RU2487873C2 - 5-замещенные индазолы в качестве ингибиторов киназы - Google Patents

5-замещенные индазолы в качестве ингибиторов киназы Download PDF

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RU2487873C2
RU2487873C2 RU2009149696/04A RU2009149696A RU2487873C2 RU 2487873 C2 RU2487873 C2 RU 2487873C2 RU 2009149696/04 A RU2009149696/04 A RU 2009149696/04A RU 2009149696 A RU2009149696 A RU 2009149696A RU 2487873 C2 RU2487873 C2 RU 2487873C2
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Russia
Prior art keywords
indazol
triazol
carboxamide
benzyl
indazole
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RU2009149696/04A
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English (en)
Russian (ru)
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RU2009149696A (ru
Inventor
Ирини АКРИТОПОУЛОУ-ЗАНЗЕ
Брайан Д. УЭЙКФИЛД
Хельмут Мак
Шон К. ТЕРНЕР
Алан Ф. ГАСИКИ
Виджая Дж. ГРАСИАС
Кэти Саррис
Дуглас М. КАЛВИН
Мелисса Дж. МИЧМЕРХУЗЕН
Ци ШУАЙ
Джиоти Р. ПАТЕЛ
Маргарета БАККЕР
Николь ТОЙШ
Эрик Ф. ДЖОНСОН
Питер Дж. КОВАР
Стивен В. ДЬЮРИК
Эндрю Дж. ЛОНГ
Анил ВАСУДЕВАН
Адриан ХОБСОН
ДЖОН МУР Найджел СТ.
Лу ВАН
Дон ДЖОРЖ
Бицинь ЛИ
Кристин ФРАНК
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Эбботт Лэборетриз
Эбботт Гмбх Унд Ко. Кг
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
RU2009149696/04A 2007-06-08 2008-06-04 5-замещенные индазолы в качестве ингибиторов киназы RU2487873C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93396007P 2007-06-08 2007-06-08
US60/933,960 2007-06-08
PCT/US2008/065727 WO2008154241A1 (en) 2007-06-08 2008-06-04 5-heteroaryl substituted indazoles as kinase inhibitors

Publications (2)

Publication Number Publication Date
RU2009149696A RU2009149696A (ru) 2011-07-20
RU2487873C2 true RU2487873C2 (ru) 2013-07-20

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RU2009149696/04A RU2487873C2 (ru) 2007-06-08 2008-06-04 5-замещенные индазолы в качестве ингибиторов киназы

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Country Link
EP (1) EP2167491A1 (ja)
JP (2) JP5451602B2 (ja)
KR (1) KR20100032886A (ja)
CN (1) CN101790526A (ja)
AU (1) AU2008262038A1 (ja)
BR (1) BRPI0811065A2 (ja)
CA (1) CA2689117A1 (ja)
IL (1) IL202318A0 (ja)
MX (1) MX2009013213A (ja)
RU (1) RU2487873C2 (ja)
SG (1) SG182187A1 (ja)
WO (1) WO2008154241A1 (ja)
ZA (1) ZA200908624B (ja)

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RU2725979C2 (ru) * 2014-06-25 2020-07-08 Ф. Хоффманн-Ля Рош Аг ИМИДАЗО[1,2-а]ПИРАЗИН-1-ИЛ-БЕНЗАМИДЫ ДЛЯ ЛЕЧЕНИЯ СПИНАЛЬНОЙ МЫШЕЧНОЙ АТРОФИИ
US10899742B1 (en) 2016-12-01 2021-01-26 Arvinas Operations, Inc. Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders

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EP1984331B1 (en) 2006-02-16 2010-10-20 Schering Corporation Pyrrolidine derivatives as erk inhibitors
US8648069B2 (en) * 2007-06-08 2014-02-11 Abbvie Inc. 5-substituted indazoles as kinase inhibitors
US20110301155A1 (en) * 2007-06-19 2011-12-08 Tsuneo Yasuma Indazole compounds for activating glucokinase
AU2008276512A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of PKB
AU2008276521B2 (en) 2007-07-17 2011-11-03 Amgen Inc. Heterocyclic modulators of PKB
JPWO2009028543A1 (ja) * 2007-08-30 2010-12-02 武田薬品工業株式会社 置換ピラゾール誘導体
SG188179A1 (en) 2008-02-21 2013-03-28 Merck Sharp & Dohme Compounds that are erk inhibitors
CL2009001158A1 (es) * 2008-05-15 2009-10-23 Nerviano Medical Sciences Srl Compuestos derivados de los acidos carboxilicos, tales como 5,6-dihiro-4h-pirrolo[3,4-c]pirazol, furo[3,2-c]pirazol, tieno[2,3-c]pirazol, 4,5,6,7-tetrahidropirazol[4,3-c]piridina e indazol; composicion farmaceutica; y su uso en el tratamiento de trastornos proliferativos celulares asociados a la actividad de proteina quinasa alterada, tal como el cancer.
AR074199A1 (es) * 2008-11-20 2010-12-29 Glaxosmithkline Llc Compuesto de 6-(4-pirimidinil)-1h-indazol, composiciones farmaceuticas que lo comprenden y su uso para preparar un medicamento util para el tratamiento o disminucion de la gravedad del cancer.
CA2770116C (en) 2009-08-10 2018-03-13 Epitherix, Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
CN102821607B (zh) 2009-12-21 2014-12-17 萨穆梅德有限公司 1H-吡唑并[3，4-b]吡啶及其治疗应用
UY33213A (es) * 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
KR101233082B1 (ko) 2010-02-25 2013-02-14 주식회사 이큐스앤자루 신규한 이미다졸피라진 유도체 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스 치료용 약학적 조성물
JP6026284B2 (ja) * 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
WO2011136264A1 (ja) * 2010-04-28 2011-11-03 第一三共株式会社 ［５，６］複素環化合物
EP2566333A4 (en) * 2010-05-07 2014-04-02 Univ Leland Stanford Junior IDENTIFICATION OF STABILIZERS OF MULTIMEDER PROTEINS
PL2655357T3 (pl) 2010-12-20 2016-12-30 Pochodne triazolowe indazolilowe jako inhibitory irak
US9173887B2 (en) 2010-12-22 2015-11-03 Abbvie Inc. Hepatitis C inhibitors and uses thereof
US9090592B2 (en) * 2010-12-30 2015-07-28 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
CN102675286B (zh) * 2011-03-07 2015-08-19 中国科学院上海药物研究所 一类吲唑类化合物及其制备方法、用途和药物组合物
CU24263B1 (es) * 2011-04-07 2017-07-04 Bayer Ip Gmbh Derivados de imidazopiridazinas inhibidores de quinasa akt, útiles para el tratamiento del cáncer
MX355852B (es) * 2011-08-12 2018-05-02 Hoffmann La Roche Compuestos de pirazolo [3,4-c] piridina y métodos de uso.
HUE041576T2 (hu) * 2011-09-14 2019-05-28 Samumed Llc Indazol-3-karboxamid-származékok és alkalmazásuk Wnt/b-katenin szignalizáló útvonal inhibitorokként
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