RU2175966C2 - 4-оксобутановые кислоты и фармацевтическая композиция на их основе - Google Patents

4-оксобутановые кислоты и фармацевтическая композиция на их основе Download PDF

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RU2175966C2
RU2175966C2 RU99105208/04A RU99105208A RU2175966C2 RU 2175966 C2 RU2175966 C2 RU 2175966C2 RU 99105208/04 A RU99105208/04 A RU 99105208/04A RU 99105208 A RU99105208 A RU 99105208A RU 2175966 C2 RU2175966 C2 RU 2175966C2
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Russia
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group
oxobutanoic acid
benzyl
formula
groups
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RU99105208/04A
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English (en)
Russian (ru)
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RU99105208A (ru
Inventor
Жерар Муане
Лилиан Доар
Мишелин Кергоа
Филипп МЕЗЕРАЙ
Дидье Мезанжо
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Мерк Патент Гмбх
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU99105208/04A 1996-08-16 1997-08-05 4-оксобутановые кислоты и фармацевтическая композиция на их основе RU2175966C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR96/10254 1996-08-16
FR9610254A FR2752422B1 (fr) 1996-08-16 1996-08-16 Composition pharmaceutique contenant des acides 4-oxo-butanoiques

Publications (2)

Publication Number Publication Date
RU99105208A RU99105208A (ru) 2001-01-20
RU2175966C2 true RU2175966C2 (ru) 2001-11-20

Family

ID=9495089

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99105208/04A RU2175966C2 (ru) 1996-08-16 1997-08-05 4-оксобутановые кислоты и фармацевтическая композиция на их основе

Country Status (29)

Country Link
US (1) US6143787A (cs)
EP (1) EP0925273B1 (cs)
JP (1) JP3105545B2 (cs)
KR (1) KR100488430B1 (cs)
CN (1) CN1082370C (cs)
AR (1) AR009251A1 (cs)
AT (1) ATE208364T1 (cs)
AU (1) AU725440B2 (cs)
BR (1) BR9711315A (cs)
CA (1) CA2263348C (cs)
CY (1) CY2298B1 (cs)
CZ (1) CZ294165B6 (cs)
DE (1) DE69708130T2 (cs)
DK (1) DK0925273T3 (cs)
ES (1) ES2166098T3 (cs)
FR (1) FR2752422B1 (cs)
HU (1) HUP0004223A3 (cs)
ID (1) ID17875A (cs)
NO (1) NO312290B1 (cs)
PL (1) PL187371B1 (cs)
PT (1) PT925273E (cs)
RU (1) RU2175966C2 (cs)
SI (1) SI0925273T1 (cs)
SK (1) SK283055B6 (cs)
TR (1) TR199900329T2 (cs)
TW (1) TW438764B (cs)
UA (1) UA57031C2 (cs)
WO (1) WO1998007681A1 (cs)
ZA (1) ZA977327B (cs)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2358722C2 (ru) * 2003-04-15 2009-06-20 Веллстат Терапьютикс Корпорейшн Соединения для лечения метаболических расстройств

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04318852A (ja) * 1991-04-18 1992-11-10 Fujitsu Ltd レジスト・パターン形成方法
CN102151262A (zh) 2001-06-12 2011-08-17 维尔斯达医疗公司 用于治疗代谢失调的化合物
FR2832633B1 (fr) * 2001-11-28 2004-09-24 Lipha Composition pharmaceutique comprenant une association metformine et un acide 4-oxo-butanoique et son utilisation pour traiter le diabete
FR2832925B1 (fr) * 2001-12-03 2006-07-14 Lipha Utilisation de derives de l'acide 4-oxobutanoique dans le traitement de l'inflammation
FR2834214B1 (fr) * 2001-12-28 2004-09-24 Lipha Composition pharmaceutique comprenant un inhibiteur d'alpha-glucosidase et un acide 4-oxo-butanoique et son utilisation pour traiter le diabete
FR2834640B1 (fr) * 2002-01-11 2004-09-24 Lipha Composition pharmaceutique comprenant une glitazone et un acide 4-oxobutanoique et son utilisation pour traiter le diabete
EP1556085A4 (en) * 2002-11-01 2012-08-22 Wellstat Therapeutics Corp COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
JP2006514101A (ja) * 2002-11-08 2006-04-27 ノボ・ノルデイスク・エー／エス 肥満症の治療のための安全な化学的脱共役剤
FR2849599B1 (fr) * 2003-01-07 2006-12-29 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete
FR2849598B1 (fr) * 2003-01-07 2006-09-22 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans
ES2368692T3 (es) 2007-12-03 2011-11-21 Merck Patent Gmbh Utilización de derivados del ácido 4-oxobutanoico en el tratamiento de patologías asociadas con trastornos inmunológicos.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1475484A3 (ru) * 1986-06-06 1989-04-23 Руссельс-Юклаф (Фирма) Способ получени (Е) 4-(2-метоксифенил)-4-оксо-2-бутеновой кислоты
FR2623507A1 (fr) * 1987-11-23 1989-05-26 Squibb & Sons Inc Derives d'alcools n-heterocycliques a action therapeutique

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK523288A (da) * 1987-10-06 1989-04-07 Hoffmann La Roche Aminosyrederivater
US5250517A (en) * 1987-10-06 1993-10-05 Hoffmann-La Roche Inc. Renin inhibiting compounds
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
FR2733750B1 (fr) 1995-05-03 1997-06-13 Synthelabo Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1475484A3 (ru) * 1986-06-06 1989-04-23 Руссельс-Юклаф (Фирма) Способ получени (Е) 4-(2-метоксифенил)-4-оксо-2-бутеновой кислоты
FR2623507A1 (fr) * 1987-11-23 1989-05-26 Squibb & Sons Inc Derives d'alcools n-heterocycliques a action therapeutique

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2358722C2 (ru) * 2003-04-15 2009-06-20 Веллстат Терапьютикс Корпорейшн Соединения для лечения метаболических расстройств

Also Published As

Publication number Publication date
EP0925273A1 (fr) 1999-06-30
TW438764B (en) 2001-06-07
FR2752422B1 (fr) 1998-11-06
ZA977327B (en) 1998-03-30
HK1021728A1 (en) 2000-06-30
NO312290B1 (no) 2002-04-22
WO1998007681A1 (fr) 1998-02-26
ATE208364T1 (de) 2001-11-15
SI0925273T1 (en) 2002-04-30
DE69708130T2 (de) 2002-06-20
KR20000068106A (ko) 2000-11-25
BR9711315A (pt) 1999-08-17
JP3105545B2 (ja) 2000-11-06
CY2298B1 (en) 2003-07-04
AU725440B2 (en) 2000-10-12
CA2263348A1 (fr) 1998-02-26
FR2752422A1 (fr) 1998-02-20
NO990707D0 (no) 1999-02-15
CN1082370C (zh) 2002-04-10
HUP0004223A3 (en) 2001-12-28
CN1227538A (zh) 1999-09-01
EP0925273B1 (fr) 2001-11-07
ID17875A (id) 1998-02-05
PL331645A1 (en) 1999-08-02
KR100488430B1 (ko) 2005-05-10
ES2166098T3 (es) 2002-04-01
SK283055B6 (sk) 2003-02-04
CZ49899A3 (cs) 1999-05-12
SK18099A3 (en) 2000-03-13
CZ294165B6 (cs) 2004-10-13
AU3942297A (en) 1998-03-06
CA2263348C (en) 2008-05-13
AR009251A1 (es) 2000-04-12
DK0925273T3 (da) 2002-02-18
TR199900329T2 (xx) 1999-04-21
UA57031C2 (uk) 2003-06-16
DE69708130D1 (de) 2001-12-13
US6143787A (en) 2000-11-07
HUP0004223A2 (hu) 2001-04-28
PL187371B1 (pl) 2004-06-30
NO990707L (no) 1999-02-15
PT925273E (pt) 2002-04-29
JP2000506543A (ja) 2000-05-30

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Effective date: 20100806