CY1118033T1 - Φθοριωμενα παραγωγα αρυλαλκυλαμινοκαρβοξαμιδιου - Google Patents

Φθοριωμενα παραγωγα αρυλαλκυλαμινοκαρβοξαμιδιου

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Publication number
CY1118033T1
CY1118033T1 CY20161100931T CY161100931T CY1118033T1 CY 1118033 T1 CY1118033 T1 CY 1118033T1 CY 20161100931 T CY20161100931 T CY 20161100931T CY 161100931 T CY161100931 T CY 161100931T CY 1118033 T1 CY1118033 T1 CY 1118033T1
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CY
Cyprus
Prior art keywords
fluorinated
derivatives
arylalkylaminocarboxamide derivatives
fluorinated arylalkylaminocarboxamide
diseases
Prior art date
Application number
CY20161100931T
Other languages
English (en)
Inventor
Paolo Pevarello
Original Assignee
Newron Pharmaceuticals S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharmaceuticals S.P.A. filed Critical Newron Pharmaceuticals S.P.A.
Publication of CY1118033T1 publication Critical patent/CY1118033T1/el

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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Abstract

Περιγράφονται φθοριωμένα παράγωγα αρυλαλκυλαμινοκαρβοξαμιδίου του τύπου (I), όπου τα W, J, n, R1, R2, R2', R3, R4, R5, και R6 έχουν τις έννοιες όπως ορίζονται στην περιγραφή και φαρμακευτικά άλατα αυτών, φαρμακευτικές συνθέσεις οι οποίες περιέχουν αυτά ως δραστικά συστατικά και η χρήση αυτών ως τροποποιητές του διαύλου νατρίου και/ή ασβεστίου, οι οποίοι είναι χρήσιμοι εις την πρόληψη, ανακούφιση και θεραπεία μιας ευρείας περιοχής παθήσεων, εις τις οποίες συμπεριλαμβάνονται νευρολογικές, ψυχιατρικές, καρδιαγγειακές, φλεγμονώδεις, οφθαλμικές, ουρολογικές και γαστρεντερικές νόσοι, εις τις οποίες οι ανωτέρω μηχανισμοί έχει περιγραφεί ότι παίζουν έναν παθολογικό ρόλο.
CY20161100931T 2011-06-27 2016-09-20 Φθοριωμενα παραγωγα αρυλαλκυλαμινοκαρβοξαμιδιου CY1118033T1 (el)

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