RU2014121984A - Бензолсульфонамидные соединения и их применение в качестве терапевтических средств - Google Patents
Бензолсульфонамидные соединения и их применение в качестве терапевтических средств Download PDFInfo
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- RU2014121984A RU2014121984A RU2014121984/04A RU2014121984A RU2014121984A RU 2014121984 A RU2014121984 A RU 2014121984A RU 2014121984/04 A RU2014121984/04 A RU 2014121984/04A RU 2014121984 A RU2014121984 A RU 2014121984A RU 2014121984 A RU2014121984 A RU 2014121984A
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- Prior art keywords
- optionally substituted
- hydrogen atom
- alkyl
- halogen
- independently represents
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- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 title claims 6
- 230000001225 therapeutic effect Effects 0.000 title claims 5
- 239000003814 drug Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 242
- 125000000217 alkyl group Chemical group 0.000 claims abstract 175
- 229910052736 halogen Inorganic materials 0.000 claims abstract 149
- 150000002367 halogens Chemical class 0.000 claims abstract 149
- 125000001188 haloalkyl group Chemical group 0.000 claims abstract 111
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 77
- 150000001875 compounds Chemical class 0.000 claims abstract 69
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 61
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 61
- 125000003107 substituted aryl group Chemical group 0.000 claims abstract 52
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 43
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims abstract 30
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 24
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 24
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 24
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 21
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract 14
- 125000002947 alkylene group Chemical group 0.000 claims abstract 12
- 229910052799 carbon Inorganic materials 0.000 claims abstract 11
- 125000005842 heteroatom Chemical group 0.000 claims abstract 7
- 125000003118 aryl group Chemical group 0.000 claims abstract 6
- 125000000547 substituted alkyl group Chemical group 0.000 claims abstract 4
- -1 halogenated Chemical group 0.000 claims 71
- 208000002193 Pain Diseases 0.000 claims 28
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 28
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 28
- 238000000034 method Methods 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 18
- 239000000651 prodrug Substances 0.000 claims 18
- 229940002612 prodrug Drugs 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 239000012453 solvate Substances 0.000 claims 18
- 241000124008 Mammalia Species 0.000 claims 16
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 13
- 108010052164 Sodium Channels Proteins 0.000 claims 9
- 102000018674 Sodium Channels Human genes 0.000 claims 9
- 102000016913 Voltage-Gated Sodium Channels Human genes 0.000 claims 7
- 108010053752 Voltage-Gated Sodium Channels Proteins 0.000 claims 7
- 230000001419 dependent effect Effects 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 125000000842 isoxazolyl group Chemical group 0.000 claims 7
- 125000002098 pyridazinyl group Chemical group 0.000 claims 7
- 125000004076 pyridyl group Chemical group 0.000 claims 7
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 7
- 125000003831 tetrazolyl group Chemical group 0.000 claims 7
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 7
- 125000000335 thiazolyl group Chemical group 0.000 claims 7
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 5
- 208000007914 Labor Pain Diseases 0.000 claims 4
- 208000035945 Labour pain Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 201000011384 erythromelalgia Diseases 0.000 claims 4
- 150000002500 ions Chemical class 0.000 claims 4
- 208000033808 peripheral neuropathy Diseases 0.000 claims 4
- 230000000069 prophylactic effect Effects 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 3
- 230000004907 flux Effects 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 206010058019 Cancer Pain Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 2
- 208000001640 Fibromyalgia Diseases 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 206010019233 Headaches Diseases 0.000 claims 2
- 206010020844 Hyperthermia malignant Diseases 0.000 claims 2
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- 208000026709 Liddle syndrome Diseases 0.000 claims 2
- 208000018717 Malignant hyperthermia of anesthesia Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 206010061533 Myotonia Diseases 0.000 claims 2
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 claims 2
- 206010029279 Neurogenic bladder Diseases 0.000 claims 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 2
- 208000012075 Paroxysmal dystonia Diseases 0.000 claims 2
- 208000004983 Phantom Limb Diseases 0.000 claims 2
- 206010056238 Phantom pain Diseases 0.000 claims 2
- 208000004550 Postoperative Pain Diseases 0.000 claims 2
- 208000037674 Primary erythromelalgia Diseases 0.000 claims 2
- 206010036772 Proctalgia Diseases 0.000 claims 2
- 208000003251 Pruritus Diseases 0.000 claims 2
- 206010037113 Pseudoaldosteronism Diseases 0.000 claims 2
- 206010039020 Rhabdomyolysis Diseases 0.000 claims 2
- 206010040744 Sinus headache Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 208000001871 Tachycardia Diseases 0.000 claims 2
- 206010057040 Temperature intolerance Diseases 0.000 claims 2
- 206010043269 Tension headache Diseases 0.000 claims 2
- 208000008548 Tension-Type Headache Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 208000005298 acute pain Diseases 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 230000006793 arrhythmia Effects 0.000 claims 2
- 208000028683 bipolar I disease Diseases 0.000 claims 2
- 208000025307 bipolar depression Diseases 0.000 claims 2
- 208000029028 brain injury Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000000973 chemotherapeutic effect Effects 0.000 claims 2
- 208000010118 dystonia Diseases 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 231100000573 exposure to toxins Toxicity 0.000 claims 2
- 230000008543 heat sensitivity Effects 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 230000000302 ischemic effect Effects 0.000 claims 2
- 201000007004 malignant hyperthermia Diseases 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- 210000000578 peripheral nerve Anatomy 0.000 claims 2
- 230000002085 persistent effect Effects 0.000 claims 2
- 208000017692 primary erythermalgia Diseases 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000306 sarcoidosis Diseases 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 208000004371 toothache Diseases 0.000 claims 2
- 230000000472 traumatic effect Effects 0.000 claims 2
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 2
- 208000003663 ventricular fibrillation Diseases 0.000 claims 2
- 208000009935 visceral pain Diseases 0.000 claims 2
- RXEGZIXPUZCKFO-RDJZCZTQSA-N (3s,4r)-3-[(2,5-difluoro-4-pyrazol-1-ylsulfonylphenoxy)methyl]-4-(4-fluorophenyl)piperidine Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C(=CC(=C(F)C=2)S(=O)(=O)N2N=CC=C2)F)CNCC1 RXEGZIXPUZCKFO-RDJZCZTQSA-N 0.000 claims 1
- 125000004516 1,2,4-thiadiazol-5-yl group Chemical group S1N=CN=C1* 0.000 claims 1
- ONEVOOWUJAOPSN-HOCLYGCPSA-N 2,5-difluoro-4-[[(1r,2r)-2-(4-fluorophenyl)cyclohexyl]methoxy]-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C(=CC(=C(F)C=2)S(=O)(=O)NC=2SN=CN=2)F)CCCC1 ONEVOOWUJAOPSN-HOCLYGCPSA-N 0.000 claims 1
- ZBELRVLBJKOYGL-VYRBHSGPSA-N 2,5-difluoro-4-[[(3S)-4-(4-methylphenyl)piperidin-3-yl]methoxy]-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound Cc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1 ZBELRVLBJKOYGL-VYRBHSGPSA-N 0.000 claims 1
- XSBUZAIFXFCWIN-ZFWWWQNUSA-N 2,5-difluoro-4-[[(3r,4r)-3-(4-fluorophenyl)piperidin-4-yl]methoxy]-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C(=CC(=C(F)C=2)S(=O)(=O)NC=2SN=CN=2)F)CCNC1 XSBUZAIFXFCWIN-ZFWWWQNUSA-N 0.000 claims 1
- HOGWTQOFGYMNOK-ZFWWWQNUSA-N 2,5-difluoro-4-[[(3s,4r)-4-(4-fluorophenyl)piperidin-3-yl]methoxy]-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C(=CC(=C(F)C=2)S(=O)(=O)NC=2SN=CN=2)F)CNCC1 HOGWTQOFGYMNOK-ZFWWWQNUSA-N 0.000 claims 1
- WNPQUCQKSFDNDS-GJZGRUSLSA-N 2,5-difluoro-4-[[(3s,4r)-4-phenylpiperidin-3-yl]methoxy]-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound C1([C@@H]2CCNC[C@H]2COC2=CC(F)=C(C=C2F)S(=O)(=O)NC=2SN=CN=2)=CC=CC=C1 WNPQUCQKSFDNDS-GJZGRUSLSA-N 0.000 claims 1
- YKHBPEAAJKQFPN-UHFFFAOYSA-N 2,5-difluoro-4-[[3-fluoro-4-(4-fluorophenyl)piperidin-3-yl]methoxy]-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound C1=CC(F)=CC=C1C1C(COC=2C(=CC(=C(F)C=2)S(=O)(=O)NC=2SN=CN=2)F)(F)CNCC1 YKHBPEAAJKQFPN-UHFFFAOYSA-N 0.000 claims 1
- LDZNFFGWKHAEMM-GDBMZVCRSA-N 4-[[(3r,4s)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methoxy]-2,5-difluoro-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound C([C@@H]1[C@H](CCN(C1)C)C=1C=CC(Cl)=CC=1)OC(C(=C1)F)=CC(F)=C1S(=O)(=O)NC1=NC=NS1 LDZNFFGWKHAEMM-GDBMZVCRSA-N 0.000 claims 1
- LDZNFFGWKHAEMM-HOCLYGCPSA-N 4-[[(3s,4r)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methoxy]-2,5-difluoro-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound C([C@H]1[C@@H](CCN(C1)C)C=1C=CC(Cl)=CC=1)OC(C(=C1)F)=CC(F)=C1S(=O)(=O)NC1=NC=NS1 LDZNFFGWKHAEMM-HOCLYGCPSA-N 0.000 claims 1
- OCGIYHGXHMLCPX-ZFWWWQNUSA-N 4-[[(3s,4r)-4-(4-chlorophenyl)piperidin-3-yl]methoxy]-2,5-difluoro-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound C1([C@@H]2CCNC[C@H]2COC2=CC(F)=C(C=C2F)S(=O)(=O)NC=2SN=CN=2)=CC=C(Cl)C=C1 OCGIYHGXHMLCPX-ZFWWWQNUSA-N 0.000 claims 1
- QHQZPTNDCRWOPP-WMZOPIPTSA-N 4-[[(3s,4r)-4-(4-chlorophenyl)piperidin-3-yl]methoxy]-2,5-difluoro-n-(2-methylpropyl)benzenesulfonamide Chemical compound C1=C(F)C(S(=O)(=O)NCC(C)C)=CC(F)=C1OC[C@H]1[C@H](C=2C=CC(Cl)=CC=2)CCNC1 QHQZPTNDCRWOPP-WMZOPIPTSA-N 0.000 claims 1
- OPEKIKRIMJMTHW-RDJZCZTQSA-N 4-[[(3s,4r)-4-(4-chlorophenyl)piperidin-3-yl]methoxy]-2,5-difluoro-n-(5-methyl-1,3-thiazol-2-yl)benzenesulfonamide Chemical compound S1C(C)=CN=C1NS(=O)(=O)C(C(=C1)F)=CC(F)=C1OC[C@H]1[C@H](C=2C=CC(Cl)=CC=2)CCNC1 OPEKIKRIMJMTHW-RDJZCZTQSA-N 0.000 claims 1
- HGVRIBHCYYWMFY-RDJZCZTQSA-N 4-[[(3s,4r)-4-(4-chlorophenyl)piperidin-3-yl]methoxy]-2,5-difluoro-n-pyrimidin-4-ylbenzenesulfonamide Chemical compound C1([C@@H]2CCNC[C@H]2COC2=CC(F)=C(C=C2F)S(=O)(=O)NC=2N=CN=CC=2)=CC=C(Cl)C=C1 HGVRIBHCYYWMFY-RDJZCZTQSA-N 0.000 claims 1
- OZYNNENNGZDQTQ-JSGCOSHPSA-N 4-[[(3s,4r)-4-(4-chlorophenyl)piperidin-3-yl]methoxy]-2,5-difluorobenzenesulfonamide Chemical compound C1=C(F)C(S(=O)(=O)N)=CC(F)=C1OC[C@H]1[C@H](C=2C=CC(Cl)=CC=2)CCNC1 OZYNNENNGZDQTQ-JSGCOSHPSA-N 0.000 claims 1
- ILFBDKXJABKTIM-RXVVDRJESA-N 4-[[(3s,4r)-4-(4-chlorophenyl)piperidin-3-yl]methoxy]-3-cyano-n-propan-2-ylbenzenesulfonamide Chemical compound N#CC1=CC(S(=O)(=O)NC(C)C)=CC=C1OC[C@H]1[C@H](C=2C=CC(Cl)=CC=2)CCNC1 ILFBDKXJABKTIM-RXVVDRJESA-N 0.000 claims 1
- PWDWJKYTQFZCLL-YOEHRIQHSA-N 4-[[(3s,4r)-4-(4-chlorophenyl)piperidin-3-yl]methoxy]-3-fluoro-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound C1([C@@H]2CCNC[C@H]2COC2=CC=C(C=C2F)S(=O)(=O)NC=2SN=CN=2)=CC=C(Cl)C=C1 PWDWJKYTQFZCLL-YOEHRIQHSA-N 0.000 claims 1
- YNYVWCSZRIZIPK-ZFWWWQNUSA-N 4-[[(3s,4r)-4-(4-chlorophenyl)piperidin-3-yl]methoxy]-n-(5-chloro-1,3-thiazol-2-yl)-2,5-difluorobenzenesulfonamide Chemical compound C1([C@@H]2CCNC[C@H]2COC2=CC(F)=C(C=C2F)S(=O)(=O)NC=2SC(Cl)=CN=2)=CC=C(Cl)C=C1 YNYVWCSZRIZIPK-ZFWWWQNUSA-N 0.000 claims 1
- BODLISSZAMYJQE-UHFFFAOYSA-N 4-[[1-(4-chlorophenyl)piperazin-2-yl]methoxy]-2,5-difluoro-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound FC1=CC(S(=O)(=O)NC=2SN=CN=2)=C(F)C=C1OCC1CNCCN1C1=CC=C(Cl)C=C1 BODLISSZAMYJQE-UHFFFAOYSA-N 0.000 claims 1
- DHAFMZGQYJAEFS-UHFFFAOYSA-N 4-[[2-(4-chlorophenyl)-5-oxocyclohexyl]methoxy]-2,5-difluoro-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound FC1=CC(S(=O)(=O)NC=2SN=CN=2)=C(F)C=C1OCC1CC(=O)CCC1C1=CC=C(Cl)C=C1 DHAFMZGQYJAEFS-UHFFFAOYSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 241000832848 Dromas Species 0.000 claims 1
- 206010028424 Myasthenic syndrome Diseases 0.000 claims 1
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- 206010003246 arthritis Diseases 0.000 claims 1
- 206010061592 cardiac fibrillation Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002600 fibrillogenic effect Effects 0.000 claims 1
- 208000003532 hypothyroidism Diseases 0.000 claims 1
- 230000002989 hypothyroidism Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 230000001538 myasthenic effect Effects 0.000 claims 1
- XOHHFIKNKLWSEB-UHFFFAOYSA-N n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide Chemical compound C=1C=CC=CC=1S(=O)(=O)NC1=NC=NS1 XOHHFIKNKLWSEB-UHFFFAOYSA-N 0.000 claims 1
- GOAIBJBKJNXGFS-HOCLYGCPSA-N n-[4-[[(3s,4r)-4-(4-chlorophenyl)piperidin-3-yl]methoxy]-2,5-difluorophenyl]sulfonylacetamide Chemical compound C1=C(F)C(S(=O)(=O)NC(=O)C)=CC(F)=C1OC[C@H]1[C@H](C=2C=CC(Cl)=CC=2)CCNC1 GOAIBJBKJNXGFS-HOCLYGCPSA-N 0.000 claims 1
- QPUNFLXJVJVFBE-WMZOPIPTSA-N n-[4-[[(3s,4r)-4-(4-chlorophenyl)piperidin-3-yl]methoxy]-2,5-difluorophenyl]sulfonylpyridine-2-carboxamide Chemical compound C1([C@@H]2CCNC[C@H]2COC2=CC(F)=C(C=C2F)S(=O)(=O)NC(=O)C=2N=CC=CC=2)=CC=C(Cl)C=C1 QPUNFLXJVJVFBE-WMZOPIPTSA-N 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- 229960003966 nicotinamide Drugs 0.000 claims 1
- 235000005152 nicotinamide Nutrition 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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| US61/553,616 | 2011-10-31 | ||
| PCT/IB2012/056031 WO2013064983A1 (en) | 2011-10-31 | 2012-10-30 | Benzenesulfonamide compounds and their use as therapeutic agents |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2635354C2 (ru) * | 2012-02-09 | 2017-11-13 | Дайити Санкио Компани, Лимитед | Циклоалкановое производное |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6014155B2 (ja) | 2011-10-31 | 2016-10-25 | ゼノン・ファーマシューティカルズ・インコーポレイテッドXenon Pharmaceuticals Inc. | ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用 |
| RU2014121984A (ru) | 2011-10-31 | 2015-12-10 | Ксенон Фармасьютикалз Инк. | Бензолсульфонамидные соединения и их применение в качестве терапевтических средств |
| CN104718188B (zh) | 2012-05-22 | 2018-08-21 | 基因泰克公司 | N-取代的苯甲酰胺类及其在治疗疼痛中的用途 |
| KR101663436B1 (ko) | 2012-07-06 | 2016-10-06 | 제넨테크, 인크. | N-치환된 벤즈아미드 및 이의 사용 방법 |
| JP2015535252A (ja) | 2012-10-26 | 2015-12-10 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 電位作動型ナトリウムチャネルにおいて選択的活性を有するn−置換インダゾールスルホンアミド化合物 |
| ES2663798T3 (es) * | 2013-03-14 | 2018-04-17 | Daiichi Sankyo Company, Limited | Fármaco para enfermedades respiratorias |
| RU2015143906A (ru) | 2013-03-14 | 2017-04-18 | Дженентек, Инк. | Замещенные триазолопиридины и способы их применения |
| BR112015023397A2 (pt) | 2013-03-15 | 2017-07-18 | Genentech Inc | benzoxazois substituídos e métodos de uso dos mesmos |
| WO2015078374A1 (en) | 2013-11-27 | 2015-06-04 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| WO2015077905A1 (en) * | 2013-11-29 | 2015-06-04 | Merck Sharp & Dohme Corp. | Bicycloamine-substituted-n-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels |
| JP2017525677A (ja) | 2014-07-07 | 2017-09-07 | ジェネンテック, インコーポレイテッド | 治療用化合物及びその使用方法 |
| HK1252567A1 (zh) | 2015-05-22 | 2019-05-31 | 基因泰克公司 | 被取代的苯甲酰胺和其使用方法 |
| JP2018526371A (ja) | 2015-08-27 | 2018-09-13 | ジェネンテック, インコーポレイテッド | 治療化合物及びその使用方法 |
| PT3344248T (pt) * | 2015-09-02 | 2022-06-29 | Trevena Inc | Compostos moduladores do recetor opioide delta contendo aza-heterocíclicos de 6 membros, composições compreendendo os mesmos e seus usos |
| CA2999769A1 (en) | 2015-09-28 | 2017-04-06 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| BR112018007161B1 (pt) * | 2015-10-09 | 2024-01-16 | Galapagos Nv | COMPOSTOS PIRAZOLO[3,4-b]PIRIDIN-6-CARBOXAMIDA N-SULFONILADA, COMPOSIÇÃO FARMACÊUTICA CONTENDO OS DITOS COMPOSTOS E USOS DOS MESMOS PARA TRATAR FIBROSE CÍSTICA |
| US10316026B2 (en) | 2015-11-06 | 2019-06-11 | Daiichi Sankyo Company, Limited | Method for removing dimethoxybenzyl group |
| EP3380466A1 (en) | 2015-11-25 | 2018-10-03 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| AU2016370554B2 (en) | 2015-12-18 | 2018-11-29 | Merck Sharp & Dohme Corp. | Hydroxyalkylamine- and hydroxycycloalkylamine-substituted diamine-arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| EP3436432B1 (en) | 2016-03-30 | 2021-01-27 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| PL3458449T3 (pl) * | 2016-05-20 | 2025-06-23 | Xenon Pharmaceuticals Inc. | Związki benzenosulfonamidowe i ich zastosowanie jako środki terapeutyczne |
| PE20190980A1 (es) * | 2016-10-17 | 2019-07-09 | Genentech Inc | Compuestos terapeuticos y metodos para utilizarlos |
| US10836758B2 (en) * | 2016-10-27 | 2020-11-17 | Bristol-Myers Squibb Company | Acyl sulfonamide NaV1.7 inhibitors |
| CN110325531B (zh) * | 2016-12-09 | 2022-05-27 | 泽农医药公司 | 苯磺酰胺及其作为治疗剂的用途 |
| US11225487B2 (en) | 2017-02-17 | 2022-01-18 | Trevena, Inc. | 7-membered aza-heterocyclic containing δ-opioid receptor modulating compounds, methods of using and making the same |
| BR112019016827A2 (pt) | 2017-02-17 | 2020-04-07 | Trevena Inc | compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 5 membros, métodos de uso e produção dos mesmos |
| JP2020511511A (ja) | 2017-03-24 | 2020-04-16 | ジェネンテック, インコーポレイテッド | ナトリウムチャネル阻害剤としての4−ピペリジン−n−(ピリミジン−4−イル)クロマン−7−スルホンアミド誘導体 |
| AR114263A1 (es) | 2018-02-26 | 2020-08-12 | Genentech Inc | Compuestos terapéuticos y métodos para utilizarlos |
| US10947251B2 (en) | 2018-03-30 | 2021-03-16 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| US10745392B2 (en) * | 2018-06-13 | 2020-08-18 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| KR20210054510A (ko) | 2018-08-31 | 2021-05-13 | 제논 파마슈티칼스 인크. | 헤테로아릴-치환된 술폰아미드 화합물 및 치료제로서의 그의 용도 |
| MA53488A (fr) | 2018-08-31 | 2021-12-08 | Xenon Pharmaceuticals Inc | Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques |
| EP3891157A4 (en) | 2018-12-05 | 2022-08-31 | Merck Sharp & Dohme Corp. | 4-AMINO- OR 4-ALKOXY-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATE SODIUM CHANNELS |
| WO2020248123A1 (en) | 2019-06-11 | 2020-12-17 | Merck Sharp & Dohme Corp. | Hydroxypyrrolidine-substituted arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| JP2024529291A (ja) * | 2021-07-06 | 2024-08-06 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | ウイルス感染症の処置および予防のための組成物および方法 |
| US20260055083A1 (en) * | 2022-08-19 | 2026-02-26 | Maze Therapeutics, Inc. | Apol1 inhibitors and methods of use |
| US20250034108A1 (en) * | 2023-07-07 | 2025-01-30 | Novartis Ag | Sodium channel blockers |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3705185A (en) | 1969-04-14 | 1972-12-05 | Minnesota Mining & Mfg | N-aroyl sulfonamides |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| GB8524157D0 (en) | 1984-10-19 | 1985-11-06 | Ici America Inc | Heterocyclic amides |
| DK24089D0 (da) | 1989-01-20 | 1989-01-20 | Hans Bundgaard | Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups |
| GB8911854D0 (en) | 1989-05-23 | 1989-07-12 | Ici Plc | Heterocyclic compounds |
| IL101860A0 (en) | 1991-05-31 | 1992-12-30 | Ici Plc | Heterocyclic derivatives |
| FI952481A0 (fi) | 1992-11-23 | 1995-05-22 | Hoechst Roussel Pharma | Substituoituja 3-(aminoalkyyliamino)-1,2-bentsisoksatoleja ja niihin liittyviä yhdisteitä |
| US5573653A (en) | 1994-07-11 | 1996-11-12 | Sandoz Ltd. | Electrochemical process for thiocyanating aminobenzene compounds |
| HU221138B1 (en) | 1994-08-30 | 2002-08-28 | Sankyo Co | Condensed isoxazolyloxy- and -thioalkylamine derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
| US5753653A (en) | 1995-12-08 | 1998-05-19 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| EP0981327B1 (en) | 1997-05-07 | 2002-11-06 | Galen (Chemicals) Limited | Intravaginal drug delivery devices for the administration of testosterone and testosterone precursors |
| GB9828442D0 (en) | 1998-12-24 | 1999-02-17 | Karobio Ab | Novel thyroid receptor ligands and method II |
| KR100789567B1 (ko) | 2001-11-06 | 2007-12-28 | 동화약품공업주식회사 | 3-아미도-1,2-벤조이소옥사졸 유도체, 그 염, 제조방법 및 용도 |
| DE10201550A1 (de) | 2002-01-17 | 2003-07-31 | Merck Patent Gmbh | Phenoxy-Piperidine |
| ATE449099T1 (de) | 2002-08-08 | 2009-12-15 | Memory Pharm Corp | Derivate des 2-trifluormethyl-6-aminopurins als phosphodiesterase 4 inhibitoren |
| PE20040801A1 (es) | 2002-12-12 | 2004-11-25 | Hoffmann La Roche | Derivados de pirazina y piridina 5-sustituidos como activadores de glucoquinasa |
| WO2004092145A1 (en) | 2003-04-15 | 2004-10-28 | Pfizer Inc. | Alpha substituted carboxylic acid as ppar modulators |
| US8202861B2 (en) | 2003-08-08 | 2012-06-19 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of voltage-gated sodium channels |
| CN101643458A (zh) * | 2003-08-08 | 2010-02-10 | 沃泰克斯药物股份有限公司 | 在疼痛的治疗中用作钠或钙通道阻断剂的杂芳基氨基磺酰基苯基衍生物 |
| AU2004278030C1 (en) | 2003-10-03 | 2010-12-02 | Portola Pharmaceuticals, Inc. | 2,4-Dioxo-3-quinazolinylaryl sulfonylureas |
| US7081539B2 (en) | 2004-03-25 | 2006-07-25 | Dainippon Sumitomo Pharma Co., Ltd. | One-pot process for the preparation of 1,2-benzisoxazole-3-methanesulfonamide |
| EP1773792A1 (en) | 2004-07-30 | 2007-04-18 | Merck & Co., Inc. | Indanone potentiators of metabotropic glutamate receptors |
| WO2006020830A2 (en) | 2004-08-12 | 2006-02-23 | Amgen Inc. | Bisaryl-sulfonamides |
| CN101031565B (zh) | 2004-09-29 | 2010-09-29 | 博尔托拉制药公司 | 取代的2h-1,3-苯并噁嗪-4(3h)-酮 |
| JP2008189549A (ja) | 2005-05-12 | 2008-08-21 | Astellas Pharma Inc | カルボン酸誘導体またはその塩 |
| DE102005038947A1 (de) | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| US7632837B2 (en) | 2005-06-17 | 2009-12-15 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid-1 receptor modulators |
| EP1922311A2 (en) | 2005-09-09 | 2008-05-21 | Brystol-Myers Squibb Company | Acyclic ikur inhibitors |
| AU2006303367A1 (en) | 2005-10-19 | 2007-04-26 | F. Hoffmann-La Roche Ag | N-phenyl phenylacetamide non-nucleoside reverse transcriptase inihibitors |
| CA2630234A1 (en) | 2005-11-23 | 2007-05-31 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
| AR058296A1 (es) * | 2005-12-09 | 2008-01-30 | Kalypsys Inc | Inhibidores de histona desacetilasa y composicion farmaceutica |
| CA2648202A1 (en) | 2006-04-11 | 2007-10-25 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of voltage-gated sodium channels |
| EP2086973B1 (en) | 2006-10-11 | 2012-01-25 | Amgen Inc., | Imidazo- and triazolo-pyridine compounds and methods of use therof |
| EP2108019A2 (en) | 2007-01-30 | 2009-10-14 | Biogen Idec MA, Inc. | 1-h-pyrazolo[3,4b]pyrimidine derivatives and their use as modulators of mitotic kinases |
| AR065194A1 (es) | 2007-02-05 | 2009-05-20 | Xenon Pharmaceuticals Inc | Compuestos de piridopirimidinona de utilidad en el tratamiento de enfermedades o condiciones patologicas mediadas por los canales de sodio |
| JP5361857B2 (ja) | 2007-03-23 | 2013-12-04 | ファイザー・リミテッド | イオンチャネルの阻害剤 |
| AU2008256937A1 (en) | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| CN101679262A (zh) | 2007-06-07 | 2010-03-24 | 安斯泰来制药株式会社 | 吡啶酮化合物 |
| US20090012103A1 (en) | 2007-07-05 | 2009-01-08 | Matthew Abelman | Substituted heterocyclic compounds |
| WO2009010784A1 (en) | 2007-07-13 | 2009-01-22 | Astrazeneca Ab | New compounds 955 |
| CA2693588C (en) * | 2007-07-13 | 2015-11-17 | Icagen, Inc. | Sodium channel inhibitors |
| WO2009022730A1 (ja) * | 2007-08-10 | 2009-02-19 | Nippon Chemiphar Co., Ltd. | P2x4受容体拮抗剤 |
| GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
| CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| JP5304785B2 (ja) | 2008-06-23 | 2013-10-02 | アステラス製薬株式会社 | スルホンアミド化合物又はその塩 |
| WO2010022055A2 (en) | 2008-08-20 | 2010-02-25 | Amgen Inc. | Inhibitors of voltage-gated sodium channels |
| CN101653458A (zh) | 2008-08-22 | 2010-02-24 | 天津生机集团股份有限公司 | 一种提高种猪繁殖性能的微量元素组合物 |
| HUE025013T2 (hu) * | 2009-01-12 | 2016-04-28 | Pfizer Ltd | Szulfonamid-származékok |
| US8952034B2 (en) | 2009-07-27 | 2015-02-10 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
| WO2011016234A1 (en) | 2009-08-04 | 2011-02-10 | Raqualia Pharma Inc. | Picolinamide derivatives as ttx-s blockers |
| BR112012006686B8 (pt) | 2009-09-25 | 2021-05-25 | Astellas Pharma Inc | compostos de amida substituída, composições farmacêuticas contendo os ditos compostos, e uso dos mesmos para prevenir e/ou tratar doenças causadas pelo lpa |
| WO2011059042A1 (ja) | 2009-11-12 | 2011-05-19 | 武田薬品工業株式会社 | 芳香環化合物 |
| US8471034B2 (en) | 2009-11-18 | 2013-06-25 | Concert Pharmaceuticals, Inc. | Niacin prodrugs and deuterated versions thereof |
| TW201139406A (en) * | 2010-01-14 | 2011-11-16 | Glaxo Group Ltd | Voltage-gated sodium channel blockers |
| EP2533638B1 (en) | 2010-02-12 | 2016-02-10 | Nivalis Therapeutics, Inc. | Novel s-nitrosoglutathione reductase inhibitors |
| WO2011153588A1 (en) | 2010-06-10 | 2011-12-15 | Biota Scientific Management Pty Ltd | Viral polymerase inhibitors |
| WO2012005842A1 (en) | 2010-06-30 | 2012-01-12 | Cardiac Pacemakers, Inc. | Lead having coil electrode with preferential bending region |
| WO2012004664A2 (en) | 2010-07-07 | 2012-01-12 | Purdue Pharma L.P. | Analogs of sodium channel peptide toxin |
| WO2012004743A1 (en) * | 2010-07-09 | 2012-01-12 | Pfizer Limited | Benzenesulfonamides useful as sodium channel inhibitors |
| JP5872552B2 (ja) | 2010-07-09 | 2016-03-01 | ファイザー・リミテッドPfizer Limited | 化学化合物 |
| WO2012004714A2 (en) | 2010-07-09 | 2012-01-12 | Pfizer Limited | Chemical compounds |
| EP2593433B1 (en) | 2010-07-12 | 2014-11-26 | Pfizer Limited | N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels |
| JP2013532185A (ja) | 2010-07-12 | 2013-08-15 | ファイザー・リミテッド | 化合物 |
| JP2013532184A (ja) | 2010-07-12 | 2013-08-15 | ファイザー・リミテッド | 電位開口型ナトリウムチャネル阻害剤として有用なn−スルホニルベンズアミド誘導体 |
| US9102621B2 (en) | 2010-07-12 | 2015-08-11 | Pfizer Limited | Acyl sulfonamide compounds |
| ES2532357T3 (es) | 2010-07-12 | 2015-03-26 | Pfizer Limited | Derivados de sulfonamida como inhibidores de Nav1.7 para el tratamiento del dolor |
| JP2013531687A (ja) | 2010-07-16 | 2013-08-08 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としてのピリジン化合物 |
| CN103221408A (zh) | 2010-09-13 | 2013-07-24 | 诺瓦提斯公司 | 三嗪-*二唑类化合物 |
| WO2012039657A1 (en) | 2010-09-22 | 2012-03-29 | Astrazeneca Ab | Novel chromane compound for the treatment of pain disorders |
| CN103429571A (zh) | 2010-12-22 | 2013-12-04 | 普渡制药公司 | 作为钠通道阻断剂的取代吡啶 |
| WO2012095781A1 (en) | 2011-01-13 | 2012-07-19 | Pfizer Limited | Indazole derivatives as sodium channel inhibitors |
| MX355907B (es) | 2011-02-02 | 2018-05-04 | Vertex Pharma | Pirrolopirazina-piperidina espirociclica-amidas como moduladores de canales de ionicos. |
| MX2014001851A (es) | 2011-08-17 | 2014-10-24 | Amgen Inc | Inhibidores del canal de heteroarilo sodio. |
| WO2013056232A2 (en) | 2011-10-13 | 2013-04-18 | Case Western Reserve University | Rxr agonists compounds and methods |
| JP2014532660A (ja) | 2011-10-28 | 2014-12-08 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 電位作動型ナトリウムチャネルにおける選択活性を有するベンゾオキサゾリノン化合物 |
| JP6014155B2 (ja) | 2011-10-31 | 2016-10-25 | ゼノン・ファーマシューティカルズ・インコーポレイテッドXenon Pharmaceuticals Inc. | ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用 |
| RU2014121984A (ru) | 2011-10-31 | 2015-12-10 | Ксенон Фармасьютикалз Инк. | Бензолсульфонамидные соединения и их применение в качестве терапевтических средств |
| US9133131B2 (en) | 2011-11-15 | 2015-09-15 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
| EP2788332A1 (en) | 2011-12-07 | 2014-10-15 | Amgen, Inc. | Bicyclic aryl and heteroaryl sodium channel inhibitors |
| CA2857603C (en) | 2011-12-15 | 2016-08-02 | Pfizer Limited | Sulfonamide derivatives |
| US20150291514A1 (en) | 2012-01-04 | 2015-10-15 | Pfizer Limted | N-Aminosulfonyl Benzamides |
| JP2015083542A (ja) | 2012-02-08 | 2015-04-30 | 大日本住友製薬株式会社 | 3位置換プロリン誘導体 |
| US8889741B2 (en) * | 2012-02-09 | 2014-11-18 | Daiichi Sankyo Company, Limited | Cycloalkane derivatives |
| US9346798B2 (en) | 2012-02-13 | 2016-05-24 | Amgen Inc. | Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors |
| US9051311B2 (en) | 2012-03-09 | 2015-06-09 | Amgen Inc. | Sulfamide sodium channel inhibitors |
| WO2013146969A1 (ja) | 2012-03-29 | 2013-10-03 | 第一三共株式会社 | 新規二置換シクロヘキサン誘導体 |
| CN104718188B (zh) | 2012-05-22 | 2018-08-21 | 基因泰克公司 | N-取代的苯甲酰胺类及其在治疗疼痛中的用途 |
| KR101663436B1 (ko) | 2012-07-06 | 2016-10-06 | 제넨테크, 인크. | N-치환된 벤즈아미드 및 이의 사용 방법 |
| US9758480B2 (en) | 2012-07-19 | 2017-09-12 | Sumitomo Dainippon Pharma Co., Ltd. | 1-(cycloalkyl-carbonyl)proline derivative |
| EP2911668A4 (en) | 2012-10-26 | 2016-07-20 | Merck Sharp & Dohme | BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-CONTROLLED SODIUM CHANNELS |
| JP2015535252A (ja) | 2012-10-26 | 2015-12-10 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 電位作動型ナトリウムチャネルにおいて選択的活性を有するn−置換インダゾールスルホンアミド化合物 |
| WO2014096941A1 (en) | 2012-12-20 | 2014-06-26 | Purdue Pharma L.P. | Cyclic sulfonamides as sodium channel blockers |
| KR102295748B1 (ko) | 2013-01-31 | 2021-09-01 | 버텍스 파마슈티칼스 인코포레이티드 | 나트륨 채널의 조절제로서의 피리돈 아미드 |
| US20140296266A1 (en) | 2013-03-01 | 2014-10-02 | Gilead Sciences, Inc. | Therapeutic compounds |
| RU2015143906A (ru) | 2013-03-14 | 2017-04-18 | Дженентек, Инк. | Замещенные триазолопиридины и способы их применения |
| BR112015023397A2 (pt) | 2013-03-15 | 2017-07-18 | Genentech Inc | benzoxazois substituídos e métodos de uso dos mesmos |
| CA2900604A1 (en) | 2013-03-15 | 2014-09-25 | Chromocell Corporation | Sodium channel modulators for the treatment of pain |
| WO2015051043A1 (en) | 2013-10-01 | 2015-04-09 | Amgen Inc. | Biaryl acyl-sulfonamide compounds as sodium channel inhibitors |
| WO2015078374A1 (en) | 2013-11-27 | 2015-06-04 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
-
2012
- 2012-10-30 RU RU2014121984/04A patent/RU2014121984A/ru not_active Application Discontinuation
- 2012-10-30 KR KR1020147014213A patent/KR20140091022A/ko not_active Withdrawn
- 2012-10-30 JP JP2014537806A patent/JP6014154B2/ja not_active Expired - Fee Related
- 2012-10-30 CN CN201280065434.9A patent/CN104024251B/zh not_active Expired - Fee Related
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2635354C2 (ru) * | 2012-02-09 | 2017-11-13 | Дайити Санкио Компани, Лимитед | Циклоалкановое производное |
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| US9630929B2 (en) | 2017-04-25 |
| MX2014005297A (es) | 2014-09-11 |
| BR112014010271A2 (pt) | 2017-04-18 |
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| EP2773637B1 (en) | 2016-06-08 |
| JP2014532640A (ja) | 2014-12-08 |
| CA2853439A1 (en) | 2013-05-10 |
| KR20140091022A (ko) | 2014-07-18 |
| CN104024251B (zh) | 2017-08-11 |
| EP2773637A1 (en) | 2014-09-10 |
| WO2013064983A1 (en) | 2013-05-10 |
| CN104024251A (zh) | 2014-09-03 |
| JP6014154B2 (ja) | 2016-10-25 |
| ES2586213T3 (es) | 2016-10-13 |
| US20140296245A1 (en) | 2014-10-02 |
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