RU2397160C9 - 2-фенилэтиламинопроизводные в качестве модуляторов кальциевых и/или натриевых каналов - Google Patents

2-фенилэтиламинопроизводные в качестве модуляторов кальциевых и/или натриевых каналов Download PDF

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RU2397160C9
RU2397160C9 RU2008130045/04A RU2008130045A RU2397160C9 RU 2397160 C9 RU2397160 C9 RU 2397160C9 RU 2008130045/04 A RU2008130045/04 A RU 2008130045/04A RU 2008130045 A RU2008130045 A RU 2008130045A RU 2397160 C9 RU2397160 C9 RU 2397160C9
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ethyl
amino
fluorobenzyloxy
methoxyphenyl
represents hydrogen
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RU2008130045/04A
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Russian (ru)
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RU2008130045A (ru
RU2397160C2 (ru
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Флориан ТАЛЕР (IT)
Флориан ТАЛЕР
Мауро НАПОЛЕТАНО (IT)
Мауро Наполетано
Чибэле САБИДО-Давид (IT)
Чибэле Сабидо-Давид
Эрманно МОРИДЖИ (IT)
Эрманно Мориджи
Карла КАЧЧЬЯ (IT)
Карла Каччья
Лаура ФАРАВЕЛЛИ (IT)
Лаура Фаравелли
Алессандра РЭСТИВО (IT)
Алессандра Рэстиво
Патрисия САЛЬВАТИ (IT)
Патрисия Сальвати
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НЬЮРОН ФАРМАСЬЮТИКАЛЗ С.п.А.
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2673622C2 (ru) * 2014-10-02 2018-11-29 Мегабайовуд Ко., Лтд. Соединения альфа-аминоамидных производных и содержащие их фармацевтические композиции
US11026924B2 (en) 2016-07-04 2021-06-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
US11535611B2 (en) 2017-12-20 2022-12-27 H. Lundbeck A/S Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors
US11634416B2 (en) 2017-12-14 2023-04-25 H. Lundbeck A/S Combination treatments comprising administration of 1H-pyrazolo[4,3-b]pyridines
US11851425B2 (en) 2017-12-14 2023-12-26 H. Lundbeck A/S Combination treatments comprising administration of 1H-pyrazolo[4,3-B]pyridines
RU2850286C2 (ru) * 2017-05-26 2025-11-07 Новассэй Са Вспомогательная субъединица альфа-2-дельта потенциалзависимых кальциевых каналов и ее применения

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070276046A1 (en) * 2003-08-25 2007-11-29 Patricia Salvati Alpha-Aminoamide Derivatives Useful as Anti-Inflammatory Agents
SI1963280T1 (sl) * 2005-12-22 2016-02-29 Newron Pharmaceuticals S.P.A. 2-feniletilamino derivati kot modulatorji kalcijevih in/ali natrijevih kanalčkov
WO2008151702A1 (en) 2007-06-15 2008-12-18 Newron Pharmaceuticals S.P.A. Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators
NZ586182A (en) 2007-12-19 2012-02-24 Newron Pharm Spa Alpha-aminoamide derivatives useful in the treatment of psychiatric disorders
HRP20161412T1 (hr) 2011-06-27 2016-12-02 Newron Pharmaceuticals S.P.A. Fluorirani derivati arilalkilaminokarboksamida
US9079878B2 (en) * 2011-10-26 2015-07-14 Pfizer Limited (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators
CN103804341B (zh) * 2012-11-13 2018-04-10 中国人民解放军军事医学科学院毒物药物研究所 酰胺衍生物及其医药用途
CN104761531B (zh) * 2014-01-03 2017-12-01 中国人民解放军军事医学科学院毒物药物研究所 镇痛活性化合物及其医药用途
EP3725769A1 (en) * 2019-04-17 2020-10-21 Newron Pharmaceuticals S.p.A. Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives
EP3725768A1 (en) * 2019-04-17 2020-10-21 Newron Pharmaceuticals S.p.A. Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB586645A (en) * 1944-07-19 1947-03-26 Burroughs Wellcome Co Improvements relating to the synthesis of amino acid derivatives and salts thereof
DE2006978A1 (de) * 1969-02-27 1970-09-17 Science Union et Cie. Societe Francaise de Recherche Medicale, Suresnes (Frankreich) Neue Aminosäuren, ihre Derivate und ihr Herstellungsverfahren
WO1990014334A1 (en) * 1989-05-25 1990-11-29 Farmitalia Carlo Erba S.R.L. N-PHENYLALKYL SUBSTITUTED α-AMINO CARBOXAMIDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
WO1999035125A1 (en) * 1997-12-31 1999-07-15 Newron Pharmaceuticals S.P.A. Alpha-aminoamide derivatives useful as analgesic agents
WO2003091219A1 (en) * 2002-04-26 2003-11-06 F. Hoffmann-La Roche Ag Isoquinoline derivatives
WO2004089353A2 (en) * 2003-04-11 2004-10-21 Newron Pharmaceuticals, S.P.A. Methods for treatment of parkinson's disease
WO2005018627A1 (en) * 2003-08-25 2005-03-03 Newron Pharmaceuticals, Spa Alpha-aminoamide derivatives useful as anti-inflammatory agents
EP1588704A1 (en) * 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1001225B (el) * 1989-09-14 1993-06-30 Fisons Plc Νέαι μακροκυκλικαί ενώσεις και νέα μέ?οδος χρήσεως τους.
US5051403A (en) 1989-11-22 1991-09-24 Neurex Corporation Method of treating ischemia-related neuronal damage
FR2665159B1 (fr) 1990-07-24 1992-11-13 Rhone Poulenc Sante Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent.
CA2151741C (en) 1991-12-30 2001-12-11 Alan Justice Methods of producing analgesia and enhancing opiate analgesia
FR2696934B1 (fr) 1992-10-20 1995-06-02 Conservatoire Nal Arts Metiers Dérivés de stéroïdes naturels 3B hydroxyles ayant des propriétés de déclenchement et de stimulation de l'immunité, composition les contenant et procédé pour les obtenir.
GB9426102D0 (en) 1994-12-23 1995-02-22 Merck Sharp & Dohme Pharmacuetical compositions
GB9500691D0 (en) 1995-01-13 1995-03-08 Smithkline Beecham Plc Compounds
GB9515412D0 (en) * 1995-07-27 1995-09-27 Pharmacia Spa 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
GB9518572D0 (en) 1995-09-12 1995-11-15 Smithkline Beecham Plc Compounds
US6372792B1 (en) 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
ATE293458T1 (de) 1996-08-23 2005-05-15 Algos Pharm Corp Antikonvulsive mitteln enthaltende zubereitung zur behandlung von neuropathischen schmerzen
US6290986B1 (en) 1996-10-24 2001-09-18 Pharmaceutical Applications Associates, Llc Method and composition for transdermal administration of pharmacologic agents
US6207685B1 (en) 1996-12-06 2001-03-27 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Therapeutic application of a thienycyclohexylamine derivative
EP0910565A1 (en) 1997-02-14 1999-04-28 Bayer Corporation Amide derivatives as selective neuropeptide y receptor antagonists
FR2760362B1 (fr) 1997-03-10 2000-08-11 Vitasterol Utilisation cosmetique ou dermatologique de steroides 7-hydroxyles
US6117841A (en) 1997-05-30 2000-09-12 Warner-Lambert Company Substituted peptidylamine calcium channel blockers
WO1999008670A1 (en) 1997-08-20 1999-02-25 Guglietta, Antonio Gaba analogs to prevent and treat gastrointestinal damage
DE19740110A1 (de) 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
IT1295423B1 (it) 1997-10-10 1999-05-12 Medivis S R L Uso della flunarizina nella terapia topica del glaucoma
ES2352739T3 (es) 1997-11-21 2011-02-22 Purdue Neuroscience Company 2-aminoacetamidas sustituidas y el uso de las mismas.
GB9727521D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Substituted 2-benzylamino-2-phenyl-acetamide compounds
US6458781B1 (en) 1998-04-27 2002-10-01 David Thomas Connor Substituted diarylalkyl amides as calcium channel antagonists
SE9801494D0 (sv) 1998-04-28 1998-04-28 Astra Pharma Prod Novel use
US6011035A (en) 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
KR20010071776A (ko) 1998-07-09 2001-07-31 로즈 암스트롱, 크리스틴 에이. 트러트웨인 대상포진의 치료를 위한 gaba 유사체 및항바이러스제를 포함하는 제약 조성물
PL345340A1 (en) 1998-07-09 2001-12-17 Warner Lambert Co Compositions comprising gaba analogs and caffeine
WO2000006559A1 (en) 1998-07-30 2000-02-10 Warner-Lambert Company Reduced dipeptide analogues as calcium channel antagonists
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
JP2002538221A (ja) 1999-03-10 2002-11-12 ワーナー−ランバート・カンパニー 抗てんかん作用を有する化合物を包含する鎮痛組成物およびその使用方法
ATE467620T1 (de) * 1999-03-26 2010-05-15 Euro Celtique Sa Arylsubstituierte pyrazole, imidazole, oxazole, thiazole und pyrrole, sowie deren verwendung
DK1169060T3 (da) 1999-04-09 2006-01-16 Euro Celtique Sa Natriumkanalblokkerpræparater og anvendelse deraf
DE60034344T2 (de) 1999-07-22 2008-01-10 University Of Rochester Methode zur behandlung der symptome hormoneller veränderungen, einschliesslich hitzewallungen
JP2003506388A (ja) 1999-08-04 2003-02-18 アイカゲン インコーポレイテッド 疼痛および不安症を処置または予防するための方法
WO2001021621A1 (en) 1999-09-22 2001-03-29 Ortho-Mcneil Pharmaceutical, Inc. BENZO-FUSED DITHIEPINO[6,5-b]PYRIDINES, AND RELATED COMPOSITIONS AND METHODS
GB9930079D0 (en) 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
ATE266666T1 (de) 2000-03-23 2004-05-15 Ortho Mcneil Pharm Inc Thiepino(3,2-b)dihydropyridine und relatierte zusammensetzungen und verfahren
US6335354B2 (en) 2000-03-31 2002-01-01 Cocensys Inc. Aminopyridines and methods of using thereof
US6521647B2 (en) 2000-04-04 2003-02-18 Pfizer Inc. Treatment of renal disorders
WO2001098779A2 (en) 2000-06-19 2001-12-27 Merck Frosst Canada & Co. Methods of identifying gabab receptor subtype-specific agonists
FR2818978B1 (fr) * 2000-12-28 2003-02-28 Sod Conseils Rech Applic Modulateurs de canaux sodiques derives de 2-piperidylimidazoles
SE0102858D0 (sv) 2001-08-27 2001-08-27 Astrazeneca Ab N-type calcium channel antagonists for the treatment of pain
PT1423168E (pt) 2001-09-03 2006-05-31 Newron Pharm Spa Composicao farmaceutica que compreende gabapentina ou um seu analogo e uma x-aminoamida e a sua utilizacao como analgesico
WO2003037865A1 (en) 2001-10-31 2003-05-08 Morphochem Aktiengesellschaft für kombinatorische Chemie Novel anticancer compounds
ES2286328T3 (es) 2001-12-27 2007-12-01 Ortho-Mcneil Pharmaceutical, Inc. Aroilpirrolheteroaril y metanoles utiles para tratar transtornos del sistema nervioso central.
FR2842808B1 (fr) * 2002-07-25 2004-09-10 Sod Conseils Rech Applic Nouveaux derives d'arylimidazoles, leur preparation et leurs applications therapeutiques
EP1438956A1 (en) 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
EP1589959A2 (en) 2003-01-30 2005-11-02 Dynogen Pharmaceuticals Inc. Methods of treating lower urinary tract disorders using sodium channel modulators
EP1596844A2 (en) 2003-01-30 2005-11-23 Dynogen Pharmaceuticals Inc. Use of sodium channel modulators for treating gastrointestinal tract disorders
WO2004087125A1 (en) 2003-04-02 2004-10-14 Ionix Pharmaceuticals Limited Amino acid derivatives as inhibitors of mammalian sodium channels
EP1535908A1 (en) * 2003-11-24 2005-06-01 Newron Pharmaceuticals S.p.A. N-acyl-N'-benzyl-alkylendiamino drivatives
EP1557166A1 (en) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
DK1809271T5 (da) 2004-09-10 2010-12-06 Newron Pharm Spa Anvendelse af (R)-(halogenbenzyloxy)benzylaminopropanamider som natrium- og/eller calciumkanalselektive modulatorer
SI1963280T1 (sl) * 2005-12-22 2016-02-29 Newron Pharmaceuticals S.P.A. 2-feniletilamino derivati kot modulatorji kalcijevih in/ali natrijevih kanalčkov

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB586645A (en) * 1944-07-19 1947-03-26 Burroughs Wellcome Co Improvements relating to the synthesis of amino acid derivatives and salts thereof
DE2006978A1 (de) * 1969-02-27 1970-09-17 Science Union et Cie. Societe Francaise de Recherche Medicale, Suresnes (Frankreich) Neue Aminosäuren, ihre Derivate und ihr Herstellungsverfahren
WO1990014334A1 (en) * 1989-05-25 1990-11-29 Farmitalia Carlo Erba S.R.L. N-PHENYLALKYL SUBSTITUTED α-AMINO CARBOXAMIDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
WO1999035125A1 (en) * 1997-12-31 1999-07-15 Newron Pharmaceuticals S.P.A. Alpha-aminoamide derivatives useful as analgesic agents
WO2003091219A1 (en) * 2002-04-26 2003-11-06 F. Hoffmann-La Roche Ag Isoquinoline derivatives
WO2004089353A2 (en) * 2003-04-11 2004-10-21 Newron Pharmaceuticals, S.P.A. Methods for treatment of parkinson's disease
WO2005018627A1 (en) * 2003-08-25 2005-03-03 Newron Pharmaceuticals, Spa Alpha-aminoamide derivatives useful as anti-inflammatory agents
EP1588704A1 (en) * 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2673622C2 (ru) * 2014-10-02 2018-11-29 Мегабайовуд Ко., Лтд. Соединения альфа-аминоамидных производных и содержащие их фармацевтические композиции
US10676425B2 (en) 2014-10-02 2020-06-09 Megabiowood Co., Ltd Alpha-aminoamide derivative compound and pharmaceutical composition comprising same
US11053190B2 (en) 2014-10-02 2021-07-06 Neurobiogen Co., Ltd. Alpha-aminoamide derivative compound and pharmaceutical composition comprising same
US11026924B2 (en) 2016-07-04 2021-06-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
US11026923B2 (en) 2016-07-04 2021-06-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
US11491140B2 (en) 2016-07-04 2022-11-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
RU2850286C2 (ru) * 2017-05-26 2025-11-07 Новассэй Са Вспомогательная субъединица альфа-2-дельта потенциалзависимых кальциевых каналов и ее применения
US11634416B2 (en) 2017-12-14 2023-04-25 H. Lundbeck A/S Combination treatments comprising administration of 1H-pyrazolo[4,3-b]pyridines
US11851425B2 (en) 2017-12-14 2023-12-26 H. Lundbeck A/S Combination treatments comprising administration of 1H-pyrazolo[4,3-B]pyridines
US11535611B2 (en) 2017-12-20 2022-12-27 H. Lundbeck A/S Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors

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