RU2018112861A - Стабильные антитела, связывающиеся с несколькими антигенами - Google Patents
Стабильные антитела, связывающиеся с несколькими антигенами Download PDFInfo
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- RU2018112861A RU2018112861A RU2018112861A RU2018112861A RU2018112861A RU 2018112861 A RU2018112861 A RU 2018112861A RU 2018112861 A RU2018112861 A RU 2018112861A RU 2018112861 A RU2018112861 A RU 2018112861A RU 2018112861 A RU2018112861 A RU 2018112861A
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- Prior art keywords
- antibody
- binds
- several antigens
- antigens according
- aho
- Prior art date
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- 239000000427 antigen Substances 0.000 title claims 25
- 102000036639 antigens Human genes 0.000 title claims 25
- 108091007433 antigens Proteins 0.000 title claims 25
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 239000004473 Threonine Chemical group 0.000 claims 8
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Chemical group CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 8
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 7
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical group OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 4
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 3
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims 3
- 101000588258 Taenia solium Paramyosin Proteins 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- 101100484454 Arabidopsis thaliana VHA-A gene Proteins 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
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- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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| EP3431495A1 (en) | 2019-01-23 |
| MX2014004521A (es) | 2014-05-28 |
| WO2013056851A3 (en) | 2013-06-13 |
| US20130101586A1 (en) | 2013-04-25 |
| AR088403A1 (es) | 2014-05-28 |
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| RU2014120154A (ru) | 2015-11-27 |
| AU2012325232A1 (en) | 2014-06-05 |
| CA2850572A1 (en) | 2013-04-25 |
| RU2652886C2 (ru) | 2018-05-03 |
| AU2012325232A8 (en) | 2014-06-26 |
| TWI577696B (zh) | 2017-04-11 |
| JP2014533239A (ja) | 2014-12-11 |
| WO2013056851A2 (en) | 2013-04-25 |
| CN103890005A (zh) | 2014-06-25 |
| AU2012325232B2 (en) | 2017-08-31 |
| BR112014009030A2 (pt) | 2017-09-12 |
| EP2768855A2 (en) | 2014-08-27 |
| US20200048336A1 (en) | 2020-02-13 |
| JP2017125066A (ja) | 2017-07-20 |
| KR20140082700A (ko) | 2014-07-02 |
| UY34404A (es) | 2013-05-31 |
| EP2768855B1 (en) | 2018-06-13 |
| JP2019104759A (ja) | 2019-06-27 |
| ES2687245T3 (es) | 2018-10-24 |
| CN109608543A (zh) | 2019-04-12 |
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