AU2013222345B2 - Sulfonamide compounds and uses as TNAP inhibitors - Google Patents
Sulfonamide compounds and uses as TNAP inhibitors Download PDFInfo
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- AU2013222345B2 AU2013222345B2 AU2013222345A AU2013222345A AU2013222345B2 AU 2013222345 B2 AU2013222345 B2 AU 2013222345B2 AU 2013222345 A AU2013222345 A AU 2013222345A AU 2013222345 A AU2013222345 A AU 2013222345A AU 2013222345 B2 AU2013222345 B2 AU 2013222345B2
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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| JP5986570B2 (ja) | 2010-09-01 | 2016-09-06 | トーマス・ジェファーソン・ユニバーシティThomas Jefferson University | 筋修復および再生のための組成物および方法 |
| BR112014020773A2 (pt) | 2012-02-22 | 2020-10-27 | Sanford-Burnham Medical Research Institute | compostos de sulfonamida e seus usos como inibidores tnap |
| JP2017502092A (ja) | 2014-01-14 | 2017-01-19 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | ヘテロアリール及びその使用 |
| TN2016000270A1 (en) | 2014-01-14 | 2017-10-06 | Millennium Pharm Inc | Heteroaryls and uses thereof. |
| CN103755628B (zh) * | 2014-01-27 | 2015-07-29 | 河北科技大学 | 2-氨基-3-碘-5-溴吡啶的合成方法 |
| WO2016054056A1 (en) * | 2014-10-01 | 2016-04-07 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Methods of treating pxe with tnap inhibitors |
| CN107207527B (zh) | 2015-07-08 | 2019-10-01 | 第一三共株式会社 | 作为tnap抑制剂的吡啶并噁嗪酮化合物 |
| ITUA20161994A1 (it) * | 2016-03-24 | 2017-09-24 | Azienda Ospedaliera Univ Senese | Uso degli inibitori ddx3 come agenti anti-iperproliferativi |
| MY200642A (en) * | 2016-06-08 | 2024-01-08 | Clementia Pharmaceuticals Inc | Method for treating heterotopic ossification |
| TW201829417A (zh) | 2016-12-23 | 2018-08-16 | 日商第一三共股份有限公司 | 氧氮呯化合物 |
| EP3559007B1 (en) * | 2016-12-23 | 2023-08-16 | Daiichi Sankyo Company, Limited | Sulfonamide compounds having tnap inhibitory activity |
| WO2020014330A1 (en) * | 2018-07-10 | 2020-01-16 | Academia Sinica | A biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis |
| KR102880470B1 (ko) | 2018-10-23 | 2025-11-03 | 다이이찌 산쿄 가부시키가이샤 | 바이아릴 유도체 |
| AU2020239048B2 (en) | 2019-03-12 | 2025-10-16 | Arcus Biosciences, Inc. | Treatment of oncogene-driven cancers |
| KR20210144821A (ko) | 2019-03-29 | 2021-11-30 | 아르커스 바이오사이언시즈 인코포레이티드 | 규명된 아데노신 지문을 이용한 암의 치료방법 |
| WO2021113512A1 (en) | 2019-12-04 | 2021-06-10 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancing blood-brain barrier drug transport by targeting endogenous regulators |
| CN113683563B (zh) * | 2021-08-31 | 2024-01-30 | 合肥工业大学 | 一种多取代3-磺酰胺喹啉化合物的合成方法 |
| CN115837023B (zh) * | 2023-02-20 | 2023-05-16 | 中山大学附属第八医院(深圳福田) | 1-甲基烟酰胺在制备抗血管钙化药物中的应用 |
| KR102790313B1 (ko) * | 2023-11-07 | 2025-04-04 | 주식회사 레드엔비아 | Tnap 저해 화합물 및 이의 용도 |
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| US20100311736A1 (en) * | 2007-10-22 | 2010-12-09 | Glaxosmithkline Llc | Pyridosulfonamide derivatives as p13 kinase inhibitors |
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| TW352384B (en) * | 1992-03-24 | 1999-02-11 | Hoechst Ag | Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals |
| JP2000247949A (ja) | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
| ES2341843T3 (es) * | 2000-02-03 | 2010-06-29 | EISAI R&D MANAGEMENT CO., LTD. | Inhibidores de la expresion de integrina. |
| CA2468745A1 (en) * | 2001-11-30 | 2003-06-12 | The Burnham Institute | Induction of apoptosis in cancer cells |
| GB0206219D0 (en) * | 2002-03-15 | 2002-05-01 | Ferring Bv | Non-Peptide GnRH antagonists |
| US20040110802A1 (en) * | 2002-08-23 | 2004-06-10 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
| AU2003265382A1 (en) * | 2002-08-23 | 2004-03-11 | Pharmacia & Upjohn Company Llc | Antibacterial benzoic acid derivatives |
| ATE363470T1 (de) | 2002-11-18 | 2007-06-15 | Chemocentryx Inc | Arylsulfonamide |
| CN100589803C (zh) * | 2004-07-28 | 2010-02-17 | 霍夫曼-拉罗奇有限公司 | 芳基-吡啶衍生物 |
| US20090142347A1 (en) * | 2004-09-29 | 2009-06-04 | The Burnham Institute For Medical Research | Tissue-Nonspecific Alkaline Phosphatase (TNAP): a Therapeutic Target for Arterial Calcification |
| SE0402735D0 (sv) * | 2004-11-09 | 2004-11-09 | Astrazeneca Ab | Novel compounds |
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| PT1860941E (pt) * | 2005-03-16 | 2008-12-22 | Basf Se | Bifenil-n-(4-piridil)metilsulfonamidas |
| WO2007014008A2 (en) * | 2005-07-22 | 2007-02-01 | Glaxo Group Limted | Benzenesulfonamide inhibitor of ccr2 chemokine receptor |
| KR20080104310A (ko) * | 2006-02-14 | 2008-12-02 | 바스프 에스이 | 해충 방제를 위한 피리딘-4-일메틸아미드 |
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- 2013-02-21 KR KR1020147025901A patent/KR102083041B1/ko not_active Expired - Fee Related
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- 2013-02-21 CA CA2865071A patent/CA2865071C/en active Active
- 2013-02-21 WO PCT/US2013/027191 patent/WO2013126608A1/en not_active Ceased
- 2013-02-21 EP EP13752050.8A patent/EP2817292B1/en active Active
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2016
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2018
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| US20080194584A1 (en) * | 2004-11-12 | 2008-08-14 | Veronique Birault | Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes |
| US20100029609A1 (en) * | 2006-09-08 | 2010-02-04 | Frederic Berst | Biaryl sulfonamide derivatives |
| US20100311736A1 (en) * | 2007-10-22 | 2010-12-09 | Glaxosmithkline Llc | Pyridosulfonamide derivatives as p13 kinase inhibitors |
| US20100292225A1 (en) * | 2009-05-15 | 2010-11-18 | Sylvie Chamoin | Aryl pyridine as aldosterone synthase inhibitors |
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| KIM, O. et al., Journal of Medicinal Chemistry (2011), Vol. 54, Pages 2455-2466 * |
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| US10370333B2 (en) | 2019-08-06 |
| US9884826B2 (en) | 2018-02-06 |
| WO2013126608A1 (en) | 2013-08-29 |
| EP2817292B1 (en) | 2019-12-18 |
| HK1203958A1 (en) | 2015-11-06 |
| US20190010126A1 (en) | 2019-01-10 |
| JP6302846B2 (ja) | 2018-03-28 |
| RU2014137402A (ru) | 2016-04-10 |
| CA2865071C (en) | 2020-06-23 |
| CN104334527A (zh) | 2015-02-04 |
| AU2013222345A1 (en) | 2014-09-11 |
| CA2865071A1 (en) | 2013-08-29 |
| RU2627701C2 (ru) | 2017-08-10 |
| JP6544545B2 (ja) | 2019-07-17 |
| KR102083041B1 (ko) | 2020-05-27 |
| US9458147B2 (en) | 2016-10-04 |
| US20150011551A1 (en) | 2015-01-08 |
| JP2015508102A (ja) | 2015-03-16 |
| BR112014020773A2 (pt) | 2020-10-27 |
| CN104334527B (zh) | 2017-05-24 |
| JP2018104434A (ja) | 2018-07-05 |
| EP2817292A1 (en) | 2014-12-31 |
| KR20140129191A (ko) | 2014-11-06 |
| EP2817292A4 (en) | 2015-08-26 |
| US20160355479A1 (en) | 2016-12-08 |
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