HUP0004223A2 - 4-Oxo-butánsav-származékok és ezeket hatóanyagként tartalmazó gyógyászati készítmények - Google Patents

4-Oxo-butánsav-származékok és ezeket hatóanyagként tartalmazó gyógyászati készítmények

Info

Publication number
HUP0004223A2
HUP0004223A2 HU0004223A HUP0004223A HUP0004223A2 HU P0004223 A2 HUP0004223 A2 HU P0004223A2 HU 0004223 A HU0004223 A HU 0004223A HU P0004223 A HUP0004223 A HU P0004223A HU P0004223 A2 HUP0004223 A2 HU P0004223A2
Authority
HU
Hungary
Prior art keywords
group
carbon atoms
general formula
substituents
pyrimidyl
Prior art date
Application number
HU0004223A
Other languages
English (en)
Inventor
Lilian Doare
Micheline Kergoat
Philippe Maizeray
Didier Mesangeau
Gérard Moinet
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HUP0004223A2 publication Critical patent/HUP0004223A2/hu
Publication of HUP0004223A3 publication Critical patent/HUP0004223A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány hatóanyagként valamely (I) általános képletű vegyületet,ennek szolvátját vagy valamely gyógyászatilag elfogadható bázissalalkotott sóját tartalmazó, elsősorban nem inzulinfüggő diabéteszkezelésére alkalmazható gyógyászati készítményekre vonatkozik. Az (I)általános képletben A és B egymástól függetlenül - 6-14 szénatomosmono-, bi- vagy triciklusos arilcsoport; - heteroaromás csoport, melypiridil-, pirimidil-, pirrolil-, furil- vagy tienilcsoport lehet; - 1-4 szénatomos alkilcsoport; - 5-8 szénatomos cikloalkilcsoport; -telített heterociklusos csoport, mely tetrahidrofuril-,tetrahidropiranil-, piperidil- vagy pirrolidinilcsoport lehet; és A ésB 1-3 szubsztituenst tartalmazhat a következők közül: alkil-, alkoxi-,arilcsoport; heteroarilcsoport, mely piridil-, pirimidil-, pirrolil-,furil- vagy tienilcsoport lehet; aril-alkil-csoport; aril-alkil-aril-csoport; halogénatom; trifluor-metil-, trifluor-metoxi-, ciano-,hidroxil-, nitro-, amino-, karboxilcsoport; alkoxi-karbonil-csoport;karbamoilcsoport; alkil-szulfonil-amino-csoport; szulfamoilcsoportvagy alkil-karbonil-amino-csoport; vagy a szubsztituensek közül kettőmetilén-dioxi-csoportot alkot. A találmány az új (I) általános képletűvegyületekre is vonatkozik, ahol a helyettesítők jelentése - bizonyosmegszorításokkal - a fenti. Ó
HU0004223A 1996-08-16 1997-08-05 4-oxo-butynic acids and pharmaceutical composition containing them as active agent HUP0004223A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9610254A FR2752422B1 (fr) 1996-08-16 1996-08-16 Composition pharmaceutique contenant des acides 4-oxo-butanoiques
PCT/EP1997/004252 WO1998007681A1 (fr) 1996-08-16 1997-08-05 Compositions pharmaceutiques contenant des acides 4-oxo-butanoiques

Publications (2)

Publication Number Publication Date
HUP0004223A2 true HUP0004223A2 (hu) 2001-04-28
HUP0004223A3 HUP0004223A3 (en) 2001-12-28

Family

ID=9495089

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004223A HUP0004223A3 (en) 1996-08-16 1997-08-05 4-oxo-butynic acids and pharmaceutical composition containing them as active agent

Country Status (30)

Country Link
US (1) US6143787A (hu)
EP (1) EP0925273B1 (hu)
JP (1) JP3105545B2 (hu)
KR (1) KR100488430B1 (hu)
CN (1) CN1082370C (hu)
AR (1) AR009251A1 (hu)
AT (1) ATE208364T1 (hu)
AU (1) AU725440B2 (hu)
BR (1) BR9711315A (hu)
CA (1) CA2263348C (hu)
CY (1) CY2298B1 (hu)
CZ (1) CZ294165B6 (hu)
DE (1) DE69708130T2 (hu)
DK (1) DK0925273T3 (hu)
ES (1) ES2166098T3 (hu)
FR (1) FR2752422B1 (hu)
HK (1) HK1021728A1 (hu)
HU (1) HUP0004223A3 (hu)
ID (1) ID17875A (hu)
NO (1) NO312290B1 (hu)
PL (1) PL187371B1 (hu)
PT (1) PT925273E (hu)
RU (1) RU2175966C2 (hu)
SI (1) SI0925273T1 (hu)
SK (1) SK283055B6 (hu)
TR (1) TR199900329T2 (hu)
TW (1) TW438764B (hu)
UA (1) UA57031C2 (hu)
WO (1) WO1998007681A1 (hu)
ZA (1) ZA977327B (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04318852A (ja) * 1991-04-18 1992-11-10 Fujitsu Ltd レジスト・パターン形成方法
WO2002100341A2 (en) 2001-06-12 2002-12-19 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
FR2832633B1 (fr) * 2001-11-28 2004-09-24 Lipha Composition pharmaceutique comprenant une association metformine et un acide 4-oxo-butanoique et son utilisation pour traiter le diabete
FR2832925B1 (fr) * 2001-12-03 2006-07-14 Lipha Utilisation de derives de l'acide 4-oxobutanoique dans le traitement de l'inflammation
FR2834214B1 (fr) * 2001-12-28 2004-09-24 Lipha Composition pharmaceutique comprenant un inhibiteur d'alpha-glucosidase et un acide 4-oxo-butanoique et son utilisation pour traiter le diabete
FR2834640B1 (fr) * 2002-01-11 2004-09-24 Lipha Composition pharmaceutique comprenant une glitazone et un acide 4-oxobutanoique et son utilisation pour traiter le diabete
EP1556085A4 (en) * 2002-11-01 2012-08-22 Wellstat Therapeutics Corp COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
AU2003275939A1 (en) * 2002-11-08 2004-06-07 Novo Nordisk A/S Safe chemical uncouplers for the treatment of obesity
FR2849598B1 (fr) * 2003-01-07 2006-09-22 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans
FR2849599B1 (fr) * 2003-01-07 2006-12-29 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete
CN101912380A (zh) * 2003-04-15 2010-12-15 维尔斯达医疗公司 用于治疗代谢紊乱的化合物
ES2368692T3 (es) 2007-12-03 2011-11-21 Merck Patent Gmbh Utilización de derivados del ácido 4-oxobutanoico en el tratamiento de patologías asociadas con trastornos inmunológicos.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK523288A (da) * 1987-10-06 1989-04-07 Hoffmann La Roche Aminosyrederivater
US5250517A (en) * 1987-10-06 1993-10-05 Hoffmann-La Roche Inc. Renin inhibiting compounds
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
CA1329680C (en) * 1987-11-23 1994-05-17 Harold Norris Weller, Iii N-heterocyclic alcohol derivatives

Also Published As

Publication number Publication date
NO312290B1 (no) 2002-04-22
BR9711315A (pt) 1999-08-17
HK1021728A1 (en) 2000-06-30
CA2263348A1 (fr) 1998-02-26
SI0925273T1 (en) 2002-04-30
UA57031C2 (uk) 2003-06-16
TR199900329T2 (xx) 1999-04-21
CN1227538A (zh) 1999-09-01
FR2752422A1 (fr) 1998-02-20
WO1998007681A1 (fr) 1998-02-26
PL331645A1 (en) 1999-08-02
PL187371B1 (pl) 2004-06-30
CN1082370C (zh) 2002-04-10
EP0925273A1 (fr) 1999-06-30
CA2263348C (en) 2008-05-13
CY2298B1 (en) 2003-07-04
CZ294165B6 (cs) 2004-10-13
KR100488430B1 (ko) 2005-05-10
SK18099A3 (en) 2000-03-13
SK283055B6 (sk) 2003-02-04
NO990707L (no) 1999-02-15
KR20000068106A (ko) 2000-11-25
DK0925273T3 (da) 2002-02-18
US6143787A (en) 2000-11-07
RU2175966C2 (ru) 2001-11-20
JP2000506543A (ja) 2000-05-30
ZA977327B (en) 1998-03-30
JP3105545B2 (ja) 2000-11-06
AR009251A1 (es) 2000-04-12
PT925273E (pt) 2002-04-29
HUP0004223A3 (en) 2001-12-28
DE69708130D1 (de) 2001-12-13
DE69708130T2 (de) 2002-06-20
AU3942297A (en) 1998-03-06
TW438764B (en) 2001-06-07
AU725440B2 (en) 2000-10-12
ES2166098T3 (es) 2002-04-01
ID17875A (id) 1998-02-05
CZ49899A3 (cs) 1999-05-12
EP0925273B1 (fr) 2001-11-07
FR2752422B1 (fr) 1998-11-06
NO990707D0 (no) 1999-02-15
ATE208364T1 (de) 2001-11-15

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees