CN101790526A - 用作激酶抑制剂的5-杂芳基取代的吲唑化合物 - Google Patents
用作激酶抑制剂的5-杂芳基取代的吲唑化合物 Download PDFInfo
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- CN101790526A CN101790526A CN200880102038A CN200880102038A CN101790526A CN 101790526 A CN101790526 A CN 101790526A CN 200880102038 A CN200880102038 A CN 200880102038A CN 200880102038 A CN200880102038 A CN 200880102038A CN 101790526 A CN101790526 A CN 101790526A
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- indazole
- triazole
- benzyl
- alkyl
- isoxazole
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- Hematology (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93396007P | 2007-06-08 | 2007-06-08 | |
US60/933,960 | 2007-06-08 | ||
PCT/US2008/065727 WO2008154241A1 (en) | 2007-06-08 | 2008-06-04 | 5-heteroaryl substituted indazoles as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101790526A true CN101790526A (zh) | 2010-07-28 |
Family
ID=39951673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880102038A Pending CN101790526A (zh) | 2007-06-08 | 2008-06-04 | 用作激酶抑制剂的5-杂芳基取代的吲唑化合物 |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP2167491A1 (ja) |
JP (2) | JP5451602B2 (ja) |
KR (1) | KR20100032886A (ja) |
CN (1) | CN101790526A (ja) |
AU (1) | AU2008262038A1 (ja) |
BR (1) | BRPI0811065A2 (ja) |
CA (1) | CA2689117A1 (ja) |
IL (1) | IL202318A0 (ja) |
MX (1) | MX2009013213A (ja) |
RU (1) | RU2487873C2 (ja) |
SG (1) | SG182187A1 (ja) |
WO (1) | WO2008154241A1 (ja) |
ZA (1) | ZA200908624B (ja) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102675286A (zh) * | 2011-03-07 | 2012-09-19 | 中国科学院上海药物研究所 | 一类吲唑类化合物及其制备方法、用途和药物组合物 |
CN103429585A (zh) * | 2010-12-20 | 2013-12-04 | 默克雪兰诺股份有限公司 | 作为白细胞介素-1受体相关激酶抑制剂的吲唑基三唑衍生物 |
CN110218694A (zh) * | 2019-05-30 | 2019-09-10 | 华中农业大学 | 一种猕猴桃果实淀粉体提取方法 |
WO2020087565A1 (zh) * | 2018-11-02 | 2020-05-07 | 安徽中科拓苒药物科学研究有限公司 | 吲唑类激酶抑制剂及其用途 |
CN111171023A (zh) * | 2020-01-10 | 2020-05-19 | 中国药科大学 | 一种具有Pim1抑制活性的化合物及其制备方法与医药用途 |
CN112266378A (zh) * | 2020-11-09 | 2021-01-26 | 延边大学 | 含吲唑结构的咪唑类衍生物及其制备方法和应用 |
CN113350347A (zh) * | 2020-03-05 | 2021-09-07 | 安徽中科拓苒药物科学研究有限公司 | 吲唑类化合物的新用途 |
CN114651898A (zh) * | 2022-03-31 | 2022-06-24 | 河南湾流生物科技有限公司 | 一种提高免疫力的三唑类饲料添加剂及其制备方法和应用 |
CN116891460A (zh) * | 2023-07-12 | 2023-10-17 | 浙江大学 | 一种吲唑类衍生物或其药用盐及应用 |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
EP1984331B1 (en) | 2006-02-16 | 2010-10-20 | Schering Corporation | Pyrrolidine derivatives as erk inhibitors |
US8648069B2 (en) * | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
US20110301155A1 (en) * | 2007-06-19 | 2011-12-08 | Tsuneo Yasuma | Indazole compounds for activating glucokinase |
AU2008276512A1 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of PKB |
AU2008276521B2 (en) | 2007-07-17 | 2011-11-03 | Amgen Inc. | Heterocyclic modulators of PKB |
JPWO2009028543A1 (ja) * | 2007-08-30 | 2010-12-02 | 武田薬品工業株式会社 | 置換ピラゾール誘導体 |
SG188179A1 (en) | 2008-02-21 | 2013-03-28 | Merck Sharp & Dohme | Compounds that are erk inhibitors |
CL2009001158A1 (es) * | 2008-05-15 | 2009-10-23 | Nerviano Medical Sciences Srl | Compuestos derivados de los acidos carboxilicos, tales como 5,6-dihiro-4h-pirrolo[3,4-c]pirazol, furo[3,2-c]pirazol, tieno[2,3-c]pirazol, 4,5,6,7-tetrahidropirazol[4,3-c]piridina e indazol; composicion farmaceutica; y su uso en el tratamiento de trastornos proliferativos celulares asociados a la actividad de proteina quinasa alterada, tal como el cancer. |
AR074199A1 (es) * | 2008-11-20 | 2010-12-29 | Glaxosmithkline Llc | Compuesto de 6-(4-pirimidinil)-1h-indazol, composiciones farmaceuticas que lo comprenden y su uso para preparar un medicamento util para el tratamiento o disminucion de la gravedad del cancer. |
CA2770116C (en) | 2009-08-10 | 2018-03-13 | Epitherix, Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
CN102821607B (zh) | 2009-12-21 | 2014-12-17 | 萨穆梅德有限公司 | 1H-吡唑并[3,4-b]吡啶及其治疗应用 |
UY33213A (es) * | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
KR101233082B1 (ko) | 2010-02-25 | 2013-02-14 | 주식회사 이큐스앤자루 | 신규한 이미다졸피라진 유도체 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스 치료용 약학적 조성물 |
JP6026284B2 (ja) * | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
WO2011136264A1 (ja) * | 2010-04-28 | 2011-11-03 | 第一三共株式会社 | [5,6]複素環化合物 |
EP2566333A4 (en) * | 2010-05-07 | 2014-04-02 | Univ Leland Stanford Junior | IDENTIFICATION OF STABILIZERS OF MULTIMEDER PROTEINS |
US9173887B2 (en) | 2010-12-22 | 2015-11-03 | Abbvie Inc. | Hepatitis C inhibitors and uses thereof |
US9090592B2 (en) * | 2010-12-30 | 2015-07-28 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
CU24263B1 (es) * | 2011-04-07 | 2017-07-04 | Bayer Ip Gmbh | Derivados de imidazopiridazinas inhibidores de quinasa akt, útiles para el tratamiento del cáncer |
MX355852B (es) * | 2011-08-12 | 2018-05-02 | Hoffmann La Roche | Compuestos de pirazolo [3,4-c] piridina y métodos de uso. |
HUE041576T2 (hu) * | 2011-09-14 | 2019-05-28 | Samumed Llc | Indazol-3-karboxamid-származékok és alkalmazásuk Wnt/b-katenin szignalizáló útvonal inhibitorokként |
ES2565067T3 (es) | 2011-12-27 | 2016-03-31 | Bayer Intellectual Property Gmbh | Derivados de heteroarilpiperidina y de heteroarilpiperazina como fungicidas |
SG11201403602WA (en) | 2012-02-21 | 2014-07-30 | Acraf | 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors |
PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
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EP2167491A1 (en) | 2010-03-31 |
CA2689117A1 (en) | 2008-12-18 |
JP2010529137A (ja) | 2010-08-26 |
KR20100032886A (ko) | 2010-03-26 |
JP2014074057A (ja) | 2014-04-24 |
SG182187A1 (en) | 2012-07-30 |
RU2009149696A (ru) | 2011-07-20 |
RU2487873C2 (ru) | 2013-07-20 |
MX2009013213A (es) | 2010-03-30 |
JP5451602B2 (ja) | 2014-03-26 |
WO2008154241A1 (en) | 2008-12-18 |
ZA200908624B (en) | 2015-08-26 |
AU2008262038A1 (en) | 2008-12-18 |
IL202318A0 (en) | 2010-06-30 |
BRPI0811065A2 (pt) | 2014-12-02 |
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