CY1117094T1 - Παραγωγα 2-φαινυλαιθυλαμινης ως τροποποιητες του διαυλου ασβεστιου και/ή νατριου - Google Patents
Παραγωγα 2-φαινυλαιθυλαμινης ως τροποποιητες του διαυλου ασβεστιου και/ή νατριουInfo
- Publication number
- CY1117094T1 CY1117094T1 CY20151101204T CY151101204T CY1117094T1 CY 1117094 T1 CY1117094 T1 CY 1117094T1 CY 20151101204 T CY20151101204 T CY 20151101204T CY 151101204 T CY151101204 T CY 151101204T CY 1117094 T1 CY1117094 T1 CY 1117094T1
- Authority
- CY
- Cyprus
- Prior art keywords
- sodium
- calcium
- phenylhythlamine
- producer
- modifications
- Prior art date
Links
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title abstract 2
- 239000011734 sodium Substances 0.000 title abstract 2
- 229910052708 sodium Inorganic materials 0.000 title abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title 1
- 239000011575 calcium Substances 0.000 title 1
- 229910052791 calcium Inorganic materials 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical group NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 abstract 2
- 230000001575 pathological effect Effects 0.000 abstract 2
- 108090000312 Calcium Channels Proteins 0.000 abstract 1
- 102000003922 Calcium Channels Human genes 0.000 abstract 1
- 108010052164 Sodium Channels Proteins 0.000 abstract 1
- 102000018674 Sodium Channels Human genes 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000007246 mechanism Effects 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
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- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (2)
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|---|---|---|---|
| EP05028147 | 2005-12-22 | ||
| EP06829177.2A EP1963280B1 (en) | 2005-12-22 | 2006-11-29 | 2-phenylethylamino derivatives as calcium and/or sodium channel modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117094T1 true CY1117094T1 (el) | 2017-04-05 |
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Family Applications (1)
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| CY20151101204T CY1117094T1 (el) | 2005-12-22 | 2015-12-30 | Παραγωγα 2-φαινυλαιθυλαμινης ως τροποποιητες του διαυλου ασβεστιου και/ή νατριου |
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| EP (1) | EP1963280B1 (enExample) |
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| KR (1) | KR101380137B1 (enExample) |
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| AR (1) | AR058720A1 (enExample) |
| AU (1) | AU2006329040C1 (enExample) |
| BR (1) | BRPI0620239B8 (enExample) |
| CA (1) | CA2629065C (enExample) |
| CY (1) | CY1117094T1 (enExample) |
| DK (1) | DK1963280T3 (enExample) |
| ES (1) | ES2556937T3 (enExample) |
| HR (1) | HRP20160005T1 (enExample) |
| HU (1) | HUE028329T2 (enExample) |
| IL (1) | IL191255A (enExample) |
| IN (1) | IN266803B (enExample) |
| NO (1) | NO341296B1 (enExample) |
| NZ (1) | NZ567540A (enExample) |
| PL (1) | PL1963280T3 (enExample) |
| PT (1) | PT1963280E (enExample) |
| RS (1) | RS54522B1 (enExample) |
| RU (1) | RU2397160C9 (enExample) |
| SI (1) | SI1963280T1 (enExample) |
| TW (1) | TWI379828B (enExample) |
| WO (1) | WO2007071311A1 (enExample) |
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| US20070276046A1 (en) * | 2003-08-25 | 2007-11-29 | Patricia Salvati | Alpha-Aminoamide Derivatives Useful as Anti-Inflammatory Agents |
| SI1963280T1 (sl) * | 2005-12-22 | 2016-02-29 | Newron Pharmaceuticals S.P.A. | 2-feniletilamino derivati kot modulatorji kalcijevih in/ali natrijevih kanalčkov |
| WO2008151702A1 (en) | 2007-06-15 | 2008-12-18 | Newron Pharmaceuticals S.P.A. | Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators |
| NZ586182A (en) | 2007-12-19 | 2012-02-24 | Newron Pharm Spa | Alpha-aminoamide derivatives useful in the treatment of psychiatric disorders |
| HRP20161412T1 (hr) | 2011-06-27 | 2016-12-02 | Newron Pharmaceuticals S.P.A. | Fluorirani derivati arilalkilaminokarboksamida |
| US9079878B2 (en) * | 2011-10-26 | 2015-07-14 | Pfizer Limited | (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators |
| CN103804341B (zh) * | 2012-11-13 | 2018-04-10 | 中国人民解放军军事医学科学院毒物药物研究所 | 酰胺衍生物及其医药用途 |
| CN104761531B (zh) * | 2014-01-03 | 2017-12-01 | 中国人民解放军军事医学科学院毒物药物研究所 | 镇痛活性化合物及其医药用途 |
| RU2673622C2 (ru) * | 2014-10-02 | 2018-11-29 | Мегабайовуд Ко., Лтд. | Соединения альфа-аминоамидных производных и содержащие их фармацевтические композиции |
| US10034861B2 (en) | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
| CN111465410B (zh) | 2017-12-14 | 2022-10-25 | H.隆德贝克有限公司 | 包括施用1h-吡唑并[4,3-b]吡啶的组合治疗 |
| AR113926A1 (es) | 2017-12-14 | 2020-07-01 | H Lundbeck As | Derivados de 1h-pirazolo[4,3-b]piridinas |
| JP7194738B2 (ja) | 2017-12-20 | 2022-12-22 | ハー・ルンドベック・アクチエゼルスカベット | PDE1阻害剤としてのピラゾロ[3,4-b]ピリジン及びイミダゾ[1,5-b]ピリダジン |
| EP3725769A1 (en) * | 2019-04-17 | 2020-10-21 | Newron Pharmaceuticals S.p.A. | Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives |
| EP3725768A1 (en) * | 2019-04-17 | 2020-10-21 | Newron Pharmaceuticals S.p.A. | Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives |
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| EP1588704A1 (en) * | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders |
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2006
- 2006-11-29 SI SI200632017T patent/SI1963280T1/sl unknown
- 2006-11-29 CA CA2629065A patent/CA2629065C/en active Active
- 2006-11-29 US US12/158,491 patent/US7855227B2/en active Active
- 2006-11-29 IN IN3820CHN2008 patent/IN266803B/en unknown
- 2006-11-29 WO PCT/EP2006/011443 patent/WO2007071311A1/en not_active Ceased
- 2006-11-29 PL PL06829177T patent/PL1963280T3/pl unknown
- 2006-11-29 RU RU2008130045/04A patent/RU2397160C9/ru active
- 2006-11-29 RS RS20160004A patent/RS54522B1/sr unknown
- 2006-11-29 ES ES06829177.2T patent/ES2556937T3/es active Active
- 2006-11-29 HR HRP20160005TT patent/HRP20160005T1/hr unknown
- 2006-11-29 PT PT68291772T patent/PT1963280E/pt unknown
- 2006-11-29 HU HUE06829177A patent/HUE028329T2/en unknown
- 2006-11-29 NZ NZ567540A patent/NZ567540A/en unknown
- 2006-11-29 KR KR1020087018027A patent/KR101380137B1/ko active Active
- 2006-11-29 EP EP06829177.2A patent/EP1963280B1/en active Active
- 2006-11-29 DK DK06829177.2T patent/DK1963280T3/en active
- 2006-11-29 JP JP2008546171A patent/JP5271087B2/ja active Active
- 2006-11-29 CN CN2006800424801A patent/CN101309909B/zh active Active
- 2006-11-29 AU AU2006329040A patent/AU2006329040C1/en active Active
- 2006-11-29 BR BRPI0620239A patent/BRPI0620239B8/pt active IP Right Grant
- 2006-12-18 TW TW095147414A patent/TWI379828B/zh active
- 2006-12-21 AR ARP060105699A patent/AR058720A1/es active IP Right Grant
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- 2008-05-05 IL IL191255A patent/IL191255A/en active IP Right Grant
- 2008-07-21 NO NO20083237A patent/NO341296B1/no unknown
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