UA102775C2 - Спосіб лікування болю із застосуванням анти-ngf антитіла - Google Patents

Спосіб лікування болю із застосуванням анти-ngf антитіла

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Publication number
UA102775C2
UA102775C2 UAA201205050A UAA201205050A UA102775C2 UA 102775 C2 UA102775 C2 UA 102775C2 UA A201205050 A UAA201205050 A UA A201205050A UA A201205050 A UAA201205050 A UA A201205050A UA 102775 C2 UA102775 C2 UA 102775C2
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UA
Ukraine
Prior art keywords
ngf
antibodies
pain
treatment
ngf antibody
Prior art date
Application number
UAA201205050A
Other languages
English (en)
Russian (ru)
Inventor
Кеннет Д. Уайлд
Джеймс Дж. С. Трінор
Хайчунь Хуань
Хезер Іну
Тай Дж. Чжан
Френк Мартін
Original Assignee
Емджен, Інк.
Медарекс, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43466840&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA102775(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Емджен, Інк., Медарекс, Інк. filed Critical Емджен, Інк.
Publication of UA102775C2 publication Critical patent/UA102775C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

Винахід стосується способу лікування болю, пов'язаного зі станом, який спричинюється підвищеною експресією фактора росту нервової тканини (NGF) або підвищеною чутливістю до NGF, що включає введення пацієнту фармацевтичної композиції, яка містить фармацевтично прийнятний носій та виділене антитіло, яке має легкий ланцюг, який включає послідовність SEQ ID NО: 44, та важкий ланцюг, який включає послідовність SEQ ID NО: 40.
UAA201205050A 2009-10-09 2010-10-08 Спосіб лікування болю із застосуванням анти-ngf антитіла UA102775C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/576,522 US9260514B2 (en) 2003-07-15 2009-10-09 Methods of treating conditions caused by increased expression of nerve growth factor (NGF) or increased sensitivity to NGF using anti-NGF neutralizing antibodies as selective NGF pathway inhibitors
PCT/US2010/051960 WO2011049758A1 (en) 2009-10-09 2010-10-08 Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors

Publications (1)

Publication Number Publication Date
UA102775C2 true UA102775C2 (uk) 2013-08-12

Family

ID=43466840

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201205050A UA102775C2 (uk) 2009-10-09 2010-10-08 Спосіб лікування болю із застосуванням анти-ngf антитіла

Country Status (26)

Country Link
US (1) US9260514B2 (uk)
EP (2) EP3028717A1 (uk)
JP (3) JP2013507385A (uk)
KR (1) KR101528393B1 (uk)
CN (1) CN102762228A (uk)
AR (1) AR078569A1 (uk)
AU (2) AU2010308418A1 (uk)
BR (1) BR112012008282A2 (uk)
CA (1) CA2775924A1 (uk)
CL (1) CL2012000881A1 (uk)
CO (1) CO6541558A2 (uk)
CR (1) CR20120198A (uk)
EA (1) EA201290189A1 (uk)
IL (1) IL218885A0 (uk)
MA (1) MA33724B1 (uk)
ME (1) ME00226B (uk)
MT (1) MTP4289B (uk)
MX (1) MX343748B (uk)
NZ (2) NZ599431A (uk)
PE (1) PE20121028A1 (uk)
SG (1) SG10201603945RA (uk)
TN (1) TN2012000136A1 (uk)
TW (1) TW201125581A (uk)
UA (1) UA102775C2 (uk)
WO (1) WO2011049758A1 (uk)
ZA (1) ZA201203135B (uk)

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