RU2009110172A - Производные 4-(n-азациклоалкил)анилидов в качестве модуляторов калиевых каналов - Google Patents
Производные 4-(n-азациклоалкил)анилидов в качестве модуляторов калиевых каналов Download PDFInfo
- Publication number
- RU2009110172A RU2009110172A RU2009110172/15A RU2009110172A RU2009110172A RU 2009110172 A RU2009110172 A RU 2009110172A RU 2009110172/15 A RU2009110172/15 A RU 2009110172/15A RU 2009110172 A RU2009110172 A RU 2009110172A RU 2009110172 A RU2009110172 A RU 2009110172A
- Authority
- RU
- Russia
- Prior art keywords
- dimethylbutanamide
- isoquinolin
- dihydro
- alkyl
- phenyl
- Prior art date
Links
- 102000004257 Potassium Channel Human genes 0.000 title claims 4
- 108020001213 potassium channel Proteins 0.000 title claims 4
- 150000003931 anilides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 59
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract 36
- 229910052736 halogen Inorganic materials 0.000 claims abstract 32
- 150000002367 halogens Chemical class 0.000 claims abstract 32
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 28
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 22
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 20
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 19
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 19
- 125000005842 heteroatom Chemical group 0.000 claims abstract 15
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract 12
- 125000000217 alkyl group Chemical group 0.000 claims abstract 12
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims abstract 11
- 125000000392 cycloalkenyl group Chemical group 0.000 claims abstract 11
- 125000003118 aryl group Chemical group 0.000 claims abstract 10
- -1 2- (N, N-dimethylamino) ethyl Chemical group 0.000 claims abstract 7
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 7
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 6
- 125000002950 monocyclic group Chemical group 0.000 claims abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 3
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 3
- 229910052731 fluorine Inorganic materials 0.000 claims 23
- 229910052801 chlorine Inorganic materials 0.000 claims 15
- 125000004076 pyridyl group Chemical group 0.000 claims 14
- 125000000168 pyrrolyl group Chemical group 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 239000012453 solvate Substances 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 9
- 239000000126 substance Substances 0.000 claims 9
- 125000001544 thienyl group Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000002971 oxazolyl group Chemical group 0.000 claims 6
- 125000000335 thiazolyl group Chemical group 0.000 claims 6
- WJLOXTPZZKOJPH-UHFFFAOYSA-N 3,3-dimethyl-n-[2-(trifluoromethyl)-4-[7-(trifluoromethyl)-3,4-dihydro-1h-isoquinolin-2-yl]phenyl]butanamide Chemical compound C1=C(C(F)(F)F)C(NC(=O)CC(C)(C)C)=CC=C1N1CC2=CC(C(F)(F)F)=CC=C2CC1 WJLOXTPZZKOJPH-UHFFFAOYSA-N 0.000 claims 5
- NYBZDKPEAWWBJW-UHFFFAOYSA-N FC=1C=C2CCN(CC2=CC1)C1=CC(=C(C=C1)NC(CC(C)(C)C)=O)C.ClC1=C(C=CC(=C1)N1CC2=CC=C(C=C2CC1)F)NC(CC(C)(C)C)=O Chemical compound FC=1C=C2CCN(CC2=CC1)C1=CC(=C(C=C1)NC(CC(C)(C)C)=O)C.ClC1=C(C=CC(=C1)N1CC2=CC=C(C=C2CC1)F)NC(CC(C)(C)C)=O NYBZDKPEAWWBJW-UHFFFAOYSA-N 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000002541 furyl group Chemical group 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- BUNUTIAYMZWFOP-UHFFFAOYSA-N n-[2,6-dimethyl-4-[6-(trifluoromethyl)-3,4-dihydro-1h-isoquinolin-2-yl]phenyl]-3,3-dimethylbutanamide Chemical compound CC1=C(NC(=O)CC(C)(C)C)C(C)=CC(N2CC3=CC=C(C=C3CC2)C(F)(F)F)=C1 BUNUTIAYMZWFOP-UHFFFAOYSA-N 0.000 claims 5
- IHLMAWNDSKTHJS-UHFFFAOYSA-N n-[2-chloro-4-(3,4-dihydro-1h-isoquinolin-2-yl)-6-(trifluoromethoxy)phenyl]-3,3-dimethylbutanamide Chemical compound C1=C(OC(F)(F)F)C(NC(=O)CC(C)(C)C)=C(Cl)C=C1N1CC2=CC=CC=C2CC1 IHLMAWNDSKTHJS-UHFFFAOYSA-N 0.000 claims 5
- JURDKTFYHWIOLE-UHFFFAOYSA-N n-[2-chloro-4-(3,4-dihydro-1h-isoquinolin-2-yl)-6-(trifluoromethyl)phenyl]-3,3-dimethylbutanamide Chemical compound C1=C(C(F)(F)F)C(NC(=O)CC(C)(C)C)=C(Cl)C=C1N1CC2=CC=CC=C2CC1 JURDKTFYHWIOLE-UHFFFAOYSA-N 0.000 claims 5
- WSVPGQIOIVUVDN-UHFFFAOYSA-N n-[2-chloro-4-(3,4-dihydro-1h-isoquinolin-2-yl)-6-(trifluoromethyl)phenyl]-3-cyclopentylpropanamide Chemical compound FC(F)(F)C1=CC(N2CC3=CC=CC=C3CC2)=CC(Cl)=C1NC(=O)CCC1CCCC1 WSVPGQIOIVUVDN-UHFFFAOYSA-N 0.000 claims 5
- RHIVKINPKAPVFG-UHFFFAOYSA-N n-[2-chloro-4-(6-chloro-3,4-dihydro-1h-isoquinolin-2-yl)-6-(trifluoromethyl)phenyl]-3,3-dimethylbutanamide Chemical compound C1=C(C(F)(F)F)C(NC(=O)CC(C)(C)C)=C(Cl)C=C1N1CC2=CC=C(Cl)C=C2CC1 RHIVKINPKAPVFG-UHFFFAOYSA-N 0.000 claims 5
- GVEWDAHCLFVWMC-UHFFFAOYSA-N n-[2-chloro-4-(6-chloro-3,4-dihydro-1h-isoquinolin-2-yl)-6-methylphenyl]-3,3-dimethylbutanamide Chemical compound ClC1=C(NC(=O)CC(C)(C)C)C(C)=CC(N2CC3=CC=C(Cl)C=C3CC2)=C1 GVEWDAHCLFVWMC-UHFFFAOYSA-N 0.000 claims 5
- AKMBUNDQKZOKEY-UHFFFAOYSA-N n-[2-chloro-4-(6-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)-6-(trifluoromethyl)phenyl]-3-cyclopentylpropanamide Chemical compound C1CC2=CC(F)=CC=C2CN1C(C=C1C(F)(F)F)=CC(Cl)=C1NC(=O)CCC1CCCC1 AKMBUNDQKZOKEY-UHFFFAOYSA-N 0.000 claims 5
- XUHYQDMOGPLCHO-UHFFFAOYSA-N n-[2-chloro-4-(6-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)-6-methylphenyl]-3,3-dimethylbutanamide Chemical compound ClC1=C(NC(=O)CC(C)(C)C)C(C)=CC(N2CC3=CC=C(F)C=C3CC2)=C1 XUHYQDMOGPLCHO-UHFFFAOYSA-N 0.000 claims 5
- IMRNLRWJFWXHIF-UHFFFAOYSA-N n-[2-chloro-4-(7-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)-6-(trifluoromethyl)phenyl]-3,3-dimethylbutanamide Chemical compound C1=C(C(F)(F)F)C(NC(=O)CC(C)(C)C)=C(Cl)C=C1N1CC2=CC(F)=CC=C2CC1 IMRNLRWJFWXHIF-UHFFFAOYSA-N 0.000 claims 5
- BZACFVHATUEBMX-UHFFFAOYSA-N n-[2-chloro-4-(7-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)-6-methylphenyl]-3,3-dimethylbutanamide Chemical compound ClC1=C(NC(=O)CC(C)(C)C)C(C)=CC(N2CC3=CC(F)=CC=C3CC2)=C1 BZACFVHATUEBMX-UHFFFAOYSA-N 0.000 claims 5
- JLKZQPXSHYGHBK-UHFFFAOYSA-N n-[2-chloro-4-[6-(trifluoromethyl)-3,4-dihydro-1h-isoquinolin-2-yl]phenyl]-3,3-dimethylbutanamide Chemical compound C1=C(Cl)C(NC(=O)CC(C)(C)C)=CC=C1N1CC2=CC=C(C(F)(F)F)C=C2CC1 JLKZQPXSHYGHBK-UHFFFAOYSA-N 0.000 claims 5
- RMPCHGWCNFMAHK-UHFFFAOYSA-N n-[2-chloro-6-(trifluoromethyl)-4-[6-(trifluoromethyl)-3,4-dihydro-1h-isoquinolin-2-yl]phenyl]-3,3-dimethylbutanamide Chemical compound C1=C(C(F)(F)F)C(NC(=O)CC(C)(C)C)=C(Cl)C=C1N1CC2=CC=C(C(F)(F)F)C=C2CC1 RMPCHGWCNFMAHK-UHFFFAOYSA-N 0.000 claims 5
- KEBOLMNDHWAEOH-UHFFFAOYSA-N n-[2-chloro-6-methyl-4-[6-(trifluoromethyl)-3,4-dihydro-1h-isoquinolin-2-yl]phenyl]-3,3-dimethylbutanamide Chemical compound ClC1=C(NC(=O)CC(C)(C)C)C(C)=CC(N2CC3=CC=C(C=C3CC2)C(F)(F)F)=C1 KEBOLMNDHWAEOH-UHFFFAOYSA-N 0.000 claims 5
- PXVUSPQWZDZSJK-UHFFFAOYSA-N n-[4-(3,4-dihydro-1h-isoquinolin-2-yl)-2,6-dimethoxyphenyl]-3,3-dimethylbutanamide Chemical compound COC1=C(NC(=O)CC(C)(C)C)C(OC)=CC(N2CC3=CC=CC=C3CC2)=C1 PXVUSPQWZDZSJK-UHFFFAOYSA-N 0.000 claims 5
- AMEVBSOCKOSCAX-UHFFFAOYSA-N n-[4-(3,4-dihydro-1h-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide Chemical compound CC1=C(NC(=O)CC(C)(C)C)C(C)=CC(N2CC3=CC=CC=C3CC2)=C1 AMEVBSOCKOSCAX-UHFFFAOYSA-N 0.000 claims 5
- WPUMBENDZFWLRX-UHFFFAOYSA-N n-[4-(3,4-dihydro-1h-isoquinolin-2-yl)-2-methoxy-6-methylphenyl]-3,3-dimethylbutanamide Chemical compound CC1=C(NC(=O)CC(C)(C)C)C(OC)=CC(N2CC3=CC=CC=C3CC2)=C1 WPUMBENDZFWLRX-UHFFFAOYSA-N 0.000 claims 5
- XTXQZLKZKXJJGF-UHFFFAOYSA-N n-[4-(6-chloro-3,4-dihydro-1h-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide Chemical compound CC1=C(NC(=O)CC(C)(C)C)C(C)=CC(N2CC3=CC=C(Cl)C=C3CC2)=C1 XTXQZLKZKXJJGF-UHFFFAOYSA-N 0.000 claims 5
- FJNPZKZPWVVSON-UHFFFAOYSA-N n-[4-(6-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide Chemical compound CC1=C(NC(=O)CC(C)(C)C)C(C)=CC(N2CC3=CC=C(F)C=C3CC2)=C1 FJNPZKZPWVVSON-UHFFFAOYSA-N 0.000 claims 5
- ABTRCHMHHBOXFV-UHFFFAOYSA-N n-[4-(6-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)-2-(trifluoromethyl)phenyl]-3,3-dimethylbutanamide Chemical compound C1=C(C(F)(F)F)C(NC(=O)CC(C)(C)C)=CC=C1N1CC2=CC=C(F)C=C2CC1 ABTRCHMHHBOXFV-UHFFFAOYSA-N 0.000 claims 5
- ZIVMHLHITXTGRE-UHFFFAOYSA-N n-[4-(6-methoxy-3,4-dihydro-1h-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide Chemical compound C1CC2=CC(OC)=CC=C2CN1C1=CC(C)=C(NC(=O)CC(C)(C)C)C(C)=C1 ZIVMHLHITXTGRE-UHFFFAOYSA-N 0.000 claims 5
- AYTUSFFMOMITAH-UHFFFAOYSA-N n-[4-(7-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide Chemical compound CC1=C(NC(=O)CC(C)(C)C)C(C)=CC(N2CC3=CC(F)=CC=C3CC2)=C1 AYTUSFFMOMITAH-UHFFFAOYSA-N 0.000 claims 5
- MGZUTAIZUGWMSW-UHFFFAOYSA-N n-[4-(7-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)-2-(trifluoromethyl)phenyl]-3,3-dimethylbutanamide Chemical compound C1=C(C(F)(F)F)C(NC(=O)CC(C)(C)C)=CC=C1N1CC2=CC(F)=CC=C2CC1 MGZUTAIZUGWMSW-UHFFFAOYSA-N 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 125000001786 isothiazolyl group Chemical group 0.000 claims 4
- QEQSCTBTOWAMGI-UHFFFAOYSA-N n-[2-chloro-4-(3,4-dihydro-1h-isoquinolin-2-yl)-6-methylphenyl]-3,3-dimethylbutanamide Chemical compound ClC1=C(NC(=O)CC(C)(C)C)C(C)=CC(N2CC3=CC=CC=C3CC2)=C1 QEQSCTBTOWAMGI-UHFFFAOYSA-N 0.000 claims 4
- ORFBJKQTXCNFHM-UHFFFAOYSA-N n-[2-chloro-4-(6-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)-6-(trifluoromethyl)phenyl]-3,3-dimethylbutanamide Chemical compound C1=C(C(F)(F)F)C(NC(=O)CC(C)(C)C)=C(Cl)C=C1N1CC2=CC=C(F)C=C2CC1 ORFBJKQTXCNFHM-UHFFFAOYSA-N 0.000 claims 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 3
- 125000000842 isoxazolyl group Chemical group 0.000 claims 3
- 108091006146 Channels Proteins 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000005412 pyrazyl group Chemical group 0.000 claims 2
- ZEMZPXWZVTUONV-UHFFFAOYSA-N 2-(2-dicyclohexylphosphanylphenyl)-n,n-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1C1=CC=CC=C1P(C1CCCCC1)C1CCCCC1 ZEMZPXWZVTUONV-UHFFFAOYSA-N 0.000 claims 1
- 206010001497 Agitation Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 108010006746 KCNQ2 Potassium Channel Proteins 0.000 claims 1
- 102100034354 Potassium voltage-gated channel subfamily KQT member 2 Human genes 0.000 claims 1
- 102000003734 Voltage-Gated Potassium Channels Human genes 0.000 claims 1
- 108090000013 Voltage-Gated Potassium Channels Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- XEVJQEIJAXJBKV-UHFFFAOYSA-N n-(4-bromo-2,6-dimethylphenyl)-3,3-dimethylbutanamide Chemical compound CC1=CC(Br)=CC(C)=C1NC(=O)CC(C)(C)C XEVJQEIJAXJBKV-UHFFFAOYSA-N 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 150000003526 tetrahydroisoquinolines Chemical class 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 1
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83994106P | 2006-08-23 | 2006-08-23 | |
| US60/839,941 | 2006-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009110172A true RU2009110172A (ru) | 2010-09-27 |
Family
ID=39107384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009110172/15A RU2009110172A (ru) | 2006-08-23 | 2007-08-22 | Производные 4-(n-азациклоалкил)анилидов в качестве модуляторов калиевых каналов |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8293911B2 (https=) |
| EP (1) | EP2061465B1 (https=) |
| JP (1) | JP5419691B2 (https=) |
| KR (1) | KR20090079191A (https=) |
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Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050089559A1 (en) * | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| NZ552397A (en) | 2004-07-15 | 2011-04-29 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| US20080045534A1 (en) * | 2006-08-18 | 2008-02-21 | Valeant Pharmaceuticals North America | Derivatives of 1,3-diamino benzene as potassium channel modulators |
| SG174095A1 (en) | 2006-08-23 | 2011-09-29 | Valeant Pharmaceuticals Int | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| CN101578259A (zh) | 2006-11-28 | 2009-11-11 | 威朗国际制药公司 | 作为钾通道调节剂的1,4-二氨基双环瑞替加滨类似物 |
| US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| JP2011525538A (ja) * | 2008-06-24 | 2011-09-22 | バレアント プハルマセウトイカルス インターナショナル | カリウムチャネルモジュレーターとして有用なベンジルオキシアニリド誘導体 |
| TW201041857A (en) * | 2009-05-11 | 2010-12-01 | Lundbeck & Co As H | Stable forms of N-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide |
| WO2010132437A1 (en) | 2009-05-12 | 2010-11-18 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
| AU2010247763B2 (en) | 2009-05-12 | 2015-12-24 | Albany Molecular Research, Inc. | 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof |
| AU2010247735B2 (en) | 2009-05-12 | 2015-07-16 | Albany Molecular Research, Inc. | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof |
| AU2011275393B2 (en) * | 2010-07-08 | 2014-04-10 | Pfizer Inc. | Piperidinyl pyrimidine amides as Kv7 potassium channel openers |
| WO2013055984A1 (en) | 2011-10-14 | 2013-04-18 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| EP2766347B1 (en) | 2011-10-14 | 2016-05-04 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| JP6033319B2 (ja) | 2011-10-14 | 2016-11-30 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 第ＸＩａ因子阻害剤としての置換テトラヒドロイソキノリン化合物 |
| CN103073455B (zh) | 2011-10-25 | 2015-08-19 | 中国科学院上海药物研究所 | 一类新型的kcnq钾通道激动剂、其制备方法和用途 |
| CN108250128A (zh) * | 2012-09-27 | 2018-07-06 | 江苏先声药业有限公司 | 作为钾通道调节剂的化合物 |
| WO2014160668A1 (en) | 2013-03-25 | 2014-10-02 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors |
| MX2018015251A (es) | 2016-06-10 | 2019-04-25 | Scifluor Life Sciences Inc | Derivados de 2-amino-4-(amino sustituido)fenil carbamato fluorinado. |
| US10329516B2 (en) * | 2016-12-20 | 2019-06-25 | International Flavors & Fragrances Inc. | Organoleptic compounds |
| WO2019118657A1 (en) * | 2017-12-13 | 2019-06-20 | Scifluor Life Sciences, Inc. | Fluorinated 4-(substituted amino)phenyl carbamate derivatives |
| EP3737677B1 (en) | 2018-01-10 | 2021-11-03 | Allinky Biopharma | Tetrahydroisoquinoline compounds |
| WO2019217924A1 (en) | 2018-05-11 | 2019-11-14 | Xenon Pharmaceuticals Inc. | Methods for enhancing the bioavailability and exposure of a voltage-gated potassium channel opener |
| CN110511220B (zh) | 2018-05-22 | 2022-04-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用 |
| CA3116339A1 (en) | 2018-10-22 | 2020-04-30 | Cadent Therapeutics, Inc. | Crystalline forms of potassium channel modulators |
| EP3917907B1 (en) | 2019-01-29 | 2025-05-21 | Universitá Degli Studi Di Salerno | Modulators of potassium ion channels and uses thereof |
| TWI886158B (zh) * | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| MX2022005490A (es) | 2019-11-08 | 2022-08-10 | Xenon Pharmaceuticals Inc | Metodos para el tratamiento de trastornos depresivos. |
| CN114786658A (zh) | 2019-12-06 | 2022-07-22 | 泽农医药公司 | Kv7钾离子通道开放剂治疗疼痛的用途 |
| CN114057641B (zh) * | 2020-08-07 | 2025-02-18 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的四氢异喹啉类化合物及其制备和应用 |
| US20220288057A1 (en) | 2021-02-09 | 2022-09-15 | Xenon Pharmaceuticals Inc. | Conjoint therapy for treating seizure disorders |
| US11957675B2 (en) * | 2021-02-09 | 2024-04-16 | Xenon Pharmaceuticals Inc. | Methods and uses for treating anhedonia |
| US20240317689A1 (en) * | 2021-08-26 | 2024-09-26 | Neushen Therapeutics (Shanghai) Co., Ltd | Potassium channel modulator, composition and application |
| CN113698345B (zh) | 2021-10-27 | 2022-02-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的化合物及其制备和应用 |
| CA3151863C (en) * | 2021-10-27 | 2024-01-02 | Shanghai Zhimeng Biopharma, Inc. | Compound as potassium channel regulator and preparation and use thereof |
| TW202333693A (zh) * | 2021-12-31 | 2023-09-01 | 大陸商上海翰森生物醫藥科技有限公司 | 苯并哌啶衍生物調節劑、其製備方法和應用 |
| CN116478068A (zh) | 2022-01-14 | 2023-07-25 | 中国科学院上海药物研究所 | 一种高选择性kcnq4钾通道激动剂、其制备方法和用途 |
| CN116535353A (zh) * | 2022-01-25 | 2023-08-04 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的酰胺类化合物及其制备和应用 |
| TW202404583A (zh) * | 2022-06-08 | 2024-02-01 | 加拿大商再諾製藥公司 | 吡啶胺衍生物及其作為鉀通道調節劑之用途 |
| CN120435316A (zh) * | 2022-08-30 | 2025-08-05 | 拜奥海芬治疗学有限公司 | 包括金属通道激活剂和nmda受体拮抗剂的组合疗法 |
| WO2024067819A1 (zh) * | 2022-09-30 | 2024-04-04 | 上海翰森生物医药科技有限公司 | 含哌啶多环类衍生物调节剂、其制备方法和应用 |
| CN118530144A (zh) * | 2023-02-21 | 2024-08-23 | 中国医学科学院药物研究所 | 一种派恩加滨的制备方法 |
| TW202521541A (zh) | 2023-08-17 | 2025-06-01 | 加拿大商再諾製藥公司 | 雜芳基胺化合物及其用途 |
| WO2025038930A1 (en) | 2023-08-17 | 2025-02-20 | Xenon Pharmaceuticals, Inc. | Azepane and pyrrolidine compounds and uses thereof |
| IL326820A (en) * | 2023-09-19 | 2026-04-01 | Xenon Pharmaceuticals Inc | Deuterium and aryl amine compounds and their uses |
| CN120441482A (zh) * | 2024-02-08 | 2025-08-08 | 上海挚盟医药科技有限公司 | 四氢异喹啉基化合物的晶型及其应用 |
| WO2025179128A1 (en) | 2024-02-22 | 2025-08-28 | Xenon Pharmaceuticals Inc. | Azetukalner for use in the treatment of depression, anhedonia or a seizure disorder such as epilepsy in pediatric subjects |
| WO2026006669A1 (en) * | 2024-06-28 | 2026-01-02 | Xenon Pharmaceuticals Inc. | Prodrugs of n-[4-(6-fluoro-3,4-dihydro-2(1 h)-isoquinolinyl)-2,6-dimethylphe nyl]-3,3-dimethyl- butanamide |
| WO2026026968A1 (zh) * | 2024-08-02 | 2026-02-05 | 江西科睿药业有限公司 | 一种含芳香稠环的化合物、其药物组合物和应用 |
| WO2026037240A1 (zh) * | 2024-08-12 | 2026-02-19 | 江西科睿药业有限公司 | 一种钾通道调节剂、其制备方法、药物组合物和应用 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4181803A (en) | 1973-12-14 | 1980-01-01 | Eisai Co., Ltd. | Propiophenone derivatives and preparation thereof |
| DE3337593A1 (de) | 1982-10-27 | 1984-05-03 | Degussa Ag, 6000 Frankfurt | 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung |
| ATE25078T1 (de) | 1982-10-27 | 1987-02-15 | Degussa | 2-amino-3-acylamino-6-benzylamino-pyridinderivate mit anti-epileptischer wirkung. |
| DE3665538D1 (en) | 1985-01-23 | 1989-10-19 | Asta Pharma Ag | Synergistic combination of flupirtin and non-steroidal anti-phlogistics |
| EP0193056B1 (de) | 1985-02-23 | 1989-06-07 | ASTA Pharma Aktiengesellschaft | Kombination von Flupirtin und anticholinergisch wirkenden Spasmolytika |
| DE3604575A1 (de) | 1985-02-23 | 1986-08-28 | Degussa Ag, 6000 Frankfurt | Kombination von flupirtin und anticholinergisch wirkenden spasmolytika |
| JP2583067B2 (ja) | 1987-08-04 | 1997-02-19 | 住友化学工業株式会社 | モノアゾ化合物およびそれを用いて疎水性繊維材料を染色または捺染する方法 |
| GB8800199D0 (en) | 1988-01-06 | 1988-02-10 | Beecham Group Plc | Pharmaceutical preparation |
| MC2029A1 (fr) | 1988-05-16 | 1990-04-25 | Asta Pharma Ag | (n-heterocyclyl)-3 diamino-2,6 pyridines substituees et leurs n-oxydes,preparation de ces composes et leur application comme medicaments |
| US5629307A (en) | 1989-10-20 | 1997-05-13 | Olney; John W. | Use of ibogaine in reducing excitotoxic brain damage |
| US6004945A (en) | 1990-05-10 | 1999-12-21 | Fukunaga; Atsuo F. | Use of adenosine compounds to relieve pain |
| IN172468B (https=) | 1990-07-14 | 1993-08-14 | Asta Medica Ag | |
| US5643921A (en) | 1990-09-26 | 1997-07-01 | E.R. Squibb & Sons, Inc. | Cardiopulmonary bypass and organ transplant using a potassium channel activator |
| US5234947A (en) | 1991-11-07 | 1993-08-10 | New York University | Potassium channel activating compounds and methods of use thereof |
| DE4200259A1 (de) | 1992-01-08 | 1993-07-15 | Asta Medica Ag | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
| US5262419A (en) | 1992-06-11 | 1993-11-16 | E. R. Squibb & Sons, Inc. | Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator |
| CA2115792C (en) | 1993-03-05 | 2005-11-01 | David J. Mayer | Method for the treatment of pain |
| US5428039A (en) | 1994-02-20 | 1995-06-27 | The Center For Innovative Technology | Method for electively achieving reversible hyperpolarized cardiac arrest |
| JP4097285B2 (ja) | 1994-09-22 | 2008-06-11 | リチャード・アラン・スミス | 種々の頑固な疾患の治療のための医薬の製造に有用な組成物 |
| US5679706A (en) | 1994-09-30 | 1997-10-21 | Bristol-Myers Squibb Company | Combination of a potassium channel activator and an antiarrhythmic agent |
| WO1996019233A2 (en) | 1994-12-12 | 1996-06-27 | Omeros Medical Systems, Inc. | Irrigation solution and method for inhibition of pain, inflammation and spasm |
| DE19539861A1 (de) | 1995-10-26 | 1997-04-30 | Asta Medica Ag | Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen |
| DE19701694A1 (de) | 1997-01-20 | 1998-07-23 | Asta Medica Ag | Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung |
| US5760007A (en) | 1997-07-16 | 1998-06-02 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating neuropathic pain |
| AU8561298A (en) | 1997-08-08 | 1999-03-01 | Chugai Seiyaku Kabushiki Kaisha | Remedies for complications of diabetes |
| US6265417B1 (en) | 1997-12-18 | 2001-07-24 | Abbott Laboratories | Potassium channel openers |
| US6593335B1 (en) | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
| US6333337B1 (en) * | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
| US6211171B1 (en) | 1998-05-19 | 2001-04-03 | Dalhousie University | Use of antidepressants for local analgesia |
| JP3441970B2 (ja) | 1998-06-30 | 2003-09-02 | 株式会社サミー | 豆腐の製造方法及び製造装置 |
| JP2000143510A (ja) | 1998-11-16 | 2000-05-23 | Taisho Pharmaceut Co Ltd | 外用組成物 |
| BR9916162A (pt) | 1998-12-14 | 2001-09-04 | Cellegy Pharma Inc | Composição e método para o tratamento de um distúrbio anorretal e para controlar a dor associada com o mesmo |
| US6281211B1 (en) | 1999-02-04 | 2001-08-28 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
| GB9903476D0 (en) | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Therapeutic agents |
| US6451857B1 (en) | 1999-03-10 | 2002-09-17 | Warner-Lambert Company | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
| AU766648B2 (en) * | 1999-03-17 | 2003-10-23 | Axys Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| AT409083B (de) | 1999-04-01 | 2002-05-27 | Sanochemia Pharmazeutika Ag | Pharmazeutische, tolperison enthaltende zubereitung zur oralen verabreichung |
| US6610324B2 (en) | 1999-04-07 | 2003-08-26 | The Mclean Hospital Corporation | Flupirtine in the treatment of fibromyalgia and related conditions |
| GB9915414D0 (en) | 1999-07-01 | 1999-09-01 | Glaxo Group Ltd | Medical use |
| PT1200073E (pt) | 1999-07-06 | 2007-03-30 | Lilly Co Eli | Antagonistas selectivos do receptor de iglur5 para o tratamento de enxaqueca |
| US6472165B1 (en) | 1999-08-03 | 2002-10-29 | Arzneimittelwerk Dresden Gmbh | Modulatory binding site in potassium channels for screening and finding new active ingredients |
| EP1200086A4 (en) | 1999-08-04 | 2009-05-27 | Icagen Inc | THERAPEUTIC OR PROPHYLACTIC METHODS OF PAIN AND ANXIETY |
| ATE380176T1 (de) | 1999-08-04 | 2007-12-15 | Icagen Inc | Benzanilide als öffner des kaliumkanals |
| US6495550B2 (en) | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| US6117900A (en) | 1999-09-27 | 2000-09-12 | Asta Medica Aktiengesellschaft | Use of retigabine for the treatment of neuropathic pain |
| US6383511B1 (en) | 1999-10-25 | 2002-05-07 | Epicept Corporation | Local prevention or amelioration of pain from surgically closed wounds |
| US6538004B2 (en) | 2000-03-03 | 2003-03-25 | Abbott Laboratories | Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers |
| US20020015730A1 (en) | 2000-03-09 | 2002-02-07 | Torsten Hoffmann | Pharmaceutical formulations and method for making |
| US6348486B1 (en) | 2000-10-17 | 2002-02-19 | American Home Products Corporation | Methods for modulating bladder function |
| US6589986B2 (en) | 2000-12-20 | 2003-07-08 | Wyeth | Methods of treating anxiety disorders |
| US6469042B1 (en) | 2001-02-20 | 2002-10-22 | Bristol-Myers Squibb Company | Fluoro oxindole derivatives as modulators if KCNQ potassium channels |
| US20020183395A1 (en) | 2001-04-04 | 2002-12-05 | Wyeth | Methods for treating hyperactive gastric motility |
| HUP0401750A2 (hu) * | 2001-05-31 | 2004-12-28 | Bristol-Myers Squibb Company | Cinnamidszármazékok mint KCNQ káliumcsatorna-modulátorok és ezeket tartalmazó gyógyszerkészítmények |
| GB0121214D0 (en) | 2001-08-31 | 2001-10-24 | Btg Int Ltd | Synthetic method |
| WO2003068769A1 (en) | 2002-02-12 | 2003-08-21 | Pfizer Inc. | Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh) |
| AUPS110302A0 (en) * | 2002-03-14 | 2002-04-18 | Biomolecular Research Institute Limited | Novel chalcone derivatives and uses thereof |
| WO2003097586A1 (en) | 2002-05-17 | 2003-11-27 | Janssen Pharmaceutica N.V. | Aminotetralin-derived urea modulators of vanilloid vr1 receptor |
| WO2003106454A1 (en) * | 2002-06-12 | 2003-12-24 | Orchid Chemicals & Pharmaceuticals Ltd | 1h-isoquinoline-oxazolidinone derivaties and their use as antibacterial agents |
| AUPS312602A0 (en) | 2002-06-21 | 2002-07-18 | James Cook University | Organ arrest, protection, preservation and recovery |
| US7419981B2 (en) | 2002-08-15 | 2008-09-02 | Pfizer Inc. | Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor |
| US7045551B2 (en) | 2002-11-22 | 2006-05-16 | Bristol-Myers Squibb Company | 1-aryl-2-hydroxyethyl amides as potassium channel openers |
| ATE488231T1 (de) | 2002-12-23 | 2010-12-15 | Icagen Inc | Quinazolinone als kaliumkanalmodulatoren |
| ES2282701T3 (es) | 2002-12-27 | 2007-10-16 | H. Lundbeck A/S | Derivados de 1,2,4-triaminobenceno utiles para tratar trastornos del sistema nervioso central. |
| EP1606247A1 (en) | 2003-03-14 | 2005-12-21 | H. Lundbeck A/S | Substituted aniline derivatives |
| WO2004082677A1 (en) | 2003-03-21 | 2004-09-30 | H. Lundbeck A/S | Substituted p-diaminobenzene derivatives |
| MXPA05010174A (es) | 2003-04-25 | 2005-11-08 | Lundbeck & Co As H | Derivados de indol e indolina sustituidos. |
| WO2004105795A1 (en) | 2003-05-27 | 2004-12-09 | Altana Pharma Ag | Pharmaceutical combinations of a proton pump inhibitor and a compound which modifies gastrointestinal motility |
| US20050070570A1 (en) | 2003-06-18 | 2005-03-31 | 4Sc Ag | Novel potassium channels modulators |
| JP2007505142A (ja) | 2003-09-10 | 2007-03-08 | セダーズ−シナイ メディカル センター | 血液脳関門を通過する薬剤のカリウムチャネル媒介性送達 |
| AU2004289186B2 (en) * | 2003-09-23 | 2010-12-16 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| US20050089559A1 (en) | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| DE10359335A1 (de) | 2003-10-23 | 2005-05-25 | Viatris Gmbh & Co. Kg | Kombinationen aus Kaliumkanalöffnern und Natriumkanalinhibitoren oder Natriumkanal beeinflussenden Wirkstoffen zur Behandlung von Schmerzzuständen |
| ES2235626B1 (es) | 2003-11-10 | 2006-11-01 | Almirall Prodesfarma, S.A. | Formas de administracion masticables, no comprimidas dosificadas individualmente. |
| TWI349666B (en) | 2004-03-12 | 2011-10-01 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivatives |
| AU2005233642A1 (en) | 2004-04-13 | 2005-10-27 | Astellas Pharma Inc. | Polycyclic pyridines as potassium ion channel modulators |
| RU2006139930A (ru) | 2004-05-03 | 2008-06-10 | Дюк Юниверсити (Сша/Сша) (Us) | Составы для содействия снижению веса |
| UA89503C2 (uk) | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
| CA2589001A1 (en) | 2004-11-19 | 2006-05-26 | Kissei Pharmaceutical Co., Ltd. | Preventive or therapeutic agent for neuropathic pain |
| EP1688141A1 (en) | 2005-01-31 | 2006-08-09 | elbion AG | The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome |
| EP1861394A1 (en) | 2005-03-03 | 2007-12-05 | H.Lundbeck A/S | Substituted pyridine derivatives |
| US7683058B2 (en) | 2005-09-09 | 2010-03-23 | H. Lundbeck A/S | Substituted pyrimidine derivatives |
| SG174095A1 (en) | 2006-08-23 | 2011-09-29 | Valeant Pharmaceuticals Int | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| CN101578259A (zh) | 2006-11-28 | 2009-11-11 | 威朗国际制药公司 | 作为钾通道调节剂的1,4-二氨基双环瑞替加滨类似物 |
-
2007
- 2007-08-22 SG SG2011060944A patent/SG174095A1/en unknown
- 2007-08-22 AU AU2007288253A patent/AU2007288253B2/en active Active
- 2007-08-22 RU RU2009110172/15A patent/RU2009110172A/ru not_active Application Discontinuation
- 2007-08-22 WO PCT/US2007/018571 patent/WO2008024398A2/en not_active Ceased
- 2007-08-22 PT PT78371994T patent/PT2061465E/pt unknown
- 2007-08-22 NZ NZ575652A patent/NZ575652A/en unknown
- 2007-08-22 MX MX2009002002A patent/MX2009002002A/es active IP Right Grant
- 2007-08-22 DK DK07837199.4T patent/DK2061465T3/da active
- 2007-08-22 US US11/894,877 patent/US8293911B2/en active Active
- 2007-08-22 JP JP2009525618A patent/JP5419691B2/ja active Active
- 2007-08-22 CN CNA2007800392650A patent/CN101563085A/zh active Pending
- 2007-08-22 PL PL07837199T patent/PL2061465T3/pl unknown
- 2007-08-22 ES ES07837199T patent/ES2420960T3/es active Active
- 2007-08-22 KR KR1020097005943A patent/KR20090079191A/ko not_active Withdrawn
- 2007-08-22 EP EP07837199.4A patent/EP2061465B1/en active Active
- 2007-08-22 BR BRPI0716715-6A patent/BRPI0716715B1/pt active IP Right Grant
- 2007-08-22 CA CA2661462A patent/CA2661462C/en active Active
- 2007-08-23 CL CL200702455A patent/CL2007002455A1/es unknown
- 2007-08-23 TW TW096131287A patent/TW200827339A/zh unknown
- 2007-08-23 AR ARP070103756A patent/AR062508A1/es unknown
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2009
- 2009-02-22 IL IL197161A patent/IL197161A/en active IP Right Grant
- 2009-03-20 ZA ZA2009/01977A patent/ZA200901977B/en unknown
- 2009-03-20 NO NO20091183A patent/NO343575B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG174095A1 (en) | 2011-09-29 |
| TW200827339A (en) | 2008-07-01 |
| WO2008024398A2 (en) | 2008-02-28 |
| WO2008024398A3 (en) | 2008-06-26 |
| BRPI0716715A2 (pt) | 2013-09-03 |
| US20080139610A1 (en) | 2008-06-12 |
| US8293911B2 (en) | 2012-10-23 |
| PT2061465E (pt) | 2013-07-15 |
| IL197161A (en) | 2015-07-30 |
| EP2061465A4 (en) | 2011-03-16 |
| CN101563085A (zh) | 2009-10-21 |
| NO20091183L (no) | 2009-05-08 |
| AR062508A1 (es) | 2008-11-12 |
| ZA200901977B (en) | 2010-02-24 |
| AU2007288253B2 (en) | 2013-05-02 |
| JP2010501568A (ja) | 2010-01-21 |
| NZ575652A (en) | 2011-08-26 |
| ES2420960T3 (es) | 2013-08-28 |
| IL197161A0 (en) | 2009-12-24 |
| JP5419691B2 (ja) | 2014-02-19 |
| EP2061465A2 (en) | 2009-05-27 |
| PL2061465T3 (pl) | 2014-03-31 |
| CA2661462C (en) | 2015-09-29 |
| CA2661462A1 (en) | 2008-02-28 |
| WO2008024398B1 (en) | 2008-08-14 |
| BRPI0716715B1 (pt) | 2021-07-06 |
| KR20090079191A (ko) | 2009-07-21 |
| DK2061465T3 (da) | 2013-07-08 |
| CL2007002455A1 (es) | 2008-04-18 |
| AU2007288253A1 (en) | 2008-02-28 |
| MX2009002002A (es) | 2009-07-22 |
| NO343575B1 (no) | 2019-04-08 |
| EP2061465B1 (en) | 2013-04-10 |
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| FA93 | Acknowledgement of application withdrawn (no request for examination) |
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