RU2627701C2 - Сульфонамидные соединения и их применение в качестве ингибиторов tnap - Google Patents
Сульфонамидные соединения и их применение в качестве ингибиторов tnap Download PDFInfo
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- RU2627701C2 RU2627701C2 RU2014137402A RU2014137402A RU2627701C2 RU 2627701 C2 RU2627701 C2 RU 2627701C2 RU 2014137402 A RU2014137402 A RU 2014137402A RU 2014137402 A RU2014137402 A RU 2014137402A RU 2627701 C2 RU2627701 C2 RU 2627701C2
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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| CN111773213B (zh) | 2010-09-01 | 2023-02-24 | 托马斯杰弗逊大学 | 用于肌肉修复和再生的组合物和方法 |
| AU2013222345B2 (en) | 2012-02-22 | 2017-09-07 | Sanford-Burnham Medical Research Institute | Sulfonamide compounds and uses as TNAP inhibitors |
| WO2015108881A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| TN2016000270A1 (en) | 2014-01-14 | 2017-10-06 | Millennium Pharm Inc | Heteroaryls and uses thereof. |
| CN103755628B (zh) * | 2014-01-27 | 2015-07-29 | 河北科技大学 | 2-氨基-3-碘-5-溴吡啶的合成方法 |
| WO2016054056A1 (en) * | 2014-10-01 | 2016-04-07 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Methods of treating pxe with tnap inhibitors |
| JP6666928B2 (ja) * | 2015-07-08 | 2020-03-18 | 第一三共株式会社 | ピリジン化合物 |
| ITUA20161994A1 (it) * | 2016-03-24 | 2017-09-24 | Azienda Ospedaliera Univ Senese | Uso degli inibitori ddx3 come agenti anti-iperproliferativi |
| ES2963348T3 (es) | 2016-06-08 | 2024-03-26 | Clementia Pharmaceuticals Inc | Métodos para tratar la osificación heterotópica |
| TW201829417A (zh) | 2016-12-23 | 2018-08-16 | 日商第一三共股份有限公司 | 氧氮呯化合物 |
| BR112019012782A2 (pt) | 2016-12-23 | 2020-03-31 | Daiichi Sankyo Company, Limited | Composto, composição farmacêutica, inibidor de tnap, uso de um composto, e, método para tratamento ou profilaxia de uma doença ou condição e para inibir tnap em um indivíduo. |
| US20210301318A1 (en) * | 2018-07-10 | 2021-09-30 | Academia Sinica | A biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis |
| WO2020086504A1 (en) | 2018-10-23 | 2020-04-30 | Daiichi Sankyo Company, Limited | Biaryl derivative |
| ES3070946T3 (en) | 2019-03-12 | 2026-06-18 | Arcus Biosciences Inc | Treatment of an oncogenene driven cancer having a kras or egfr mutation by decreasing adenosine production or antagonizing adenosine activation |
| CA3135487A1 (en) | 2019-03-29 | 2020-10-08 | Arcus Biosciences, Inc. | Treatment of cancer utilizing an identified adenosine fingerprint |
| WO2021101927A1 (en) | 2019-11-18 | 2021-05-27 | Vanderbilt University | Wdr5-myc inhibitors |
| AU2020398216A1 (en) | 2019-12-04 | 2022-06-30 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancing blood-brain barrier drug transport by targeting endogenous regulators |
| CN113683563B (zh) * | 2021-08-31 | 2024-01-30 | 合肥工业大学 | 一种多取代3-磺酰胺喹啉化合物的合成方法 |
| CN115837023B (zh) * | 2023-02-20 | 2023-05-16 | 中山大学附属第八医院(深圳福田) | 1-甲基烟酰胺在制备抗血管钙化药物中的应用 |
| KR102790313B1 (ko) * | 2023-11-07 | 2025-04-04 | 주식회사 레드엔비아 | Tnap 저해 화합물 및 이의 용도 |
| WO2025188508A1 (en) * | 2024-03-07 | 2025-09-12 | The Regents Of The University Of California | E3 ligase and bex inhibitors and methods of use thereof |
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| DE60141889D1 (de) * | 2000-02-03 | 2010-06-02 | Eisai R&D Man Co Ltd | Inhibitoren der integrinexpression |
| WO2003048101A1 (en) * | 2001-11-30 | 2003-06-12 | The Burnham Institute | Induction of apoptosis in cancer cells |
| GB0206219D0 (en) * | 2002-03-15 | 2002-05-01 | Ferring Bv | Non-Peptide GnRH antagonists |
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| GB0425026D0 (en) * | 2004-11-12 | 2004-12-15 | Biofocus Discovery Ltd | Compounds which bind to the active site of protein kinase enzymes |
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-
2013
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- 2013-02-21 KR KR1020147025901A patent/KR102083041B1/ko not_active Expired - Fee Related
- 2013-02-21 WO PCT/US2013/027191 patent/WO2013126608A1/en not_active Ceased
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2016
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2018
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| WO2004018461A2 (en) * | 2002-08-23 | 2004-03-04 | Pharmacia & Upjohn Company Llc | Antibacterial benzoic acid derivatives |
| EA012526B1 (ru) * | 2005-03-16 | 2009-10-30 | Басф Акциенгезельшафт | Бифенил-n-(4-пиридил)метилсульфонамиды |
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| US20150011551A1 (en) | 2015-01-08 |
| US20160355479A1 (en) | 2016-12-08 |
| CN104334527B (zh) | 2017-05-24 |
| BR112014020773A2 (pt) | 2020-10-27 |
| CA2865071C (en) | 2020-06-23 |
| RU2014137402A (ru) | 2016-04-10 |
| JP2018104434A (ja) | 2018-07-05 |
| HK1203958A1 (en) | 2015-11-06 |
| CA2865071A1 (en) | 2013-08-29 |
| KR102083041B1 (ko) | 2020-05-27 |
| US10370333B2 (en) | 2019-08-06 |
| CN104334527A (zh) | 2015-02-04 |
| AU2013222345A1 (en) | 2014-09-11 |
| EP2817292B1 (en) | 2019-12-18 |
| US9458147B2 (en) | 2016-10-04 |
| AU2013222345B2 (en) | 2017-09-07 |
| WO2013126608A1 (en) | 2013-08-29 |
| US9884826B2 (en) | 2018-02-06 |
| EP2817292A4 (en) | 2015-08-26 |
| KR20140129191A (ko) | 2014-11-06 |
| JP6544545B2 (ja) | 2019-07-17 |
| EP2817292A1 (en) | 2014-12-31 |
| JP2015508102A (ja) | 2015-03-16 |
| JP6302846B2 (ja) | 2018-03-28 |
| US20190010126A1 (en) | 2019-01-10 |
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