HUP0101912A2 - Különleges hatóanyag-hordozó tüdőben való alkalmazáshoz - Google Patents

Különleges hatóanyag-hordozó tüdőben való alkalmazáshoz

Info

Publication number
HUP0101912A2
HUP0101912A2 HU0101912A HUP0101912A HUP0101912A2 HU P0101912 A2 HUP0101912 A2 HU P0101912A2 HU 0101912 A HU0101912 A HU 0101912A HU P0101912 A HUP0101912 A HU P0101912A HU P0101912 A2 HUP0101912 A2 HU P0101912A2
Authority
HU
Hungary
Prior art keywords
active agent
particulate active
agent support
pulmonary application
active substance
Prior art date
Application number
HU0101912A
Other languages
English (en)
Inventor
Holger Bengs
Jürgen Grande
Original Assignee
Axiva Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axiva Gmbh filed Critical Axiva Gmbh
Publication of HUP0101912A2 publication Critical patent/HUP0101912A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

A találmány különleges hatóanyag hordozóra, ennek előállítására, ésebből készült gyógyászati kompozícióra vonatkozik, amely tüdőbenalkalmazható. A szárazon formázható, biológiailag összeférhető,különleges hatóanyag-hordozó részben vagy - egészben lineáris, vízbenoldhatatlan poliszacharidokból, előnyösen poli(1,4-a-D-glukán)-ból vanelőállítva homogén, egységes méretben előnyösen valamely biológiaitranszformációs eljárással, és ez a hordozó csomó vagy agglomerátumkialakítására képes. A találmány különösen előnyösen a szárazporinhaláló berendezésekben alkalmazható. Ó
HU0101912A 1998-04-09 1999-04-08 Különleges hatóanyag-hordozó tüdőben való alkalmazáshoz HUP0101912A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19816085 1998-04-09
PCT/EP1999/002385 WO1999052506A1 (de) 1998-04-09 1999-04-08 Partikulärer wirkstoffträger für die pulmonale applikation

Publications (1)

Publication Number Publication Date
HUP0101912A2 true HUP0101912A2 (hu) 2001-10-28

Family

ID=7864224

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101912A HUP0101912A2 (hu) 1998-04-09 1999-04-08 Különleges hatóanyag-hordozó tüdőben való alkalmazáshoz

Country Status (12)

Country Link
EP (1) EP1069889B1 (hu)
JP (1) JP2002511399A (hu)
KR (1) KR20010034755A (hu)
CN (1) CN1423553A (hu)
AT (1) ATE270097T1 (hu)
AU (1) AU3421099A (hu)
CA (1) CA2340340A1 (hu)
DE (1) DE59909854D1 (hu)
HU (1) HUP0101912A2 (hu)
NO (1) NO20004980L (hu)
PL (1) PL343342A1 (hu)
WO (1) WO1999052506A1 (hu)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19847593A1 (de) * 1998-10-15 2000-04-20 Aventis Res & Tech Gmbh & Co Zusammensetzung für die parenterale Applikation von Wirkstoffen
ES2526707T3 (es) 1999-06-29 2015-01-14 Mannkind Corporation Purificación y estabilización de péptidos y proteínas en agentes farmacéuticos
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
SI1494732T1 (sl) 2002-03-20 2008-08-31 Mannking Corp Inhalacijski aparat
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
JP5078014B2 (ja) 2004-08-20 2012-11-21 マンカインド コーポレイション ジケトピペラジン合成の触媒反応
HUE025151T2 (hu) 2004-08-23 2016-01-28 Mannkind Corp Diketo-piperazin-sók gyógyszeradagolás céljára
EP1928423B1 (en) 2005-09-14 2015-12-09 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
EP1986679B1 (en) 2006-02-22 2017-10-25 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
KR101558026B1 (ko) 2008-06-13 2015-10-06 맨카인드 코포레이션 건조 분말 흡입기 및 약물 투여 시스템
CA2728523C (en) 2008-06-20 2020-03-10 Mannkind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
EP2440184B1 (en) 2009-06-12 2023-04-05 MannKind Corporation Diketopiperazine microparticles with defined specific surface areas
EP2440186B1 (en) 2009-06-12 2019-08-07 MannKind Corporation Diketopiperazine microparticles with defined isomer contents
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
CA2801936C (en) 2010-06-21 2021-06-01 Mannkind Corporation Dry powder drug delivery system and methods
KR101940832B1 (ko) 2011-04-01 2019-01-21 맨카인드 코포레이션 의약 카트리지용 블리스터 패키지
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
EP2776053A1 (en) 2011-10-24 2014-09-17 MannKind Corporation Methods and compositions for treating pain
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
BR112015010601B1 (pt) * 2012-11-09 2022-07-19 Civitas Therapeutics, Inc. Composição farmacêutica e uso da composição
WO2014144895A1 (en) 2013-03-15 2014-09-18 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2018222581A1 (en) * 2017-05-29 2018-12-06 Resinnate Therapeutics Llc Methods and formulations for administering beta glucan

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB937303A (en) * 1959-01-02 1963-09-18 Benger Lab Ltd Improvements in and relating to the application of drugs in finely divided condition
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
GB9606188D0 (en) * 1996-03-23 1996-05-29 Danbiosyst Uk Pollysaccharide microspheres for the pulmonary delivery of drugs
DE19737481A1 (de) * 1997-08-28 1999-03-04 Hoechst Ag Sphärische lineare Polysaccharide enthaltende Mikropartikel

Also Published As

Publication number Publication date
KR20010034755A (ko) 2001-04-25
JP2002511399A (ja) 2002-04-16
NO20004980D0 (no) 2000-10-03
ATE270097T1 (de) 2004-07-15
NO20004980L (no) 2000-12-08
EP1069889B1 (de) 2004-06-30
AU3421099A (en) 1999-11-01
CN1423553A (zh) 2003-06-11
DE59909854D1 (de) 2004-08-05
PL343342A1 (en) 2001-08-13
CA2340340A1 (en) 1999-10-21
EP1069889A1 (de) 2001-01-24
WO1999052506A1 (de) 1999-10-21
WO1999052506B1 (de) 1999-11-25

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