CN101309909B - 作为钙和/或钠通道调节剂的2-苯基乙基氨基衍生物 - Google Patents
作为钙和/或钠通道调节剂的2-苯基乙基氨基衍生物 Download PDFInfo
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- CN101309909B CN101309909B CN2006800424801A CN200680042480A CN101309909B CN 101309909 B CN101309909 B CN 101309909B CN 2006800424801 A CN2006800424801 A CN 2006800424801A CN 200680042480 A CN200680042480 A CN 200680042480A CN 101309909 B CN101309909 B CN 101309909B
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- 0 C[C@@](*)(C=C*)C=C(C=C(C=C([N+]([O-])=O)O*)C=NC)N Chemical compound C[C@@](*)(C=C*)C=C(C=C(C=C([N+]([O-])=O)O*)C=NC)N 0.000 description 6
- CXUADCDQBMCGKF-UHFFFAOYSA-N CC(C(OC)=O)N(CCc1cccc(OCc2ccccc2)c1)CC1CC1 Chemical compound CC(C(OC)=O)N(CCc1cccc(OCc2ccccc2)c1)CC1CC1 CXUADCDQBMCGKF-UHFFFAOYSA-N 0.000 description 1
- BCGMGXAJIJUXHC-UHFFFAOYSA-N CC(C(OC)=O)NCCc(cc1)cc(OC)c1OCc1cc(F)ccc1 Chemical compound CC(C(OC)=O)NCCc(cc1)cc(OC)c1OCc1cc(F)ccc1 BCGMGXAJIJUXHC-UHFFFAOYSA-N 0.000 description 1
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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| PCT/EP2006/011443 WO2007071311A1 (en) | 2005-12-22 | 2006-11-29 | 2 -phenylethylamino derivatives as calcium and/or sodium channel modulators |
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| PT1658062E (pt) * | 2003-08-25 | 2010-03-31 | Newron Pharm Spa | Derivados de alfa-amino amida úteis como agentes antiinflamatórios |
| NZ567540A (en) * | 2005-12-22 | 2010-07-30 | Newron Pharm Spa | 2-Phenylethylamino derivatives as calcium and/or sodium channel modulators |
| AU2008261325B2 (en) | 2007-06-15 | 2012-12-06 | Newron Pharmaceuticals S.P.A. | Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators |
| EA019529B1 (ru) | 2007-12-19 | 2014-04-30 | Ньюрон Фармасьютикалс С.П.А. | Альфа-аминоамидные производные, применяемые в лечении психиатрических расстройств |
| ES2602140T3 (es) * | 2011-06-27 | 2017-02-17 | Newron Pharmaceuticals S.P.A. | Derivados de arilalquilaminocarboxamida fluorados |
| MD20140037A2 (ro) | 2011-10-26 | 2014-08-31 | Pfizer Limited | Derivaţi de (4-fenilimidazol-2-il)etilamină utili ca modulatori ai canalului de sodiu |
| CN103804341B (zh) * | 2012-11-13 | 2018-04-10 | 中国人民解放军军事医学科学院毒物药物研究所 | 酰胺衍生物及其医药用途 |
| CN104761531B (zh) * | 2014-01-03 | 2017-12-01 | 中国人民解放军军事医学科学院毒物药物研究所 | 镇痛活性化合物及其医药用途 |
| US10676425B2 (en) | 2014-10-02 | 2020-06-09 | Megabiowood Co., Ltd | Alpha-aminoamide derivative compound and pharmaceutical composition comprising same |
| US10034861B2 (en) | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
| MX2020006174A (es) | 2017-12-14 | 2022-09-27 | H Lundbeck As | Tratamientos de combinación que comprenden la administración de 1h-pirazol[4,3-b]piridinas. |
| AR113926A1 (es) | 2017-12-14 | 2020-07-01 | H Lundbeck As | Derivados de 1h-pirazolo[4,3-b]piridinas |
| CN111511742B (zh) | 2017-12-20 | 2023-10-27 | H.隆德贝克有限公司 | 作为PDE1抑制剂的吡唑并[4,3-b]吡啶和咪唑并[1,5-a]嘧啶 |
| EP3725769A1 (en) * | 2019-04-17 | 2020-10-21 | Newron Pharmaceuticals S.p.A. | Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives |
| EP3725768A1 (en) * | 2019-04-17 | 2020-10-21 | Newron Pharmaceuticals S.p.A. | Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives |
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| GB586645A (en) * | 1944-07-19 | 1947-03-26 | Burroughs Wellcome Co | Improvements relating to the synthesis of amino acid derivatives and salts thereof |
| DE2006978A1 (de) * | 1969-02-27 | 1970-09-17 | Science Union et Cie. Societe Francaise de Recherche Medicale, Suresnes (Frankreich) | Neue Aminosäuren, ihre Derivate und ihr Herstellungsverfahren |
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