GB937303A - Improvements in and relating to the application of drugs in finely divided condition - Google Patents

Improvements in and relating to the application of drugs in finely divided condition

Info

Publication number
GB937303A
GB937303A GB28559A GB28559A GB937303A GB 937303 A GB937303 A GB 937303A GB 28559 A GB28559 A GB 28559A GB 28559 A GB28559 A GB 28559A GB 937303 A GB937303 A GB 937303A
Authority
GB
United Kingdom
Prior art keywords
drug
solvent
mean diameter
solvents
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28559A
Inventor
Frank Fowler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BENGER LAB Ltd
Original Assignee
BENGER LAB Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BENGER LAB Ltd filed Critical BENGER LAB Ltd
Priority to GB28559A priority Critical patent/GB937303A/en
Publication of GB937303A publication Critical patent/GB937303A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Abstract

The invention relates to a drug in the form of a homogeneous ultra-fine powder for administration by inhalation at least two-thirds, preferably 80%, of whose weight consists of particles within the range 2-6m , preferably 3m , mean diameter and which contains substantially no particles larger than 10m , preferably 7m , mean diameter and a negligible proportion by weight of particles smaller than 1m mean diameter. Specified drugs are chymotrypsin or isoprenaline sulphate. The drug in homogeneous ultra-fine powder form is prepared by forming a suspension of the drug in finely divided form by precipitating the drug from a solution thereof in a solvent therefor by addition of a solvent miscible with said solvent but in which the drug is insoluble, freezing the suspension, if desired after washing and/or concentration, to a microcrystalline form and subsequently removing the frozen liquid, by distillation, under reduced pressure. Homogeneity is improved by high-speed stirring during mixing of the two liquids, subjecting the mixed liquids to ultrasonic vibrations or seeding with nuclei from a previous run. The powdered drug may also be prepared by forming a medicinally inert carrier, e.g. a low molecular weight dextran fraction as above and absorbing the drug therein from solution and freeze drying as above. Specified solvents employed are water, water-miscible solvents, e.g. methanol, ethanol, isopropanol, tertiary butanol or acetone or waterimmiscible solvents, e.g. ether or benzene. The wet preparation obtained by precipitation or absorbtion on a preformed carrier precipitate may prior to freezing be washed, concentrated by filtration or decantation with another solvent having different physical characteristics to that in which the powder is suspended, i.e. any liquid in which the drug and inert carrier, if present, are insoluble. Specification 898,649 is referred to.
GB28559A 1959-01-02 1959-01-02 Improvements in and relating to the application of drugs in finely divided condition Expired GB937303A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB28559A GB937303A (en) 1959-01-02 1959-01-02 Improvements in and relating to the application of drugs in finely divided condition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB28559A GB937303A (en) 1959-01-02 1959-01-02 Improvements in and relating to the application of drugs in finely divided condition

Publications (1)

Publication Number Publication Date
GB937303A true GB937303A (en) 1963-09-18

Family

ID=9701676

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28559A Expired GB937303A (en) 1959-01-02 1959-01-02 Improvements in and relating to the application of drugs in finely divided condition

Country Status (1)

Country Link
GB (1) GB937303A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2423218A1 (en) * 1977-11-30 1979-11-16 Fisons Ltd PHARMACEUTICAL COMPOSITION BASED ON BECLOMETHASONE DIPROPIONATE
EP0465841A2 (en) * 1990-06-13 1992-01-15 Hoechst Aktiengesellschaft Quick acting pharmaceutical inhalation forms of diuretics
WO1999034778A1 (en) * 1997-12-31 1999-07-15 Leiras Oy A method for making a pharmaceutical formulation
WO1999052506A1 (en) * 1998-04-09 1999-10-21 Axiva Gmbh Particulate active agent support for pulmonary application

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2423218A1 (en) * 1977-11-30 1979-11-16 Fisons Ltd PHARMACEUTICAL COMPOSITION BASED ON BECLOMETHASONE DIPROPIONATE
EP0465841A2 (en) * 1990-06-13 1992-01-15 Hoechst Aktiengesellschaft Quick acting pharmaceutical inhalation forms of diuretics
EP0465841A3 (en) * 1990-06-13 1992-10-14 Hoechst Aktiengesellschaft Quick acting pharmaceutical inhalation forms of diuretics
WO1999034778A1 (en) * 1997-12-31 1999-07-15 Leiras Oy A method for making a pharmaceutical formulation
US6616945B1 (en) 1997-12-31 2003-09-09 Leiras Oy Method for making a pharmaceutical formulation
WO1999052506A1 (en) * 1998-04-09 1999-10-21 Axiva Gmbh Particulate active agent support for pulmonary application

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