JP2014533239A - 安定な複数抗原結合抗体 - Google Patents

安定な複数抗原結合抗体 Download PDF

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Publication number
JP2014533239A
JP2014533239A JP2014536147A JP2014536147A JP2014533239A JP 2014533239 A JP2014533239 A JP 2014533239A JP 2014536147 A JP2014536147 A JP 2014536147A JP 2014536147 A JP2014536147 A JP 2014536147A JP 2014533239 A JP2014533239 A JP 2014533239A
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Prior art keywords
antigen
binding antibody
linker
aho position
chain variable
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JP2014536147A
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JP2014533239A5 (enExample
Inventor
アシュトリト ツェー． リーグラー，
アシュトリト ツェー． リーグラー，
レオナルド ボラス，
レオナルド ボラス，
ロベルト ゾマヴィラ，
ロベルト ゾマヴィラ，
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Esbatech a Novartis Co LLC
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Esbatech An Alcon Biomedical Research Unit LLC
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Publication of JP2014533239A publication Critical patent/JP2014533239A/ja
Publication of JP2014533239A5 publication Critical patent/JP2014533239A5/ja
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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JP2014536147A 2011-10-20 2012-10-19 安定な複数抗原結合抗体 Withdrawn JP2014533239A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161549482P 2011-10-20 2011-10-20
US61/549,482 2011-10-20
PCT/EP2012/004404 WO2013056851A2 (en) 2011-10-20 2012-10-19 Stable multiple antigen-binding antibody

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2017084447A Division JP2017125066A (ja) 2011-10-20 2017-04-21 安定な複数抗原結合抗体
JP2019067016A Division JP2019104759A (ja) 2011-10-20 2019-03-29 安定な複数抗原結合抗体

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JP2014533239A true JP2014533239A (ja) 2014-12-11
JP2014533239A5 JP2014533239A5 (enExample) 2015-08-06

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021073994A (ja) * 2019-11-05 2021-05-20 国立大学法人 琉球大学 耐熱性を付与した抗真菌タンパク質，ならびにこれを有効成分とする薬剤とその使用

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
EP2598530A2 (en) 2010-07-29 2013-06-05 Xencor, Inc. Antibodies with modified isoelectric points
US10851178B2 (en) 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
KR102391731B1 (ko) 2013-01-14 2022-04-27 젠코어 인코포레이티드 신규한 이형이량체 단백질
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
US9701759B2 (en) 2013-01-14 2017-07-11 Xencor, Inc. Heterodimeric proteins
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
WO2014113510A1 (en) 2013-01-15 2014-07-24 Xencor, Inc. Rapid clearance of antigen complexes using novel antibodies
US10519242B2 (en) 2013-03-15 2019-12-31 Xencor, Inc. Targeting regulatory T cells with heterodimeric proteins
US10106624B2 (en) 2013-03-15 2018-10-23 Xencor, Inc. Heterodimeric proteins
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
EP3421495A3 (en) 2013-03-15 2019-05-15 Xencor, Inc. Modulation of t cells with bispecific antibodies and fc fusions
PL3122781T3 (pl) 2014-03-28 2020-06-15 Xencor, Inc. Dwuswoiste przeciwciała, które wiążą się z CD38 i CD3
JP6223898B2 (ja) * 2014-04-24 2017-11-01 株式会社パイロットコーポレーション スタンプ用水性インキ組成物及びそれを内蔵したスタンプ
TWI806150B (zh) * 2014-11-07 2023-06-21 瑞士商諾華公司 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
HK1245171A1 (zh) 2014-11-26 2018-08-24 Xencor, Inc. 结合cd3和cd38的异二聚体抗体
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
JP6696982B2 (ja) 2014-11-26 2020-05-20 ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． Ｃｄ３および腫瘍抗原に結合するヘテロ二量体抗体
US10428155B2 (en) 2014-12-22 2019-10-01 Xencor, Inc. Trispecific antibodies
US10227411B2 (en) 2015-03-05 2019-03-12 Xencor, Inc. Modulation of T cells with bispecific antibodies and FC fusions
EP3387013B1 (en) 2015-12-07 2022-06-08 Xencor, Inc. Heterodimeric antibodies that bind cd3 and psma
CA3026151A1 (en) 2016-06-14 2017-12-21 Xencor, Inc. Bispecific checkpoint inhibitor antibodies
RU2019102008A (ru) 2016-06-28 2020-07-28 Ксенкор, Инк. Гетеродимерные антитела, которые связывают рецептор соматостатина 2-го типа
CN106222129A (zh) * 2016-07-29 2016-12-14 广东东阳光药业有限公司 一种提高抗体纯度的细胞培养基和培养方法
US10793632B2 (en) 2016-08-30 2020-10-06 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
MX2019004327A (es) 2016-10-14 2019-10-14 Xencor Inc Proteinas de fusion heterodimericas biespecificas que contienen proteinas de fusion fc il-15/il-15ra y fragmentos de anticuerpo pd-1.
AU2018291497A1 (en) 2017-06-30 2020-01-16 Xencor, Inc. Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains
AU2018366199A1 (en) 2017-11-08 2020-05-28 Xencor, Inc. Bispecific and monospecific antibodies using novel anti-PD-1 sequences
US10981992B2 (en) 2017-11-08 2021-04-20 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
JP7765181B2 (ja) 2017-12-19 2025-11-06 ゼンコア インコーポレイテッド 改変されたｉｌ－２ ｆｃ融合タンパク質
CN112469477A (zh) 2018-04-04 2021-03-09 Xencor股份有限公司 与成纤维细胞活化蛋白结合的异源二聚体抗体
KR20210003814A (ko) 2018-04-18 2021-01-12 젠코어 인코포레이티드 IL-15/IL-15Rα Fc-융합 단백질 및 TIM-3 항원 결합 도메인을 함유하는 TIM-3 표적화 이종이량체 융합 단백질
CA3097593A1 (en) 2018-04-18 2019-10-24 Xencor, Inc. Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof
KR102884523B1 (ko) 2018-10-03 2025-11-10 젠코어 인코포레이티드 IL-12 이종이량체 Fc-융합 단백질
SG11202107129QA (en) * 2019-01-03 2021-07-29 Amgen Inc Engineering monoclonal antibodies to improve stability and production titer
EP3930850A1 (en) 2019-03-01 2022-01-05 Xencor, Inc. Heterodimeric antibodies that bind enpp3 and cd3
WO2021231976A1 (en) 2020-05-14 2021-11-18 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
EP4149632A1 (en) 2020-05-14 2023-03-22 Xencor, Inc. Heterodimeric antibodies that bind msln and cd3
US11919958B2 (en) 2020-08-19 2024-03-05 Xencor, Inc. Anti-CD28 compositions
EP4305067A1 (en) 2021-03-09 2024-01-17 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cldn6
US11859012B2 (en) 2021-03-10 2024-01-02 Xencor, Inc. Heterodimeric antibodies that bind CD3 and GPC3
US20260096562A1 (en) * 2022-12-30 2026-04-09 Biotalys NV Self-emulsifiable concentrate

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006085518A1 (ja) * 2005-02-08 2006-08-17 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute 抗体の改良方法
JP2008017848A (ja) * 2001-12-28 2008-01-31 Chugai Pharmaceut Co Ltd タンパク質安定化方法
WO2009082624A2 (en) * 2007-12-10 2009-07-02 Zymogenetics, Inc. Antagonists of il-17a, il-17f, and il-23 and methods of using the same
JP2009531028A (ja) * 2006-03-17 2009-09-03 バイオジェン・アイデック・エムエイ・インコーポレイテッド 安定化されたポリペプチド化合物
WO2010008690A1 (en) * 2008-07-14 2010-01-21 Uchicago Argonne, Llc Methods for systematic control of protein stability
JP2010531145A (ja) * 2007-06-25 2010-09-24 エスバテック アン アルコン バイオメディカル リサーチ ユニット エルエルシー 抗体の修飾方法並びに改善された機能特性を有する修飾された抗体
JP2011525358A (ja) * 2008-06-25 2011-09-22 エスバテック、アン アルコン バイオメディカル リサーチ ユニット、エルエルシー ＴＮＦαを阻害する安定かつ可溶性の抗体

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
ATE239041T1 (de) * 1996-02-09 2003-05-15 Basf Ag Humane antikörper welche an humanen tnfalpha binden
HUP9900956A2 (hu) * 1998-04-09 2002-04-29 Aventis Pharma Deutschland Gmbh. Egyláncú, több antigéntkötőhely kialakítására képes molekulák, előállításuk és alkalmazásuk
DE19819846B4 (de) 1998-05-05 2016-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Multivalente Antikörper-Konstrukte
JP5007409B2 (ja) * 2000-05-08 2012-08-22 セルデックス リサーチ コーポレーション 樹状細胞に対するヒトモノクローナル抗体
CN102093477B (zh) 2002-05-22 2014-02-26 艾斯巴技术-诺华有限责任公司 在胞内环境中表现出增强的稳定性的免疫球蛋白构架及其鉴定方法
WO2003106497A1 (en) * 2002-06-14 2003-12-24 Immunomedics, Inc. Monoclonal antibody pam4 and its use for diagnosis and therapy of pancreatic cancer
AU2003264009A1 (en) * 2002-08-15 2004-03-03 Epitomics, Inc. Humanized rabbit antibodies
MY150740A (en) * 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
JP5085322B2 (ja) * 2005-06-10 2012-11-28 中外製薬株式会社 ｓｃ（Ｆｖ）２を含有する医薬組成物
WO2008004834A1 (en) 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor
EP2158221B1 (en) * 2007-06-21 2018-08-29 MacroGenics, Inc. Covalent diabodies and uses thereof
PL2307458T3 (pl) 2008-06-25 2018-08-31 Esbatech, An Alcon Biomedical Research Unit Llc Humanizacja przeciwciał króliczych z zastosowaniem uniwersalnego zrębu przeciwciała
RU2582244C2 (ru) 2008-06-30 2016-04-20 ИЭсБиЭйТЕК, ЭН АЛЬКОН БАЙОМЕДИКАЛ РИСЕРЧ ЮНИТ ЭлЭлСи Функционализированные полипептиды
KR20110047255A (ko) * 2008-09-26 2011-05-06 로슈 글리카트 아게 이중특이적 항-ｅｇｆｒ／항-ｉｇｆ-１ｒ 항체
US8268314B2 (en) * 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
KR20110094307A (ko) * 2008-11-13 2011-08-23 펨타 파마슈티컬스, 인크. 인간화된 항-ｉｌ-6 항체
UY33679A (es) * 2010-10-22 2012-03-30 Esbatech Anticuerpos estables y solubles

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008017848A (ja) * 2001-12-28 2008-01-31 Chugai Pharmaceut Co Ltd タンパク質安定化方法
WO2006085518A1 (ja) * 2005-02-08 2006-08-17 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute 抗体の改良方法
JP2009531028A (ja) * 2006-03-17 2009-09-03 バイオジェン・アイデック・エムエイ・インコーポレイテッド 安定化されたポリペプチド化合物
JP2010531145A (ja) * 2007-06-25 2010-09-24 エスバテック アン アルコン バイオメディカル リサーチ ユニット エルエルシー 抗体の修飾方法並びに改善された機能特性を有する修飾された抗体
WO2009082624A2 (en) * 2007-12-10 2009-07-02 Zymogenetics, Inc. Antagonists of il-17a, il-17f, and il-23 and methods of using the same
JP2011525358A (ja) * 2008-06-25 2011-09-22 エスバテック、アン アルコン バイオメディカル リサーチ ユニット、エルエルシー ＴＮＦαを阻害する安定かつ可溶性の抗体
WO2010008690A1 (en) * 2008-07-14 2010-01-21 Uchicago Argonne, Llc Methods for systematic control of protein stability

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MILLER BRIAN R., PROTEIN ENGINEERING DESIGN & SELECTION, vol. 23, no. 7, JPN5014011385, 2010, pages 549 - 557, ISSN: 0003316204 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021073994A (ja) * 2019-11-05 2021-05-20 国立大学法人 琉球大学 耐熱性を付与した抗真菌タンパク質，ならびにこれを有効成分とする薬剤とその使用
JP7692188B2 (ja) 2019-11-05 2025-06-13 国立大学法人 琉球大学 耐熱性を付与した抗真菌タンパク質，ならびにこれを有効成分とする薬剤とその使用

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