RU2408580C2 - Пиридильное неароматическое азотсодержащее гетероцикло-1-карбоксилатное производное - Google Patents

Пиридильное неароматическое азотсодержащее гетероцикло-1-карбоксилатное производное Download PDF

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RU2408580C2
RU2408580C2 RU2009121774/04A RU2009121774A RU2408580C2 RU 2408580 C2 RU2408580 C2 RU 2408580C2 RU 2009121774/04 A RU2009121774/04 A RU 2009121774/04A RU 2009121774 A RU2009121774 A RU 2009121774A RU 2408580 C2 RU2408580 C2 RU 2408580C2
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group
alk
optionally substituted
solution
added
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RU2009121774/04A
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RU2009121774A (ru
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Такахиро ИСИИ (JP)
Такахиро ИСИИ
Такаси СУГАНЕ (JP)
Такаси Сугане
Дзун МАЕДА (JP)
Дзун МАЕДА
Фумие НАРАЗАКИ (JP)
Фумие НАРАЗАКИ
Акио КАКЕФУДА (JP)
Акио Какефуда
Кентаро САТО (JP)
Кентаро САТО
Тацухиса ТАКАХАСИ (JP)
Тацухиса ТАКАХАСИ
Такатоси КАНАЯМА (JP)
Такатоси КАНАЯМА
Тикаси САИТОХ (JP)
Тикаси САИТОХ
Дзотаро СУЗУКИ (JP)
Дзотаро СУЗУКИ
Тисато КАНАИ (JP)
Тисато КАНАИ
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Астеллас Фарма Инк.
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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RU2009121774/04A 2005-02-17 2006-02-16 Пиридильное неароматическое азотсодержащее гетероцикло-1-карбоксилатное производное RU2408580C2 (ru)

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Application Number Priority Date Filing Date Title
JP2005040197 2005-02-17
JP2005-040197 2005-02-17
JP2005-303065 2005-10-18
JP2005303065 2005-10-18

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RU2007134441/04A Division RU2376289C2 (ru) 2005-02-17 2006-02-16 Пиридильное неароматическое азотсодержащее гетероцикло-1-карбоксилатное производное

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RU2408580C2 true RU2408580C2 (ru) 2011-01-10

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RU2007134441/04A RU2376289C2 (ru) 2005-02-17 2006-02-16 Пиридильное неароматическое азотсодержащее гетероцикло-1-карбоксилатное производное
RU2009121775/04A RU2408581C2 (ru) 2005-02-17 2006-02-16 Пиридильное неароматическое азотсодержащее гетероцикло-1-карбоксилатное производное

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RU2009121775/04A RU2408581C2 (ru) 2005-02-17 2006-02-16 Пиридильное неароматическое азотсодержащее гетероцикло-1-карбоксилатное производное

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EP (2) EP2607362B1 (enExample)
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RU (3) RU2408580C2 (enExample)
SI (2) SI1849773T1 (enExample)
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Families Citing this family (42)

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Publication number Priority date Publication date Assignee Title
TW200633990A (en) 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
JP2008545010A (ja) * 2005-06-30 2008-12-11 プロシディオン・リミテッド Ｇタンパク質共役受容体アゴニスト
WO2007005510A1 (en) 2005-06-30 2007-01-11 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
KR20080027908A (ko) * 2005-06-30 2008-03-28 프로시디온 리미티드 Ｇｐｃｒ 효능제
EP1991233A4 (en) * 2006-02-17 2009-07-01 Avalon Pharmaceuticals Hydroxypiperidine derivatives and their use
EP2065369A4 (en) 2006-08-23 2011-12-28 Astellas Pharma Inc UREA CONNECTION OR SALT THEREOF
GEP20125425B (en) 2006-10-18 2012-03-26 Pfizer Prod Inc Biaryl ether urea compounds
WO2008145681A2 (en) 2007-05-31 2008-12-04 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists and uses thereof
ES2442926T3 (es) 2007-08-22 2014-02-14 Astrazeneca Ab Derivados de ciclopropilamida `978
EP2271619A1 (en) * 2008-04-07 2011-01-12 Irm Llc Compounds and compositions as modulators of gpr119 activity
WO2009143404A1 (en) * 2008-05-23 2009-11-26 Wyeth Piperazine metabotropic glutamate receptor 5 (mglur5) negative allosteric modulators for anxiety/depression
TWI434842B (zh) * 2008-07-14 2014-04-21 Astellas Pharma Inc Azole compounds
KR20110091508A (ko) 2008-11-06 2011-08-11 아스텔라스세이야쿠 가부시키가이샤 카르바메이트 화합물 또는 그의 염
CN102256963B (zh) 2008-12-19 2014-06-11 贝林格尔.英格海姆国际有限公司 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺
TW201039825A (en) 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
PT2513093E (pt) 2009-12-17 2014-10-22 Boehringer Ingelheim Int Novos antagonistas do receptor ccr2 e suas utilizações
US20130150346A1 (en) 2010-01-08 2013-06-13 Quest Ventures Ltd. Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
AU2010344973B2 (en) * 2010-02-05 2016-06-16 Merck Patent Gmbh Hetaryl-[1,8]naphthyridine derivatives
NZ602110A (en) 2010-02-18 2014-09-26 Astrazeneca Ab Processes for making cyclopropyl amide derivatives and intermediates associated therewith
WO2011123719A2 (en) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating abdominal, visceral and pelvic pain
JP2013147430A (ja) * 2010-04-28 2013-08-01 Astellas Pharma Inc 夜間頻尿の予防又は治療剤
TW201206440A (en) * 2010-04-28 2012-02-16 Astellas Pharma Inc Prophylactic or therapeutic agent for diseases associated with pains in urinary organs
US8946218B2 (en) 2010-05-12 2015-02-03 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2569298B1 (en) 2010-05-12 2015-11-25 Boehringer Ingelheim International GmbH Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP5647339B2 (ja) 2010-05-17 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２アンタゴニスト及びこれらの使用
JP5636094B2 (ja) 2010-05-25 2014-12-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２受容体アンタゴニスト
US8962656B2 (en) 2010-06-01 2015-02-24 Boehringer Ingelheim International Gmbh CCR2 antagonists
JP5786258B2 (ja) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規かつ選択的なｃｃｒ２拮抗薬
SI2890684T1 (en) * 2012-07-24 2018-06-29 Bial-Portela & Ca, S.A. THE CLOTHING MACHINE AND THEIR USE AS ENCLOSURE INHIBITORS
DE102012018115A1 (de) 2012-09-13 2014-03-13 Matthias Lehr Aryl-N-(arylalkyl)carbamate als Hemmstoffe der Fatty Acid Amide Hydrolase
GB201218084D0 (en) * 2012-10-09 2012-11-21 Univ Aston Novel compounds and methods for use in medicine
HUP1300139A2 (en) 2013-03-06 2014-09-29 Richter Gedeon Nyrt Phenoxypiperidine h3 antagonists
DE102013016573A1 (de) 2013-10-04 2015-04-09 Matthias Lehr 1-Tetrazolylpropan-2-one als Inhibitoren von cytosolischer Phospholipase A2 und Fatty Acid Amide Hydrolase, insbesondere geeignet zur topischen Anwendung
MA41168A (fr) * 2014-12-17 2017-10-24 Acraf Nouveaux composés antibactériens
AU2016287584B2 (en) 2015-07-02 2020-03-26 Centrexion Therapeutics Corporation (4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
CN117510468A (zh) * 2017-03-13 2024-02-06 灵北拉荷亚研究中心公司 双重magl和faah抑制剂
MY172113A (en) * 2017-07-05 2019-11-14 Frimline Private Ltd A pharmaceutical composition for neuropathic pain
JP7346425B2 (ja) * 2018-01-11 2023-09-19 セントラス セラピューティクス 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤
MY210363A (en) 2018-09-13 2025-09-13 Celgene Corp Crystalline (r)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl) piperazine-1-carboxylate, compositions and methods of use thereof
AU2019427489B2 (en) * 2019-01-28 2025-03-13 Mitochondria Emotion, Inc. Mitofusin activators and methods of use thereof
CA3163089A1 (en) 2019-11-29 2021-06-03 Autobahn Therapeutics, Inc. Novel thyromimetics
EP4594294A1 (en) * 2022-09-30 2025-08-06 The United States of America, as represented by the Secretary, Department of Health and Human Services Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU98105684A (ru) * 1996-06-29 2000-02-10 Самдзин Фармасьютикал Ко., Лтд. Производные пиперазина и способ их получения

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200462B (enExample) 1990-09-27 1993-02-21 Hoechst Roussel Pharma
US5744485A (en) 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
CZ288002B6 (cs) 1995-01-11 2001-03-14 Samjin Pharmaceutical Co., Ltd. Piperazinové deriváty a farmaceutický prostředek s protinádorovou aktivitou je obsahující
CZ59398A3 (cs) * 1996-06-29 1998-07-15 Samjin Pharmaceutical Co., Ltd. Piperazinové deriváty a způsob jejich přípravy
US5870472A (en) * 1996-11-12 1999-02-09 General Instrument Corporation Dynamic relocation of the service data channel
US5780484A (en) * 1996-11-13 1998-07-14 Vertex Pharmaceuticals Incorporated Methods for stimulating neurite growth with piperidine compounds
WO1999037304A1 (en) 1998-01-27 1999-07-29 Aventis Pharmaceuticals Products Inc. SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS
JP3581103B2 (ja) * 1999-04-01 2004-10-27 ファイザー・プロダクツ・インク ソルビトールデヒドロゲナーゼ阻害薬としてのアミノピリミジン
CZ2002323A3 (cs) 1999-07-28 2002-05-15 Aventis Pharmaceuticals Products Inc. Substituované oxoazaheterocyklylové sloučeniny a farmaceutické prostředky, které je obsahují
WO2002043762A2 (en) 2000-11-30 2002-06-06 Pfizer Products Inc. Combination of gaba agonists and sorbitol dehydrogenase inhibitors
DE60216830T2 (de) 2001-02-06 2007-06-14 Pfizer Products Inc., Groton Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen
JP2005518376A (ja) 2001-12-14 2005-06-23 ノボ　ノルディスク　アクティーゼルスカブ 化合物およびホルモン感受性リパーゼの活性を低下させるためのその使用
JP2003192659A (ja) 2001-12-26 2003-07-09 Bayer Ag フェニル尿素誘導体
AU2002358700A1 (en) 2001-12-26 2003-07-15 Bayer Aktiengesellschaft Urea derivatives as vr1- antagonists
AU2003210824A1 (en) 2002-02-08 2003-09-02 Bristol-Myers Squibb Company (oxime)carbamoyl fatty acid amide hydrolase inhibitors
FR2843964B1 (fr) 2002-08-29 2004-10-01 Sanofi Synthelabo Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
AU2003279877B2 (en) * 2002-10-07 2010-05-20 The Regents Of The University Of California Modulation of anxiety through blockade of anandamide hydrolysis
AR043633A1 (es) 2003-03-20 2005-08-03 Schering Corp Ligandos de receptores de canabinoides
MXPA05013225A (es) 2003-06-12 2006-03-09 Novo Nordisk As Derivados de 1-aril-4-(ariloxicarbonil)-piperazina para uso como inhibidores de la lipasa sensible a hormonas.
KR20060021881A (ko) 2003-06-12 2006-03-08 노보 노르디스크 에이/에스 호르몬 민감성 리파제의 억제제로서의 사용을 위한 치환된피페리딘 카르바메이트
WO2004111004A1 (en) 2003-06-12 2004-12-23 Novo Nordisk A/S Substituted piperazine carbamates for use as inhibitors of hormone sensitive lipase
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
FR2864080B1 (fr) 2003-12-23 2006-02-03 Sanofi Synthelabo Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique
FR2865205B1 (fr) 2004-01-16 2006-02-24 Sanofi Synthelabo Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique
FR2866884B1 (fr) 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
FR2866888B1 (fr) 2004-02-26 2006-05-05 Sanofi Synthelabo Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique
CA2608957C (en) * 2005-05-19 2013-12-10 Astellas Pharma Inc. Pyrrolidine derivative or salt thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU98105684A (ru) * 1996-06-29 2000-02-10 Самдзин Фармасьютикал Ко., Лтд. Производные пиперазина и способ их получения

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. Med. Chem. vol.11., no.4 (1968), p.720-729. *
J. Pharm. Sci, vol.81, no.4, 1992, p.380-385. Chemische berichte, vol.118, no.2, 1985, p.468-482. *

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