RU2012116335A - Таблетки, преобразуемые в ротовой полости - Google Patents
Таблетки, преобразуемые в ротовой полости Download PDFInfo
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- RU2012116335A RU2012116335A RU2012116335/15A RU2012116335A RU2012116335A RU 2012116335 A RU2012116335 A RU 2012116335A RU 2012116335/15 A RU2012116335/15 A RU 2012116335/15A RU 2012116335 A RU2012116335 A RU 2012116335A RU 2012116335 A RU2012116335 A RU 2012116335A
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- Prior art keywords
- tablet
- binder
- pharmaceutically active
- seconds
- active substance
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- 239000011230 binding agent Substances 0.000 claims abstract 25
- 239000013543 active substance Substances 0.000 claims abstract 18
- 238000000034 method Methods 0.000 claims abstract 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 11
- 230000005855 radiation Effects 0.000 claims abstract 9
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims abstract 6
- 239000002562 thickening agent Substances 0.000 claims abstract 6
- 239000000126 substance Substances 0.000 claims abstract 4
- 238000002844 melting Methods 0.000 claims abstract 3
- 230000008018 melting Effects 0.000 claims abstract 3
- 229960005489 paracetamol Drugs 0.000 claims abstract 3
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims abstract 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract 2
- 229940069428 antacid Drugs 0.000 claims abstract 2
- 239000003159 antacid agent Substances 0.000 claims abstract 2
- 150000001720 carbohydrates Chemical class 0.000 claims abstract 2
- 235000014633 carbohydrates Nutrition 0.000 claims abstract 2
- 230000006378 damage Effects 0.000 claims abstract 2
- 229960001680 ibuprofen Drugs 0.000 claims abstract 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims abstract 2
- 229960003105 metformin Drugs 0.000 claims abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 238000002791 soaking Methods 0.000 claims abstract 2
- 239000011782 vitamin Substances 0.000 claims abstract 2
- 229940088594 vitamin Drugs 0.000 claims abstract 2
- 229930003231 vitamin Natural products 0.000 claims abstract 2
- 235000013343 vitamin Nutrition 0.000 claims abstract 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract 2
- 239000000463 material Substances 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000000843 powder Substances 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 2
- 230000018044 dehydration Effects 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
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- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
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Abstract
1. Таблетка, содержащая одно или несколько фармацевтически активных веществ, один или несколько загустителей и одно или несколько связующих веществ, причем указанная таблетка содержит по меньшей мере 200 мг указанного фармацевтически активного(ых) вещества (веществ), и указанную таблетку сплавляли с указанным(и) связующим(и) веществом(ами) таким образом, что указанная таблетка (i) пропитывается водой меньше чем за 60 секунд и (ii) разрушается в условияхболее чем за 60 секунд.2. Таблетка по п. 1, где время пропитывания указанной таблетки водой составляет менее 30 секунд.3. Таблетка по п. 1, где время разрушения указанной таблетки в условияхсоставляет более 180 секунд.4. Таблетка по п. 1, содержащая по меньшей мере 5% вес. указанного(ых) связующего(их) вещества (веществ).5. Таблетка по п. 1, в которой указанное(ые) связующее(ие) вещество(а) представляет(ют) собой связующее вещество, расплавляемое РЧ-излучением, с температурой плавления от приблизительно 40°C до приблизительно 140°C.6. Таблетка по п. 1, содержащая связующее вещество полиэтиленгликоль.7. Таблетка по п. 1, в которой указанное связующее вещество представляет собой связующий материал, активируемый водой.8. Таблетка по п. 1, содержащая по меньшей мере 50% вес. указанного(ых) фармацевтически активного(ых) вещества (веществ).9. Таблетка по п. 1, содержащая фармацевтически активное вещество, выбранное из ибупрофена, ацетаминофена, антацидов, витамина, метформина и их фармацевтически приемлемых солей.10. Таблетка по п. 1, содержащая загуститель полиэтиленоксид.11. Таблетка по п. 1, содержащая менее 10 процентов вес. углеводов.12. Способ введения одного или нескольких фармацевтически активных веще�
Claims (22)
1. Таблетка, содержащая одно или несколько фармацевтически активных веществ, один или несколько загустителей и одно или несколько связующих веществ, причем указанная таблетка содержит по меньшей мере 200 мг указанного фармацевтически активного(ых) вещества (веществ), и указанную таблетку сплавляли с указанным(и) связующим(и) веществом(ами) таким образом, что указанная таблетка (i) пропитывается водой меньше чем за 60 секунд и (ii) разрушается в условиях in vitro более чем за 60 секунд.
2. Таблетка по п. 1, где время пропитывания указанной таблетки водой составляет менее 30 секунд.
3. Таблетка по п. 1, где время разрушения указанной таблетки в условиях in vitro составляет более 180 секунд.
4. Таблетка по п. 1, содержащая по меньшей мере 5% вес. указанного(ых) связующего(их) вещества (веществ).
5. Таблетка по п. 1, в которой указанное(ые) связующее(ие) вещество(а) представляет(ют) собой связующее вещество, расплавляемое РЧ-излучением, с температурой плавления от приблизительно 40°C до приблизительно 140°C.
6. Таблетка по п. 1, содержащая связующее вещество полиэтиленгликоль.
7. Таблетка по п. 1, в которой указанное связующее вещество представляет собой связующий материал, активируемый водой.
8. Таблетка по п. 1, содержащая по меньшей мере 50% вес. указанного(ых) фармацевтически активного(ых) вещества (веществ).
9. Таблетка по п. 1, содержащая фармацевтически активное вещество, выбранное из ибупрофена, ацетаминофена, антацидов, витамина, метформина и их фармацевтически приемлемых солей.
10. Таблетка по п. 1, содержащая загуститель полиэтиленоксид.
11. Таблетка по п. 1, содержащая менее 10 процентов вес. углеводов.
12. Способ введения одного или нескольких фармацевтически активных веществ, включающий размещение твердой таблетки, содержащей указанное фармацевтически активное(ые) вещество(а), в полости рта с последующим запиванием жидкостью, причем указанная таблетка содержит по меньшей мере 200 мг указанного(ых) фармацевтически активного(ых) вещества (веществ), и указанная таблетка (i) пропитывается водой меньше чем за 60 секунд и (ii) разрушается в условиях in vitro более чем за 60 секунд.
13.Способ по п. 12, в котором указанная таблетка содержит по меньшей мере 50% вес. указанного(ых) фармацевтически активного(ых) вещества (веществ).
14. Способ по п. 12, в котором указанная таблетка содержит по меньшей мере 325 мг фармацевтически активного вещества ацетаминофена.
15. Способ по п. 12, в котором указанная таблетка дополнительно содержит загуститель.
16. Способ получения таблетки, содержащей одно или более фармацевтически активных веществ, одно или более загустителей и одно или более связующих веществ, причем указанный способ содержит следующие этапы:
(a) получение таблетированной формы из порошковой смеси, содержащей указанное(ые) фармацевтически активное(ые) вещество(а) и связующее вещество; и
(b) облучение указанной таблетированной формы в течение времени, достаточного для активизации указанного(ых) связующего(их) вещества (веществ) в указанной таблетированной форме, для сплавления указанной таблетированной формы в указанную таблетку таким образом, что указанная таблетка (i) пропитывается водой меньше чем за 60 секунд и (ii) разрушается в условиях in vitro более чем за 60 секунд.
17. Способ по п. 16, в котором указанное связующее вещество представляет собой плавкий материал с температурой плавления от приблизительно 40°C до приблизительно 140°C, и указанная таблетированная форма подвергается воздействию указанного излучения в течение времени, достаточного для расплавления или размягчения указанного плавкого материала.
18. Способ по п. 16, в котором указанное связующее вещество представляет собой связующее вещество, расплавляемое РЧ-излучением, и указанная таблетированная форма подвергается воздействию РЧ-излучения в течение времени, достаточного для расплавления или размягчения указанного плавкого материала.
19. Способ по п. 16, в котором указанное связующее вещество представляет собой связующее вещество, активируемое водой, указанная порошковая смесь дополнительно содержит водосодержащий материал, и указанная таблетированная форма подвергается воздействию указанного излучения в течение времени, достаточного для нагревания водосодержащего материала до температуры выше его температуры дегидратации.
20. Способ по п. 16, в котором указанная порошковая смесь спрессована в плите пресс-формы, и указанное излучение воздействует на указанную таблетированную форму внутри указанной плиты пресс-формы.
21. Способ по п. 16, в котором указанная порошковая смесь содержит частицы, содержащие указанное фармацевтически активное вещество, причем указанная частица покрыта указанным связующим веществом.
22. Способ по п. 1, в котором поверхность указанной таблетки дополнительно подвергается инфракрасному облучению, при этом большинство значений длины волн указанного инфракрасного излучения находится в диапазоне от приблизительно 0,5 до приблизительно 5 микрометров.
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- 2010-09-22 US US12/887,564 patent/US20110070301A1/en not_active Abandoned
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