AU2012325232B2 - Stable multiple antigen-binding antibody - Google Patents

Stable multiple antigen-binding antibody Download PDF

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Publication number
AU2012325232B2
AU2012325232B2 AU2012325232A AU2012325232A AU2012325232B2 AU 2012325232 B2 AU2012325232 B2 AU 2012325232B2 AU 2012325232 A AU2012325232 A AU 2012325232A AU 2012325232 A AU2012325232 A AU 2012325232A AU 2012325232 B2 AU2012325232 B2 AU 2012325232B2
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AU
Australia
Prior art keywords
aho position
linker
binding antibody
multiple antigen
chain variable
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AU2012325232A
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AU2012325232A1 (en
AU2012325232A8 (en
Inventor
Leonardo Borras
Astrid C. RIEGLER
Roberto Sommavilla
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Esbatech a Novartis Co LLC
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Esbatech a Novartis Co LLC
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07KPEPTIDES
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
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    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
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    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
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    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • CCHEMISTRY; METALLURGY
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2317/622Single chain antibody (scFv)
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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AU2012325232A 2011-10-20 2012-10-19 Stable multiple antigen-binding antibody Ceased AU2012325232B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161549482P 2011-10-20 2011-10-20
US61/549,482 2011-10-20
PCT/EP2012/004404 WO2013056851A2 (en) 2011-10-20 2012-10-19 Stable multiple antigen-binding antibody

Publications (3)

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AU2012325232A1 AU2012325232A1 (en) 2014-06-05
AU2012325232A8 AU2012325232A8 (en) 2014-06-26
AU2012325232B2 true AU2012325232B2 (en) 2017-08-31

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AU2012325232A Ceased AU2012325232B2 (en) 2011-10-20 2012-10-19 Stable multiple antigen-binding antibody

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US (2) US20130101586A1 (enExample)
EP (2) EP3431495A1 (enExample)
JP (3) JP2014533239A (enExample)
KR (1) KR20140082700A (enExample)
CN (2) CN109608543A (enExample)
AR (1) AR088403A1 (enExample)
AU (1) AU2012325232B2 (enExample)
BR (1) BR112014009030A2 (enExample)
CA (1) CA2850572A1 (enExample)
ES (1) ES2687245T3 (enExample)
MX (1) MX2014004521A (enExample)
RU (2) RU2018112861A (enExample)
TW (1) TWI577696B (enExample)
UY (1) UY34404A (enExample)
WO (1) WO2013056851A2 (enExample)

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US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
CA2806252C (en) 2010-07-29 2019-05-14 Xencor, Inc. Antibodies with modified isoelectric points
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US10851178B2 (en) 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
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