CN1050534C - 干法处理的粒子的制备方法 - Google Patents
干法处理的粒子的制备方法 Download PDFInfo
- Publication number
- CN1050534C CN1050534C CN94105512A CN94105512A CN1050534C CN 1050534 C CN1050534 C CN 1050534C CN 94105512 A CN94105512 A CN 94105512A CN 94105512 A CN94105512 A CN 94105512A CN 1050534 C CN1050534 C CN 1050534C
- Authority
- CN
- China
- Prior art keywords
- active component
- bioavailable polymer
- polymer
- support
- particle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002245 particle Substances 0.000 title claims description 103
- 238000000034 method Methods 0.000 title claims description 50
- 238000002360 preparation method Methods 0.000 title claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 title description 4
- 229920000642 polymer Polymers 0.000 claims abstract description 104
- 239000000203 mixture Substances 0.000 claims abstract description 60
- 238000003756 stirring Methods 0.000 claims abstract description 51
- 229920002545 silicone oil Polymers 0.000 claims abstract description 17
- 229920000249 biocompatible polymer Polymers 0.000 claims abstract description 6
- 239000004005 microsphere Substances 0.000 claims description 37
- 239000012071 phase Substances 0.000 claims description 29
- 238000013019 agitation Methods 0.000 claims description 25
- 239000007791 liquid phase Substances 0.000 claims description 17
- 238000004017 vitrification Methods 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 15
- 238000001816 cooling Methods 0.000 claims description 14
- 239000000499 gel Substances 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 8
- 238000012216 screening Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 4
- 229920002988 biodegradable polymer Polymers 0.000 claims description 3
- 239000004621 biodegradable polymer Substances 0.000 claims description 3
- 239000000017 hydrogel Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000011806 microball Substances 0.000 abstract 4
- 239000004615 ingredient Substances 0.000 abstract 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 21
- 108090000765 processed proteins & peptides Proteins 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000010790 dilution Methods 0.000 description 8
- 239000012895 dilution Substances 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 7
- RPVGLMKJGQMQSN-UHFFFAOYSA-N tiliquinol Chemical compound C1=CC=C2C(C)=CC=C(O)C2=N1 RPVGLMKJGQMQSN-UHFFFAOYSA-N 0.000 description 7
- 229950005513 tiliquinol Drugs 0.000 description 7
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 6
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 6
- 239000011162 core material Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000000227 grinding Methods 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- 239000004531 microgranule Substances 0.000 description 4
- 229920001610 polycaprolactone Polymers 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229920001519 homopolymer Polymers 0.000 description 3
- 229960003387 progesterone Drugs 0.000 description 3
- 239000000186 progesterone Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000007790 solid phase Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000000038 blue colorant Substances 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- -1 hydroxypropyl Chemical group 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 2
- 229960004824 triptorelin Drugs 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- PUDHBTGHUJUUFI-SCTWWAJVSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-n-[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2r)-2-amino-3-naphthalen-2-ylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-p Chemical compound C([C@H]1C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](N)CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)=O)C(C)C)C1=CC=C(O)C=C1 PUDHBTGHUJUUFI-SCTWWAJVSA-N 0.000 description 1
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 description 1
- 229920001651 Cyanoacrylate Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920003091 Methocel™ Polymers 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000000110 cooling liquid Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- JBFHTYHTHYHCDJ-UHFFFAOYSA-N gamma-caprolactone Chemical compound CCC1CCC(=O)O1 JBFHTYHTHYHCDJ-UHFFFAOYSA-N 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229960004275 glycolic acid Drugs 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 1
- 108010021336 lanreotide Proteins 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000001543 purgative effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000003396 thiol group Chemical class [H]S* 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9310030.3 | 1993-05-15 | ||
| GB939310030A GB9310030D0 (en) | 1993-05-15 | 1993-05-15 | Dry processed particles and process for the preparation of the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1104557A CN1104557A (zh) | 1995-07-05 |
| CN1050534C true CN1050534C (zh) | 2000-03-22 |
Family
ID=10735537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94105512A Expired - Fee Related CN1050534C (zh) | 1993-05-15 | 1994-05-13 | 干法处理的粒子的制备方法 |
Country Status (35)
| Country | Link |
|---|---|
| JP (1) | JP3139913B2 (ru) |
| KR (1) | KR100341261B1 (ru) |
| CN (1) | CN1050534C (ru) |
| AT (1) | AT406017B (ru) |
| AU (1) | AU685094B2 (ru) |
| BE (1) | BE1008323A3 (ru) |
| BR (1) | BR9401968A (ru) |
| CA (1) | CA2123481C (ru) |
| CH (1) | CH688572A5 (ru) |
| DE (1) | DE4416812C2 (ru) |
| DK (1) | DK171454B1 (ru) |
| DZ (1) | DZ1779A1 (ru) |
| ES (1) | ES2097083B1 (ru) |
| FI (1) | FI112915B (ru) |
| FR (1) | FR2705232B1 (ru) |
| GB (2) | GB9310030D0 (ru) |
| GR (1) | GR1002034B (ru) |
| HK (1) | HK1002831A1 (ru) |
| HU (1) | HU220617B1 (ru) |
| IE (1) | IE940392A1 (ru) |
| IN (1) | IN182330B (ru) |
| IT (1) | IT1269508B (ru) |
| LU (1) | LU88482A1 (ru) |
| MA (1) | MA23194A1 (ru) |
| NL (1) | NL9400795A (ru) |
| NO (1) | NO307403B1 (ru) |
| NZ (1) | NZ260520A (ru) |
| OA (1) | OA09939A (ru) |
| PL (1) | PL175780B1 (ru) |
| PT (1) | PT101518B (ru) |
| RU (1) | RU2125869C1 (ru) |
| SE (1) | SE519004C2 (ru) |
| SG (1) | SG46631A1 (ru) |
| TN (1) | TNSN94046A1 (ru) |
| ZA (1) | ZA943316B (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU220137B (hu) * | 1993-01-06 | 2001-11-28 | Kinerton Ltd. | Biológiailag lebontható poliészterek és biológiailag aktív polipeptidek ionos molekuláris konjugátumai, eljárás ezek előállítására és eljárás mikrorészecskék előállítására |
| DE69435055T2 (de) * | 1993-01-06 | 2008-12-04 | IPSEN Manufacturing Ireland Ltd., Blanchardstown | Bioabbaubare Polyester zur Herstellung ionischer molekularer Konjugate mit bioaktiven Polypeptiden |
| DE19604744A1 (de) | 1996-02-09 | 1997-08-14 | Henkel Kgaa | Technische Di-/Triglyceridgemische |
| IE960308A1 (en) | 1996-04-23 | 1997-11-05 | Kinerton Ltd | Sustained release ionic conjugate |
| DE19617137C1 (de) * | 1996-04-29 | 1997-02-27 | Henkel Kgaa | Verwendung von Copolymerestern für die Herstellung von Mikrosphären |
| US5858531A (en) * | 1996-10-24 | 1999-01-12 | Bio Syntech | Method for preparation of polymer microparticles free of organic solvent traces |
| US6867181B1 (en) | 1997-06-02 | 2005-03-15 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| CA2685349C (en) | 1999-11-15 | 2013-09-17 | Bio Syntech Canada Inc. | Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution |
| US6646083B2 (en) | 2000-06-16 | 2003-11-11 | Nippon Shokubai Co., Ltd. | Crosslinked polymers containing tertiary amine and/or quaternary ammonium salt structures, processes for making and uses thereof |
| GB0705159D0 (en) * | 2007-03-19 | 2007-04-25 | Prosonix Ltd | Process for making crystals |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2070153A1 (ru) * | 1969-10-23 | 1971-09-10 | Du Pont | |
| EP0058481A1 (en) * | 1981-02-16 | 1982-08-25 | Zeneca Limited | Continuous release pharmaceutical compositions |
| GB2246514A (en) * | 1990-08-01 | 1992-02-05 | Scras | Sustained release particles preparation |
| WO1992021326A1 (en) * | 1991-05-27 | 1992-12-10 | Medinvent | Method of producing reproducible particles |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH672887A5 (ru) * | 1987-10-14 | 1990-01-15 | Debiopharm Sa | |
| WO1989003678A1 (en) * | 1987-10-30 | 1989-05-05 | Stolle Research & Development Corporation | Low residual solvent microspheres and microencapsulation process |
| DE3916020C2 (de) * | 1989-05-17 | 1994-06-01 | Burkhard Dr Wichert | Retardierende Mikropartikel aus bioabbaubaren Polyestern; Verfahren zu deren Herstellung unter Verzicht auf toxische Lösungsmittel und diese Mikropartikel enthaltende pharmazentische Zubereitungen |
| DE69123075T2 (de) * | 1990-04-12 | 1997-03-20 | Shionogi Seiyaku Kk | Ueberzogene Zusammensetzung sowie Verfahren zu ihrer Herstellung |
| JP3116311B2 (ja) * | 1990-06-13 | 2000-12-11 | エーザイ株式会社 | マイクロスフィアの製法 |
| GB9016885D0 (en) * | 1990-08-01 | 1990-09-12 | Scras | Sustained release pharmaceutical compositions |
| SE9003296L (sv) * | 1990-10-16 | 1992-04-17 | Kabi Pharmacia Ab | Foerfarande foer att formulera laekemedel |
| CA2055522A1 (en) * | 1990-12-12 | 1992-06-13 | Masako Andoh | Microspheres for ophthalmic use |
| GB9203689D0 (en) * | 1992-02-20 | 1992-04-08 | Euro Celtique Sa | Pharmaceutical composition |
| JPH07507768A (ja) * | 1992-03-12 | 1995-08-31 | アルカーメス コントロールド セラピューティクス，インコーポレイテッド | Ａｃｔｈ含有マイクロスフェアの制御放出 |
| SE9200858L (sv) * | 1992-03-20 | 1993-09-21 | Kabi Pharmacia Ab | Metod för framställning av pellets med fördröjd frisättning |
| ATE222500T1 (de) * | 1992-06-11 | 2002-09-15 | Alkermes Inc | Enythropoietin enthaltendes arzneimittelabgabesystem |
| US5350584A (en) * | 1992-06-26 | 1994-09-27 | Merck & Co., Inc. | Spheronization process using charged resins |
| JP2651320B2 (ja) * | 1992-07-16 | 1997-09-10 | 田辺製薬株式会社 | 徐放性マイクロスフェア製剤の製造方法 |
| FR2693905B1 (fr) * | 1992-07-27 | 1994-09-02 | Rhone Merieux | Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues. |
| GB2273874A (en) * | 1992-12-31 | 1994-07-06 | Pertti Olavi Toermaelae | Preparation of pharmaceuticals in a polymer matrix |
-
1993
- 1993-05-15 GB GB939310030A patent/GB9310030D0/en active Pending
-
1994
- 1994-04-28 GR GR940100215A patent/GR1002034B/el not_active IP Right Cessation
- 1994-05-05 SE SE9401557A patent/SE519004C2/sv not_active IP Right Cessation
- 1994-05-06 HU HU9401412A patent/HU220617B1/hu not_active IP Right Cessation
- 1994-05-09 BE BE9400480A patent/BE1008323A3/fr not_active IP Right Cessation
- 1994-05-09 CH CH01436/94A patent/CH688572A5/fr not_active IP Right Cessation
- 1994-05-11 OA OA60510A patent/OA09939A/fr unknown
- 1994-05-11 IT ITMI940931A patent/IT1269508B/it active IP Right Grant
- 1994-05-11 LU LU88482A patent/LU88482A1/fr unknown
- 1994-05-11 FR FR9405782A patent/FR2705232B1/fr not_active Expired - Fee Related
- 1994-05-11 ES ES09400996A patent/ES2097083B1/es not_active Expired - Fee Related
- 1994-05-11 AT AT0098794A patent/AT406017B/de not_active IP Right Cessation
- 1994-05-12 CA CA002123481A patent/CA2123481C/en not_active Expired - Fee Related
- 1994-05-12 IE IE039294A patent/IE940392A1/en not_active IP Right Cessation
- 1994-05-13 IN IN595DE1994 patent/IN182330B/en unknown
- 1994-05-13 MA MA23503A patent/MA23194A1/fr unknown
- 1994-05-13 RU RU94016386A patent/RU2125869C1/ru active
- 1994-05-13 DK DK054994A patent/DK171454B1/da not_active IP Right Cessation
- 1994-05-13 PT PT101518A patent/PT101518B/pt not_active IP Right Cessation
- 1994-05-13 GB GB9409565A patent/GB2277915B/en not_active Expired - Fee Related
- 1994-05-13 TN TNTNSN94046A patent/TNSN94046A1/fr unknown
- 1994-05-13 SG SG1996006870A patent/SG46631A1/en unknown
- 1994-05-13 ZA ZA943316A patent/ZA943316B/xx unknown
- 1994-05-13 DE DE4416812A patent/DE4416812C2/de not_active Expired - Fee Related
- 1994-05-13 NZ NZ260520A patent/NZ260520A/en not_active IP Right Cessation
- 1994-05-13 NO NO941810A patent/NO307403B1/no not_active IP Right Cessation
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- 1994-05-13 AU AU63084/94A patent/AU685094B2/en not_active Ceased
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- 1994-05-15 DZ DZ940045A patent/DZ1779A1/fr active
- 1994-05-16 NL NL9400795A patent/NL9400795A/nl active Search and Examination
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1998
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2070153A1 (ru) * | 1969-10-23 | 1971-09-10 | Du Pont | |
| EP0058481A1 (en) * | 1981-02-16 | 1982-08-25 | Zeneca Limited | Continuous release pharmaceutical compositions |
| GB2246514A (en) * | 1990-08-01 | 1992-02-05 | Scras | Sustained release particles preparation |
| WO1992021326A1 (en) * | 1991-05-27 | 1992-12-10 | Medinvent | Method of producing reproducible particles |
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