CN112004798A - 一种苯甲酰胺类化合物、中间体、制备方法及应用 - Google Patents

一种苯甲酰胺类化合物、中间体、制备方法及应用 Download PDF

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Publication number
CN112004798A
CN112004798A CN201980019552.8A CN201980019552A CN112004798A CN 112004798 A CN112004798 A CN 112004798A CN 201980019552 A CN201980019552 A CN 201980019552A CN 112004798 A CN112004798 A CN 112004798A
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substituted
alkyl
unsubstituted
formula
butyl
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CN201980019552.8A
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蒋青
乐小勇
陈新
胡代强
朱健
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Jiangsu Kaidien Medicine Technology Co ltd
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Jiangsu Kaidien Medicine Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了一种苯甲酰胺类化合物、中间体、制备方法及应用。本发明提供了一种如式I所示的苯甲酰胺类化合物、其药学上可接受的盐、其水合物、其溶剂化物、其多晶型、其代谢产物、其立体异构体、其互变异构体或其前药。该苯甲酰胺类化合物具有诱导刺激间充质干细胞(MSC)分化成软骨细胞，修复软骨的应用。还提供了治疗、预防或改善关节炎或关节损伤的组合物和方法，通过本发明的化合物或组合物施用于关节、软骨组织或软骨近端组织或全身来进行。本发明还提供用于诱导间充质干细胞(MSC)分化成软骨细胞的组合物和方法。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN201980019552.8A 2019-01-07 2019-01-07 一种苯甲酰胺类化合物、中间体、制备方法及应用 Pending CN112004798A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/070573 WO2020142865A1 (zh) 2019-01-07 2019-01-07 一种苯甲酰胺类化合物、中间体、制备方法及应用

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CN112004798A true CN112004798A (zh) 2020-11-27

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CN (1) CN112004798A (zh)
WO (1) WO2020142865A1 (zh)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910211A (en) * 1987-08-07 1990-03-20 Kanebo Ltd. Novel benzothiazole and antirheumatic agent comprising it as an active ingredient
JPH02207078A (ja) * 1989-02-06 1990-08-16 Kanebo Ltd ベンゾチアゾール誘導体
CN1144217A (zh) * 1995-06-05 1997-03-05 布里斯托尔-迈尔斯斯奎布公司 具有类视色素样活性的化合物
US20030055287A1 (en) * 1997-11-25 2003-03-20 Masanori Tohnishi Phthalic acid diamide derivatives, fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides
US20030055263A1 (en) * 2001-07-11 2003-03-20 Boehringer Ingelheim Pharma Kg Carboxylic acid derivatives, medicaments comprising these compounds, their use and processes for their production
CN1826339A (zh) * 2003-04-25 2006-08-30 赛诺菲安万特 2－酰氨基－4－苯基噻唑衍生物,其制备方法及其在治疗学上的应用
US20100305124A1 (en) * 2009-04-03 2010-12-02 Bayer Cropscience Ag Acylated Aminopyridine and Aminopyridazine Insecticides
CN102477001A (zh) * 2010-11-29 2012-05-30 江苏先声药物研究有限公司 一种苯甲酰胺类组蛋白去乙酰化酶抑制剂
CN105228626A (zh) * 2013-03-15 2016-01-06 加州生物医学研究所 用于诱导软骨形成的化合物和方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910211A (en) * 1987-08-07 1990-03-20 Kanebo Ltd. Novel benzothiazole and antirheumatic agent comprising it as an active ingredient
JPH02207078A (ja) * 1989-02-06 1990-08-16 Kanebo Ltd ベンゾチアゾール誘導体
CN1144217A (zh) * 1995-06-05 1997-03-05 布里斯托尔-迈尔斯斯奎布公司 具有类视色素样活性的化合物
US20030055287A1 (en) * 1997-11-25 2003-03-20 Masanori Tohnishi Phthalic acid diamide derivatives, fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides
US20030055263A1 (en) * 2001-07-11 2003-03-20 Boehringer Ingelheim Pharma Kg Carboxylic acid derivatives, medicaments comprising these compounds, their use and processes for their production
CN1826339A (zh) * 2003-04-25 2006-08-30 赛诺菲安万特 2－酰氨基－4－苯基噻唑衍生物,其制备方法及其在治疗学上的应用
US20100305124A1 (en) * 2009-04-03 2010-12-02 Bayer Cropscience Ag Acylated Aminopyridine and Aminopyridazine Insecticides
CN102477001A (zh) * 2010-11-29 2012-05-30 江苏先声药物研究有限公司 一种苯甲酰胺类组蛋白去乙酰化酶抑制剂
CN105228626A (zh) * 2013-03-15 2016-01-06 加州生物医学研究所 用于诱导软骨形成的化合物和方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KOBAYASHI, KAZUHIRO 等: "Synthesis of 3-iminobenzo[c]thiophen-1(3H)-one De¬rivatives Based on the Reaction of 2-Lithio-N, N-dimethylbenzamides with isothiocyanates", 《HETEROCYCLES》 *
PAN WANG等: "Electrochemical intramolecular dehydrogenative C–S bond formation for the synthesis of benzothiazoles", 《GREEN CHEMISTRY》 *
ROBERT J. PERRY等: "Polyimide Formation through the Palladium-Mediated Carbonylation and Coupling of Bis(o-iodo amides) and Diamines", 《MACROMOLECULES》 *
W.Q. ZHOU等: "Theoretical studies on nonlinear polarizability of substitution thiourea", 《JOURNAL OF MOLECULAR STRUCTURE》 *
ZHANG QIANG等: "Efficient New Approach for the Synthesis of N, N-dialkylamino-1,2,4-triazoles", 《HETEROCYCLES》 *

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