KR20140082700A - 안정적인 다중 항원-결합 항체 - Google Patents

안정적인 다중 항원-결합 항체 Download PDF

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KR20140082700A
KR20140082700A KR1020147009866A KR20147009866A KR20140082700A KR 20140082700 A KR20140082700 A KR 20140082700A KR 1020147009866 A KR1020147009866 A KR 1020147009866A KR 20147009866 A KR20147009866 A KR 20147009866A KR 20140082700 A KR20140082700 A KR 20140082700A
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xaa xaa
aho position
linker
antibody
antigen
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아스트리드 씨. 리에그레르
레오나르도 보라스
로베르토 솜마빌라
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에스바테크 - 어 노바티스 컴파니 엘엘씨
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    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • C07K16/22Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
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    • C07K16/24Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
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    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • CCHEMISTRY; METALLURGY
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
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    • CCHEMISTRY; METALLURGY
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
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    • C07K2317/626Diabody or triabody
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Molecular Biology (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
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  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
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KR1020147009866A 2011-10-20 2012-10-19 안정적인 다중 항원-결합 항체 Ceased KR20140082700A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161549482P 2011-10-20 2011-10-20
US61/549,482 2011-10-20
PCT/EP2012/004404 WO2013056851A2 (en) 2011-10-20 2012-10-19 Stable multiple antigen-binding antibody

Publications (1)

Publication Number Publication Date
KR20140082700A true KR20140082700A (ko) 2014-07-02

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KR1020147009866A Ceased KR20140082700A (ko) 2011-10-20 2012-10-19 안정적인 다중 항원-결합 항체

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US (2) US20130101586A1 (enExample)
EP (2) EP2768855B1 (enExample)
JP (3) JP2014533239A (enExample)
KR (1) KR20140082700A (enExample)
CN (2) CN109608543A (enExample)
AR (1) AR088403A1 (enExample)
AU (1) AU2012325232B2 (enExample)
BR (1) BR112014009030A2 (enExample)
CA (1) CA2850572A1 (enExample)
ES (1) ES2687245T3 (enExample)
MX (1) MX2014004521A (enExample)
RU (2) RU2018112861A (enExample)
TW (1) TWI577696B (enExample)
UY (1) UY34404A (enExample)
WO (1) WO2013056851A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170076781A (ko) * 2014-11-07 2017-07-04 노파르티스 아게 고농도의 항-vegf 항체를 포함하는 안정한 단백질 용액 제제

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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