BR112012008282A2 - anticorpos de neutralização anti-nfg humanos como inibidores de curso de ngf seletivos - Google Patents

anticorpos de neutralização anti-nfg humanos como inibidores de curso de ngf seletivos

Info

Publication number
BR112012008282A2
BR112012008282A2 BR112012008282A BR112012008282A BR112012008282A2 BR 112012008282 A2 BR112012008282 A2 BR 112012008282A2 BR 112012008282 A BR112012008282 A BR 112012008282A BR 112012008282 A BR112012008282 A BR 112012008282A BR 112012008282 A2 BR112012008282 A2 BR 112012008282A2
Authority
BR
Brazil
Prior art keywords
ngf
antibodies
inhibitors
course
nfg
Prior art date
Application number
BR112012008282A
Other languages
English (en)
Inventor
Frank Martin
Haichun Huang
Heather Inoue
James J S Treanor
Kenneth D Wild
Tie J Zhang
Original Assignee
Amgen Inc
Medarex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43466840&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012008282(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc, Medarex Inc filed Critical Amgen Inc
Publication of BR112012008282A2 publication Critical patent/BR112012008282A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
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    • G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
    • G03F7/004—Photosensitive materials
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    • G03F7/091—Photosensitive materials characterised by structural details, e.g. supports, auxiliary layers characterised by antireflection means or light filtering or absorbing means, e.g. anti-halation, contrast enhancement
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
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  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)

Abstract

anticorpos de neutralização anti-ngf humanos como inidores de curso de ngf seletivos. a presente invenção refere-se a anticorpos que interagem com ou se ligam a fator de crescimento de nervo humano (ngf) e neutralizam a função de ngf consequentemente. a invenção também provê composições farmacêuticas dos ditos anticorpos e métodos para neutralização da função de ngf e particularmente para tratamento de distúrbios relacionados com ngf (por exemplo, dor crônica) através da administração de uma quantidade farmaceuticamente eficaz de anticorpos anti-ngf. métodos de detecção da quantidade de ngf em uma amostra usando anticorpos anti-ngf são também providos.
BR112012008282A 2009-10-09 2010-10-08 anticorpos de neutralização anti-nfg humanos como inibidores de curso de ngf seletivos BR112012008282A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/576,522 US9260514B2 (en) 2003-07-15 2009-10-09 Methods of treating conditions caused by increased expression of nerve growth factor (NGF) or increased sensitivity to NGF using anti-NGF neutralizing antibodies as selective NGF pathway inhibitors
PCT/US2010/051960 WO2011049758A1 (en) 2009-10-09 2010-10-08 Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors

Publications (1)

Publication Number Publication Date
BR112012008282A2 true BR112012008282A2 (pt) 2016-11-22

Family

ID=43466840

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012008282A BR112012008282A2 (pt) 2009-10-09 2010-10-08 anticorpos de neutralização anti-nfg humanos como inibidores de curso de ngf seletivos

Country Status (26)

Country Link
US (1) US9260514B2 (pt)
EP (2) EP3028717A1 (pt)
JP (3) JP2013507385A (pt)
KR (1) KR101528393B1 (pt)
CN (1) CN102762228A (pt)
AR (1) AR078569A1 (pt)
AU (2) AU2010308418A1 (pt)
BR (1) BR112012008282A2 (pt)
CA (1) CA2775924A1 (pt)
CL (1) CL2012000881A1 (pt)
CO (1) CO6541558A2 (pt)
CR (1) CR20120198A (pt)
EA (1) EA201290189A1 (pt)
IL (1) IL218885A0 (pt)
MA (1) MA33724B1 (pt)
ME (1) ME00226B (pt)
MT (1) MTP4289B (pt)
MX (1) MX343748B (pt)
NZ (2) NZ625391A (pt)
PE (1) PE20121028A1 (pt)
SG (1) SG10201603945RA (pt)
TN (1) TN2012000136A1 (pt)
TW (1) TW201125581A (pt)
UA (1) UA102775C2 (pt)
WO (1) WO2011049758A1 (pt)
ZA (1) ZA201203135B (pt)

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ITRM20050290A1 (it) * 2005-06-07 2006-12-08 Lay Line Genomics Spa Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
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