MA53488A - Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques - Google Patents
Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiquesInfo
- Publication number
- MA53488A MA53488A MA053488A MA53488A MA53488A MA 53488 A MA53488 A MA 53488A MA 053488 A MA053488 A MA 053488A MA 53488 A MA53488 A MA 53488A MA 53488 A MA53488 A MA 53488A
- Authority
- MA
- Morocco
- Prior art keywords
- sodium channel
- channel blockers
- heteroaryl substituted
- sulphonamide compounds
- substituted sulphonamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/16—Halogenated acetic acids
- C07C53/18—Halogenated acetic acids containing fluorine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862725960P | 2018-08-31 | 2018-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA53488A true MA53488A (fr) | 2021-12-08 |
Family
ID=67953871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA053488A MA53488A (fr) | 2018-08-31 | 2019-08-29 | Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10752623B2 (fr) |
| EP (1) | EP3844158A1 (fr) |
| JP (1) | JP7383012B2 (fr) |
| CN (1) | CN112638898B (fr) |
| CA (1) | CA3104913A1 (fr) |
| MA (1) | MA53488A (fr) |
| WO (1) | WO2020047312A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018073849A2 (pt) | 2016-05-20 | 2019-02-26 | Xenon Pharmaceuticals Inc. | compostos benzenossulfonamida e seu uso como agentes terapêuticos |
| CA3042004A1 (fr) | 2016-12-09 | 2018-06-14 | Xenon Pharmaceuticals Inc. | Composes de benzenesulfonamide et leur utilisation en tant qu'agents therapeutiques |
| PE20211389A1 (es) | 2018-06-13 | 2021-07-27 | Xenon Pharmaceuticals Inc | Compuestos de bencenosulfonamida y su uso como agentes terapeuticos |
| JOP20200337A1 (ar) | 2018-08-31 | 2020-12-24 | Xenon Pharmaceuticals Inc | مركبات سولفوناميد بها استبدال بأريل غير متجانس واستخدامها كعوامل علاجية |
Family Cites Families (61)
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| US5877193A (en) | 1996-07-19 | 1999-03-02 | Hoffmann-La Roche Inc. | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides |
| US6416780B1 (en) | 1997-05-07 | 2002-07-09 | Galen (Chemicals) Limited | Intravaginal drug delivery devices for the administration of testosterone and testosterone precursors |
| DE69928286T2 (de) | 1999-01-13 | 2006-07-13 | Warner-Lambert Co. Llc | Benzenesulfonamid-derivative und ihre verwendung als mek-inhibitoren |
| IL147618A0 (en) | 1999-07-16 | 2002-08-14 | Warner Lambert Co | Method for treating chronic pain using mek inhibitors |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| FR2836917B1 (fr) | 2002-03-11 | 2006-02-24 | Lipha | Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif |
| KR101116627B1 (ko) | 2002-06-27 | 2012-10-09 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
| WO2004092123A2 (fr) | 2003-04-10 | 2004-10-28 | Microbia, Inc. | Inhibiteurs d'invasion fongique |
| WO2005000309A2 (fr) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Composes chimiques |
| US7538135B2 (en) | 2003-07-08 | 2009-05-26 | Novartis Ag | Benzenesulfonylamino compounds and pharmaceutical compositions containing these compounds |
| PE20050358A1 (es) | 2003-08-08 | 2005-05-16 | Vertex Pharma | Composiciones referidas a inhibidores de canales ionicos regulados por voltaje |
| ZA200601942B (en) * | 2003-08-08 | 2007-05-30 | Vertex Pharma | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain |
| HU227684B1 (en) | 2003-08-29 | 2011-11-28 | Sanofi Aventis | Adamantane and azabicyclo-octane and nonane derivatives and their use as dpp-iv inhibitors |
| WO2006066109A2 (fr) | 2004-12-17 | 2006-06-22 | Takeda San Diego, Inc. | Inhibiteurs des hydroxysteroides deshydrogenases |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| AU2006299085A1 (en) | 2005-10-06 | 2007-04-12 | Sanofi-Aventis | 4-oxy-N-[1 ,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals |
| CA2633653A1 (fr) | 2005-12-21 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Derives heterocycliques utilises comme modulateurs de canaux ioniques |
| EP2054385A2 (fr) | 2006-08-15 | 2009-05-06 | F. Hoffmann-Roche AG | Dérivés phényliques, de la pyridine et de la quinoléine |
| EP2078018B1 (fr) | 2006-10-19 | 2012-03-14 | Signal Pharmaceuticals LLC | Composés hétéroaryle, compositions de ceux-ci et utilisation de ceux-ci comme inhibiteurs de protéines kinases |
| CA2693588C (fr) | 2007-07-13 | 2015-11-17 | Icagen, Inc. | Inhibiteurs des canaux sodiques |
| US8853250B2 (en) | 2007-07-13 | 2014-10-07 | Icagen, Inc. | Sodium channel inhibitors |
| WO2009013171A2 (fr) | 2007-07-24 | 2009-01-29 | F. Hoffmann-La Roche Ag | Composés antiviraux hétérocycliques |
| AU2008310660A1 (en) * | 2007-10-11 | 2009-04-16 | Vertex Pharmaceuticals Incorporated | Heteroaryl amides useful as inhibitors of voltage-gated sodium channels |
| MX2010014571A (es) | 2008-06-25 | 2011-03-25 | Daiichi Sankyo Co Ltd | Compuestos de acido carboxilico. |
| KR20110025855A (ko) | 2008-07-01 | 2011-03-11 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널의 조절제로서의 헤테로사이클릭 유도체 |
| GB0815947D0 (en) | 2008-09-02 | 2008-10-08 | Univ Dundee | Compounds |
| WO2010029300A1 (fr) | 2008-09-12 | 2010-03-18 | Biolipox Ab | Composés bis-aromatiques pour utilisation dans le traitement de l’inflammation |
| WO2010079443A1 (fr) | 2009-01-12 | 2010-07-15 | Pfizer Limited | Dérivés sulfonamides |
| CA2804593C (fr) | 2010-07-09 | 2015-11-24 | Pfizer Limited | Derives de biphenyloxybenzensulphonamide utiles en tant qu'inhibiteurs du canal sodique |
| KR101541086B1 (ko) | 2010-08-20 | 2015-08-03 | 허치슨 메디파르마 리미티드 | 피롤로피리미딘 화합물 및 그 용도 |
| MX2014001851A (es) | 2011-08-17 | 2014-10-24 | Amgen Inc | Inhibidores del canal de heteroarilo sodio. |
| KR20140095067A (ko) | 2011-10-28 | 2014-07-31 | 머크 샤프 앤드 돔 코포레이션 | 전압-게이팅 나트륨 채널에서의 선택적 활성을 갖는 벤족사졸리논 화합물 |
| RU2014121984A (ru) * | 2011-10-31 | 2015-12-10 | Ксенон Фармасьютикалз Инк. | Бензолсульфонамидные соединения и их применение в качестве терапевтических средств |
| MX2014005304A (es) | 2011-10-31 | 2015-03-20 | Xenon Pharmaceuticals Inc | Biaril eter sulfonamidas y su uso como agentes terapeuticos. |
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| WO2013122897A1 (fr) | 2012-02-13 | 2013-08-22 | Amgen Inc. | Inhibiteurs des canaux sodiques de type dihydrobenzoxazine et tétrahydroquinoxaline |
| AU2013266398A1 (en) * | 2012-05-22 | 2015-01-22 | Genentech, Inc. | N-substituted benzamides and their use in the treatment of pain |
| CA2887845C (fr) | 2012-10-15 | 2020-12-15 | Daewoong Pharmaceutical Co., Ltd. | Bloqueurs de canal sodique, leur procede de preparation et leur utilisation |
| BR112015008987A2 (pt) | 2012-10-26 | 2017-07-04 | Merck Sharp & Dohme | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de uma composição farmacêutica |
| AU2013334663A1 (en) | 2012-10-26 | 2015-05-07 | Merck Sharp & Dohme Corp. | Benzoxazolinone compounds with selective activity in voltage-gated sodium channels |
| TW201443025A (zh) | 2013-04-19 | 2014-11-16 | Pfizer Ltd | 化學化合物 |
| TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
| WO2014201173A1 (fr) | 2013-06-12 | 2014-12-18 | Amgen Inc. | Composés de sulfonamide bicycliques utilisés en tant qu'inhibiteurs des canaux sodiques |
| GB201310542D0 (en) | 2013-06-13 | 2013-07-31 | Antabio Sas | Compounds |
| US9663469B2 (en) | 2013-09-09 | 2017-05-30 | Bristol-Myers Squibb Company | RORγ modulators |
| ES2687598T3 (es) | 2013-09-10 | 2018-10-26 | Chromocell Corporation | Moduladores del canal de sodio para el tratamiento del dolor y la diabetes |
| WO2015077905A1 (fr) | 2013-11-29 | 2015-06-04 | Merck Sharp & Dohme Corp. | Composés de benzènesulfonamide à substitution bicycloamine ayant une activité sélective dans les canaux sodiques sensibles à la tension |
| WO2015099841A1 (fr) | 2013-12-23 | 2015-07-02 | Purdue Pharma L.P. | Indazoles et leur utilisation |
| EP3110794A1 (fr) * | 2014-02-27 | 2017-01-04 | Merck Patent GmbH | Composés hétérocycliques en tant qu'inhibiteurs du canal nav, et leurs utilisations |
| LT3203840T (lt) * | 2014-10-06 | 2020-10-26 | Vertex Pharmaceuticals Incorporated | Cistinės fibrozės transmembraninio laidumo reguliatoriaus moduliatoriai |
| KR102412146B1 (ko) * | 2015-02-11 | 2022-06-22 | 주식회사 아이엔테라퓨틱스 | 소디움 채널 차단제 |
| WO2016177340A1 (fr) | 2015-05-05 | 2016-11-10 | 上海海雁医药科技有限公司 | Dérivé de benzènesulfonamide substitué bicyclique, et procédé de préparation et utilisation pharmaceutique de celui-ci |
| KR20180096683A (ko) | 2015-12-18 | 2018-08-29 | 머크 샤프 앤드 돔 코포레이션 | 전압-게이팅 나트륨 채널에서 선택적 활성을 갖는 디아미노-알킬아미노-연결 아릴술폰아미드 화합물 |
| BR112018073849A2 (pt) * | 2016-05-20 | 2019-02-26 | Xenon Pharmaceuticals Inc. | compostos benzenossulfonamida e seu uso como agentes terapêuticos |
| US10668067B2 (en) | 2016-07-20 | 2020-06-02 | Amgen Inc. | Pyridine sulfonamides |
| TW201811766A (zh) * | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
| WO2018093694A1 (fr) | 2016-11-17 | 2018-05-24 | Merck Sharp & Dohme Corp. | Composés d'arylsulfonamide à liaisons diamino-alkylamino présentant une activité sélective dans les canaux sodiques sensibles à la tension |
| CA3042004A1 (fr) | 2016-12-09 | 2018-06-14 | Xenon Pharmaceuticals Inc. | Composes de benzenesulfonamide et leur utilisation en tant qu'agents therapeutiques |
| MA53329A (fr) * | 2018-07-27 | 2022-03-02 | Xenon Pharmaceuticals Inc | Méthodes de traitement de l'épilepsie |
-
2019
- 2019-08-29 US US16/555,983 patent/US10752623B2/en active Active
- 2019-08-29 MA MA053488A patent/MA53488A/fr unknown
- 2019-08-29 CN CN201980056968.7A patent/CN112638898B/zh active Active
- 2019-08-29 CA CA3104913A patent/CA3104913A1/fr active Pending
- 2019-08-29 JP JP2021510446A patent/JP7383012B2/ja active Active
- 2019-08-29 EP EP19768958.1A patent/EP3844158A1/fr active Pending
- 2019-08-29 WO PCT/US2019/048900 patent/WO2020047312A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US10752623B2 (en) | 2020-08-25 |
| CN112638898A (zh) | 2021-04-09 |
| CA3104913A1 (fr) | 2020-03-05 |
| JP7383012B2 (ja) | 2023-11-17 |
| WO2020047312A1 (fr) | 2020-03-05 |
| JP2021535137A (ja) | 2021-12-16 |
| CN112638898B (zh) | 2024-04-09 |
| EP3844158A1 (fr) | 2021-07-07 |
| US20200071313A1 (en) | 2020-03-05 |
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