SG182187A1 - 5-heteroaryl substituted indazoles as kinase inhibitors - Google Patents

Info

Publication number

SG182187A1

SG182187A1 SG2012043113A SG2012043113A SG182187A1 SG 182187 A1 SG182187 A1 SG 182187A1 SG 2012043113 A SG2012043113 A SG 2012043113A SG 2012043113 A SG2012043113 A SG 2012043113A SG 182187 A1 SG182187 A1 SG 182187A1

Authority

SG

Singapore

Prior art keywords

indazol

benzyl

triazol

carboxamide

indazole

Prior art date

2007-06-08

Links

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• Global Dossier
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• 150000002473 indoazoles Chemical class 0.000 title abstract description 4
• 229940043355 kinase inhibitor Drugs 0.000 title description 2
• 239000003757 phosphotransferase inhibitor Substances 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 572
• 238000000034 method Methods 0.000 claims abstract description 321
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• 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 claims abstract description 75
• 108091000080 Phosphotransferase Proteins 0.000 claims abstract description 34
• 102000020233 phosphotransferase Human genes 0.000 claims abstract description 34
• 230000002401 inhibitory effect Effects 0.000 claims abstract description 24
• 108010024121 Janus Kinases Proteins 0.000 claims abstract description 15
• 102000015617 Janus Kinases Human genes 0.000 claims abstract description 15
• 239000011435 rock Substances 0.000 claims abstract description 15
• 150000003839 salts Chemical class 0.000 claims abstract description 6
• 102000000568 rho-Associated Kinases Human genes 0.000 claims abstract description 4
• 108010041788 rho-Associated Kinases Proteins 0.000 claims abstract description 4
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 177
• -1 alkoxvalicyt Chemical group 0.000 claims description 174
• 229910052739 hydrogen Inorganic materials 0.000 claims description 143
• 239000001257 hydrogen Substances 0.000 claims description 142
• 125000000217 alkyl group Chemical group 0.000 claims description 97
• 125000003118 aryl group Chemical group 0.000 claims description 93
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• 125000000753 cycloalkyl group Chemical group 0.000 claims description 52
• 230000005764 inhibitory process Effects 0.000 claims description 52
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 48
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• 125000003710 aryl alkyl group Chemical group 0.000 claims description 41
• LKYNGTHMKCTTQC-UHFFFAOYSA-N 1,2-oxazole-3-carboxamide Chemical compound NC(=O)C=1C=CON=1 LKYNGTHMKCTTQC-UHFFFAOYSA-N 0.000 claims description 39
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• CUYKNJBYIJFRCU-UHFFFAOYSA-N 3-aminopyridine Chemical compound NC1=CC=CN=C1 CUYKNJBYIJFRCU-UHFFFAOYSA-N 0.000 claims description 6
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• 150000003852 triazoles Chemical group 0.000 claims description 4
• QRAOZQGIUIDZQZ-UHFFFAOYSA-N 4-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1,4-benzoxazine Chemical compound C=1C=C2N(C)CCOC2=CC=1B1OC(C)(C)C(C)(C)O1 QRAOZQGIUIDZQZ-UHFFFAOYSA-N 0.000 claims description 3
• DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 claims description 3
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