RU2416618C2 - Соединения, представляющие собой пептидные аналоги стимуляторов секреции гормона роста, и содержащие их препараты - Google Patents

Соединения, представляющие собой пептидные аналоги стимуляторов секреции гормона роста, и содержащие их препараты Download PDF

Info

Publication number
RU2416618C2
RU2416618C2 RU2008138569/10A RU2008138569A RU2416618C2 RU 2416618 C2 RU2416618 C2 RU 2416618C2 RU 2008138569/10 A RU2008138569/10 A RU 2008138569/10A RU 2008138569 A RU2008138569 A RU 2008138569A RU 2416618 C2 RU2416618 C2 RU 2416618C2
Authority
RU
Russia
Prior art keywords
ghrelin
ghs
compounds
growth hormone
peptide
Prior art date
Application number
RU2008138569/10A
Other languages
English (en)
Russian (ru)
Other versions
RU2008138569A (ru
Inventor
ФЕРНАНДЕС Роландо Эдуардо РОДРИГЕС (CU)
ФЕРНАНДЕС Роландо Эдуардо РОДРИГЕС
ЛА НУЕС ВЕУЛЕНС Ания ДЕ (CU)
ЛА НУЕС ВЕУЛЕНС Ания ДЕ
ГАРСИЯ Марио Пабло ЭСТРАДА (CU)
Гарсия Марио Пабло Эстрада
РОДРИГЕС Ребека МАРТИНЕС (CU)
Родригес Ребека Мартинес
САНТЬЯГО Глай ЧИНЕА (CU)
САНТЬЯГО Глай ЧИНЕА
АКОСТА Освальдо РЕЙЕС (CU)
АКОСТА Освальдо РЕЙЕС
МАССО Хулио Рауль ФЕРНАНДЕС (CU)
Массо Хулио Рауль Фернандес
ДЕЛЬ БАРКО ЭРРЕРА Диана ГАРСИЯ (CU)
Дель Барко Эррера Диана Гарсия
АКОСТА Хорхе Амадор БЕРЛАНГА (CU)
АКОСТА Хорхе Амадор БЕРЛАНГА
ЛАСА Алексис МУСАКЧИО (CU)
ЛАСА Алексис МУСАКЧИО
Original Assignee
Сентро Де Инхеньерия Хенетика И Биотекнолохия
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40130780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2416618(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Сентро Де Инхеньерия Хенетика И Биотекнолохия filed Critical Сентро Де Инхеньерия Хенетика И Биотекнолохия
Publication of RU2008138569A publication Critical patent/RU2008138569A/ru
Application granted granted Critical
Publication of RU2416618C2 publication Critical patent/RU2416618C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
RU2008138569/10A 2006-02-28 2007-02-28 Соединения, представляющие собой пептидные аналоги стимуляторов секреции гормона роста, и содержащие их препараты RU2416618C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU20060050A CU23558A1 (es) 2006-02-28 2006-02-28 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
CU2006-0050 2006-05-28

Publications (2)

Publication Number Publication Date
RU2008138569A RU2008138569A (ru) 2010-04-10
RU2416618C2 true RU2416618C2 (ru) 2011-04-20

Family

ID=40130780

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008138569/10A RU2416618C2 (ru) 2006-02-28 2007-02-28 Соединения, представляющие собой пептидные аналоги стимуляторов секреции гормона роста, и содержащие их препараты

Country Status (18)

Country Link
US (1) US8367620B2 (https=)
EP (1) EP1997827B1 (https=)
JP (1) JP5183496B2 (https=)
KR (1) KR101409277B1 (https=)
CN (1) CN101432294B (https=)
AR (1) AR059646A1 (https=)
AU (1) AU2007219569B2 (https=)
BR (1) BRPI0708366A2 (https=)
CA (1) CA2637593C (https=)
CL (2) CL2007000528A1 (https=)
CU (1) CU23558A1 (https=)
ES (1) ES2441441T3 (https=)
MX (1) MX2008011142A (https=)
MY (1) MY184130A (https=)
NO (1) NO20084118L (https=)
RU (1) RU2416618C2 (https=)
WO (1) WO2007098716A1 (https=)
ZA (1) ZA200807162B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2734835C1 (ru) * 2020-02-11 2020-10-23 Федеральное государственное бюджетное учреждение науки Лимнологический институт Сибирского отделение Российской академии наук (ЛИН СО РАН) Способ повышения жизнестойкости эмбрионов рыб в аквакультуре
RU2768134C2 (ru) * 2016-11-01 2022-03-23 Сентро Де Инхеньерия Хенетика И Биотекнолохия Применение пептида, усиливающего секрецию соматотропного гормона, в качестве адъюванта вакцины
RU2779835C1 (ru) * 2018-08-21 2022-09-13 Сентро Де Инхеньерия Хенетика И Биотекнолохия Применение ghrp-6 в качестве кардиозащитного и кардиовосстанавливающего лекарственного средства для позднего лечения

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4831551B2 (ja) * 2008-11-06 2011-12-07 国立大学法人名古屋大学 非虚血性心筋障害に対する医薬

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849597B2 (en) * 1999-12-28 2005-02-01 Kaken Pharmaceutical Co., Ltd. Neuroprotective drug
US6939880B2 (en) * 1995-12-22 2005-09-06 Novo Nordisk A/S Compounds with growth hormone releasing properties

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3239345A (en) 1965-02-15 1966-03-08 Estrogenic compounds and animal growth promoters
US4411890A (en) 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4036979A (en) 1974-01-25 1977-07-19 American Cyanamid Company Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or derivatives and methods of enhancing growth rate
AU628322B2 (en) 1988-01-28 1992-09-17 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
DE68922602T2 (de) 1988-01-28 1995-12-07 Polygen Holding Corp Polypeptide mit hormonwachstumsbefreiender wirkung.
JP2670680B2 (ja) 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
DK0554381T3 (da) 1990-10-25 1996-04-09 Genentech Inc Anvendelse af beskyttende midler mod reaktive oxygenforbindelser
US5663146A (en) 1991-08-22 1997-09-02 Administrators Of The Tulane Educational Fund Polypeptide analogues having growth hormone releasing activity
EP0669830A4 (en) 1992-11-06 1997-02-26 Merck & Co Inc SUBSTITUTED DIPEPTIDE ANALOGS, WHICH SUPPORT THE RELEASE OF GROWTH HORMONE.
US5726319A (en) 1992-11-06 1998-03-10 Merck & Co., Inc. Biphenyl substituted dipeptide analogs promote release of growth hormone
US5536716A (en) 1992-12-11 1996-07-16 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone
NZ258412A (en) 1992-12-11 1997-01-29 Merck & Co Inc Spiro-fused piperidine derivatives and pharmaceutical compositions
HUT75224A (en) 1993-10-19 1997-04-28 Merck & Co Inc Combination of bisphosphonates and growth hormone secretagogues
PL322706A1 (en) 1993-11-09 1998-02-16 Merck & Co Inc Piperidines, pyrolidines and hexahydro-1h-azepins enhancing growth hormone liberation
US5494919A (en) 1993-11-09 1996-02-27 Merck & Co., Inc. 2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
US5492916A (en) 1993-12-23 1996-02-20 Merck & Co., Inc. Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
CA2176140A1 (en) 1993-11-24 1995-06-01 Meng Hsin Chen Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s)
US5721251A (en) 1993-12-10 1998-02-24 Merck & Co., Inc. Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone
HU224345B1 (hu) 1993-12-23 2005-08-29 Novo Nordisk A/S. Növekedési hormont felszabadító tulajdonságú peptidek, ezeket hatóanyagként tartalmazó gyógyszerkészítmények és alkalmazásuk
US5721250A (en) 1993-12-23 1998-02-24 Merck & Co. Inc. Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
JP3759748B2 (ja) 1993-12-23 2006-03-29 ノボ ノルディスク アクティーゼルスカブ 成長ホルモン放出性を有する化合物
WO1995034311A1 (en) 1994-06-13 1995-12-21 Merck & Co., Inc. Piperazine compounds promote release of growth hormone
US5783582A (en) 1994-07-20 1998-07-21 Merck & Co., Inc. Piperidines and hexahydro-1H-azepines spiro substituted at the 4-position promote release of growth hormone
US5798337A (en) 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
WO1996022996A1 (en) 1995-01-25 1996-08-01 Nippon Chemiphar Co., Ltd. Dihydrophenazine derivatives
WO1996022997A1 (en) 1995-01-27 1996-08-01 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU4534696A (en) 1995-02-09 1996-08-27 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1996024580A1 (en) 1995-02-09 1996-08-15 Novo Nordisk A/S Compounds with growth hormone releasing properties
US5559128A (en) 1995-04-18 1996-09-24 Merck & Co., Inc. 3-substituted piperidines promote release of growth hormone
EP0823904A4 (en) 1995-04-19 1998-09-09 Merck & Co Inc Process for the preparation of spiroindolines
WO1996035713A1 (en) 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides which promote release of growth hormone
ATE288444T1 (de) 1995-05-29 2005-02-15 Pfizer Dipeptide, die die ausschüttung von wachstumshormonen stimulieren
BR9608909A (pt) 1995-06-22 1999-03-02 Novo Nordisk As Composto composição farmacêutica processos para estimular a liberação do hormônio do crescimento da patuitária e aumentar a velocidade e extensão do crescimento dos animais para aumentar a produção de leite ou lã de animais ou para para doenças e uso do composto
WO1997007117A1 (en) 1995-08-21 1997-02-27 Eli Lilly And Company 2-acylaminopropanamines as growth hormone secretagogues
CA2203428A1 (en) 1995-08-21 1997-02-27 Philip Arthur Hipskind 2-acylaminopropanamides as growth hormone secretagogues
EP0766966A3 (en) 1995-09-08 2001-02-28 Eli Lilly And Company Method of treating insulin resistance
WO1997011697A1 (en) 1995-09-26 1997-04-03 Merck & Co., Inc. 3-spirolactam, 3-spiroamino, 3-spirolactone and 3-spirobenzopyran piperidines and pyrrolidines promote release of growth hormone
US5767124A (en) 1995-10-27 1998-06-16 Merck & Co., Inc. Polymorphic forms of a growth hormone secretagogue
EA199800337A1 (ru) 1995-10-27 1998-10-29 Мерк Энд Ко., Инк. Способ получения гормона роста, усиливающего секрецию
CA2234817A1 (en) 1995-10-27 1997-05-01 Mandana Asgharnejad Wet granulation formulation of a growth hormone secretagogue
SK51198A3 (en) 1995-10-27 1998-11-04 Merck & Co Inc Method for producing n-[1(r)-[(1,2-dihydro-1- -methanesulfonylspiro[3h-indole-3,4'-piperidine-1'-yl)carbonyl]- -2-(phenylmethyloxy)ethyl]-2-amino-2-methylpropanamide
EP0870199B1 (en) 1995-12-13 2006-07-26 Merck & Co., Inc. Assays for growth hormone secretagogue receptors
ATE279440T1 (de) 1995-12-13 2004-10-15 Merck & Co Inc Wachstumshormonsekretionsförderer rezeptorfamilie
IT1277113B1 (it) 1995-12-20 1997-11-04 Romano Deghenghi Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
WO1997022367A1 (en) 1995-12-20 1997-06-26 Merck & Co., Inc. Radiolabeled growth hormone secretagogue
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
WO1997034604A1 (en) 1996-03-21 1997-09-25 Merck & Co., Inc. 4-spiroindoline piperidines promote release of growth hormone
WO1997036873A1 (en) 1996-04-03 1997-10-09 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
SE9601397D0 (sv) 1996-04-12 1996-04-12 Pharmacia Ab Use of growth hormone
JP2000510453A (ja) 1996-04-19 2000-08-15 ノボ ノルディスク アクティーゼルスカブ 成長ホルモン遊離特性を有する化合物
WO1997040023A1 (en) 1996-04-24 1997-10-30 Novo Nordisk A/S Compounds with growth hormone releasing properties
US5919777A (en) 1996-04-24 1999-07-06 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU711884B2 (en) 1996-05-07 1999-10-21 Merck & Co., Inc. Enhancement of sleep with a growth hormone secretagogue
WO1997041878A1 (en) 1996-05-07 1997-11-13 Merck & Co., Inc. Treatment of mood disorders with a growth hormone secretagogue
AU2764797A (en) 1996-05-14 1997-12-05 Novo Nordisk A/S Somatostatin agonists and antagonists
AU3220097A (en) 1996-05-22 1997-12-09 Arch Development Corporation Sleep quality improvement using a growth hormone secretagogue
KR20000016204A (ko) 1996-05-31 2000-03-25 한센 핀 베네드, 안네 제헤르 골다공증의 주기적(연계) 치료에 있어 성장호르몬 성분 및 뼈의항흡수 약물
WO1998003473A1 (en) 1996-07-22 1998-01-29 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1998010653A1 (en) 1996-09-13 1998-03-19 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
WO1998018815A1 (en) 1996-10-25 1998-05-07 Merck & Co., Inc. Convergent process for the preparation of a growth hormone secretagogue
SE9703929D0 (sv) 1996-11-22 1997-10-28 Pharmacia & Upjohn Ab Therapeutical use and method
WO1998046569A1 (fr) 1997-04-11 1998-10-22 Sumitomo Pharmaceuticals Co., Ltd. Derives de benzene
JP2000514838A (ja) 1997-05-14 2000-11-07 藤沢薬品工業株式会社 成長ホルモンの放出を促進するピペリジノ誘導体
US5861149A (en) 1997-06-04 1999-01-19 Polyheal Ltd. Methods for wound treatment
WO1998058950A1 (en) 1997-06-20 1998-12-30 Novo Nordisk A/S Compounds with growth hormone releasing properties
UA53716C2 (uk) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)
UA64751C2 (uk) 1997-06-25 2004-03-15 Пфайзер Продактс Інк. Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти)
US6251902B1 (en) 1997-06-25 2001-06-26 Pfizer Inc. Dipeptide derivatives as growth hormone secretagogues
ZA987383B (en) 1997-08-19 2000-02-17 Lilly Co Eli Treatment of congestive heart failure with growth hormone secretagogues.
ATE344667T1 (de) 1997-08-22 2006-11-15 Kaken Pharma Co Ltd Amide zur förderung der ausschüttung von wachstumshormonen
IL137007A0 (en) 1998-01-16 2001-06-14 Novo Nordisk As Compounds with growth hormone releasing properties
WO1999039730A1 (en) 1998-02-09 1999-08-12 Kaken Pharmaceutical Co., Ltd. Oral preparations containing peptides promoting the secretion of growth hormone
AU3247899A (en) 1998-03-03 1999-09-20 Novo Nordisk A/S New salt forms of (2e)- 5-amino-5- methylhex-2- enoic acid n-methyl-n-((1r)-1-(n- methyl-n-((1r)-1-(methylcarbamoyl)-2- phenylethyl)carbamoyl)-2- (2-naphtyl)ethyl)amide
PT1077941E (pt) 1998-05-11 2010-07-01 Novo Nordisk As Compostos com propriedades de libertaã†o da hormona de crescimento
EP1093463A1 (en) 1998-06-09 2001-04-25 Novo Nordisk A/S A method for preparing a compound with growth hormone releasing properties
JP2002518328A (ja) 1998-06-16 2002-06-25 ファイザー・プロダクツ・インク 筋骨格虚弱の治療用の（選択的）エストロゲン受容体モジュレーター（ｓｅｒｍ）および成長ホルモン分泌促進薬（ｇｈｓ）の治療的組合せ
HN1999000097A (es) 1998-06-16 1999-11-03 Pfizer Prod Inc Terapia de combinacion para la fragilidad muscoloesqueletica
BRPI9911756B1 (pt) 1998-06-30 2016-06-14 Helsinn Healthcare Sa composto, uso do mesmo, e composição farmaceutica
CA2340701C (en) 1998-08-20 2009-05-26 Sumitomo Pharmaceuticals Co., Ltd. Oxindole derivatives as growth hormone releasers
US6358951B1 (en) 1998-08-21 2002-03-19 Pfizer Inc. Growth hormone secretagogues
CA2411667A1 (en) 2000-05-30 2001-12-06 Merck & Co. Inc. Ghrelin analogs
ATE446758T1 (de) 2000-05-31 2009-11-15 Pfizer Prod Inc Verwendung von wachstumshormonsekretagoga zur förderung der beweglichkeit des verdauungstrakts
AR029941A1 (es) 2000-06-13 2003-07-23 Zentaris Gmbh Compuestos utiles para elevar el nivel plasmatico de la hormona del crecimiento y las composiciones farmaceuticas que las contienen
AU2001274601A1 (en) 2000-06-23 2002-01-02 Kaken Pharmaceutical Co., Ltd. Preventives or remedies for heart failure
ITMI20011445A1 (it) 2001-07-06 2003-01-06 Europ Geie Analoghi della cortistantina capaci di legarsi selettivamente ai recettori dei secretagoghi dell'ormone della crescita
CU23043A1 (es) 2001-12-20 2005-05-20 Ct Ingenieria Genetica Biotech Composicion farmaceutica que contiene factor de crecimiento epidrmico (egf) para la prevencion de la amputacion de pie diabetico.
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
WO2005039625A1 (en) 2003-10-28 2005-05-06 Rheoscience A/S Growth hormone secretagogue receptor agonists
US7504506B2 (en) 2003-11-04 2009-03-17 Elixir Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
WO2005048916A2 (en) 2003-11-20 2005-06-02 Biovitrum Ab Tetrahydrospiro-beta-carboline-1,3 '-pyrrolidine derivatives and their use in ghsr-related disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939880B2 (en) * 1995-12-22 2005-09-06 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6849597B2 (en) * 1999-12-28 2005-02-01 Kaken Pharmaceutical Co., Ltd. Neuroprotective drug

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CORT J.H. et al. Regional and systemic haemodynamic effects of some vasopressin, Europ. J. Clin. Invest., 1975, 5, 165-175. LAMMEK В. et al. Synthesis of three NH2-terminally extended arginine vasopressin with prolonged biological activities, Experentia, 1987, 43, 1211-1212. ШУНДЕРОВИЧ М.Д. и др. Исследование пространственной структуры des-Gly9-[Arg8]вазопрессина методами двумерной спектроскопии ЯМР и теоретического конформационного анализа, Биоорганическая химия, 1985, 11 (9), 1180-1191. *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2768134C2 (ru) * 2016-11-01 2022-03-23 Сентро Де Инхеньерия Хенетика И Биотекнолохия Применение пептида, усиливающего секрецию соматотропного гормона, в качестве адъюванта вакцины
RU2779835C1 (ru) * 2018-08-21 2022-09-13 Сентро Де Инхеньерия Хенетика И Биотекнолохия Применение ghrp-6 в качестве кардиозащитного и кардиовосстанавливающего лекарственного средства для позднего лечения
RU2734835C1 (ru) * 2020-02-11 2020-10-23 Федеральное государственное бюджетное учреждение науки Лимнологический институт Сибирского отделение Российской академии наук (ЛИН СО РАН) Способ повышения жизнестойкости эмбрионов рыб в аквакультуре

Also Published As

Publication number Publication date
CN101432294B (zh) 2013-09-11
NO20084118L (no) 2008-09-29
WO2007098716A8 (es) 2008-12-18
AU2007219569B2 (en) 2012-03-15
RU2008138569A (ru) 2010-04-10
ES2441441T3 (es) 2014-02-04
EP1997827A1 (en) 2008-12-03
MX2008011142A (es) 2008-09-08
WO2007098716A1 (es) 2007-09-07
MY184130A (en) 2021-03-19
CN101432294A (zh) 2009-05-13
CL2016001648A1 (es) 2017-02-24
JP2009528303A (ja) 2009-08-06
AR059646A1 (es) 2008-04-16
AU2007219569A1 (en) 2007-09-07
US20100055118A1 (en) 2010-03-04
JP5183496B2 (ja) 2013-04-17
ZA200807162B (en) 2009-06-24
EP1997827B1 (en) 2013-10-09
CA2637593A1 (en) 2007-09-07
US8367620B2 (en) 2013-02-05
CU23558A1 (es) 2010-07-20
KR101409277B1 (ko) 2014-06-24
CA2637593C (en) 2015-04-14
KR20080110763A (ko) 2008-12-19
CL2007000528A1 (es) 2008-01-18
BRPI0708366A2 (pt) 2011-05-24

Similar Documents

Publication Publication Date Title
Smith Development of growth hormone secretagogues
KR20160142322A (ko) 펩티드 이중 glp-1/글루카곤 수용체 효능제로서의 엑센딘-4 유도체
EP2272524A2 (en) Y2 selective receptor agonists for therapeutic interventions
Vodnik et al. Ghrelin receptor ligands reaching clinical trials: from peptides to peptidomimetics; from agonists to antagonists
CN100425282C (zh) 用于治疗性干预的y2/y4选择性受体激动剂
ES2818556T3 (es) Péptido con eficacia antiobesidad y antidiabética y uso del mismo
Wan et al. Characterization of neuromedin U (NMU), neuromedin S (NMS) and their receptors (NMUR1, NMUR2) in chickens
Gonzalez et al. Pituitary adenylate cyclase-activating polypeptide
Eliakim et al. Exercise, training, and the GH-IGF-I axis
US20240279278A1 (en) Nmu receptor 2 agonists
RU2416618C2 (ru) Соединения, представляющие собой пептидные аналоги стимуляторов секреции гормона роста, и содержащие их препараты
Masuda et al. PEGylated neuromedin U-8 shows long-lasting anorectic activity and anti-obesity effect in mice by peripheral administration
Goetze et al. Procholecystokinin expression and processing in cardiac myocytes
Tachibana et al. Central ghrelin acts as an anti-dipsogenic peptide in chicks
Fang et al. Cardiovascular effects of intravenous administered 26RFa, a novel RFamide peptide ligand for GPR103, in anaesthetised rats
KR101920047B1 (ko) 항비만 및 항당뇨 효능을 갖는 펩타이드 및 이의 용도
Muccioli et al. Known and unknown growth hormone secretagogue receptors and their ligands
Kojima et al. Discovery of Ghrelin, an Endogenous Ligand for the Growth-Hormone Secret Agogue Receptor
KOJIMA et al. Ghrelin, an Endogenous Ligand for the Growth Hormone Secretagogue Receptor
Soll et al. On the role of neuropeptides in the hypothalamic regulation of food intake
Kojima et al. Screening and Identification of Ghrelin, an Endogenous Ligand for GHS-R

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20180301