CH688572A5 - Procédé pour la préparation à sec de particules, particules préparées à sec ainsi obtenues et compositions pharmaceutiques contenant de telle particules. - Google Patents

Procédé pour la préparation à sec de particules, particules préparées à sec ainsi obtenues et compositions pharmaceutiques contenant de telle particules. Download PDF

Info

Publication number
CH688572A5
CH688572A5 CH01436/94A CH143694A CH688572A5 CH 688572 A5 CH688572 A5 CH 688572A5 CH 01436/94 A CH01436/94 A CH 01436/94A CH 143694 A CH143694 A CH 143694A CH 688572 A5 CH688572 A5 CH 688572A5
Authority
CH
Switzerland
Prior art keywords
biocompatible polymer
particles
active principle
support phase
stirring
Prior art date
Application number
CH01436/94A
Other languages
English (en)
French (fr)
Inventor
Jean-Marc Ruiz
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of CH688572A5 publication Critical patent/CH688572A5/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
CH01436/94A 1993-05-15 1994-05-09 Procédé pour la préparation à sec de particules, particules préparées à sec ainsi obtenues et compositions pharmaceutiques contenant de telle particules. CH688572A5 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939310030A GB9310030D0 (en) 1993-05-15 1993-05-15 Dry processed particles and process for the preparation of the same

Publications (1)

Publication Number Publication Date
CH688572A5 true CH688572A5 (fr) 1997-11-28

Family

ID=10735537

Family Applications (1)

Application Number Title Priority Date Filing Date
CH01436/94A CH688572A5 (fr) 1993-05-15 1994-05-09 Procédé pour la préparation à sec de particules, particules préparées à sec ainsi obtenues et compositions pharmaceutiques contenant de telle particules.

Country Status (35)

Country Link
JP (1) JP3139913B2 (ru)
KR (1) KR100341261B1 (ru)
CN (1) CN1050534C (ru)
AT (1) AT406017B (ru)
AU (1) AU685094B2 (ru)
BE (1) BE1008323A3 (ru)
BR (1) BR9401968A (ru)
CA (1) CA2123481C (ru)
CH (1) CH688572A5 (ru)
DE (1) DE4416812C2 (ru)
DK (1) DK171454B1 (ru)
DZ (1) DZ1779A1 (ru)
ES (1) ES2097083B1 (ru)
FI (1) FI112915B (ru)
FR (1) FR2705232B1 (ru)
GB (2) GB9310030D0 (ru)
GR (1) GR1002034B (ru)
HK (1) HK1002831A1 (ru)
HU (1) HU220617B1 (ru)
IE (1) IE940392A1 (ru)
IN (1) IN182330B (ru)
IT (1) IT1269508B (ru)
LU (1) LU88482A1 (ru)
MA (1) MA23194A1 (ru)
NL (1) NL9400795A (ru)
NO (1) NO307403B1 (ru)
NZ (1) NZ260520A (ru)
OA (1) OA09939A (ru)
PL (1) PL175780B1 (ru)
PT (1) PT101518B (ru)
RU (1) RU2125869C1 (ru)
SE (1) SE519004C2 (ru)
SG (1) SG46631A1 (ru)
TN (1) TNSN94046A1 (ru)
ZA (1) ZA943316B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK74495A3 (en) * 1993-01-06 1997-01-08 Kinerton Ltd Ionic molecular conjugates of biodegradable polyesters with bioactive polypeptides and a method of preparation thereof
ATE381349T1 (de) * 1993-01-06 2008-01-15 Ipsen Mfg Ireland Ltd Bioabbaubare polyester zur herstellung ionischer molekularer konjugate mit bioaktiven polypeptiden
DE19604744A1 (de) 1996-02-09 1997-08-14 Henkel Kgaa Technische Di-/Triglyceridgemische
IE960308A1 (en) 1996-04-23 1997-11-05 Kinerton Ltd Sustained release ionic conjugate
DE19617137C1 (de) * 1996-04-29 1997-02-27 Henkel Kgaa Verwendung von Copolymerestern für die Herstellung von Mikrosphären
US5858531A (en) * 1996-10-24 1999-01-12 Bio Syntech Method for preparation of polymer microparticles free of organic solvent traces
US6867181B1 (en) 1997-06-02 2005-03-15 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
AU1375301A (en) 1999-11-15 2001-05-30 Bio Syntech Canada Inc Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
US6646083B2 (en) 2000-06-16 2003-11-11 Nippon Shokubai Co., Ltd. Crosslinked polymers containing tertiary amine and/or quaternary ammonium salt structures, processes for making and uses thereof
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CH672887A5 (ru) * 1987-10-14 1990-01-15 Debiopharm Sa
AU2810189A (en) * 1987-10-30 1989-05-23 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
DE3916020C2 (de) * 1989-05-17 1994-06-01 Burkhard Dr Wichert Retardierende Mikropartikel aus bioabbaubaren Polyestern; Verfahren zu deren Herstellung unter Verzicht auf toxische Lösungsmittel und diese Mikropartikel enthaltende pharmazentische Zubereitungen
KR0168849B1 (ko) * 1990-04-12 1999-01-15 요시또시 가즈오 피목 조성물 및 그의 제조방법
JP3116311B2 (ja) * 1990-06-13 2000-12-11 エーザイ株式会社 マイクロスフィアの製法
GB2246514B (en) * 1990-08-01 1993-12-15 Scras Sustained release pharmaceutical compositions and the preparation of particles for use therein
GB9016885D0 (en) * 1990-08-01 1990-09-12 Scras Sustained release pharmaceutical compositions
SE9003296L (sv) * 1990-10-16 1992-04-17 Kabi Pharmacia Ab Foerfarande foer att formulera laekemedel
CA2055522A1 (en) * 1990-12-12 1992-06-13 Masako Andoh Microspheres for ophthalmic use
SE9101603L (sv) * 1991-05-27 1992-09-21 Bengt Hjalmar Aagerup Med Firm Metod foer att framstaella reproducerbara partiklar av definierad storlek
GB9203689D0 (en) * 1992-02-20 1992-04-08 Euro Celtique Sa Pharmaceutical composition
EP0630234B1 (en) * 1992-03-12 1997-06-11 Alkermes Controlled Therapeutics, Inc. Controlled release acth containing microspheres
SE9200858L (sv) * 1992-03-20 1993-09-21 Kabi Pharmacia Ab Metod för framställning av pellets med fördröjd frisättning
WO1993025221A1 (en) * 1992-06-11 1993-12-23 Alkermes Controlled Therapeutics, Inc. Erythropoietin drug delivery system
US5350584A (en) * 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
JP2651320B2 (ja) * 1992-07-16 1997-09-10 田辺製薬株式会社 徐放性マイクロスフェア製剤の製造方法
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
GB2273874A (en) * 1992-12-31 1994-07-06 Pertti Olavi Toermaelae Preparation of pharmaceuticals in a polymer matrix

Also Published As

Publication number Publication date
GB2277915B (en) 1997-10-29
GB9310030D0 (en) 1993-06-30
HK1002831A1 (en) 1998-09-18
BE1008323A3 (fr) 1996-04-02
RU2125869C1 (ru) 1999-02-10
IN182330B (ru) 1999-03-20
FI942222A (fi) 1994-11-16
JPH072652A (ja) 1995-01-06
FR2705232B1 (fr) 1995-08-25
SE9401557L (sv) 1994-11-16
HU9401412D0 (en) 1994-08-29
ITMI940931A1 (it) 1995-11-11
TNSN94046A1 (fr) 1995-04-25
IE940392A1 (en) 1994-11-16
ZA943316B (en) 1995-01-16
ATA98794A (de) 1999-06-15
OA09939A (fr) 1994-11-15
ITMI940931A0 (it) 1994-05-11
GR1002034B (en) 1995-10-31
GB9409565D0 (en) 1994-07-06
DE4416812C2 (de) 2003-02-06
DK54994A (da) 1994-11-16
AT406017B (de) 2000-01-25
FR2705232A1 (fr) 1994-11-25
IT1269508B (it) 1997-04-01
DZ1779A1 (fr) 2002-02-17
FI942222A0 (fi) 1994-05-13
NO307403B1 (no) 2000-04-03
HU220617B1 (hu) 2002-03-28
DE4416812A1 (de) 1994-11-17
PT101518A (pt) 1995-03-01
ES2097083B1 (es) 1997-12-01
NL9400795A (nl) 1994-12-01
PL175780B1 (pl) 1999-02-26
NO941810L (no) 1994-11-16
SE519004C2 (sv) 2002-12-17
NZ260520A (en) 1994-12-22
HUT67599A (en) 1995-04-28
BR9401968A (pt) 1994-12-13
NO941810D0 (no) 1994-05-13
CN1104557A (zh) 1995-07-05
PT101518B (pt) 2000-12-29
AU6308494A (en) 1994-11-17
DK171454B1 (da) 1996-11-04
GB2277915A (en) 1994-11-16
AU685094B2 (en) 1998-01-15
FI112915B (fi) 2004-02-13
KR100341261B1 (ko) 2002-09-27
CN1050534C (zh) 2000-03-22
CA2123481A1 (en) 1994-11-16
LU88482A1 (fr) 1994-12-01
SE9401557D0 (sv) 1994-05-05
CA2123481C (en) 2005-01-11
MA23194A1 (fr) 1994-12-31
ES2097083A1 (es) 1997-03-16
SG46631A1 (en) 1998-02-20
JP3139913B2 (ja) 2001-03-05

Similar Documents

Publication Publication Date Title
EP0585151B1 (fr) Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues
EP0608207B1 (fr) Compositions pharmaceutiques contenant des nanocapsules
DK1343480T4 (en) Induced phase transition method for the preparation of microparticles containing hydrophobic active agents.
EP0804173B1 (fr) Microspheres biodegradables a liberation controlee et leur procede de preparation
EP1450766B1 (fr) Microspheres biodegradables a liberation prolongee et leur procede de preparation
BE1008323A3 (fr) Procede pour la preparation de particules preparees a sec, particules preparees a sec ainsi obtenues et compositions pharmaceutiques contenant de telles particules.
EP0646001B1 (fr) Microspheres en polymere bioresorbable, exemptes de tensioactif, leur preparation et leur application comme medicament
EP0690747B1 (fr) Procede de preparation de particules renfermant un ingredient actif par extrusion et lyophilisation
FR2484281A1 (fr) Procede de preparation de microspheres comportant un noyau solide et une matiere polymere
LU87982A1 (fr) Procede de preparation de compositions a liberation prolongee et compositions ainsi obtenues
KR102383448B1 (ko) 락트산 또는 글리콜산을 포함하는 미립구형 서방출 제제 및 그의 제조방법
WO2006072685A2 (fr) Procede de preparation d'une composition pharmaceutique solide a liberation prolongee et controlee par traitement sous hautes pressions
EP0542855B1 (fr) Microcapsules a paroi mixte d'atelocollagene et de polyholosides coagulee par un cation bivalent
FR2719770A1 (fr) Système matriciel pour administration transdermique d'ibuprofène et procédé de préparation.
FR2797784A1 (fr) Procede d'encapsulation de matieres actives par coacervation de polymeres en solvant organique non-chlore
FR2702375A1 (fr) Microcapsules à libération progressive, leur procédé de préparation et compositions pharmaceutiques ou vétérinaires les contenant.
WO2018056019A1 (ja) 徐放性薬剤の製造方法及び徐放性薬剤
KR20200087594A (ko) 레티노익산을 포함하는 미립구형 서방출 제제 및 그의 제조방법
EP0900564A1 (fr) Comprimé antiseptique vaginal à action prolongée
WO2000067727A1 (fr) Formulations galeniques d'agents antithrombiotques pour administration sous-cutanee
EP1683568A1 (fr) Procédé de coacervation amélioré pour la préparation de microcapsules de principe actif hydrophobe isolées filtrables et redispersables dans l'eau

Legal Events

Date Code Title Description
PL Patent ceased