RU2401863C2 - Способ получения рекомбинантного белка тат-нохв4н для использования в качестве стимулятора гемопоэза in vivo - Google Patents

Способ получения рекомбинантного белка тат-нохв4н для использования в качестве стимулятора гемопоэза in vivo Download PDF

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RU2401863C2
RU2401863C2 RU2008134247/10A RU2008134247A RU2401863C2 RU 2401863 C2 RU2401863 C2 RU 2401863C2 RU 2008134247/10 A RU2008134247/10 A RU 2008134247/10A RU 2008134247 A RU2008134247 A RU 2008134247A RU 2401863 C2 RU2401863 C2 RU 2401863C2
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protein
tat
hoxb4h
mmol
composition according
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RU2008134247A (ru
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Коу-Джуей ВУ (TW)
Коу-Джуей ВУ
Чи-Хунг ХУАНГ (TW)
Чи-Хунг ХУАНГ
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Тайвань Адвансе Био-Фарм Инк.
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/34Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU2008134247/10A 2008-03-04 2008-08-20 Способ получения рекомбинантного белка тат-нохв4н для использования в качестве стимулятора гемопоэза in vivo RU2401863C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/042,097 2008-03-04
US12/042,097 US8222206B2 (en) 2008-03-04 2008-03-04 Method of enhancing the mobilization of hematopoietic stem cells using TAT-HOXB4H

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RU2008134247A RU2008134247A (ru) 2010-02-27
RU2401863C2 true RU2401863C2 (ru) 2010-10-20

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RU2008134247/10A RU2401863C2 (ru) 2008-03-04 2008-08-20 Способ получения рекомбинантного белка тат-нохв4н для использования в качестве стимулятора гемопоэза in vivo

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US (4) US8222206B2 (pt)
EP (2) EP2455099B1 (pt)
JP (2) JP4755224B2 (pt)
KR (1) KR101160381B1 (pt)
CN (3) CN102805859B (pt)
BR (1) BRPI0803381A2 (pt)
CA (1) CA2658231C (pt)
ES (2) ES2464777T3 (pt)
HK (2) HK1170933A1 (pt)
HU (1) HUE027513T2 (pt)
MY (1) MY164521A (pt)
PL (2) PL2455099T3 (pt)
PT (1) PT2100968E (pt)
RU (1) RU2401863C2 (pt)
TW (1) TWI414598B (pt)

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RU2495125C2 (ru) * 2011-12-07 2013-10-10 Федеральное государственное бюджетное учреждение "Новосибирский научно-исследовательский институт патологии кровообращения имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "ННИИПК им. акад. Е.Н. Мешалкина" Минздрава России) РЕКОМБИНАНТНАЯ ПЛАЗМИДА pOK-DsRed2, КОДИРУЮЩАЯ БЕЛКИ ОСТ4 И KLF4 ЧЕЛОВЕКА И ФЛУОРЕСЦЕНТНЫЙ БЕЛОК DsRed2, ПРЕДНАЗНАЧЕНАЯ ДЛЯ ПОЛУЧЕНИЯ ИНДУЦИРОВАННЫХ ПЛЮРИПОТЕНТНЫХ СТВОЛОВЫХ КЛЕТОК ЧЕЛОВЕКА

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US10354407B2 (en) 2013-03-15 2019-07-16 Spatial Cam Llc Camera for locating hidden objects
KR101903339B1 (ko) * 2011-03-22 2018-10-01 플루리스템 리미티드 방사선 또는 화학적 손상을 치료하는 방법
WO2014120714A1 (en) * 2013-01-30 2014-08-07 Cornell University Compositions and methods for the expansion of stem cells
CN105246500A (zh) * 2013-04-05 2016-01-13 克劳迪娅·齐尔贝尔博格 基质金属蛋白酶及其用途
TWI548748B (zh) * 2015-04-16 2016-09-11 台灣尖端先進生技醫藥股份有限公司 造血幹/先驅細胞之體外放大培養方法及其立即可使用之組成物
US11564942B2 (en) 2016-02-19 2023-01-31 The General Hospital Corporation Methods for generating universal and custom MHC/HLA-compatible hematopoietic progenitor cells
AU2019347922B2 (en) 2018-09-24 2021-07-15 Boston Scientific Scimed, Inc. Aggressive featured clips with improved tissue retention
TW202026307A (zh) * 2019-01-11 2020-07-16 台灣尖端先進生技醫藥股份有限公司 N-端標記組胺酸之重組tat-hox家族蛋白質及其製造方法
TWI756518B (zh) * 2019-02-27 2022-03-01 台灣尖端先進生技醫藥股份有限公司 突變型hoxb4重組蛋白質之製造方法與用途

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2495125C2 (ru) * 2011-12-07 2013-10-10 Федеральное государственное бюджетное учреждение "Новосибирский научно-исследовательский институт патологии кровообращения имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "ННИИПК им. акад. Е.Н. Мешалкина" Минздрава России) РЕКОМБИНАНТНАЯ ПЛАЗМИДА pOK-DsRed2, КОДИРУЮЩАЯ БЕЛКИ ОСТ4 И KLF4 ЧЕЛОВЕКА И ФЛУОРЕСЦЕНТНЫЙ БЕЛОК DsRed2, ПРЕДНАЗНАЧЕНАЯ ДЛЯ ПОЛУЧЕНИЯ ИНДУЦИРОВАННЫХ ПЛЮРИПОТЕНТНЫХ СТВОЛОВЫХ КЛЕТОК ЧЕЛОВЕКА

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EP2100968A1 (en) 2009-09-16
JP5738636B2 (ja) 2015-06-24
ES2567780T3 (es) 2016-04-26
RU2008134247A (ru) 2010-02-27
TWI414598B (zh) 2013-11-11
JP4755224B2 (ja) 2011-08-24
JP2009207482A (ja) 2009-09-17
TW200938632A (en) 2009-09-16
CN102805859B (zh) 2016-06-01
CN104650210A (zh) 2015-05-27
CN104650210B (zh) 2018-01-23
EP2455099B1 (en) 2016-01-20
HK1130290A1 (en) 2009-12-24
CN101524527B (zh) 2016-06-01
US8124377B2 (en) 2012-02-28
EP2100968B1 (en) 2014-02-26
CN102805859A (zh) 2012-12-05
US20120322979A1 (en) 2012-12-20
BRPI0803381A2 (pt) 2011-08-23
HUE027513T2 (en) 2016-10-28
CA2658231A1 (en) 2009-09-04
JP2011168597A (ja) 2011-09-01
US20110092412A1 (en) 2011-04-21
EP2455099A1 (en) 2012-05-23
PL2455099T3 (pl) 2016-07-29
PL2100968T3 (pl) 2014-08-29
US8222206B2 (en) 2012-07-17
KR20090095473A (ko) 2009-09-09
US8450458B2 (en) 2013-05-28
HK1170933A1 (zh) 2013-03-15
CA2658231C (en) 2014-09-23
KR101160381B1 (ko) 2012-06-26
US8222207B2 (en) 2012-07-17
MY164521A (en) 2017-12-29
ES2464777T3 (es) 2014-06-04
US20110092450A1 (en) 2011-04-21
PT2100968E (pt) 2014-05-30
US20090227496A1 (en) 2009-09-10
CN101524527A (zh) 2009-09-09

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