2003-07-11 2005-01-20 Asahi Kasei Chemicals Corporation 機能性澱粉粉末
DE102005022639B4 (de) * 2005-05-11 2009-01-15 Technische Universität Clausthal Verfahren zur Extraktion von Nano- bis Mikropartikeln
WO2007038126A1 (en) * 2005-09-21 2007-04-05 Surmodics, Inc. In vivo formed matrices including natural biodegradable polysaccharides and ophthalmic uses thereof
WO2007040557A1 (en) * 2005-09-21 2007-04-12 Surmodics, Inc. Coatings and articles including natural biodegradable polysaccharides
US20080286410A1 (en) * 2007-03-06 2008-11-20 Richmond Patricia A Production of Resistant Starch Product
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US20090022805A1 (en) * 2007-06-28 2009-01-22 Joram Slager Polypeptide microparticles having sustained release characteristics, methods and uses
JP5763525B2 (ja) * 2008-05-07 2015-08-12 サーモディクス,インコーポレイティド 粒子からの核酸複合体の送達
EP2246366A1 (en) 2009-03-24 2010-11-03 Mondi Limited South Africa Process and device for preparing starch microgel particles for the paper industry
EP2246472A1 (en) 2009-03-24 2010-11-03 Mondi Limited South Africa Process for preparing polysaccharide gel particles and pulp furnish for use in paper making
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
FR3026105B1 (fr) * 2014-09-24 2019-04-19 Greenpharma Composition contenant au moins un inhibiteur de certaines chimiokines, son procede d'obtention et son utilisation dermocosmetique ou pharmaceutique
US20220396673A1 (en) * 2019-11-14 2022-12-15 Kyushu University, National University Corporation Method for hydrating water-insoluble polymer capable of containing intermediate water

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS551244B1 (hu) * 1970-12-29 1980-01-12
US3915800A (en) * 1972-03-30 1975-10-28 Kelco Co Polysaccharide and bacterial fermentation process for its preparation
JPS511372A (en) * 1974-06-22 1976-01-08 Sumitomo Chemical Co Zoryu hifukuhoho
JPS5326867A (en) * 1976-08-24 1978-03-13 Hayashibara Biochem Lab Method of endowment of waterrproof ability of formed product belonging to poluran series
US4438200A (en) * 1982-09-13 1984-03-20 Forsyth Dental Infirmary For Children Method for the preparation of glucosylranferase
US4992540A (en) * 1984-11-28 1991-02-12 Massachusetts Institute Of Technology Glucan composition and process for preparation thereof
EP0309527B1 (en) 1987-04-16 1993-01-20 Christian Bindschaedler Process for preparing a powder of water-insoluble polymer which can be redispersed in a liquid phase and process for preparing a dispersion of the powdered polymer
US5032401A (en) * 1989-06-15 1991-07-16 Alpha Beta Technology Glucan drug delivery system and adjuvant
JP2926434B2 (ja) * 1990-07-26 1999-07-28 株式会社林原生物化学研究所 アミロース粒子とその製造方法
DE4120760A1 (de) * 1991-06-24 1993-03-04 3 M Medica Gmbh Traegersysteme fuer arzneimittel
NL9201196A (nl) * 1992-07-03 1994-02-01 Tno Preparaat voor de gereguleerde afgifte van een werkzame stof en werkwijze ter bereiding van een dergelijk preparaat.
US5472859A (en) * 1993-08-02 1995-12-05 Brown, Jr.; R. Malcolm Enzymatic method for synthesis of cellulose 1
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
JP3555086B2 (ja) * 1994-05-18 2004-08-18 プランテック バイオテクノロジスク ゲーエムベーハー フォーシュング アンド エンテゥウィックラング 植物、真菌および微生物中で直鎖型α−1,4グルカンの合成を促進することができる酵素をコードするDNA配列
US5576015A (en) 1995-03-02 1996-11-19 Donzis; Byron A. Substantially purified beta (1,3) finely ground yeast cell wall glucan composition with dermatological and nutritional uses
DE19737481A1 (de) * 1997-08-28 1999-03-04 Hoechst Ag Sphärische lineare Polysaccharide enthaltende Mikropartikel
DE19839216C1 (de) * 1998-08-28 2000-01-20 Aventis Res & Tech Gmbh & Co Verfahren zur Herstellung von sphärischen Mikropartikeln, die ganz oder teilweise aus mindestens einem wasserunlöslichen Verzweigungen enthaltenden Polyglucan bestehen, sowie mit diesem Verfahren erhältliche Mikropartikel und die Verwendung
DE19839212C2 (de) * 1998-08-28 2002-05-23 Celanese Ventures Gmbh Verfahren zur Herstellung von sphärischen Nanopartikeln, die ganz oder teilweise aus mindestens einem wasserunlöslichen linearen Polysaccharid bestehen
DE19839214C1 (de) * 1998-08-28 2000-05-25 Aventis Res & Tech Gmbh & Co Verfahren zur Herstellung von sphärischen Mikropartikeln mit glatter Oberfläche, die ganz oder teilweise aus mindestens einem wasserunlöslichen linearen Polysaccharid bestehen, sowie mit diesem Verfahren erhältliche Mikropartikel und deren Verwendung

Also Published As

Publication number Publication date
US6703048B1 (en) 2004-03-09
EP1012204B1 (de) 2003-01-29
CN1268153A (zh) 2000-09-27
WO1999011695A1 (de) 1999-03-11
PL338802A1 (en) 2000-11-20
KR20010023330A (ko) 2001-03-26
NO20000913L (no) 2000-02-24
AU9532798A (en) 1999-03-22
CN1177884C (zh) 2004-12-01
US20040161830A1 (en) 2004-08-19
ZA987786B (en) 1999-03-05
JP2001514315A (ja) 2001-09-11
ES2191970T3 (es) 2003-09-16
DE19737481A1 (de) 1999-03-04
HUP0003482A3 (en) 2001-06-28
EP1012204A1 (de) 2000-06-28
DE59807084D1 (de) 2003-03-06
NO20000913D0 (no) 2000-02-24
CA2302346A1 (en) 1999-03-11

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