JP2004502670A5 - - Google Patents
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- Publication number
- JP2004502670A5 JP2004502670A5 JP2002507770A JP2002507770A JP2004502670A5 JP 2004502670 A5 JP2004502670 A5 JP 2004502670A5 JP 2002507770 A JP2002507770 A JP 2002507770A JP 2002507770 A JP2002507770 A JP 2002507770A JP 2004502670 A5 JP2004502670 A5 JP 2004502670A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- amino
- carbonyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 49
- 150000001875 compounds Chemical class 0.000 claims 35
- 150000003839 salts Chemical class 0.000 claims 29
- 229940002612 prodrug Drugs 0.000 claims 27
- 239000000651 prodrug Substances 0.000 claims 27
- 239000012453 solvate Substances 0.000 claims 26
- 125000003545 alkoxy group Chemical group 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 18
- 125000000623 heterocyclic group Chemical group 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- -1 piperidino, morpholino, piperazinyl Chemical group 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 206010057671 Female sexual dysfunction Diseases 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- FWXXCSISWQQOGS-UHFFFAOYSA-N uk-414,495 Chemical compound N=1N=C(CC)SC=1NC(=O)C1(CC(CCC)C(O)=O)CCCC1 FWXXCSISWQQOGS-UHFFFAOYSA-N 0.000 claims 2
- GQXPQLZHUYKTKG-SFHVURJKSA-N (2r)-2-[[1-[[2-(hydroxymethyl)-1,3-dihydroinden-2-yl]carbamoyl]cyclopentyl]methyl]-4-methoxybutanoic acid Chemical compound C1C2=CC=CC=C2CC1(CO)NC(=O)C1(C[C@H](CCOC)C(O)=O)CCCC1 GQXPQLZHUYKTKG-SFHVURJKSA-N 0.000 claims 1
- FWXXCSISWQQOGS-NSHDSACASA-N (2s)-2-[[1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl]pentanoic acid Chemical compound N=1N=C(CC)SC=1NC(=O)C1(C[C@H](CCC)C(O)=O)CCCC1 FWXXCSISWQQOGS-NSHDSACASA-N 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- FKASFBLJDCHBNZ-UHFFFAOYSA-N 1,3,4-oxadiazole Chemical compound C1=NN=CO1 FKASFBLJDCHBNZ-UHFFFAOYSA-N 0.000 claims 1
- MBIZXFATKUQOOA-UHFFFAOYSA-N 1,3,4-thiadiazole Chemical compound C1=NN=CS1 MBIZXFATKUQOOA-UHFFFAOYSA-N 0.000 claims 1
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 claims 1
- YZARWDCIOJWNOX-UHFFFAOYSA-N 2-[[1-[(1-benzyl-6-oxopyridin-3-yl)carbamoyl]cyclopentyl]methyl]-4-methoxybutanoic acid Chemical compound C1=CC(=O)N(CC=2C=CC=CC=2)C=C1NC(=O)C1(CC(CCOC)C(O)=O)CCCC1 YZARWDCIOJWNOX-UHFFFAOYSA-N 0.000 claims 1
- RHGOAASQRMLTGQ-UHFFFAOYSA-N 2-[[1-[(1-benzyl-6-oxopyridin-3-yl)carbamoyl]cyclopentyl]methyl]pentanoic acid Chemical compound C1=CC(=O)N(CC=2C=CC=CC=2)C=C1NC(=O)C1(CC(CCC)C(O)=O)CCCC1 RHGOAASQRMLTGQ-UHFFFAOYSA-N 0.000 claims 1
- KEKHBLUYFLCJEF-UHFFFAOYSA-N 2-[[1-[(3-benzylphenyl)carbamoyl]cyclopentyl]methyl]pentanoic acid Chemical compound C=1C=CC(CC=2C=CC=CC=2)=CC=1NC(=O)C1(CC(CCC)C(O)=O)CCCC1 KEKHBLUYFLCJEF-UHFFFAOYSA-N 0.000 claims 1
- LZQQBLZDXZIRRO-UHFFFAOYSA-N 2-[[1-[(4-butylpyridin-2-yl)carbamoyl]cyclopentyl]methyl]-4-methoxybutanoic acid Chemical compound CCCCC1=CC=NC(NC(=O)C2(CC(CCOC)C(O)=O)CCCC2)=C1 LZQQBLZDXZIRRO-UHFFFAOYSA-N 0.000 claims 1
- YMFSGRQEKSFORX-UHFFFAOYSA-N 2-[[1-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl]-4-methoxybutanoic acid Chemical compound N=1N=C(CC=2C=CC=CC=2)SC=1NC(=O)C1(CC(CCOC)C(O)=O)CCCC1 YMFSGRQEKSFORX-UHFFFAOYSA-N 0.000 claims 1
- IMMHCYKIUWIVAJ-UHFFFAOYSA-N 2-[[1-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl]-4-phenylbutanoic acid Chemical compound S1C(C)=NN=C1NC(=O)C1(CC(CCC=2C=CC=CC=2)C(O)=O)CCCC1 IMMHCYKIUWIVAJ-UHFFFAOYSA-N 0.000 claims 1
- LVCHSTCJUAYHML-MWSTZMHHSA-N 2-[[1-[[(1r,2s)-2-(4-chlorophenyl)cyclopropyl]carbamoyl]cyclopentyl]methyl]-3-methoxypropanoic acid Chemical compound N([C@H]1[C@@H](C1)C=1C=CC(Cl)=CC=1)C(=O)C1(CC(COC)C(O)=O)CCCC1 LVCHSTCJUAYHML-MWSTZMHHSA-N 0.000 claims 1
- GKOGEVNOPBAJCF-GCWMRRSQSA-N 2-[[1-[[(1r,3s,4r)-3-butyl-4-carbamoylcyclohexyl]carbamoyl]cyclopentyl]methyl]pentanoic acid Chemical compound C1C[C@@H](C(N)=O)[C@@H](CCCC)C[C@@H]1NC(=O)C1(CC(CCC)C(O)=O)CCCC1 GKOGEVNOPBAJCF-GCWMRRSQSA-N 0.000 claims 1
- GHCIIBWFGYESPY-UHFFFAOYSA-N 2-[[1-[[1-(hydroxymethyl)-3-phenylcyclopentyl]carbamoyl]cyclopentyl]methyl]-4-methoxybutanoic acid Chemical compound C1CC(C=2C=CC=CC=2)CC1(CO)NC(=O)C1(CC(CCOC)C(O)=O)CCCC1 GHCIIBWFGYESPY-UHFFFAOYSA-N 0.000 claims 1
- GQXPQLZHUYKTKG-UHFFFAOYSA-N 2-[[1-[[2-(hydroxymethyl)-1,3-dihydroinden-2-yl]carbamoyl]cyclopentyl]methyl]-4-methoxybutanoic acid Chemical compound C1C2=CC=CC=C2CC1(CO)NC(=O)C1(CC(CCOC)C(O)=O)CCCC1 GQXPQLZHUYKTKG-UHFFFAOYSA-N 0.000 claims 1
- RTDUGMHGFGCUBK-UHFFFAOYSA-N 2-[[1-[[2-(hydroxymethyl)-1,3-dihydroinden-2-yl]carbamoyl]cyclopentyl]methyl]-4-phenylbutanoic acid Chemical compound C1C2=CC=CC=C2CC1(CO)NC(=O)C1(CC(CCC=2C=CC=CC=2)C(O)=O)CCCC1 RTDUGMHGFGCUBK-UHFFFAOYSA-N 0.000 claims 1
- WRLJDWUKTUNXCU-UHFFFAOYSA-N 2-[[1-[[2-(hydroxymethyl)-1,3-dihydroinden-2-yl]carbamoyl]cyclopentyl]methyl]pentanoic acid Chemical compound C1C2=CC=CC=C2CC1(CO)NC(=O)C1(CC(CCC)C(O)=O)CCCC1 WRLJDWUKTUNXCU-UHFFFAOYSA-N 0.000 claims 1
- ICIYRQNWDGEKFO-UHFFFAOYSA-N 4-methoxy-2-[[1-[(4-phenylpyridin-2-yl)carbamoyl]cyclopentyl]methyl]butanoic acid Chemical compound C=1C(C=2C=CC=CC=2)=CC=NC=1NC(=O)C1(CC(CCOC)C(O)=O)CCCC1 ICIYRQNWDGEKFO-UHFFFAOYSA-N 0.000 claims 1
- BINPFDWVPOZRNS-PWZMFNOBSA-N 4-methoxy-2-[[1-[[(1r,2r)-2-pentylcyclopropyl]carbamoyl]cyclopentyl]methyl]butanoic acid Chemical compound CCCCC[C@@H]1C[C@H]1NC(=O)C1(CC(CCOC)C(O)=O)CCCC1 BINPFDWVPOZRNS-PWZMFNOBSA-N 0.000 claims 1
- WAFMGROHMCCENJ-NGFYBIIMSA-N 4-methoxy-2-[[1-[[(1r,2s)-2-(4-methoxyphenyl)cyclopropyl]carbamoyl]cyclopentyl]methyl]butanoic acid Chemical compound N([C@H]1[C@@H](C1)C=1C=CC(OC)=CC=1)C(=O)C1(CC(CCOC)C(O)=O)CCCC1 WAFMGROHMCCENJ-NGFYBIIMSA-N 0.000 claims 1
- JVVALULODDVILM-UQJFVLDMSA-N 4-methoxy-2-[[1-[[(1r,2s)-2-phenylcyclopropyl]carbamoyl]cyclopentyl]methyl]butanoic acid Chemical compound N([C@H]1[C@@H](C1)C=1C=CC=CC=1)C(=O)C1(CC(CCOC)C(O)=O)CCCC1 JVVALULODDVILM-UQJFVLDMSA-N 0.000 claims 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 102000003729 Neprilysin Human genes 0.000 claims 1
- 108090000028 Neprilysin Proteins 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000005236 alkanoylamino group Chemical group 0.000 claims 1
- 125000004171 alkoxy aryl group Chemical group 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 230000037007 arousal Effects 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- JKFAIQOWCVVSKC-UHFFFAOYSA-N furazan Chemical compound C=1C=NON=1 JKFAIQOWCVVSKC-UHFFFAOYSA-N 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims 1
- 125000005956 isoquinolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 150000003951 lactams Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229950009215 phenylbutanoic acid Drugs 0.000 claims 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims 1
- 125000005494 pyridonyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 230000004797 therapeutic response Effects 0.000 claims 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0016684A GB0016684D0 (en) | 2000-07-06 | 2000-07-06 | Pharmaceutical composition |
| GB0101584A GB0101584D0 (en) | 2001-01-22 | 2001-01-22 | Pharmaceutical composition |
| PCT/IB2001/001205 WO2002002513A1 (en) | 2000-07-06 | 2001-07-02 | Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004502670A JP2004502670A (ja) | 2004-01-29 |
| JP2004502670A5 true JP2004502670A5 (https=) | 2005-02-03 |
Family
ID=26244612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002507770A Pending JP2004502670A (ja) | 2000-07-06 | 2001-07-02 | 中性エンドペプチダーゼの阻害剤としてのシクロペンチル置換グルタルアミド誘導体 |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US20020052370A1 (https=) |
| EP (1) | EP1296938A1 (https=) |
| JP (1) | JP2004502670A (https=) |
| KR (1) | KR20030017611A (https=) |
| CN (1) | CN1438991A (https=) |
| AP (1) | AP2001002205A0 (https=) |
| AR (1) | AR029696A1 (https=) |
| AU (1) | AU2001267770A1 (https=) |
| BG (1) | BG107229A (https=) |
| BR (1) | BR0112370A (https=) |
| CA (1) | CA2414881A1 (https=) |
| CZ (1) | CZ20024167A3 (https=) |
| DO (1) | DOP2001000205A (https=) |
| EA (1) | EA200201071A1 (https=) |
| HN (1) | HN2001000145A (https=) |
| HR (1) | HRP20030007A2 (https=) |
| HU (1) | HUP0301683A3 (https=) |
| IL (1) | IL152784A0 (https=) |
| IS (1) | IS6601A (https=) |
| MA (1) | MA26925A1 (https=) |
| MX (1) | MXPA03000066A (https=) |
| NO (1) | NO20026262D0 (https=) |
| NZ (1) | NZ522368A (https=) |
| OA (1) | OA12303A (https=) |
| PA (1) | PA8521801A1 (https=) |
| PE (1) | PE20020145A1 (https=) |
| PL (1) | PL361699A1 (https=) |
| SK (1) | SK18182002A3 (https=) |
| SV (1) | SV2002000519A (https=) |
| TN (1) | TNSN01100A1 (https=) |
| UY (1) | UY26820A1 (https=) |
| WO (1) | WO2002002513A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL139457A0 (en) * | 1999-11-08 | 2001-11-25 | Pfizer | Compounds for the treatment of female sexual dysfunction |
| US20020065286A1 (en) * | 2000-08-21 | 2002-05-30 | Davies Michael John | Treatment of wounds |
| WO2002079143A1 (en) * | 2001-03-28 | 2002-10-10 | Pfizer Limited | N-phenpropylcyclopentyl-substituted glutaramide derivatives as nep inhibitors for fsad |
| US6660756B2 (en) | 2001-03-28 | 2003-12-09 | Pfizer Inc. | N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| TWI259079B (en) | 2002-02-08 | 2006-08-01 | Merck & Co Inc | N-biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives |
| US7091380B2 (en) | 2002-02-08 | 2006-08-15 | Merck & Co., Inc. | N-biphenylmethyl aminocycloalkanecarboxamide derivatives |
| MXPA04010780A (es) * | 2002-05-03 | 2005-03-07 | Warner Lambert Co | Antagonistas de bombesina. |
| AU2003267728A1 (en) * | 2002-10-18 | 2004-05-04 | Pfizer Products Inc. | Cannabinoid receptor ligands and uses thereof |
| GB0230036D0 (en) * | 2002-12-23 | 2003-01-29 | Pfizer Ltd | Novel pharmaceuticals |
| BRPI0411985A (pt) * | 2003-07-16 | 2006-08-29 | Pfizer | tratamento da disfunção sexual |
| US7649002B2 (en) | 2004-02-04 | 2010-01-19 | Pfizer Inc | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists |
| US20050267072A1 (en) * | 2004-05-14 | 2005-12-01 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction |
| US20050267124A1 (en) * | 2004-05-14 | 2005-12-01 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors |
| CN101087757B (zh) * | 2004-10-12 | 2013-01-02 | 格兰马克药品股份有限公司 | 二肽基肽酶ⅳ抑制剂、含有它们的药用组合物及其制备方法 |
| BRPI0516340A (pt) | 2004-10-12 | 2008-09-16 | Glenmark Pharmaceuticals Sa | composto, composição farmacêutica, método para tratar uma condição que é regulada ou normalizada via inibição de dpp-iv, método para tratar um distúrbio metabólico, método para tratar diabete tipo ii, método para diminuir glicose no sangue, método para tratamento e profilaxia de uma doença, método para tratar toleráncia não prejudicada a glicose insulino-resistente, método para a manufatura de uma composição farmacêutica e processo para a preparação de compostos |
| ES2646326T3 (es) | 2005-08-03 | 2017-12-13 | Sprout Pharmaceuticals, Inc. | Uso de flibanserina en el tratamiento de la obesidad |
| JP2009541443A (ja) | 2006-06-30 | 2009-11-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 尿失禁及び関連疾患の治療のためのフリバンセリン |
| CA2673076A1 (en) * | 2006-12-21 | 2008-07-03 | Abbott Laboratories | Process for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane carboxylates |
| CL2008002693A1 (es) | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad |
| CA2686480A1 (en) | 2008-12-15 | 2010-06-15 | Boehringer Ingelheim International Gmbh | New salts |
| CA2771568A1 (en) * | 2009-09-04 | 2011-03-10 | Novartis Ag | Heteroaryl compounds as kinase inhibitors |
| CA2789189A1 (en) * | 2010-03-10 | 2011-09-15 | Ingenium Pharmaceuticals Gmbh | Inhibitors of protein kinases |
| CN102985402B (zh) * | 2010-04-20 | 2015-04-29 | 罗马大学 | 反苯环丙胺衍生物作为组蛋白去甲基酶lsd1和/或lsd2的抑制剂 |
| NZ735398A (en) | 2015-02-13 | 2024-07-05 | Oxford Drug Design Ltd | Novel n-acyl-arylsulfonamide derivatives as aminoacyl-trna synthetase inhibitors |
| GB201617064D0 (en) | 2016-10-07 | 2016-11-23 | Inhibox Limited And Latvian Institute Of Organic Synthesis The | Compounds and their therapeutic use |
| AU2021268204A1 (en) | 2020-05-08 | 2022-12-08 | Psilera Inc. | Novel compositions of matter and pharmaceutical compositions |
| IL308816A (en) | 2021-05-25 | 2024-01-01 | Atai Therapeutics Inc | New n,n-dimethyltryptamine salts and crystalline salt forms |
| JP2024545787A (ja) | 2021-12-30 | 2024-12-11 | アタイ セラピューティクス， インコーポレイテッド | 一酸化窒素送達剤としてのジメチルトリプタミン類似体 |
| TW202430149A (zh) * | 2022-12-01 | 2024-08-01 | 美商雅特益醫療公司 | Ｎ，ｎ－二甲基色胺之結晶形式及其使用方法 |
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| US5389610A (en) * | 1989-11-21 | 1995-02-14 | Schering Corporation | Carboxyalkylcarbonyl aminoacid endopeptidase inhibitors |
| GB9000725D0 (en) * | 1990-01-12 | 1990-03-14 | Pfizer Ltd | Therapeutic agents |
| DE19510566A1 (de) * | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US6486207B2 (en) * | 1998-12-10 | 2002-11-26 | Nexmed (Holdings), Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
| IL139457A0 (en) * | 1999-11-08 | 2001-11-25 | Pfizer | Compounds for the treatment of female sexual dysfunction |
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2001
- 2001-06-28 US US09/893,585 patent/US20020052370A1/en not_active Abandoned
- 2001-07-02 HU HU0301683A patent/HUP0301683A3/hu unknown
- 2001-07-02 OA OA1200200396A patent/OA12303A/en unknown
- 2001-07-02 PL PL36169901A patent/PL361699A1/xx not_active Application Discontinuation
- 2001-07-02 MX MXPA03000066A patent/MXPA03000066A/es unknown
- 2001-07-02 KR KR10-2003-7000162A patent/KR20030017611A/ko not_active Ceased
- 2001-07-02 SK SK1818-2002A patent/SK18182002A3/sk unknown
- 2001-07-02 BR BR0112370-0A patent/BR0112370A/pt not_active IP Right Cessation
- 2001-07-02 AU AU2001267770A patent/AU2001267770A1/en not_active Abandoned
- 2001-07-02 CZ CZ20024167A patent/CZ20024167A3/cs unknown
- 2001-07-02 AP APAP/P/2001/002205A patent/AP2001002205A0/en unknown
- 2001-07-02 NZ NZ522368A patent/NZ522368A/xx unknown
- 2001-07-02 HR HR20030007A patent/HRP20030007A2/xx not_active Application Discontinuation
- 2001-07-02 CA CA002414881A patent/CA2414881A1/en not_active Abandoned
- 2001-07-02 CN CN01811677A patent/CN1438991A/zh active Pending
- 2001-07-02 JP JP2002507770A patent/JP2004502670A/ja active Pending
- 2001-07-02 IL IL15278401A patent/IL152784A0/xx unknown
- 2001-07-02 EP EP01945557A patent/EP1296938A1/en not_active Withdrawn
- 2001-07-02 EA EA200201071A patent/EA200201071A1/ru unknown
- 2001-07-02 WO PCT/IB2001/001205 patent/WO2002002513A1/en not_active Ceased
- 2001-07-04 HN HN2001000145A patent/HN2001000145A/es unknown
- 2001-07-04 DO DO2001000205A patent/DOP2001000205A/es unknown
- 2001-07-04 PE PE2001000662A patent/PE20020145A1/es not_active Application Discontinuation
- 2001-07-05 PA PA20018521801A patent/PA8521801A1/es unknown
- 2001-07-05 AR ARP010103212A patent/AR029696A1/es not_active Application Discontinuation
- 2001-07-05 SV SV2001000519A patent/SV2002000519A/es not_active Application Discontinuation
- 2001-07-05 TN TNTNSN01100A patent/TNSN01100A1/fr unknown
- 2001-07-06 UY UY26820A patent/UY26820A1/es not_active Application Discontinuation
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2002
- 2002-10-29 IS IS6601A patent/IS6601A/is unknown
- 2002-10-29 BG BG107229A patent/BG107229A/bg unknown
- 2002-12-27 NO NO20026262A patent/NO20026262D0/no not_active Application Discontinuation
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2003
- 2003-01-02 MA MA26988A patent/MA26925A1/fr unknown
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