EA201290189A1 - Человеческие нейтрализующие антитела анти-ngf в качестве селективных ингибиторов метаболических путей фактора роста нервов - Google Patents

Человеческие нейтрализующие антитела анти-ngf в качестве селективных ингибиторов метаболических путей фактора роста нервов

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EA201290189A1
EA201290189A1 EA201290189A EA201290189A EA201290189A1 EA 201290189 A1 EA201290189 A1 EA 201290189A1 EA 201290189 A EA201290189 A EA 201290189A EA 201290189 A EA201290189 A EA 201290189A EA 201290189 A1 EA201290189 A1 EA 201290189A1
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Prior art keywords
ngf
growth factor
antibodies
selective inhibitors
neutralizing anti
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EA201290189A
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English (en)
Inventor
Кеннет Д. мл. Уайлд
Джэймс Дж. С. Тринор
Хайчунь Хуан
Хизер Иноу
Те Дж. Чжан
Франк Мартин
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Амджен Инк.
Медарекс, Инк.
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Application filed by Амджен Инк., Медарекс, Инк. filed Critical Амджен Инк.
Publication of EA201290189A1 publication Critical patent/EA201290189A1/ru

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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

В данном изобретении предложены антитела, которые связываются с фактором роста нервов (NGF) человека и посредством этого нейтрализуют функцию NGF. В изобретении также предложены фармацевтические композиции указанных антител и способы нейтрализации функции NGF, и в частности лечения связанных с NGF расстройств (например хронической боли) путем введения фармацевтически эффективного количества антител против NGF. Также предложены способы обнаружения количества NGF в биологическом образце с использованием антител против NGF.
EA201290189A 2009-10-09 2010-10-08 Человеческие нейтрализующие антитела анти-ngf в качестве селективных ингибиторов метаболических путей фактора роста нервов EA201290189A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/576,522 US9260514B2 (en) 2003-07-15 2009-10-09 Methods of treating conditions caused by increased expression of nerve growth factor (NGF) or increased sensitivity to NGF using anti-NGF neutralizing antibodies as selective NGF pathway inhibitors
PCT/US2010/051960 WO2011049758A1 (en) 2009-10-09 2010-10-08 Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors

Publications (1)

Publication Number Publication Date
EA201290189A1 true EA201290189A1 (ru) 2012-10-30

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ID=43466840

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EA201290189A EA201290189A1 (ru) 2009-10-09 2010-10-08 Человеческие нейтрализующие антитела анти-ngf в качестве селективных ингибиторов метаболических путей фактора роста нервов

Country Status (26)

Country Link
US (1) US9260514B2 (ru)
EP (2) EP3028717A1 (ru)
JP (3) JP2013507385A (ru)
KR (1) KR101528393B1 (ru)
CN (1) CN102762228A (ru)
AR (1) AR078569A1 (ru)
AU (2) AU2010308418A1 (ru)
BR (1) BR112012008282A2 (ru)
CA (1) CA2775924A1 (ru)
CL (1) CL2012000881A1 (ru)
CO (1) CO6541558A2 (ru)
CR (1) CR20120198A (ru)
EA (1) EA201290189A1 (ru)
IL (1) IL218885A0 (ru)
MA (1) MA33724B1 (ru)
ME (1) ME00226B (ru)
MT (1) MTP4289B (ru)
MX (1) MX343748B (ru)
NZ (2) NZ625391A (ru)
PE (1) PE20121028A1 (ru)
SG (1) SG10201603945RA (ru)
TN (1) TN2012000136A1 (ru)
TW (1) TW201125581A (ru)
UA (1) UA102775C2 (ru)
WO (1) WO2011049758A1 (ru)
ZA (1) ZA201203135B (ru)

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