HK1224172A1 - 用於誘導軟骨形成的化合物和方法 - Google Patents
用於誘導軟骨形成的化合物和方法Info
- Publication number
- HK1224172A1 HK1224172A1 HK16107019.4A HK16107019A HK1224172A1 HK 1224172 A1 HK1224172 A1 HK 1224172A1 HK 16107019 A HK16107019 A HK 16107019A HK 1224172 A1 HK1224172 A1 HK 1224172A1
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- HK
- Hong Kong
- Prior art keywords
- compounds
- methods
- inducing chondrogenesis
- chondrogenesis
- inducing
- Prior art date
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
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PCT/US2014/026722 WO2014151953A1 (en) | 2013-03-15 | 2014-03-13 | Compounds and methods for inducing chondrogenesis |
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Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012129562A2 (en) * | 2011-03-24 | 2012-09-27 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
WO2014151953A1 (en) | 2013-03-15 | 2014-09-25 | The California Institute For Biomedical Research | Compounds and methods for inducing chondrogenesis |
CN105294533A (zh) * | 2015-12-02 | 2016-02-03 | 宋彤云 | 一种治疗骨病的药物组合物 |
JP2019535707A (ja) * | 2016-11-14 | 2019-12-12 | ノバルティス アーゲー | 軟骨損傷および関節炎の処置のための方法および組成物 |
CN110809468A (zh) * | 2017-04-24 | 2020-02-18 | 斯克利普斯研究所 | 诱导软骨发生的方法 |
JOP20190282A1 (ar) * | 2017-06-09 | 2019-12-05 | Novartis Ag | مركبات وتركيبات لحث تكوّن الغضاريف |
CN107056677A (zh) * | 2017-06-19 | 2017-08-18 | 常州大学 | 一种3‑烷基2,3‑二氢异吲哚啉酮衍生物的合成方法 |
AU2019243561A1 (en) * | 2018-03-29 | 2020-09-24 | Elex Biotech, Inc. | Compounds for treatment of cardiac arrhythmias and heart failure |
CN110937987B (zh) * | 2018-09-25 | 2022-09-06 | 深圳市灵兰生物医药科技有限公司 | 一种化合物的合成路线及在抗糖尿病药物制备领域的应用 |
AU2019362747A1 (en) * | 2018-10-15 | 2021-06-03 | Gero Pte. Ltd. | PFKFB3 inhibitors and their uses |
CN114105902B (zh) * | 2018-12-28 | 2023-11-03 | 中山大学 | 噻唑苯甲酰胺衍生物及其在制备抗骨质疏松药物中的应用 |
CN112004798A (zh) * | 2019-01-07 | 2020-11-27 | 江苏凯迪恩医药科技有限公司 | 一种苯甲酰胺类化合物、中间体、制备方法及应用 |
CN114763346A (zh) * | 2021-01-15 | 2022-07-19 | 华东师范大学 | 一类用于诱导软骨形成的化合物及其应用 |
CN114763347B (zh) * | 2021-01-15 | 2024-06-21 | 华东师范大学 | 一类用于诱导间充质干细胞向软骨分化的化合物及其应用 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1016623A (en) | 1911-09-06 | 1912-02-06 | Harry Haller Jr | Photographic-printing device. |
CH489993A (de) | 1967-12-19 | 1970-05-15 | Ciba Geigy | Das Pflanzenwachstum regulierendes und phytocides Mittel |
FR2059977A1 (zh) | 1969-08-14 | 1971-06-11 | Socibre | |
KR0143565B1 (ko) | 1988-06-13 | 1998-07-15 | 사노 가즈오 | 피발산의 p-치환된 페닐 에스테르 유도체, 그의 제조 방법 및 이를 포함하는 조성물. |
JPH0320253A (ja) * | 1988-06-13 | 1991-01-29 | Ono Pharmaceut Co Ltd | ピバル酸 p―置換フェニルエステル誘導体、それらの製造方法およびそれらを有効成分として含有するエラスターゼ阻害剤 |
JPH0959236A (ja) * | 1995-08-23 | 1997-03-04 | Dai Ichi Seiyaku Co Ltd | ベンズアミド化合物 |
US5729014A (en) | 1996-07-11 | 1998-03-17 | Varian Associates, Inc. | Method for injection of externally produced ions into a quadrupole ion trap |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
HUP0001880A3 (en) * | 1997-05-22 | 2002-03-28 | G D Searle & Co Chicago | Substituted pyrazoles as p38 kinase inhibitors |
US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
US6632961B1 (en) | 1998-05-22 | 2003-10-14 | Abbott Laboratories | Antiangiogenic drug to treat cancer, arthritis and retinopathy |
AR035773A1 (es) * | 2000-12-20 | 2004-07-14 | Bristol Myers Squibb Pharma Co | Compuestos diamino ciclico, composicion farmaceutica y su uso en la fabricacion de un medicamento util para modular la actividad de una quimioquina |
JP2005194191A (ja) * | 2001-12-28 | 2005-07-21 | Ajinomoto Co Inc | 抗肥満薬、脂肪肝治療薬 |
WO2003075853A2 (en) * | 2002-03-08 | 2003-09-18 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
US7288538B2 (en) | 2003-02-20 | 2007-10-30 | Encysive Pharmaceuticals, Inc. | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists |
ES2281801T3 (es) | 2003-05-12 | 2007-10-01 | Pfizer Products Inc. | Inhibidores benzamida del receptor p2x7. |
EP1660072A2 (en) * | 2003-07-29 | 2006-05-31 | Universitätsklinikum Münster | Means and methods for treating a disease which is associated with an excess transport of hyaluronan across a lipid bilayer |
US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
US7863317B2 (en) * | 2003-08-21 | 2011-01-04 | Bristol-Myers Squibb Company | Lactams of alkylated acyclic diamine derivatives as modulators of chemokine receptor activity |
US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
US7776869B2 (en) * | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
US7999132B2 (en) * | 2004-12-07 | 2011-08-16 | Toyama Chemical Co., Ltd. | Anthranilic acid derivative or salt thereof |
KR100787131B1 (ko) * | 2006-07-04 | 2007-12-21 | 한국생명공학연구원 | Hif―1 활성을 저해하는 화합물, 이의 제조방법 및이를 유효성분으로 함유하는 약학적 조성물 |
WO2009014100A1 (ja) | 2007-07-20 | 2009-01-29 | Chugai Seiyaku Kabushiki Kaisha | p27蛋白質誘導剤 |
BRPI0817483A2 (pt) * | 2007-10-05 | 2016-07-26 | Sanofi Aventis Deutschland | uso de n-fenilamidas de ácido 2-sulfonilaminobenzoico substituídas por sulfonila no tratamento da dor |
US8143269B2 (en) | 2008-10-03 | 2012-03-27 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
PE20120570A1 (es) | 2009-07-14 | 2012-05-19 | Irm Llc | Diferenciacion de celulas madre mesenquimales |
ES2549979T3 (es) | 2010-05-26 | 2015-11-03 | Adverio Pharma Gmbh | El uso de estimuladores de la sGC, activadores de la sGC, solos y en combinaciones con inhibidores de la PDE5 para el tratamiento de esclerosis sistémica (EcS) |
WO2012129562A2 (en) | 2011-03-24 | 2012-09-27 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
WO2014151953A1 (en) | 2013-03-15 | 2014-09-25 | The California Institute For Biomedical Research | Compounds and methods for inducing chondrogenesis |
MY186570A (en) | 2014-05-13 | 2021-07-27 | Novartis Ag | Compounds and compositions for inducing chondrogenesis |
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ES2900815T3 (es) | 2022-03-18 |
EP2968330A4 (en) | 2017-01-25 |
CN107007587A (zh) | 2017-08-04 |
CN105228626A (zh) | 2016-01-06 |
US20140271955A1 (en) | 2014-09-18 |
KR20150139844A (ko) | 2015-12-14 |
JP2016519659A (ja) | 2016-07-07 |
KR102283996B1 (ko) | 2021-07-29 |
US9452170B2 (en) | 2016-09-27 |
US11045476B2 (en) | 2021-06-29 |
EP2968330B1 (en) | 2021-09-29 |
CN116059196A (zh) | 2023-05-05 |
US20160045514A1 (en) | 2016-02-18 |
AU2014236719B2 (en) | 2018-06-21 |
US10500210B2 (en) | 2019-12-10 |
EP2968330A1 (en) | 2016-01-20 |
US20200188407A1 (en) | 2020-06-18 |
WO2014151953A1 (en) | 2014-09-25 |
CA2904160C (en) | 2022-08-23 |
AU2014236719A1 (en) | 2015-09-10 |
JP6579623B2 (ja) | 2019-09-25 |
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