UA102775C2 - Спосіб лікування болю із застосуванням анти-ngf антитіла - Google Patents

Спосіб лікування болю із застосуванням анти-ngf антитіла

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Publication number
UA102775C2
UA102775C2 UAA201205050A UAA201205050A UA102775C2 UA 102775 C2 UA102775 C2 UA 102775C2 UA A201205050 A UAA201205050 A UA A201205050A UA A201205050 A UAA201205050 A UA A201205050A UA 102775 C2 UA102775 C2 UA 102775C2
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UA
Ukraine
Prior art keywords
ngf
antibodies
pain
treatment
ngf antibody
Prior art date
Application number
UAA201205050A
Other languages
English (en)
Russian (ru)
Inventor
Кеннет Д. Уайлд
Джеймс Дж. С. Трінор
Хайчунь Хуань
Хезер Іну
Тай Дж. Чжан
Френк Мартін
Original Assignee
Емджен, Інк.
Медарекс, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43466840&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA102775(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Емджен, Інк., Медарекс, Інк. filed Critical Емджен, Інк.
Publication of UA102775C2 publication Critical patent/UA102775C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C12N15/67—General methods for enhancing the expression
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    • G01—MEASURING; TESTING
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Virology (AREA)
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  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)

Abstract

Винахід стосується способу лікування болю, пов'язаного зі станом, який спричинюється підвищеною експресією фактора росту нервової тканини (NGF) або підвищеною чутливістю до NGF, що включає введення пацієнту фармацевтичної композиції, яка містить фармацевтично прийнятний носій та виділене антитіло, яке має легкий ланцюг, який включає послідовність SEQ ID NО: 44, та важкий ланцюг, який включає послідовність SEQ ID NО: 40.
UAA201205050A 2009-10-09 2010-10-08 Спосіб лікування болю із застосуванням анти-ngf антитіла UA102775C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/576,522 US9260514B2 (en) 2003-07-15 2009-10-09 Methods of treating conditions caused by increased expression of nerve growth factor (NGF) or increased sensitivity to NGF using anti-NGF neutralizing antibodies as selective NGF pathway inhibitors
PCT/US2010/051960 WO2011049758A1 (en) 2009-10-09 2010-10-08 Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors

Publications (1)

Publication Number Publication Date
UA102775C2 true UA102775C2 (uk) 2013-08-12

Family

ID=43466840

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201205050A UA102775C2 (uk) 2009-10-09 2010-10-08 Спосіб лікування болю із застосуванням анти-ngf антитіла

Country Status (28)

Country Link
US (1) US9260514B2 (uk)
EP (2) EP2485760B1 (uk)
JP (3) JP2013507385A (uk)
KR (1) KR101528393B1 (uk)
CN (1) CN102762228A (uk)
AR (1) AR078569A1 (uk)
AU (2) AU2010308418A1 (uk)
BR (1) BR112012008282A2 (uk)
CA (1) CA2775924A1 (uk)
CL (1) CL2012000881A1 (uk)
CO (1) CO6541558A2 (uk)
CR (1) CR20120198A (uk)
EA (1) EA201290189A1 (uk)
IL (1) IL218885A0 (uk)
MA (1) MA33724B1 (uk)
ME (1) ME00226B (uk)
MT (1) MTP4289B (uk)
MX (1) MX343748B (uk)
MY (1) MY172283A (uk)
NZ (2) NZ625391A (uk)
PE (1) PE20121028A1 (uk)
PH (1) PH12012500668A1 (uk)
SG (1) SG10201603945RA (uk)
TN (1) TN2012000136A1 (uk)
TW (1) TW201125581A (uk)
UA (1) UA102775C2 (uk)
WO (1) WO2011049758A1 (uk)
ZA (1) ZA201203135B (uk)

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ITRM20030601A1 (it) * 2003-12-24 2005-06-25 Lay Line Genomics Spa Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
ITRM20050290A1 (it) * 2005-06-07 2006-12-08 Lay Line Genomics Spa Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
CN102459337B (zh) 2009-05-04 2015-05-20 雅培研究有限责任公司 具有增强的体内稳定性的抗神经生长因子(ngf)抗体
KR20190112175A (ko) 2010-12-01 2019-10-02 앨더바이오 홀딩스 엘엘씨 항―ｎｇｆ 조성물 및 그의 용도
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9617334B2 (en) 2012-06-06 2017-04-11 Zoetis Services Llc Caninized anti-NGF antibodies and methods thereof
US9603775B2 (en) 2013-04-24 2017-03-28 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
KR102362002B1 (ko) * 2013-11-29 2022-02-10 제넨테크, 인크. 항체 선택 장치 및 방법
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