JP6302846B2 - Ｔｎａｐ阻害剤としてのスルホンアミド化合物およびその使用 - Google Patents

Ｔｎａｐ阻害剤としてのスルホンアミド化合物およびその使用 Download PDF

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JP6302846B2
JP6302846B2 JP2014558836A JP2014558836A JP6302846B2 JP 6302846 B2 JP6302846 B2 JP 6302846B2 JP 2014558836 A JP2014558836 A JP 2014558836A JP 2014558836 A JP2014558836 A JP 2014558836A JP 6302846 B2 JP6302846 B2 JP 6302846B2
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JP2015508102A5 (enExample
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ピンカートン，アンソニー，ビー．
ダール，ラッセル
コスフォード，ニコラス，ディー．ピー．
ミラン，ホセ，ルイス
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サンフォード−バーンハム メディカル リサーチ インスティテュート
サンフォード−バーンハム メディカル リサーチ インスティテュート
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111773213B (zh) 2010-09-01 2023-02-24 托马斯杰弗逊大学 用于肌肉修复和再生的组合物和方法
AU2013222345B2 (en) 2012-02-22 2017-09-07 Sanford-Burnham Medical Research Institute Sulfonamide compounds and uses as TNAP inhibitors
WO2015108881A1 (en) 2014-01-14 2015-07-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
TN2016000270A1 (en) 2014-01-14 2017-10-06 Millennium Pharm Inc Heteroaryls and uses thereof.
CN103755628B (zh) * 2014-01-27 2015-07-29 河北科技大学 2-氨基-3-碘-5-溴吡啶的合成方法
WO2016054056A1 (en) * 2014-10-01 2016-04-07 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Methods of treating pxe with tnap inhibitors
JP6666928B2 (ja) * 2015-07-08 2020-03-18 第一三共株式会社 ピリジン化合物
ITUA20161994A1 (it) * 2016-03-24 2017-09-24 Azienda Ospedaliera Univ Senese Uso degli inibitori ddx3 come agenti anti-iperproliferativi
ES2963348T3 (es) 2016-06-08 2024-03-26 Clementia Pharmaceuticals Inc Métodos para tratar la osificación heterotópica
TW201829417A (zh) 2016-12-23 2018-08-16 日商第一三共股份有限公司 氧氮呯化合物
BR112019012782A2 (pt) 2016-12-23 2020-03-31 Daiichi Sankyo Company, Limited Composto, composição farmacêutica, inibidor de tnap, uso de um composto, e, método para tratamento ou profilaxia de uma doença ou condição e para inibir tnap em um indivíduo.
US20210301318A1 (en) * 2018-07-10 2021-09-30 Academia Sinica A biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis
WO2020086504A1 (en) 2018-10-23 2020-04-30 Daiichi Sankyo Company, Limited Biaryl derivative
ES3070946T3 (en) 2019-03-12 2026-06-18 Arcus Biosciences Inc Treatment of an oncogenene driven cancer having a kras or egfr mutation by decreasing adenosine production or antagonizing adenosine activation
CA3135487A1 (en) 2019-03-29 2020-10-08 Arcus Biosciences, Inc. Treatment of cancer utilizing an identified adenosine fingerprint
WO2021101927A1 (en) 2019-11-18 2021-05-27 Vanderbilt University Wdr5-myc inhibitors
AU2020398216A1 (en) 2019-12-04 2022-06-30 The Board Of Trustees Of The Leland Stanford Junior University Enhancing blood-brain barrier drug transport by targeting endogenous regulators
CN113683563B (zh) * 2021-08-31 2024-01-30 合肥工业大学 一种多取代3-磺酰胺喹啉化合物的合成方法
CN115837023B (zh) * 2023-02-20 2023-05-16 中山大学附属第八医院（深圳福田） 1-甲基烟酰胺在制备抗血管钙化药物中的应用
KR102790313B1 (ko) * 2023-11-07 2025-04-04 주식회사 레드엔비아 Tnap 저해 화합물 및 이의 용도
WO2025188508A1 (en) * 2024-03-07 2025-09-12 The Regents Of The University Of California E3 ligase and bex inhibitors and methods of use thereof

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
JP2000247949A (ja) 1999-02-26 2000-09-12 Eisai Co Ltd スルホンアミド含有インドール化合物
DE60141889D1 (de) * 2000-02-03 2010-06-02 Eisai R&D Man Co Ltd Inhibitoren der integrinexpression
WO2003048101A1 (en) * 2001-11-30 2003-06-12 The Burnham Institute Induction of apoptosis in cancer cells
GB0206219D0 (en) * 2002-03-15 2002-05-01 Ferring Bv Non-Peptide GnRH antagonists
US20040142981A1 (en) * 2002-08-23 2004-07-22 Atli Thorarensen Antibacterial benzoic acid derivatives
US20040110802A1 (en) 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives
AU2003298661B2 (en) 2002-11-18 2007-05-10 Chemocentryx, Inc. Aryl sulfonamides
EP1789041B1 (en) * 2004-07-28 2008-07-09 F. Hoffmann-Roche AG Aryl-pyridine derivatives as 11-beta-hsd1 inhibitors
US20090142347A1 (en) * 2004-09-29 2009-06-04 The Burnham Institute For Medical Research Tissue-Nonspecific Alkaline Phosphatase (TNAP): a Therapeutic Target for Arterial Calcification
SE0402735D0 (sv) * 2004-11-09 2004-11-09 Astrazeneca Ab Novel compounds
GB0425026D0 (en) * 2004-11-12 2004-12-15 Biofocus Discovery Ltd Compounds which bind to the active site of protein kinase enzymes
EP1814856A1 (en) * 2004-11-12 2007-08-08 Galapagos N.V. Nitrogen heteroaromatic compounds which bind to the active site of protein kinase enzymes
EP1860941B1 (en) * 2005-03-16 2008-11-12 Basf Se Biphenyl-n-(4-pyridyl) methylsufonamides
WO2007014008A2 (en) * 2005-07-22 2007-02-01 Glaxo Group Limted Benzenesulfonamide inhibitor of ccr2 chemokine receptor
WO2007093599A1 (en) 2006-02-14 2007-08-23 Basf Se Pyridin-4 -ylmethylamides for combating pests
JP2009535386A (ja) * 2006-05-03 2009-10-01 アストラゼネカ アクチボラグ チアゾール誘導体および抗腫瘍剤としてのその使用
US20090118336A1 (en) * 2006-05-03 2009-05-07 Laurent David Pyrazole derivatives and their use as pi3k inhibitors
RU2009112719A (ru) * 2006-09-08 2010-10-20 Новартис АГ (CH) Производные n-биарил(гетеро)арилсульфонамида, применимые в лечении заболеваний, опосредованных взаимодействием лимфоцитов
WO2008042867A2 (en) * 2006-09-29 2008-04-10 Emiliem Inc. Modulators of multiple kinases
US8119693B2 (en) * 2007-05-08 2012-02-21 Sanford-Burnham Medical Research Institute Tissue non-specific alkaline phosphatase inhibitors and uses thereof for treating vascular calcification
WO2009042294A2 (en) * 2007-08-10 2009-04-02 Burnham Institute For Medical Research Tissue-nonspecific alkaline phosphatase (tnap) activators and uses thereof
US8039493B2 (en) * 2007-09-27 2011-10-18 Hoffmann-La Roche Inc. Biaryl sulfonamide derivatives
JP2011500823A (ja) * 2007-10-22 2011-01-06 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｐｉ３キナーゼ阻害物質としてのピリドスルホンアミド誘導体
US8268834B2 (en) * 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
WO2009143150A2 (en) * 2008-05-19 2009-11-26 Burnham Institute For Medical Research Intestinal alkaline phosphatase modulators and uses thereof
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
TW201016676A (en) * 2008-10-03 2010-05-01 Astrazeneca Ab Heterocyclic derivatives and methods of use thereof
WO2010130638A1 (en) * 2009-05-14 2010-11-18 Evotec Ag Sulfonamide compounds, pharmaceutical compositions and uses thereof
ES2459468T3 (es) * 2009-05-15 2014-05-09 Novartis Ag Arilpiridinas como inhibidores de aldosterona sintasa
PE20120693A1 (es) * 2009-06-29 2012-07-04 Agios Pharmaceuticals Inc Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2)
FR2970967B1 (fr) * 2011-01-27 2013-02-15 Pf Medicament Derives de type azaindazole ou diazaindazole comme medicament
AU2013222345B2 (en) 2012-02-22 2017-09-07 Sanford-Burnham Medical Research Institute Sulfonamide compounds and uses as TNAP inhibitors
WO2016054056A1 (en) * 2014-10-01 2016-04-07 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Methods of treating pxe with tnap inhibitors

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