PT2616465E - Triazino-oxadiazoles - Google Patents
Triazino-oxadiazoles Download PDFInfo
- Publication number
- PT2616465E PT2616465E PT117572941T PT11757294T PT2616465E PT 2616465 E PT2616465 E PT 2616465E PT 117572941 T PT117572941 T PT 117572941T PT 11757294 T PT11757294 T PT 11757294T PT 2616465 E PT2616465 E PT 2616465E
- Authority
- PT
- Portugal
- Prior art keywords
- oxadiazoles
- triazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38215810P | 2010-09-13 | 2010-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2616465E true PT2616465E (pt) | 2016-03-09 |
Family
ID=44651777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT117572941T PT2616465E (pt) | 2010-09-13 | 2011-09-13 | Triazino-oxadiazoles |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8895733B2 (pt) |
| EP (1) | EP2616465B1 (pt) |
| JP (1) | JP2013537180A (pt) |
| KR (1) | KR101843600B1 (pt) |
| CN (1) | CN103221408A (pt) |
| AU (1) | AU2011303978B2 (pt) |
| BR (1) | BR112013005889A2 (pt) |
| CA (1) | CA2812081A1 (pt) |
| CL (1) | CL2013000685A1 (pt) |
| CO (1) | CO6690768A2 (pt) |
| CR (1) | CR20130111A (pt) |
| CU (1) | CU20130036A7 (pt) |
| DK (1) | DK2616465T3 (pt) |
| EA (1) | EA026132B1 (pt) |
| ES (1) | ES2559449T3 (pt) |
| HR (1) | HRP20160094T1 (pt) |
| HU (1) | HUE027256T2 (pt) |
| MX (1) | MX2013002864A (pt) |
| NZ (1) | NZ608116A (pt) |
| PE (1) | PE20131377A1 (pt) |
| PL (1) | PL2616465T3 (pt) |
| PT (1) | PT2616465E (pt) |
| RS (1) | RS54544B1 (pt) |
| SG (1) | SG188438A1 (pt) |
| SI (1) | SI2616465T1 (pt) |
| WO (1) | WO2012035023A1 (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103221408A (zh) * | 2010-09-13 | 2013-07-24 | 诺瓦提斯公司 | 三嗪-*二唑类化合物 |
| CA2855019A1 (en) | 2011-10-31 | 2013-05-10 | Xenon Pharmaceuticals Inc. | Biaryl ether sulfonamides and their use as therapeutic agents |
| WO2013064983A1 (en) | 2011-10-31 | 2013-05-10 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| IN2014MN02574A (pt) | 2012-05-22 | 2015-07-24 | Genentech Inc | |
| WO2014008458A2 (en) | 2012-07-06 | 2014-01-09 | Genentech, Inc. | N-substituted benzamides and methods of use thereof |
| EA035349B1 (ru) | 2012-11-21 | 2020-05-29 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | ЗАМЕЩЕННЫЕ ПИРИМИДИНОВЫЕ ОБРАТНЫЕ ИНГИБИТОРЫ Bmi-1 |
| BR112015022488A2 (pt) | 2013-03-14 | 2017-07-18 | Genentech Inc | triazolopiridinas substituídas e métodos de uso das mesmas |
| WO2014144545A2 (en) | 2013-03-15 | 2014-09-18 | Genentech, Inc. | Substituted benzoxazoles and methods of use thereof |
| TWI692477B (zh) | 2013-08-30 | 2020-05-01 | 美商Ｐｔｃ治療公司 | 經取代嘧啶ｂｍｉ-１抑制劑 |
| US9975878B2 (en) | 2013-11-21 | 2018-05-22 | Ptc Therapeutics, Inc. | Substituted triazine BMI-1 inhibitors |
| EP3071553A4 (en) | 2013-11-21 | 2017-08-02 | PTC Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
| EA201691085A1 (ru) | 2013-11-27 | 2017-02-28 | Дженентек, Инк. | Замещенные бензамиды и способы их применения |
| WO2016007534A1 (en) | 2014-07-07 | 2016-01-14 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| NZ737536A (en) | 2015-05-22 | 2019-04-26 | Genentech Inc | Substituted benzamides and methods of use thereof |
| EP3341353A1 (en) | 2015-08-27 | 2018-07-04 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| SG10202007787RA (en) | 2015-09-28 | 2020-09-29 | Genentech Inc | Therapeutic compounds and methods of use thereof |
| WO2017091592A1 (en) | 2015-11-25 | 2017-06-01 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| EP3854782A1 (en) | 2016-03-30 | 2021-07-28 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| JOP20190072A1 (ar) * | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| CR20190236A (es) | 2016-10-17 | 2019-09-09 | Genentech Inc | Compuestos terapéuticos y métodos para utilizarlos |
| CN110099898B (zh) * | 2016-10-24 | 2023-07-25 | 优曼尼蒂治疗公司 | 化合物及其用途 |
| EP3601273B1 (en) | 2017-03-24 | 2021-12-01 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
| EP3700934A4 (en) | 2017-10-24 | 2021-10-27 | Yumanity Therapeutics, Inc. | COMPOUNDS AND USES OF THESE COMPOUNDS |
| AU2018388404B2 (en) | 2017-12-22 | 2023-11-02 | HiberCell Inc. | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| EP3759098A1 (en) | 2018-02-26 | 2021-01-06 | Genentech, Inc. | Pyridine-sulfonamide compounds and their use against pain and related conditions |
| JP2021519788A (ja) | 2018-03-30 | 2021-08-12 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ナトリウムチャネル阻害剤としての縮合環ヒドロピリド化合物 |
| WO2021195360A1 (en) * | 2020-03-27 | 2021-09-30 | Landos Biopharma, Inc. | Plxdc2 ligands |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
| US6274620B1 (en) | 1999-06-07 | 2001-08-14 | Biochem Pharma Inc. | Thiophene integrin inhibitors |
| US7205298B2 (en) | 2002-07-18 | 2007-04-17 | Janssen Pharmaceutica N.V. | Substituted triazine kinase inhibitors |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| AU2004253962A1 (en) * | 2003-07-02 | 2005-01-13 | Vertex Pharmaceuticals Incorporated | Pyrimidines useful as modulators of voltage-gated ion channels |
| WO2007109324A2 (en) | 2006-03-21 | 2007-09-27 | Xenon Pharmaceuticals, Inc. | Potent and selective nav 1.7 sodium channel blockers |
| US20080227799A1 (en) | 2006-07-11 | 2008-09-18 | Liotta Dennis C | CXCR4 Antagonists Including Heteroatoms for the Treatment of Medical Disorders |
| AU2008256937A1 (en) * | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| BRPI0813212A2 (pt) | 2007-06-26 | 2014-12-23 | Lexicon Pharmaceuticals Inc | Métodos de tratamento de doenças e distúrbios mediados por serotonina |
| TW200911766A (en) * | 2007-07-13 | 2009-03-16 | Astrazeneca Ab | New compounds |
| US20120009151A1 (en) | 2007-12-21 | 2012-01-12 | Progenics Pharmaceuticals, Inc. | Triazines And Related Compounds Having Antiviral Activity, Compositions And Methods Thereof |
| GB0805477D0 (en) | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
| US8236880B2 (en) | 2008-04-23 | 2012-08-07 | Taylor Made Golf Company, Inc. | Compositions comprising an amino triazine and ionomer or ionomer precursor |
| WO2010017368A2 (en) | 2008-08-06 | 2010-02-11 | Hydra Biosciences, Inc. | Methods and compositions for treating anxiety |
| WO2010022055A2 (en) | 2008-08-20 | 2010-02-25 | Amgen Inc. | Inhibitors of voltage-gated sodium channels |
| MX2012009561A (es) * | 2010-02-17 | 2012-11-23 | Amgen Inc | Carboxamidas como inhibidores de canales de sodio dependientes del voltaje. |
| CN103221408A (zh) * | 2010-09-13 | 2013-07-24 | 诺瓦提斯公司 | 三嗪-*二唑类化合物 |
-
2011
- 2011-09-13 CN CN2011800544823A patent/CN103221408A/zh active Pending
- 2011-09-13 SG SG2013016829A patent/SG188438A1/en unknown
- 2011-09-13 AU AU2011303978A patent/AU2011303978B2/en not_active Ceased
- 2011-09-13 ES ES11757294.1T patent/ES2559449T3/es active Active
- 2011-09-13 DK DK11757294.1T patent/DK2616465T3/da active
- 2011-09-13 SI SI201130707T patent/SI2616465T1/sl unknown
- 2011-09-13 EA EA201390381A patent/EA026132B1/ru not_active IP Right Cessation
- 2011-09-13 PE PE2013000506A patent/PE20131377A1/es not_active Application Discontinuation
- 2011-09-13 HU HUE11757294A patent/HUE027256T2/en unknown
- 2011-09-13 PL PL11757294T patent/PL2616465T3/pl unknown
- 2011-09-13 MX MX2013002864A patent/MX2013002864A/es not_active Application Discontinuation
- 2011-09-13 BR BR112013005889-7A patent/BR112013005889A2/pt not_active IP Right Cessation
- 2011-09-13 RS RS20160045A patent/RS54544B1/en unknown
- 2011-09-13 JP JP2013527645A patent/JP2013537180A/ja active Pending
- 2011-09-13 CA CA2812081A patent/CA2812081A1/en not_active Abandoned
- 2011-09-13 KR KR1020137009331A patent/KR101843600B1/ko active IP Right Grant
- 2011-09-13 WO PCT/EP2011/065868 patent/WO2012035023A1/en active Application Filing
- 2011-09-13 PT PT117572941T patent/PT2616465E/pt unknown
- 2011-09-13 EP EP11757294.1A patent/EP2616465B1/en active Active
- 2011-09-13 NZ NZ608116A patent/NZ608116A/en not_active IP Right Cessation
-
2013
- 2013-03-13 CU CU2013000036A patent/CU20130036A7/es unknown
- 2013-03-13 CR CR20130111A patent/CR20130111A/es unknown
- 2013-03-13 CL CL2013000685A patent/CL2013000685A1/es unknown
- 2013-03-13 CO CO13050505A patent/CO6690768A2/es unknown
- 2013-10-15 US US14/054,221 patent/US8895733B2/en not_active Expired - Fee Related
-
2014
- 2014-10-08 US US14/509,705 patent/US20150025057A1/en not_active Abandoned
-
2016
- 2016-01-27 HR HRP20160094TT patent/HRP20160094T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2013002864A (es) | 2013-08-29 |
| US20150025057A1 (en) | 2015-01-22 |
| DK2616465T3 (da) | 2016-02-01 |
| CU20130036A7 (es) | 2013-05-31 |
| PL2616465T3 (pl) | 2016-04-29 |
| CN103221408A (zh) | 2013-07-24 |
| ES2559449T3 (es) | 2016-02-12 |
| EP2616465A1 (en) | 2013-07-24 |
| CR20130111A (es) | 2013-05-29 |
| US20140051676A1 (en) | 2014-02-20 |
| NZ608116A (en) | 2014-05-30 |
| HUE027256T2 (en) | 2016-08-29 |
| PE20131377A1 (es) | 2013-11-30 |
| SI2616465T1 (sl) | 2016-02-29 |
| AU2011303978B2 (en) | 2014-07-03 |
| KR20130105657A (ko) | 2013-09-25 |
| KR101843600B1 (ko) | 2018-03-29 |
| CO6690768A2 (es) | 2013-06-17 |
| RS54544B1 (en) | 2016-06-30 |
| WO2012035023A1 (en) | 2012-03-22 |
| JP2013537180A (ja) | 2013-09-30 |
| EA026132B1 (ru) | 2017-03-31 |
| CA2812081A1 (en) | 2012-03-22 |
| AU2011303978A1 (en) | 2013-03-21 |
| CL2013000685A1 (es) | 2013-10-04 |
| BR112013005889A2 (pt) | 2020-08-25 |
| SG188438A1 (en) | 2013-05-31 |
| EP2616465B1 (en) | 2015-11-04 |
| HRP20160094T1 (hr) | 2016-02-26 |
| US8895733B2 (en) | 2014-11-25 |
| EA201390381A1 (ru) | 2013-08-30 |
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