RU2014118741A - Композиции для лечения ревматоидного артрита и способы их применения - Google Patents
Композиции для лечения ревматоидного артрита и способы их применения Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract 28
- 206010039073 rheumatoid arthritis Diseases 0.000 title claims abstract 7
- 239000000203 mixture Substances 0.000 title 1
- 229950006348 sarilumab Drugs 0.000 claims abstract 16
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims abstract 12
- 229960000485 methotrexate Drugs 0.000 claims abstract 12
- 239000005557 antagonist Substances 0.000 claims abstract 9
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 claims abstract 8
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 claims abstract 8
- 229960004171 hydroxychloroquine Drugs 0.000 claims abstract 8
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 claims abstract 8
- 229960000681 leflunomide Drugs 0.000 claims abstract 8
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 claims abstract 8
- 229960001940 sulfasalazine Drugs 0.000 claims abstract 8
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 claims abstract 8
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims abstract 7
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims abstract 7
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims abstract 7
- 201000010099 disease Diseases 0.000 claims abstract 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108010008165 Etanercept Proteins 0.000 claims 1
- 229960002964 adalimumab Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960000403 etanercept Drugs 0.000 claims 1
- 229960001743 golimumab Drugs 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
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Abstract
1. Способ лечения ревматоидного артрита у пациента, получавшего ранее лечение метотрексатом, лефлуномидом, сульфасалазином и/или гидроксихлорохином, включающий введение пациенту эффективного количества сарилумаба (SAR153191), где сарилумаб вводят в дозе 150 мг раз в две недели или 200 мг раз в две недели.2. Способ по п. 1, где пациента ранее неэффективно лечили от ревматоидного артрита путем введения метотрексата, лефлуномида, сульфасалазина и/или гидроксихлорохина.3. Способ по п. 2, где метотрексат, лефлуномид, сульфасалазин и/или гидроксихлорохин вводят вместе с сарилумабом.4. Способ по п. 3, где сарилумаб и метотрексат вводят вместе.5. Способ по п. 4, где метотрексат вводят в дозе от 6 до 25 мг в неделю.6. Способ по п. 1, где сарилумаб вводят в дозе 150 мг раз в две недели.7. Способ по п. 1, где сарилумаб вводят в дозе 200 мг раз в две недели.8. Способ по п. 1, где пациент достигает 20%-ного улучшения по критериям основного заболевания Американской Коллегии ревматологов после 12 недель лечения.9. Способ по п. 1, где пациент достигает 50%-ного улучшения по критериям основного заболевания Американской Коллегии ревматологов после 12 недель лечения.10. Способ по п. 1, где пациент достигает 70%-ного улучшения по критериям основного заболевания Американской Коллегии ревматологов после 12 недель лечения.11. Способ по п. 1, где пациента ранее неэффективно лечили от ревматоидного артрита путем введения антагониста TNF-α.12. Способ по п. 11, где пациента лечили анти-TNF-α антагонистом в течение, по меньшей мере, 3 месяцев за последние 2 года или пациент не переносит, по меньшей мере, один антагонист TNF-α.13. Способ по п. 11 или 12, где антагонист TNF-α представляет собой биологиче�
Claims (16)
1. Способ лечения ревматоидного артрита у пациента, получавшего ранее лечение метотрексатом, лефлуномидом, сульфасалазином и/или гидроксихлорохином, включающий введение пациенту эффективного количества сарилумаба (SAR153191), где сарилумаб вводят в дозе 150 мг раз в две недели или 200 мг раз в две недели.
2. Способ по п. 1, где пациента ранее неэффективно лечили от ревматоидного артрита путем введения метотрексата, лефлуномида, сульфасалазина и/или гидроксихлорохина.
3. Способ по п. 2, где метотрексат, лефлуномид, сульфасалазин и/или гидроксихлорохин вводят вместе с сарилумабом.
4. Способ по п. 3, где сарилумаб и метотрексат вводят вместе.
5. Способ по п. 4, где метотрексат вводят в дозе от 6 до 25 мг в неделю.
6. Способ по п. 1, где сарилумаб вводят в дозе 150 мг раз в две недели.
7. Способ по п. 1, где сарилумаб вводят в дозе 200 мг раз в две недели.
8. Способ по п. 1, где пациент достигает 20%-ного улучшения по критериям основного заболевания Американской Коллегии ревматологов после 12 недель лечения.
9. Способ по п. 1, где пациент достигает 50%-ного улучшения по критериям основного заболевания Американской Коллегии ревматологов после 12 недель лечения.
10. Способ по п. 1, где пациент достигает 70%-ного улучшения по критериям основного заболевания Американской Коллегии ревматологов после 12 недель лечения.
11. Способ по п. 1, где пациента ранее неэффективно лечили от ревматоидного артрита путем введения антагониста TNF-α.
12. Способ по п. 11, где пациента лечили анти-TNF-α антагонистом в течение, по меньшей мере, 3 месяцев за последние 2 года или пациент не переносит, по меньшей мере, один антагонист TNF-α.
13. Способ по п. 11 или 12, где антагонист TNF-α представляет собой биологический анти-TNF-α.
14. Способ по п. 13, где антагонист TNF-α выбирают из группы, состоящей из этанерцепта, инфликсимаба, адалимумаба, голимумаба и/или сертолизумаба пегол.
15. Фармацевтическая композиция, содержащая эффективное количество сарилумаба и члена группы, состоящей из метотрексата, лефлуномида, сульфасалазина и гидроксихлорохина.
16. Комбинация:
a. фармацевтической композиции, содержащей сарилумаб, и
b. фармацевтической композиции, содержащей метотрексат, лефлуномид, сульфасалазин или гидроксихлорохин для последовательного или одновременного применения в качестве лекарственного средства.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545864P | 2011-10-11 | 2011-10-11 | |
| US61/545,864 | 2011-10-11 | ||
| EP12305889 | 2012-07-20 | ||
| EP12305889.3 | 2012-07-20 | ||
| PCT/EP2012/070052 WO2013053751A1 (en) | 2011-10-11 | 2012-10-10 | Compositions for the treatment of rheumatoid arthritis and methods of using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014118741A true RU2014118741A (ru) | 2015-11-20 |
| RU2664697C2 RU2664697C2 (ru) | 2018-08-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2014118741A RU2664697C2 (ru) | 2011-10-11 | 2012-10-10 | Композиции для лечения ревматоидного артрита и способы их применения |
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| Country | Link |
|---|---|
| US (2) | US10927435B2 (ru) |
| EP (1) | EP2766039B1 (ru) |
| JP (5) | JP6122018B2 (ru) |
| KR (3) | KR20140123474A (ru) |
| CN (2) | CN108310376A (ru) |
| AR (1) | AR088289A1 (ru) |
| AU (1) | AU2012323062B2 (ru) |
| BR (1) | BR112014008764A8 (ru) |
| CA (1) | CA2851751A1 (ru) |
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